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Studies in Natural Products Chemistry
1st Edition - January 20, 2015
Author: Atta-ur Rahman
Hardback ISBN:9780444634603
9 7 8 - 0 - 4 4 4 - 6 3 4 6 0 - 3
eBook ISBN:9780444634702
9 7 8 - 0 - 4 4 4 - 6 3 4 7 0 - 2
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the… Read more
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Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Focuses on the chemistry of bioactive natural products
Contains contributions by leading authorities in the field
Presents sources of new pharmacophores
Natural product chemists, medicinal chemists, pharmacologists as well as researchers, particularly those in academia and in the pharmaceutical industry
Contributors
Preface
Chapter 1: Terpenoids and Sterols from Mushrooms
Abstract
Keywords
Introduction
Sesquiterpenoids
Triterpenoids
Sterols
Meroterpenoids
Conclusions
Abbreviations
Chapter 2: From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)
Abstract
Keywords
Introduction
Neglected Tropical Diseases
Conclusions
Abbreviations
Chapter 3: Febrifugine and Its Analogs: Studies for Their Antimalarial and Other Therapeutic Properties
Abstract
Keywords
Introduction
Discovery
Structure Elucidation
Chemical and Physical Properties of Febrifugine
Synthesis of Febrifugine
Pharmacology of Febrifugine
Anticoccidial Activity
Toxicity
Febrifugine Analogs
Halofuginone
Polypharmacy
Concluding Remarks
Acknowledgments
Abbreviations
Chapter 4: Macrocyclic N-Methylated Cyclic Peptides and Depsipeptides
Abstract
Keywords
Introduction
Aureobasidins
Cyclosporins
Dolastatin
Didemnins
Miscellaneous Cyclopeptides and Cyclodepsipeptide
Conclusion
Abbreviations
Chapter 5: Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products
Abstract
Keywords
Introduction
Tubulin/Microtubule-Targeted Anticancer Agents
Heat Shock Protein 90 Inhibitors as Anticancer Agents
Histone Deacetylase Inhibitors as Anticancer Agents
Inhibitors of Tyrosine Kinases as Anticancer Agents
Inhibitors of Cyclin-Dependent Kinases as Anticancer Agents
Acknowledgments
Abbreviations
Chapter 6: Synthetic Aspects of Brassinosteroids
Abstract
Keywords
Introduction
Methodology
Natural BS
Isotopically Labeled BS
BS Analogs
Inhibitors of BS Biosynthesis
Conjugates
Acknowledgment
Abbreviations
Chapter 7: The Chemistry and Bioactivity of Macrolides from Marine Microorganisms
Abstract
Introduction
Isolation, Identification, and Biological Activities
Chemical Synthesis
Conclusion
Abbreviations
Chapter 8: Protein Kinase Inhibitors from Microorganisms
Polyphenols and Other Related Compounds (Table 8.4)
Peptides (Table 8.5)
Miscellaneous (Table 8.6)
Concluding Remarks
Abbreviations
Chapter 9: Possible Anti-Parkinson’s Disease Therapeutics From Nature: A Review
Abstract
Introduction
Anti-PD Activity of Plant-derived Natural Compounds
Anti-PD Activity of Crude/Semipurified Plant Extracts/Fractions
Anti-PD Herbal Formulations
Discussion
Concluding Remarks
Abbreviations
Index
No. of pages: 552
Language: English
Published: January 20, 2015
Imprint: Elsevier
Hardback ISBN: 9780444634603
eBook ISBN: 9780444634702
AR
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan