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Elsevier

Books in Life sciences

  • Ingredient X

    The Production of Effective Drugs
    • 1st Edition
    • Louis C. Schroeter
    • English
    Ingredient X: The Production of Effective Drugs deals with various aspects of pharmaceutical research and development, with emphasis on the importance of formulation ingredients on drug effectiveness and the role of the pharmaceutical development scientist in designing dosage forms for modern drugs. More than 50 illustrations are used to explain experiments and ""tools of the trade"". This book is comprised of four chapters and opens with an overview of research and development in the pharmaceutical industry, paying particular attention to the kind of work done by scientists according to the degree or level of training. The additives or so-called ""inert"" ingredients used in drug formulation are also considered. The next chapter explains how adding just the right amount of some ""inert"" ingredient—a factor X—can enhance the acceptability of a product to the user. The importance of maintaining drug potency in a dosage form, mainly through refrigeration or storage in cool places, is then discussed. The final chapter looks at the factors to consider to achieve the best possible drug formulation and most effective dosage form, including the safety factor. The need to establish correlations between laboratory quality tests and product performance during the development phase is highlighted. This monograph will be a useful resource for pharmacologists and pharmaceutical development scientists.

  • Fundamentals of Biochemical Pharmacology

    • 1st Edition
    • Z. M. Bacq
    • English
    Fundamentals of Biochemical Pharmacology is a basic introduction to the fundamental aspects of pharmacology. It explains the molecular aspects of drugs, as well as the different biochemical systems and cellular strategies that they cause. The book is divided into two sections, the first of which covers physiochemical methods, histological methods, and physiological methods. The second section covers biochemical lesions; functions of subcellular structures; transfer of ions and molecules across cellular membrane; pharmacokinetics; drug receptor interactions; effects of drugs on structure; biosynthesis; catabolism; and biotransformation of drugs. The book is a good reference for pharmacology students who are learning about the the basic underlying concepts of biochemical pharmacology. It will also appeal to researchers with a background in chemistry, biochemistry, biology, microbiology, botany, or zoology.

  • Neurobiology of Motor Programme Selection

    New Approaches to the Study of Behavioural Choice
    • 1st Edition
    • J. Kien + 2 more
    • English
    The traditional view of motor systems as a linear chain of elements switched on and off by command neurons has become increasingly difficult to maintain in the face of accumulating evidence against the existence of command elements. So far, however, the general formulation of an alternative approach has been lacking. This book, by summarising the evidence against the linear approach to motor systems, argues forcefully against it. Analyses are presented of motor systems ranging from the lobster stomatogastric system through molluscan systems, leech movement, insect singing and locomotion, fish and amphibian behaviour, to goal-directed a movements in primates and volitional movements in humans. Comparison of these motor systems reveal the existence of some general principles underlying motor control and behavioural choice such that motor systems appear generally to be parallel, distributed processing networks. By discussing the treatment of motor systems in terms of parallel distributed processing systems, this book presents in concentrated form an alternative to the earlier view of motor systems. As such, the book is a must for all neuroscientists interested in the organisation of motor systems and the neuronal substrates of behavioural choice.

  • Plate Tectonics & Crustal Evolution

    • 2nd Edition
    • Kent C. Condie
    • English
    Plate Tectonics & Crustal Evolution, Second Edition covers the role of plate tectonics in the geologic past in light of existing geologic evidence, and examples of plate reconstructions. The book discusses the important physical and chemical properties of the crust and upper mantle in terms of models for crustal origin and evolution. The text also describes sea-floor spreading; magma associations; plate tectonics and continental drift. The phanerozoic orogenic systems and the precambrian crustal development are also tackled. The book will be invaluable to students in the earth sciences and to various specialists in the geological sciences.

  • An Atlas of the Commoner Skin Diseases

    With 153 Plates Reproduced by Direct Colour Photography from the Living Subject
    • 5th Edition
    • Henry C. G. Semon
    • English
    An Atlas of the Commoner Skin Diseases focuses on dermatoses most frequently observed in the routine outpatient practice. The book provides abbreviated clinical descriptions, diagnosis, and prognosis, as well as outline of treatment. The book first offers information on the differential diagnosis and treatment of acne and its variants, alopecia areata, cellulitis, cheiropompholyx, and chilblains. The text also ponders on the diagnosis, treatment, and prophylaxis of dermatitis and its variants. The publication also takes a look at the treatment, antihistaminic agents, and psychotherapy of eczema and its variants, differential diagnosis, prognosis, and treatment of epithelioma and its variants, and the diagnosis and treatment of erythema induratum and its variants. The manuscript also takes a look at the prognosis and treatment of granuloma and its variants, herpes zoster, impetigo, lichen planus, neurodermatitis and its variants, and psoriasis. The manuscript is a dependable reference for readers interested in the commoner disease.

  • Human Ecology in the Tropics

    Symposia of The Society for The Study of Human Biology
    • 1st Edition
    • J. P. Garlick + 1 more
    • English
    Symposia of the Society for the Study of Human Biology, Volume 9: Human Ecology in the Tropics covers papers related to the impact of human on the natural ecosystems in tropical countries. The volume presents papers about the operation of typical plant-soil systems in relation to human activity in West Africa; the interrelationships of habitat, economy, and society among three Guiana people; tropical health; and the use and production of tropical food potentials. The book also describes papers about the ecology of African schistosomiasis, as well as the interaction between the trypanosome-tsetse-w... fauna ecosystem and the surrounding human communities of southern Busoga in Uganda. The volume concludes by discussing the development of young children in a West African village. Ecologists and biologists will find the book invaluable.

