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Elsevier

Books in Life sciences

  • Clinical Immunobiology

    • 1st Edition
    • Volume 4
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 4 is a 13-chapter text that covers the advances in understanding of the concepts and practical applications of lymphoid subpopulations and the major histocompatibility complex (MHC). The first chapter presents an overview of the problems of various subpopulations of cells involved in the immune system. The succeeding chapters describe the techniques used for cell classification, either by their cell surface phenotype or by their responsiveness to a series of different stimuli. These chapters include surveys of the methods of detection of complement receptors and expression of these receptors on the surface of both normal and leukemic human lymphocytes. A discussion of the evidence that different T-lymphocyte populations differentially express receptor for IgG and IgM is also provided. Other chapters describe the relationship of MHC to serology of cell surface antigens and reactivity in the mixed leukocyte culture test. This work also explores the methods that employ the so-called "proliferative and cytotoxic responses". The remaining chapters look into the association between HLA antigens and a variety of different diseases. These chapters also discuss other genetic markers in the HLA linkage group. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 19
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 19 is a seven-chapter text that covers the physical and biological aspects of lipid metabolism. The first chapter deals with the interactions between circulating lipids and lipid proteins and the arterial tissue matrix. The subsequent chapter discusses the apolipoprotein C metabolism, the roles of lecithin-cholesterol acyltransferase and cholesterol ester transfer protein in intravascular cholesterol transport. Other chapters explore the significance of bile acid biosynthesis for cholesterol homeostasis, the metabolism of phosphatidylserine, and gas chromatographic and mass spectrometry analysis of prostanoids. The last chapter considers the role of dietary fiber in health and disease. This book is of great value to lipid and enzyme chemists, biochemists, and researchers.

  • Immobilized Enzyme Principles

    Applied Biochemistry and Bioengineering, Vol. 1
    • 1st Edition
    • Volume 1
    • Lemuel B. Wingard + 2 more
    • English
    Applied Biochemistry and Bioengineering, Volume 1: Immobilized Enzyme Principles focuses on the utilization of immobilization techniques for the study and application of enzyme catalysts in a variety of potential end-uses. This book emphasizes the preparation of enzyme-support systems, effects caused by the concurrent phenomena of enzyme-catalyzed reaction kinetics and mass transfer resistances, and how these reactions are incorporated into the design of enzyme-catalyzed reactor systems. The magnitude of the perturbation of the apparent kinetic parameters of an immobilized enzyme that could serve in principle as a measure of the effective concentrations of substrate, modifier, or inhibitor at the site of the enzymic reaction is also explained. This volume is recommended for biological scientists and engineers, as well as researchers interested in the biochemical common denominator that causes the interaction of engineering practice and biological sciences for technological development.

  • From Metabolite, to Metabolism, to Metabolon

    • 1st Edition
    • Volume 33
    • Earl R. Stadtman + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 33: From Metabolite, to Metabolism, to Metabolon is a collection of articles on the study of the machinery of the living cell. The book is also a tribute to Paul Srere, an eminent biochemist, on the occasion of his sixty-fifth birthday. The book contains contributions written by students, postdoctoral fellows, and biochemists within Paul Srere's broad sphere of influence. The text provides articles that discuss topics on cellular infrastructure and metabolic organization; how carbohydrates cross the lipid membrane of bacterial cells; and macromolecular processes. The structural aspects of citrate biochemistry; the electron transport systems; nucleotide biosynthesis; enzyme organization and the direction of metabolic flow; and bioengineering applications are tackled as well. Biochemists, cytologists, and cell biologists will find the book very insightful.

