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Studies in Natural Products Chemistry

1st Edition - January 20, 2015

Author: Atta-ur Rahman

Hardback ISBN:

9 7 8 - 0 - 4 4 4 - 6 3 4 6 0 - 3

eBook ISBN:

9 7 8 - 0 - 4 4 4 - 6 3 4 7 0 - 2

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the… Read more

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Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

Contributors
Preface
Chapter 1: Terpenoids and Sterols from Mushrooms
- Abstract
- Keywords
- Introduction
- Sesquiterpenoids
- Triterpenoids
- Sterols
- Meroterpenoids
- Conclusions
- Abbreviations
Chapter 2: From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)
- Abstract
- Keywords
- Introduction
- Neglected Tropical Diseases
- Conclusions
- Abbreviations
Chapter 3: Febrifugine and Its Analogs: Studies for Their Antimalarial and Other Therapeutic Properties
- Abstract
- Keywords
- Introduction
- Discovery
- Structure Elucidation
- Chemical and Physical Properties of Febrifugine
- Synthesis of Febrifugine
- Pharmacology of Febrifugine
- Anticoccidial Activity
- Toxicity
- Febrifugine Analogs
- Halofuginone
- Polypharmacy
- Concluding Remarks
- Acknowledgments
- Abbreviations
Chapter 4: Macrocyclic N-Methylated Cyclic Peptides and Depsipeptides
- Abstract
- Keywords
- Introduction
- Aureobasidins
- Cyclosporins
- Dolastatin
- Didemnins
- Miscellaneous Cyclopeptides and Cyclodepsipeptide
- Conclusion
- Abbreviations
Chapter 5: Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products
- Abstract
- Keywords
- Introduction
- Tubulin/Microtubule-Targeted Anticancer Agents
- Heat Shock Protein 90 Inhibitors as Anticancer Agents
- Histone Deacetylase Inhibitors as Anticancer Agents
- Inhibitors of Tyrosine Kinases as Anticancer Agents
- Inhibitors of Cyclin-Dependent Kinases as Anticancer Agents
- Acknowledgments
- Abbreviations
Chapter 6: Synthetic Aspects of Brassinosteroids
- Abstract
- Keywords
- Introduction
- Methodology
- Natural BS
- Isotopically Labeled BS
- BS Analogs
- Inhibitors of BS Biosynthesis
- Conjugates
- Acknowledgment
- Abbreviations
Chapter 7: The Chemistry and Bioactivity of Macrolides from Marine Microorganisms
- Abstract
- Introduction
- Isolation, Identification, and Biological Activities
- Chemical Synthesis
- Conclusion
- Abbreviations
Chapter 8: Protein Kinase Inhibitors from Microorganisms
- Abstract
- Introduction
- Microbial Alkaloids as Protein Kinase Inhibitors
- Miscellaneous Alkaloidal Kinase Inhibitors (Table 8.2)
- Benzoquinones (Table 8.3)
- Polyphenols and Other Related Compounds (Table 8.4)
- Peptides (Table 8.5)
- Miscellaneous (Table 8.6)
- Concluding Remarks
- Abbreviations
Chapter 9: Possible Anti-Parkinson’s Disease Therapeutics From Nature: A Review
- Abstract
- Introduction
- Anti-PD Activity of Plant-derived Natural Compounds
- Anti-PD Activity of Crude/Semipurified Plant Extracts/Fractions
- Anti-PD Herbal Formulations
- Discussion
- Concluding Remarks
- Abbreviations
Index