  • Mechanisms of Animal Discrimination Learning

    • 1st Edition
    • N. S. Sutherland + 1 more
    • English
    Mechanisms of Animal Discrimination Learning provides a review of the field of animal discrimination learning, with discussions into other areas such as generalization, partial reinforcement, and some aspects of comparative psychology. This book elaborates the origins of continuity-noncontin... controversy, analysis of attentional learning, Lashley and Wade's account of generalization, and evidence for a two-process analysis of the ORE. The reversal and nonreversal shifts, response unit hypothesis, inconsistent reinforcement and extinction of choice behavior, and aims and problems of comparative psychology are likewise described This text likewise covers the Zeaman and House model, Lovejoy's Model III, determinants of generalization gradients, cognitive dissonance hypothesis, and theoretical relevance of comparative psychology. This publication is a good source for biologists and researchers concerned with animal discrimination learning.

  • The Principal Diseases of Lower Vertebrates

    • 1st Edition
    • H. Reichenbach-Klinke + 1 more
    • English
    The Principal Diseases of Lower Vertebrates presents the material published by Heinz H. Reichenbach-Klinke between 1957 and 1962 in three separate volumes as ""Krankheiten der Aquarienfische"" (Alfred Kernen, Stuttgart), ""Krankheiten der Amphibien,"" and ""Krankheiten der Reptilien"" (Gustav Fischer, Stuttgart). The scope of the work has been enlarged with material contributed by E. Elkan who has also done the translation. Representatives of the main groups of parasites affecting fish have been presented as far as possible. The book is organized into three parts covering the diseases of fishes, amphibians, and reptiles. Experience has shown that those who keep, or are interested in, one kind of lower vertebrate will sooner or later also take an interest in one of the other groups. It was therefore thought expedient to include what is at present known of lower vertebrate pathology in one volume, even at the risk of some repetition where fishes, amphibians, and reptiles suffer from similar diseases or are the victims of identical parasites.

  • Studies in Neurolinguistics

    • 1st Edition
    • Haiganoosh Whitaker + 1 more
    • English
    Studies in Neurolinguistics, Volume 3 presents detailed case histories, multi-subject experimental studies, literature reviews, and research papers that employ a variety of experimental and observational techniques. This volume contains seven chapters that focus on a wide range of research in the field of neurolinguistics. Chapter 1 discusses the various approaches to the problem of auditory comprehension in aphasia. A survey of the world's literature on bilingualism and aphasia is provided in chapter 2. The third chapter examines the different models and explanations for conduction aphasia. Chapter 4 provides a synthesis of the anatomic, physiologic, and behavioral research on the role of the limbic system in human communication. Chapter 5 presents a model of individual differences in hemispheric functioning, in which a number of theories about the left and right hemispheres are analyzed and compared. Chapter 6 shows how different levels of language are revealed. The last chapter addresses "The Question of Electrophysiological Asymmetries Preceding Speech" in a study of the readiness potentials over the motor and premotor regions in eight subjects. Linguists, psychologists, and neurologists will find the book highly informative.

  • Herbal Simples

    Approved for Modern Uses of Cure
    • 2nd Edition
    • W. T. Fernie
    • English
    Herbal Simples Approved for Modern Uses of Cure, Second Edition considers the medical nature of herbal simples based on accurate and precise chemical analysis. This book examines the positive remedial actions of numerous herbal plants in terms of their chemical constituents and their curing capacity. Leading herbal simples are reviewed alphabetically, and to ensure accuracy, the genus and species of each plant are particularized. This text reconsiders those safe and sound herbal curative remedies and medicine that were formerly most in vogue as homely simples, whether to be taken or to be outwardly applied. The issue of whether the herbal simples be employed as auxiliaries by the physician in attendance or are welcomed for prompt service in a household emergency is discussed. This book will be of great value to biologists, herbalists, and research workers in the fields related to herbal medicines.

  • Progress in Theoretical Biology

    Volume 5
    • 1st Edition
    • Robert J. Rosen + 1 more
    • English
    Progress in Theoretical Biology, Volume 5 covers the developments in theoretical biology. The book discusses the dynamic behaviors exhibited by cellular control circuits and the role of the cell as a morphogenetic and physiological unit; the stable dynamics of genetic networks; and the organization principles and models of the function of the simplest genetic systems controlling ontogenesis. The text also describes the conceptual framework shifts in immunogenetics: the anatomy of the Ag system; the basic problems of memory in behavioural and developmental biology; and the self-organization and performance of sensory-motor codes, maps, and plans. Physiologists, biophysicists, geneticists, mathematicians, and cytologists will find the book useful.

  • Mitochondrial Dysfunction

    Methods in Toxicology, Vol. 2
    • 1st Edition
    • Lawrence H. Lash + 1 more
    • English
    Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

  • Pharmacology of Conditioning, Learning and Retention

    Proceedings of the Second International Pharmacological Meeting
    • 1st Edition
    • M. Ya. Mikhel'son + 1 more
    • English
    Proceedings of the Second International Pharmacological Meeting, Volume 1: Pharmacology of Conditioning, Learning and Retention is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This book is organized into two sections encompassing 28 chapters. The first section defines the main problem in psychopharmacology, which is the establishment of methods that will enable to appreciate in animals the value of psychotropic drugs in the therapy of human mental diseases. This section also describes the specific activation of the central nervous system and its significance in psychopharmacologica... research. The second section explores the electrophysiological phenomena observed during pharmacological conditioning, with emphasis on the modifications of electrical activity during the establishment and the performance of the conditioned responses. This section also deals with the electrical correlated of various kinds of conditioned behavior in animals and the alterations of spontaneous rhythm and evoked potentials. This book is of value to psychopharmacologist... and electrophysiologists...

  • Pharmacology of Cardiac Function

    Section of Pharmacology of the International Union of Physiological Sciences
    • 1st Edition
    • Otto Krayer
    • English
    Pharmacology of Cardiac Function brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of cardiac function and addressed topics ranging from the link between muscle physiology and the heart to the development of tension in cardiac muscle. This volume is comprised of 21 chapters and begins with an overview of the structural aspects of contraction in cardiac and skeletal muscle, followed by a description of muscle physiology and its effect on the heart. The next section deals with the effects of drugs on the interval-strength relationship of heart muscle, paying particular attention to acetylstrophanthidin... levarterenol, and carbacliol as well as metabolic inhibitors. The nature of the restitution process occurring between beats in cardiac muscle is also considered. Subsequent chapters explore how the heart is affected by the action of the vagus and of acetylcholine and other parasympathomimetic drugs; membrane effects of epinephrine and digitalis; and the mode of action of antifibrillatory drugs. This book will be of particular value to pharmacologists and physiologists.

  • Anabolic Steroids

    • 1st Edition
    • H.-L. Krüskemper
    • English
    Anabolic Steroids attempts to trace the development of anabolic steroids in the chemical, experimental biological, and clinical disciplines, and presents a precise outline of the current state of substantiated knowledge. This book deals with anabolic steroids derived from natural androgens and characterized by their stimulatory action on the biosynthesis of tissue protein and by their simultaneous low androgenicity. The biochemical part is a review of substantiated and current knowledge based largely on experimental results with animals, while the clinical part attempts to bring out the pathophysiological rationale of therapy with anabolic steroids, again based on experimental data. The book begins with a discussion of the nomenclature and chemistry of anabolic steroids. This is followed by separate chapters on the metabolism, activities, and mechanism of action of anabolic steroids; clinical application of anabolic steroids, side effects, and test procedures.

  • The Common Liver Fluke

    Fasciola Bepatica L.
    • 1st Edition
    • E. M. Pantelouris
    • G. A. Kerkut
    • English
    The Common Liver Fluke: Fasciola hepatica L. emphasizes the biological, physiological, pathological, and ecology and control of the common liver fluke. The book provides a thorough review of the life of the animal, from its bodily structure to where it thrives. Since this animal can also cause disease, both in livestock and humans, a detailed discussion on its control are also provided.

  • Progress in Chemical Toxicology

    Volume 1
    • 1st Edition
    • Abraham Stolman
    • English
    Progress in Chemical Toxicology, Volume 1 covers the developments in toxicology, including the usefulness of the developed techniques and methods with necessary modifications for toxicological studies. The book describes the isolation and separation techniques for the identification of poisons; the application of gas chromatograph to toxicology; and the pharmacological and toxicological effects aliphatic alcohols. The text also discusses the isolation, purification, identication, and the toxicology of acidic and neutral poisons, ataraxics and nonbarbiturate sedatives. The determination of antiarthritics, antihistamines, and thymoleptics; the physicochemical properties for the identification of narcotics and related bases; and the toxicity of air pollutants are also considered. The book further tackles the analytical methods for air pollutants; the occurrence, symptoms, and treatment of mushroom poisoning; and the toxic components of poisonous seeds and fruits poisonous seeds and fruits. Toxicologists, chemists, and scientists in forensic science laboratories will find the text invaluable.

  • Microsomes and Drug Oxidations

    • 1st Edition
    • James R. Gillette + 2 more
    • English
    Microsomes and Drug Oxidations documents the proceedings of symposium on microsomes and drug oxidations held at Bethesda, Maryland, 16-17 February 1968. The theme of the symposium centered on the morphology of the liver endoplasmic reticulum, the localization of enzyme systems, the mechanisms for regulating enzyme activity, and the mechanisms of enzyme action. The results of this symposium presented in this book illustrate the complexity of the enzyme systems under investigation and the multiplicity of the variables altering their function. It is hoped the information presented will serve as a stimulus to other investigators in the elucidation of these problems. The book contains 27 papers organized into four parts. The papers in Part I examine the morphological and biochemical characteristics of microsomes. Part II presents studies on electron transfer components. Part III examines alterations of microsomal enzymes while Part IV focuses on drugs and protein synthesis.

  • Genetics in Aquaculture

    Proceedings of the Fourth International Symposium on Genetics in Aquaculture
    • 1st Edition
    • Graham A.E. Gall + 1 more
    • English
    This volume, the proceedings of the Fourth International Symposium on Genetics in Aquaculture, builds on the foundations laid down at the first symposium, held in Galway, Ireland in 1982 (Aquaculture, Volume 33), as well as those laid down at the second, held in Davis, California, USA in 1985 (Genetics in Aquaculture II), and the third, held in Trondheim, Norway in 1988 (Genetics in Aquaculture III). It addresses specific problems and developments in this field, demonstrating the tremendous breadth of research activity as well as the complexity of issues in aquaculture genetics. This book will be of great value to aquaculturists, fisheries scientists and marine biologists.(The above-mentioned proceedings of the first three conferences are still available).

  • Recent Progress in Hormone Research - Volume 49

    Proceedings of the 1992 Laurentian Hormone Conference
    • 1st Edition
    • C. Wayne Bardin
    • English
    Among the topics covered in Volume 49 are neurotransmitter transporters circadian rhythms, transgenic model for studying isles development, protein phosphateses, the androgen receptor, molecular genetics of steroid 5oz-reductases and benign and malignant prostatic neoplasms.

  • Drugs and Enzymes

    Proceedings of The Second International Pharmacological Meeting, Vol. 4
    • 1st Edition
    • Bernard B. Brodie + 1 more
    • English
    Second International Pharmacological Meeting, Volume 4: Drugs and Enzymes is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This volume is organized into two sections encompassing 41 chapters. The first section discusses the relationship between biochemical effects of drugs in vitro and their pharmacological effect in vivo. This section specifically examines the correlation between the action of substances on isolated smooth muscle and on the central nervous system, as well as the behavior of a centrally-acting drug and enzyme in the ion movement in the system. The second section surveys the biochemical mechanisms of drug toxicity. Considerable chapters in this section are devoted to the effect of drug toxicity, such as altered drug metabolism, enzyme induction, morphological changes, hepatic effects, and photosensitivity. This book will prove useful to pharmacologists, neurologists, biochemists, and researchers who are interested the fields of drugs and drug toxicity.

  • General Botany

    • 1st Edition
    • Wilhelm Nultsch
    • English
    General Botany covers certain aspects of general botany, such as morphology, anatomy, and histology. The book discusses the molecular constitution of plants; the structural constitution of the protoplasm, the cell, and the cytoplasm; and the differentiation of the cell. The text also describes the types of organization in plants; the internal and external structure of the stem, the leaf, and the root; and water and salt balance, with regard to the translocation of materials. The energy procurement and the synthetic processes in autotrophic plants; the respiration and energy transformations; and nitrogen metabolism are also considered. The book further tackles heterotrophy; reproduction; heredity; development; and the movement of plants. Botanists, cytologists, plant physiologists, and students taking related courses will find the text invaluable.

  • Field and Laboratory Guide to Tree Pathology

    • 2nd Edition
    • Robert O. Blanchard + 1 more
    • English
    The Second Edition of this classic text is completely up-to-date with new chapters, new information on diseases, updated citations, and revised taxonomy and terminology of the fungi, bacteria, and other organisms that affect trees. Field and Laboratory Guide to Tree Pathology presents field and laboratory techniques as well as basic information for students, foresters, plant scientists, and arboriculturalists on tree disease pathology. The revised edition includes expanded historical documentation, updated taxonomy and terminology for both pests and diseases, an entirely new introduction, new chapters on tree biology, general control strategies, and diagnostic techniques. A new section of color plates will help readers in the identification of tree pathogens. All the references have been comprehensively updated, and the exercises included for students have been revised, making this guide a useful tool for students, teachers, and practitioners interested in tree disease.

  • Specific Heart Muscle Disease

    • 1st Edition
    • Cecil Symons + 2 more
    • English
    Specific Heart Muscle Disease presents the primary syndromes in which heart muscle disease is an intrinsic part of another clinical syndrome. This book discusses the cardiomyopathies and shows how they are related to the different forms of specific heart muscle disease. Organized into 11 chapters, this book begins with an overview of the recognition of the various types of cardiomyopathy based on a detailed analysis of function and structure. This text then examines the structure of the amyloid fibril and the pattern of deposition of it in the body. Other chapters consider the possible link between endomyocardial disease and adherent thrombi. This book discusses as well the therapeutic measures to remove the majority of the iron load in hemochromatosis. The final chapter deals with the survival rates in cardiac transplantation and reviews some of the homograft pathology affecting survival in long-term cardiac recipients. This book is a valuable resource for cardiologists and general physicians.

  • Life Sciences and Space Research

    Proceedings of the Open Meeting of the Working Group on Space Biology of the Twenty-Second Plenary Meeting of COSPAR, Bangalore, India, 29 May - 9 June 1979
    • 1st Edition
    • R. Holmquist
    • English
    Life Sciences and Space Research, Volume XVIII is a collection of articles on space biology. The book describes the presence of organic molecules found in interstellar space, comets, and meteorites. The text also addresses the role of comets in giving rise to new studies in cometary chemistry, as the source of plasma, or as supplying the mechanism for the formation of amino acids, glycine, and guanine. One paper addresses the possibility of life on the planet Mars touching on chemical reactions of nutrient compound decay and other physio-chemical changes. The book also notes the contribution of cometary volatiles to the study of the primitive earth plus the possible role of metal ions and clays in prebiotic chemistry. Other papers discuss radiation biology concerning both radiobiological results from experiments done in spaceflight and ground laboratories such as the degeneration of rabbit tissues after heavy irradiation. The book then evaluates gravitational biology, including topics such as physiological reactions during acute adaptation to reduced gravity; land plant evolution and gravity; and the development of Polyporus brumalis basidomycete, a kind of fungi, in conditions of weightlessness. Molecular biologists, space engineers, biologists, meteorologists, and genetic engineers will find this book highly valuable.

  • Protides of the Biological Fluids

    Proceedings of the Eighteenth Colloquium, Bruges, 1970
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids contains the proceedings of the XVIIIth Colloquium held in Bruges, Belgium in 1970. The papers focus on protides of the biological fluids, with emphasis on three main topics related to protein chemistry: proteins during development and the recurrence of fetal proteins in cancer; protein-protein interactions; and trends and technical refinements in the insolubilization of proteins. This book is comprised of 95 chapters and begins with an assessment of the relationships and functions of the apoprotein and lipid moieties of lipoproteins, followed by a discussion on the characteristics and structure of the alpha-fetoproteins. The protein patterns in the post-natal period, as well as specific patterns encountered during development of the various organs, are then considered. Subsequent chapters explore the recurrence of various fetoproteins in hepatoma and in tumors of the digestive system; protein-protein interactions occurring during association or aggregation of some proteins such as myosin, fibrin, and casein; and preparation of insolubilized enzymes, together with the isolation and purification of antibodies. The final section is devoted to immunological studies and methods such as thin-layer ultracentrifugation. This monograph will be a useful resource for biologists and chemists alike.

  • Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System

    Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978
    • 1st Edition
    • Vincenzo Zappia + 2 more
    • English
    Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System contains the proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System held in Naples, Italy, on May 2, 1978. The papers explore the biochemical and pharmacological roles of S-adenosylmethionine (SAM), with particular emphasis on its functions in the central nervous system (CNS). This book consists of 13 chapters and opens with an introduction to some novel biochemical aspects of SAM and related sulfur compounds, paying particular attention to transmethylation reactions; polyamine biosynthesis and unusual biological roles of adenosylmethionine; metabolic pathways related to adenosine-sulfur compounds; and transport of adenosylmethionine. The following chapters discuss a number of chemical and biochemical properties of SAM as well as its pharmacological aspects within the CNS. The relation between folate and adenosylmethionine metabolism in the brain is examined, along with the effect of SAM administration on noradrenaline and serotonin metabolism in rat brain; cerebral utilization of adenosylmethionine and adenosylhomocysteine... and antidepressant effects of adenosylmethionine. Methylation in schizophrenia is also considered. This monograph will be a valuable source of information for biochemists and pharmacologists.

  • Business of Biotechnology

    From the Bench to the Street
    • 1st Edition
    • R. Ono
    • English
    The Business of Biotechnology: From the Bench to the Street thoroughly examines the existing and future business challenges for biotechnology, providing a unique insight into the intricate web of critical factors with which biotechnology entrepreneurs must come to terms if they wish to be successful. The book begins with discussions of the evolution of biotechnology; entrepreneurship in the biotechnology industry; university-industry technology transfer process; and the life cycle of a biotechnology company. It considers the prospects for biotechnology, from the perspective of a venture capitalist and human resource practitioner. There are separate chapters that deal with the cloning and expression of recombinant gene products; developing strategies to reduce the cost-to-produce (CTP) therapeutic proteins; intellectual property protection; and the regulation of commercial biotechnology. The final chapters cover the marketing of biotechnology companies and products; the performance of biotechnology stocks; mergers and acquisitions in the biotechnology industry, and prospects for the Japanese and European biotechnology industry.

  • Neuro-psychopharmacology

    Proceedings of the Tenth Congress of the Collegium Internationale Neuro-Psychopharmacologicum Québec, July 4-9, 1976
    • 1st Edition
    • P. Deniker + 2 more
    • English

  • Prostanoids

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • Valéria Kecskeméti
    • English
    Prostanoids, Volume VI, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Prostaglandin research is an exciting and rapidly developing field in chemical and biological sciences. It is the recently discovered prostacyclin that has brought about a breakthrough in prostaglandin research giving new impetus to clinical investigation. This volume contains 22 papers read at the ""Prostanoids Symposium"" by participants from eight different countries. Numerous new data concerning the synthesis of prostacyclin and different stable prostacyclin analogues are presented. Besides the problems of synthetic chemistry, data are given about the pharmacological properties of these prostacyclin analogues, analyzing their effects on heat and smooth muscles. Several papers dealing with the involvement of different pharmacologically active agents and hormones in the biosynthesis of prostaglandins emphasize the important role of prostanoids in various pathophysiological processes and diseases. The clinical use of prostacyclin, having already earned an outstanding position in medicine, is stressed.

  • Novel Approaches to Cancer Chemotherapy

    • 1st Edition
    • Prasad S. Sunkara
    • English
    Novel Approaches to Cancer Chemotherapy compiles theories in tumor biology, emphasizing their potential use in developing therapeutic approaches to cancer therapy. This book emphasizes the unique property of a cancer cell and describes in detail how a novel therapeutic approach can be developed. This compilation consists of 11 chapters. Chapters 1, 2, 5, 6, and 7 deal with emerging areas of cancer therapy, such as the use of interferon, monoclonal antibodies, liposomes, lymphokines, and immunomodulators. The rest of the chapters cover some of the biochemical and enzyme targets in cancer cells, such as polyamines, prostaglandin, thromboxane, leukotrienes, 5a-reductase, aromatase, cell membrane glycoproteins, and sodium flux. The developments in relation to cancer therapy are mentioned in chapters dealing with biochemical approaches. This book is valuable to biologists, biochemists, immunologists, and molecular biologists intending to exploit the unique properties of cancer cells.

  • Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism

    Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985
    • 1st Edition
    • E. S. Vizi + 2 more
    • English
    Advances in Pharmacological Research and Practice, Volume 2: Receptors and Centrally Acting Drugs presents the proceeding of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the developments in the fields of receptors and centrally acting drugs as well as in pharmacokinetics and drug metabolism. Organized into two sections encompassing 25 chapters, this volume begins with an overview of prejunctional regulation of neuromuscular transmission. This text then explores the whole-body autoradiography that is used extensively in toxicological research and screening. Other chapters consider the three major classes of models used in pharmacokinetics. This book discusses as well the various aspects of melanin–drug interactions. The final chapter deals with the investigation on the melanin affinity of amphetamine derivatives. This book is a valuable resource for pharmacologists, pharmacokineticists, and researchers.

  • Membrane Fluidity in Biology

    Cellular Aspects
    • 1st Edition
    • Roland C. Aloia + 1 more
    • English
    Membrane Fluidity in Biology, Volume 4: Cellular Aspects provides a unique interpretation of membrane and cellular activity, as well as cellular aspects of membrane fluidity. This book discusses the influence of membrane fluidity on enzyme activity, function of the sarcoplasmic reticulum in skeletal muscle, role of cholesterol in membrane function, phospholipid methylation, glycosyltransferases... and membrane fusion. The realm of normal cellular function and mechanisms involved in the modulation of cellular function by membrane lipids are also elaborated in this publication. This volume is intended for cell and molecular biologists and clinical-medical scientists, but is also beneficial to individuals researching on the effects of membrane lipids and fluidity in cellular function.

  • Hormones and the Fetus

    • 1st Edition
    • J. R. Pasqualini + 2 more
    • English
    Volume One of Hormones and the Fetus contained a generalization of the role of hormones during fetal life. In this second volume, the main topics focus on hormonal binding to fetal and maternal plasma proteins, amniotic fluid and placenta; the presence of hormone receptors in the fetal compartment; and the mechanism of action of various hormones in different target tissues of the fetus and placenta. This up-to-date information is of major importance in the study of hormonal activity in fetal life, and the biological effect of hormones through the receptor. The mechanism of fetal sexual differentiation, in which hormones play an important role, is extensively covered.

  • Oogenesis

    The Storage of Developmental Information
    • 1st Edition
    • Chr. P. Raven
    • G. A. Kerkut
    • English
    International Series of Monographs on Pure and Applied Biology, Volume 10: Oogenesis: The Storage of Developmental Information focuses on the processes, reactions, and transformations involved in oogenesis. The book first offers information on embryonic development as a communication problem, formation of the egg cells, and the egg nucleus during oogenesis. Topics include decoding of developmental information, egg membranes, oogenesis, phase of nuclear activity, cytochemistry of the nucleus, and the egg cell. The manuscript also ponders on the cytoplasm and its inclusions and the relationships between the egg cell and the auxiliary cells. The text elaborates on the metabolism of the oocyte, cortex, and polarity and symmetry. The book also examines the storage of developmental information and information theory and biology. Genotypical information, physical foundation of developmental biology, and information and finality are discussed. The manuscript is a dependable reference for readers interested in oogenesis.

  • Flash Photolysis and Pulse Radiolysis

    Contributions to the Chemistry of Biology and Medicine
    • 1st Edition
    • R. V. Bensasson + 2 more
    • English
    Flash Photolysis and Pulse Radiolysis: Contributions to the Chemistry of Biology and Medicine presents the interaction of radiation with biomolecules, which is either beneficial o deleterious to life. This book discusses the biochemical reactions that are not radiation-induced by selectively generating certain types of free radicals present in normal metabolic processes. Organized into nine chapters, this book begins with an overview of the principle of both pulse radiolysis and flash photolysis with photoelectric detection. This text then examines the applications of flash photolysis and pulse radiolysis to the chlorophylls, bile pigments, hemoglobin and myoglobin, and the porphyrins. Other chapters consider the carotenoids related to photosynthesis. This book discusses as well the role of proteins in nearly all biological processes, including enzymatic catalysis, muscular contraction, immune protection, mechanical support, and genetic information. The final chapter deals with the structures and importance of radiosensitizers. This book is a valuable resource for chemists and biochemists.

  • The Science of Food

    An Introduction to Food Science, Nutrition and Microbiology
    • 2nd Edition
    • P. M. Gaman + 1 more
    • English
    The Science of Food: An Introduction to Food Science, Nutrition and Microbiology, Second Edition conveys basic scientific facts and principles, necessary for the understanding of food science, nutrition, and microbiology. Organized into 17 chapters, this book begins with a discussion on measurement, metrication, basic chemistry, and organic chemistry of foods. Nutrients such as carbohydrates, fats, proteins, vitamins, mineral elements, and water in food are then described. The book also covers aspects of food poisoning, food spoilage, and food preservation. This book will be useful to students following TEC diploma courses in Catering, Home Economics, Food Science, FoodTechnology, Dietetics, and Nutrition.

  • Structure and Ultrastructure of Microorganisms

    An Introduction to a Comparative Substructural Anatomy of Cellular Organization
    • 1st Edition
    • E. M. Brieger
    • English
    Structure and Ultrastructure of Microorganisms: An Introduction to a Comparative Substructural Anatomy of Cellular Organization presents the structure or principle of operation of the electron microscope. This book provides an introduction to the submicroscopical anatomy of the cell in ultrathin sections of tissues or of single-cell organisms. Organized into 30 chapters, this book begins with an overview of the structures discovered by the use of an optical tool for observation. This text then examines the anatomical principle to the nucleus. Other chapters consider the structural organization of chromatin as revealed in electron micrographs of thin sections through cells in different stages of division. This book discusses as well the macronuclei of the ciliates, which plays a significant part in the reproductive mechanism. The final chapter deals with the micromolecular organization of bacterial flagella. This book is a valuable resource for scientists, biologist, physicists, protozoologists, cytologists, biochemists, biophysicists, and research workers.