  • Veterinary Virology

    • 1st Edition
    • Frank J. Fenner + 2 more
    • English
    Veterinary Virology deals with basic biomedical virology and the clinical discipline of infectious diseases. The book discusses the principles of virology as effecting future developments in the search for preventive and management of infectious diseases in animals, whether singly or as a whole herd or flock. Part I explains the principles of animal virology including the structure, composition, classification, nomenclature, cultivation, and assay of viruses. This part also discusses viral genetics, replication, and evolution (including mutation and genetic engineering). The book also reviews the pathogenesis of viruses, host resistance and susceptibility, as well as the mechanisms of persistent infections and tumor induction. Part II deals with viruses found in domestic animals; this part also explains in detail the properties, replication methods, pathogenesis, immunity, diagnosis, and control of some common viruses. The book discusses some other families of viruses of which no members are yet known as to have caused serious or important diseases in animals. Veterinarians, immunologists, virologists, molecular researchers, students, and academicians in the discipline of virology and cellular biology, as well as livestock owners will find this book helpful.

  • Methods in Virology

    Volume V
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume V focuses on the methods used in virology, including hybridization, gel electrophoresis, freeze-etching technique, and ultracentrifugation. The selection first offers information on the fusion of cells for virus studies and production of cell hybrids; approaches to ultracentrifugation; and polyacrylamide gel electrophoresis of viral RNA. Discussions focus on applications to virological problems and analysis of results; analysis of the distribution of RNA on polyacrylamide gels after electrophoresis; and biological analysis of DNA components. The book then examines the polyacrylamide gel electrophoresis of viral proteins, DNA-RNA and DNA-DNA hybridization in virus research, and techniques of RNA-DNA hybridization in solution for the study of viral transcription. Topics include preparation of nucleic acids, hybridization and elution procedures that minimize RNA degradation, and procedures for acrylamide gel electrophoresis. The text takes a look at freeze-etching technique for the study of virus ultrastructure; procedures to increase virus yield from infected plants; and the immunoperoxidase technique. Concerns include principles of the immunoperoxidase technique, histochemical detection of peroxidase activity, sequence of events in virus infection, and factors affecting virus yield. The selection is a valuable source of data for researchers interested in the methods employed in virology.

  • Comparative Virology

    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Comparative Virology provides an integrated comparison of viruses, based on their chemical and morphological characteristics. These descriptions will not only give the reader a background but also a detailed analysis of the various groups. In some instances the groups are still host related, as in the case of bacteriophages and polyhedral insect viruses. In others, for instance in pox viruses, the group comprises viruses of vertebrates and invertebrates. The hosts of the bacilliform Rhabdovirales range from man and other warm-blooded vertebrates through invertebrate animals to plants. A special chapter is devoted to viruses devoid of protein—a group that is of great interest and that has only recently been recognized. Since there is historical and practical interest in écologie groupings, such as arboviruses and oncogenic viruses, chapters on such groups have also been included. The book opens with a discussion on the classification of viruses. Chapters dealing with DNA viruses and RNA viruses follow, and the ecologically and disease-oriented groups complete the volume. It is hoped that ""Comparative Virology"" will help bring unity to the science of virology through the comparative approach that is not dependent on virus-host interactions. The combined efforts of eminent contributors to discuss and evaluate new information will hopefully benefit all who are interested in virology

  • Methods in Virology

    Volume VII
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume VII focuses on the methods used in virology, including radioimmunoassays, microscopy, hybridization, and mutagenesis. The selection first elaborates on monoclonal antibody techniques applied to viruses; competition radioimmunoassays for characterization of antibody reactions to viral antigens; and enzyme immunosorbent assays in plant virology. Discussions focus on the principles of enzyme immunosorbent assay, choice of enzyme and preparation of conjugate, determination of immunoglobulin class, and maintenance and specificity testing of hybridomas. The text then elaborates on electron microscopy for the identification of plant viruses in in vitro preparations and cloning and expression of viral antigens in Escherichia coli and other microorganisms, including influenza virus, expression of foreign coding sequences in Escherichia coli, hepatitis B virus, electron microscope, immunoelectron microscopy, and imaging of nucleic acids. The manuscript takes a look at the detection and characterization of subgenomic RNA in plant viruses; exploring the gene organization of baculoviruses; and spot hybridization for detection of viroids and viruses. Topics include application to viral diseases, mapping mutuations of baculoviruses, transcriptional mapping of baculovirus genomes, and genetic mapping by blot hybridization. The selection is a valuable source of information for researchers interested in the methods employed in virology.

  • Textbook of Medical Virology

    • 1st Edition
    • Erik Lycke + 1 more
    • English
    Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.

  • Immunobiology of the Complement System

    An Introduction for Research and Clinical Medicine
    • 1st Edition
    • Gordon D. Ross
    • English
    Immunobiology of the Complement System: An Introduction for Research and Clinical Medicine provides an introduction to the complement system. The intention was to create a primer that would provide the basic knowledge of complement required for either research or clinical medicine in diseases involving the complement system. The book begins with a historical background of complement research; it introduces certain key investigators from the past who have made important contributions. Separate chapters on the basic aspects of complement function are followed by chapters on the molecular genetics of complement and the role of complement in different diseases. Key topics discussed include the activation of complement via the classical pathway and the alternative pathway; complement mediators of inflammation; opsonization and membrane complement receptors; assembly and functions of the terminal components; and complement-dependent mechanisms of virus neutralization. This book has been written primarily for students and scientists who have not been specifically trained in complement research.

  • Biological and Biochemical Oscillators

    • 1st Edition
    • Britton Chance + 2 more
    • English
    Biological and Biochemical Oscillators compiles papers on biochemical and biological oscillators from a theoretical and experimental standpoint. This book discusses the oscillatory behavior, excitability, and propagation phenomena on membranes and membrane-like interfaces; two-dimensional analysis of chemical oscillators; and chemiluminescence in oscillatory oxidation reactions catalyzed. The problems associated with the computer simulation of oscillating systems; mechanism of single-frequency glycolytic oscillations; excitation wave propagation during heart fibrillation; and biochemical cycle of excitation are also elaborated. This compilation likewise covers the physiological rhythms in Saccharomyces cerevisiae populations; integral and indissociable property of eukaryotic gene-action systems; and role of actidione in the temperature jump response of the circadian rhythm in Euglena gracilis. This publication is valuable to biochemists interested in biochemical and biological oscillations.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 21
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 21 covers several significant and emerging areas in lipid metabolism, including apolipoprotein metabolism and leukotrienes. This book discusses the role of fat in the functioning of the immune system. Organized into eight chapters, this volume begins with an overview of the metabolism of apolipoprotein B, which is the principal protein of chylomicrons, very low density, and low density lipoprotein. This text then describes the metabolism, biosynthesis, and pharmacology of leukotrienes. Other chapters consider the relation of lipids to immunology and explain the roles played by lipids in the structure and function of yeast membrane. This book discusses as well the general importance in the plant kingdom and the place of some carotenoids in human biology. The final chapter deals with the influence of proteins on configuration and function of reconstituted lipid membranes. This book is a valuable resource for biologists, chemists, biochemists, scientists, and research workers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 9
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 9 is a seven-chapter text that highlights the advances in methodology to steroid chemistry. The opening chapter describes the important aspect of autoradiography and its coupling with light and electron microscopic analysis. The next chapters deal with the carbon source in the fatty acid biosynthesis, with particular emphasis on the biosynthesis by the aortic the issue. These topics are followed by discussions of the membrane structure and the lipids in membranes. Other chapters consider the biochemistry and analysis of glycosphingolipids and the progress in the in lipid chemistry, including pregnane derivatives and C21 steroids. The concluding chapter reviews the composition of vegetable oil and other aspects of fat metabolism, specifically cholesterol metabolism. This book will prove useful to lipid chemists, biochemists, and organic chemists.

  • Behavior of Nonhuman Primates

    Modern Research Trends
    • 1st Edition
    • Volume 5
    • Allan M. Schrier + 1 more
    • English
    Behavior of Nonhuman Primates: Modern Research Trends, Volume 5 is a collection of papers on research trends in the study of the various aspects of primate behavior. Chapters in the book discuss topics on the history of the study of cognitive processes in primates; ways in which visual stimuli in monkeys are perceived, stored in memory, and retrieved; and behavior of prosimians. The book will be of value to primatologists, psychologists, and zoologists.

  • Anaerobic Bacteriology

    Clinical and Laboratory Practice
    • 3rd Edition
    • A. Trevor Willis
    • English
    Anaerobic Bacteriology: Clinical and Laboratory Practice, Third edition discusses the importance of the non-sporing anaerobic bacteria as a significant cause of infection in man. This edition updates the anaerobic methodology, systematics, and ecological and pathogenetic associations of the non-sporing anaerobes. The descriptive bacteriology of the non-clostridial anaerobes and clinical syndromes produced by them in man are also considered. Other topics discussed include the anaerobic jar, inoculation of media, and antibiotic susceptibility testing of anaerobes. The histotoxic clostridia of infected wounds, anaerobic cocci, and infections related to the gastrointestinal tract are also elaborated. This text likewise covers the uterine gas gangrenous infections and other clostridial infections. This book is a good source for medical practitioners, clinicians, and medical students concerned with anaerobic bacteria.

  • Bacterial Metabolism

    • 2nd Edition
    • H. W. Doelle
    • English
    Bacterial Metabolism, Second Edition describes microbial systematics and microbial chemistry and focuses on catabolic events. This book deals with the progress made in bacterial metabolism that includes data on regulatory mechanisms; comparison of bacterial growth kinetics with enzyme kinetics; aerobic amino acid catabolism; and the glucose transport mechanism. This text also emphasizes the development of photosynthetic phosphorylation in the different bacterial families. This book explains anaerobic respiration and carbohydrate metabolism—glucose, fructose, lactose, mannose, allose, and sorbitol. This text then describes aerobic respiration including the "Nitroso" and "Nitro" groups of genera, and the Knallgas bacteria, which use the reaction between molecular hydrogen and molecular oxygen as their source of energy. This book also explains the microbial transformation of iron as caused by either specific organisms (e.g. Ferrobacillus ferrooxidans) or nonspecific organisms. This selection also explains the process of fermentation by Enterobacteriaceae, lactic acid bacteria, and proteolytic clostridia. This text can be valuable for microchemists, microbiologists, students, and academicians whose disciplines are in biological chemistry and cellular biology.

  • Protein Turnover and Lysosome Function

    • 1st Edition
    • Harold L. Segal + 1 more
    • English
    Protein Turnover and Lysosome Function comprises the proceedings of a symposium under the same title held at the State University of New York at Buffalo on August 21-26, 1977. The book discusses mechanisms of protein turnover, as well as the identification and characterization of intracellular proteases. The text also describes the internalization of macromolecules into the intracellular digestive system; the types of specificity entailed; and the fate of the membrane material involved in the vacuolization process. Biochemists, pathologists, cell biologists, molecular biologists, and physiologists will find the book invaluable.

  • Immunobiology of the Macrophage

    • 1st Edition
    • David S. Nelson
    • English
    Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunol... of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.

  • Current Topics in Bioenergetics

    Structure, Biogenesis, and Assembly of Energy Transducing Enzyme Systems
    • 1st Edition
    • C. P. Lee
    • English
    Current Topics in Bioenergetics, Volume 15: Structure, Biogenesis, and Assembly of Energy Transducing Enzyme Systems presents the reaction mechanisms involved in membrane-associated energy transducing processes at the molecular level. This book discusses the developments in the energy transducing systems. Organized into 11 chapters, this volume begins with an overview of the composition and structural aspects of the four respiratory chain complexes. This text then discusses the genetic aspects of various energy transducing systems. Other chapters consider the electron transfer chains of chloroplast, mitochondria, and some photosynthetic bacteria, which contain a multiprotein complex with similar functional and structural properties. This book discusses as well the structure and function of multiple and variable amounts of subunits in cytochrome-c oxidase from various organisms. The final chapter deals with the interdisciplinary path of bioenergetics, with the center of gravity moving from chemistry through genetics to physics. This book is a valuable resource for biologists.

  • Immunodiffusion

    • 2nd Edition
    • Alfred J. Crowle
    • English
    Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.

  • Photochemistry

    An Introduction
    • 1st Edition
    • D. R. Arnold + 2 more
    • English
    Photochemistry: An Introduction covers topics such as industrial photochemistry, solid state photochemistry, spectroscopy and photochemistry of the solid state, industrial applications of photochemistry, and photochromism. The book discusses the application of bonding, structure, energetics, and reactivity of the ground states of molecules to describe the same properties for molecules in their electronically excited states; the electronic spectra of excited states; and how the excited states react to form chemical transients. The text also describes light sources, techniques for measuring light intensities and quantum yields, methods used to detect transient photochemical products, and some ancilliary techniques. A review of some features of typical photochemical processes conducted in the vapor state and a survey of the reactions of the urban atmosphere, are also considered. The book further tackles the mechanisms of organic photochemical reactions; the synthetic applications of organic photochemistry; and the photochemistry of the solid state. The text also looks into photochromism and the industrial applications of photochemistry. People involved in the field of photochemistry will find the book useful.

  • Current Topics in Bioenergetics

    Volume 5
    • 1st Edition
    • D. Rao Sanadi + 1 more
    • English
    Current Topics in Bioenergetics, Volume 5 provides information pertinent to the molecular properties of purified enzymes and defined reactions. This book presents the development in the research on oxidative phosphorylation. Organized into nine chapters, this volume begins with an overview of the contributions to the knowledge of membrane structure based on X-ray diffraction analysis. This text then examines the reactions of chlorophyll in model systems and the luminescence linked with light absorptions, which relate to the early events in photosynthesis. Other chapters relate spectroscopic and EPR measurements to redox changes linked with energy coupling in the mitochondrial electron carriers. This book discusses as well the role of soluble proteins in the energy transfer process of oxidative phosphorylation. The final chapter deals with the chemical and structural properties of the photoreceptors in the visual process. This book is a valuable resource for biophysicists, physiologists, biologists, biochemists, physical chemists, and research workers.

  • Current Topics in Bioenergetics

    Volume 12
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 12 presents the remarkable potential of protein chemistry to contribute to the understanding of the process of membrane transport. This book provides information pertinent to the fundamental aspects of bioluminescence. Organized into four chapters, this volume begins with an overview of the ATP synthase complex. This text then examines the energy-linked reactions in Paracoccus denitrificans, which possess a very similar respiratory chain to that of mammalian mitochondria. Other chapters consider the interdigitation of the cytochrome system with the hydrogenase reactions. This book discusses as well the mechanistic features of electron transport, H+-translocation in bacterial chromatophore membranes, and the nature of the immediate energy source for ATP synthesis. The final chapter deals with the study of bacterial photosynthesis, which offers the possibility of tackling experimentally many of the most important problems in the field of membrane bioenergetics. This book is a valuable resource for biologists, biochemists, and research workers.

  • Blood and Tissue Antigens

    International Symposium on Blood and Tissue Antigens Held at the University of Michigan Medical Center, September 17-19, 1969
    • 1st Edition
    • David Aminoff
    • English
    Blood and Tissue Antigens documents the proceedings of the International Symposium on Blood and Tissue Antigens held in Ann Arbor, Michigan on September 17-19, 1969. This book focuses on the immunogenetic and biochemical aspects of the blood and tissue antigens. The topics discussed include the genetics of blood groups; blood groups and serum phosphatase; immunogenetics of the mouse H-2 system; and glycolipids as membrane antigens. The carbohydrate composition of epithelial mucins; glycolipids in SV40 and polyoma virus transformed mouse cell lines; and metabolic variations of serum proteins and enzymes are also elaborated. This text likewise covers the action of glycosidases on erythrocytes; blood group specific oligosaccharides in urine; biosynthesis of submaxillary mucins; and genes, glycosyltransferases... and blood types. This publication is a good source for students and individuals researching on blood and tissue antigens.