  • Drugs and Driving

    • 1st Edition
    • Herbert Moskowitz
    • English
    Drugs and Driving is a compendium of papers from a symposium of the same title presented at the U.S. Transportation Research Board. This collection reviews the effects of five classes of drugs on driving (amphetamines, tranquilizers, barbiturates, narcotics, cannabis), the other studies being made on drugs and driving, as well as some countermeasure programs against drunk driving. The papers report that amphetamines can induce risky driving behavior, tranquilizers can increase traffic accident risks, barbiturates can degrade driving skills especially when the drug is combined with alcohol, while marijuana use can impair important driving skills. Another paper evaluates drug use and driving risk among high school students in Toronto: results show that the total effect of infrequent use of drugs on accidents is small compared to alcohol use. A study of out-patients in Finland notes that the combined used of alcohol and drugs tend to increase accident frequency. One paper refutes that Alcohol Safety Action Programs in the United States are ineffective. This collection can be helpful for sociologist, psychologists, psychiatrists, traffic safety officers, and heads of urban safety and traffic divisions.

  • Principles of Bone X-Ray Diagnosis

    • 2nd Edition
    • George Simon
    • English
    Principles of Bone X-Ray Diagnosis follows the method set by Principles of Chest X-ray Diagnosis (Simon, 1956) in placing more value in the grouping of x-ray material according to the type of x-ray shadow rather than the clinical disease label. Biochemical and hematological values quoted throughout the book, especially in the captions to figures, are all from the Department of Pathology, St. Bartholomew's Hospital. This book is organized into 12 chapters. Much of the original text has been used in this third edition, though some changes of order have been made to give a more logical approach to the description of the bone changes seen in various diseases. A chapter on widespread and regional reduction in bone density has been completely rewritten. This volume provides radiographs to illustrate every condition described. These radiographs were selected to illustrate the principles of bone x-ray diagnosis rather than to make a complete catalogue of all the conditions referred. This book will be of interest to persons dealing with studies on the diagnostic value of bone x-ray.

  • Synthetic Pyrethroids and Other Pesticides

    Analytical Methods for Pesticides and Plant Growth Regulators, Vol. 13
    • 1st Edition
    • Gunter Zweig + 1 more
    • English
    Analytical Methods for Pesticides and Plant Growth Regulators, Volume XIII: Synthetic Pyrethroids and Other Pesticides covers the important role of the synthetic pyrethroids as pesticides. The book discusses discussion the analytical methods used for synthetic pyrethroids. The text describes analytical methods for carbaryl, diflubenzuron, asulam, betasan, diuron, eptam, fluometuron, propanil, and Sutan. A detailed description of methods of analysis for technical-grade products, formulations, and residues of pesticides is also provided. Toxicologists and people involved in the analysis of pesticide formulations will find the book invaluable.

  • Human Afflictions and Chromosomal Aberrations

    International Series of Monographs in Pure and Applied Biology: Modern Trends in Physiological Sciences
    • 1st Edition
    • Raymond Turpin + 1 more
    • P. Alexander + 1 more
    • English
    Modern Trends in Physiological Sciences, Volume 32: Human Afflictions and Chromosomal Aberrations presents the study of the links between chromosome aberrations and physical and mental congenital anomalies. This book discusses the possibilities of human cytogenetic research as well as its difficulties. Organized into 15 chapters, this volume begins with an overview of the development of human chromosome investigations. This text then explains the methods for studying human chromosomes, which can be applied without controlling the atmosphere of the incubator. Other chapters describe the structural features of the normal human karyotype. This book discusses as well the early appearance of a chromosome aberration that produces a change in the hereditary patrimony manifest in a constitutional disorder of the individual. The final chapter deals with the biochemical effects that correspond to numerical or structural anomalies in chromosome 21. This book is a valuable resource for genetecists, cytogeneticists, physicians, and clinical researchers.

  • The Catecholamines in Psychiatric and Neurologic Disorders

    • 1st Edition
    • C. Raymond Lake + 1 more
    • English
    The Catecholamines in Psychiatric and Neurologic Disorders focuses on the contributions of catecholamines (CA) in the modulation of blood pressure, stress and exercise, body movements, memory, learning, emotions, thought processing, appetite, and mediation of psychotropic drug action. The selection first elaborates on the techniques for the assessment and interpretation of catecholamine measurements in neuropsychiatric patients and catecholaminergic response to stress and exercise. Discussions focus on noradrenergic response to isometric exercise, isotonic exercise, effect of acceleration on sympathetic activity, techniques for sympathetic nervous system evaluation, and measurements of CA and their metabolites in cerebrospinal fluid. The text then takes a look at urinary CA in behavioral research on stress; CA in anxiety disorders and mitral valve prolapse; and interaction with neurotransmitters in normal subjects and in patients with selected neurologic diseases. The selection examines noradrenergic responses in postural hypotension, norepinephrine, alcohol, and alcoholism, and catecholamine metabolism in anorexia nervosa. Topics include cerebral catecholamine metabolism in anorexia nervosa; central nervous system norepinephrine and voluntary alcohol drinking; and overview of norepinephrine in selected pediatric disorders. The book is a dependable reference for neuropsychiatrists and readers interested in the contributions of catecholamines on psychiatric disorders.

  • The Teacher and the Needs of Society in Evolution

    • 1st Edition
    • Edmund J. King
    • English
    The Teacher and the Needs of Society in Evolution deals with the needs of the teacher in an evolving society. Emphasis is placed on the schools' changing context and perspectives, the evolving institutions and methods of education, and response in research and development. The chapters directly relate a rich fund of information and wide sensibility to current discussions undertaken by teachers and other educators everywhere. This volume consists of 12 chapters organized into three sections and begins with a discussion of the social context and the dynamics of change. It explores changing perspectives in the educational process, the direction schools are already, and the cultivation of skill and the best use of human ability. Inequalities in educational opportunity in Britain today, and the ways in which they may be reduced, are also considered. The next section focuses on the changing role of teachers, their preparation and orientation, the use of new media in education, and future prospects. The role of teachers in research or curricular development is highlighted. The final section examines the evolution in educational thinking, with emphasis on the problem of authority and responsibility in the teaching of the new humanities, the rise in school enrollments, and the hunger for learning. This book is intended for educators who want to improve their teaching skills for the benefit of society.

  • The Common Agricultural Policy beyond the MacSharry Reform

    • 1st Edition
    • Volume 230
    • C. Folmer + 4 more
    • J. Tinbergen
    • English
    The reform of the Common Agricultural Policy (CAP) which is now being implemented, reduces the support for a selected number of agricultural products. This book uses welfare theory and applied general equilibrium analysis to assess the medium to long term consequences of this reform, if the new policies remain in place until the beginning of the next century. It analyses the implications of two alternative scenarios: a) a further trade liberalisation covering all commodities; and b) increased protectionism with high prices, constraints on production and export subsidies (financed by the farmers themselves). The study also investigates the implications of financial renationalisation, whereby the European Union member-states would cover the costs of their own support measures.

  • Infant Nutrition

    Its Physiological Basis
    • 1st Edition
    • F. W. Clements
    • English
    Infant Nutrition: Its Physiological Basis covers the physiological aspects of the nutrition of the fetus and young infant. This book is composed of 12 chapters that evaluate the data on the physical and chemical properties of the human and cow’s milk. It effectively addresses the aspects of tissue metabolism and the composition of a new born infant. The first chapters deal with the factors affecting placenta permeability; features of placenta; maternal supply and placental transmission of individual nutrients; secretion and components of human milk; and the constitution, chemical, and biological properties of milk. A comparison of the amino acid content of human and cow’s milk is also covered. Other chapters consider the analysis of the sucking and swallowing motion of the infant, as well as the physiological weight loss of the neo-natal period. The calorie and nutritional requirement of infants and children are presented. The last chapter is devoted to the protein requirements of young infants. The book can provide useful information to doctors, pediatricians, students, and researchers.

  • International Review of General and Experimental Zoology

    Volume 2
    • 1st Edition
    • William J. L. Felts + 1 more
    • English
    International Review of General and Experimental Zoology, Volume 2 is a collection of world literature concerning developments in general and experimental zoology. This book is composed of six chapters, and begins with a survey of the biochemical and serological techniques and their application in experimental taxonomy. The succeeding chapters review the field of general and comparative endocrinology in lower vertebrates, as well as the problems of understanding the fine structure of the synaptic cleft of presumed chemically transmitting synapses. These topics are followed by discussions on structural and functional aspects of the avian lungs and air sacs; the metabolic aspect of heat transfer in biological systems; and the external energy transfer from the organism to the surrounding environment. The final chapter focuses on the experimental studies of neurocranium morphology and growth. This book will prove useful to zoologists and taxonomists.

  • New and Updated Methods

    Analytical Methods for Pesticides and Plant Growth Regulators, Vol. 10
    • 1st Edition
    • Gunter Zweig + 1 more
    • English
    Analytical Methods for Pesticides and Plant Growth Regulators, Volume X: New and Updated Methods covers the specific methods (i.e. gas chromatography, thin-layer chromatography, spectroscopy, high-performance liquid chromatography, and thin-layer densitometry) of analysis for formulations and residues of pesticides (i.e. insecticides, fungicides, herbicides, plant growth regulators, nematicides, and soil fumigants) of international importance. Toxicologists and people involved in the research of analytical methods for the formulations of pesticides will find the book invaluable.

  • Progress in Chemical Toxicology

    Volume 5
    • 1st Edition
    • Abraham Stolman
    • English
    Progress in Chemical Toxicology, Volume 5 covers topics on the improved isolation and detection procedures and quantitation methods for volatile poisons, stimulants, hallucinogenic drugs, and marihuana. The book discusses the absorption, distribution, and excretion of drugs and poisons and their metabolites; the system for the toxicological analysis of drugs in biological specimens; and the isolation and analysis of phenothiazines. The text also describes the use of fluorescence in toxicology and the toxicology of new synthetic organic polymers used in containers for food, pharmaceutical compounds, and drinkable water. Some microcrystal tests for drugs and advances in polarography as applied to toxicological analysis are also considered. Biochemists, toxicologists, and scientists involved in the study of narcotics will find the book invaluable.

  • Food and Agriculture in Global Perspective

    Discussions in the Committee of the Whole of the United Nations
    • 1st Edition
    • Toivo Miljan + 2 more
    • English
    Food and Agriculture in Global Perspective: Discussions in the Committee of the Whole of the United Nations presents the problem of food and agriculture in its total global international perspective from the point of view of the specialized agencies of the United Nations system and the States Members of the United Nations. The book discusses the problem of food and agriculture and its handling in the global perspective; groups the statements of the problem around international agency views and around the views of Member States; and presents the progress report of efforts by international agencies and by States. The text also describes the excerpts from the technical documents, and statements of Agency representatives and Member States in the seven specific issue areas found in the Agreed Conclusions of the Committee.

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