  • Light and Biological Rhythms in Man

    • 1st Edition
    • L. Wetterberg
    • English
    In this volume, current knowledge on light as a regulator of biological rhythms is considered from both basic science and clinical perspectives. Chapters by leading experts cover the whole range of biological rhythms, from infradian and circadian to the longer ultradian rhythms, in a wide variety of mammalian species. The chapters on humans provide a basis on which to establish mechanisms for mediating the therapeutic and physiologically beneficial effects of light as a regulator of rhythms in health and disease.

  • Advances in Steroid Biochemistry and Pharmacology

    • 1st Edition
    • M. H. Briggs + 1 more
    • English
    Advances in Steroid Biochemistry and Pharmacology, Volume 4 provides information pertinent to the fundamental aspects of steroid biochemistry and pharmacology. This book covers a variety of topics, including cellular biochemistry, pituitary hormones, corticosteroids, and steroid hormones. Organized into seven chapters, this volume begins with an overview of the potential effects of steroids on cellular biochemistry. This text then examines the development of sleep-monitoring methods, together with methods of plasma sampling that enable very frequent specimen to be taken without disturbing the subject. Other chapters consider the usefulness of sleep-related growth hormone release in diagnosis in both children and adult. This book discusses as well the versatile effect of corticosteroids on the cellular components of the connective tissue. The final chapter deals with the functioning of the adrenal cortex and its control by adrenocorticotropic hormone (ACTH). This book is a valuable resource for biochemists, histochemists, biologists, pharmacologists, clinicians, and experimental endocrinologists.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 15
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 15 is a four-chapter text that covers important aspects of lipid chemistry, including biomembranes and fungal lipids. The first chapter is devoted to the long-range order in biomembranes. This chapter presents evidence that the proteins and lipids of biological membranes are partitioned into functional and structural aggregates in the plane of the membrane. The second chapter surveys the pharmacology and toxicology of steroids and related compounds. This chapter also provides the methodology, physiologic and transport mechanisms, and effects on the central nervous system. The third chapter explores all aspects of lipid composition of all classes of fungi. This chapter also discusses the intracellular distribution and biosynthesis of the lipid components of fungi. The fourth chapter considers the biochemistry of plant sterols, including structure, stereochemistry, biosynthesis, metabolism, and function. This book will be of value to lipid chemists, biochemists, and researchers.

  • Molecular Mechanisms of Immunological Self-Recognition

    • 1st Edition
    • Frederick Alt + 1 more
    • English
    Molecular Mechanisms of Immunological Self-Recognition covers the understanding of immunological self-recognition. The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. The text concludes by furnishing orienting perspectives and highlighting new information presented. The novel findings characterized as impressive advances pertain to the areas of B cell development and the generation of molecular diversity; V gene usage, especially from transgenes, in positive and negative thymic selection; the handling of positive and negative signals by T and B cells; anergy in postthymic T cells; the design of peptide-based therapy for autoimmune diseases; and the design of therapy with the aid of monoclonal antibodies. Immunologists will find the text useful.

  • Experimental Manipulation of Gene Expression

    • 1st Edition
    • Masayori Inouye
    • English
    Experimental Manipulation of Gene Expression discusses a wide range of host systems in which to clone and express a gene of interest. The aims are for readers to quickly learn the versatility of the systems and obtain an overview of the technology involved in the manipulation of gene expression. Furthermore, it is hoped that the reader will learn enough from the various approaches to be able to develop systems and to arrange for a gene of particular interest to express in a particular system. The book opens with a chapter on the design and construction of a plasmid vector system used to achieve high-level expression of a particular phage regulatory protein normally found in minute amounts in a phage-infected bacterial cell. This is followed by separate chapters on topics such as high-level expression vectors that utilize efficient Escherichia coli lipoprotein promoter as well as various other portions of the lipoprotein gene Ipp; DNA cloning systems for streptomycetes; and the design and application of vectors for high-level, inducible synthesis of the product of a cloned gene in yeast.

  • Mechanisms of Eukaryotic DNA Recombination

    • 1st Edition
    • Max E Gottesman + 1 more
    • English
    Mechanisms of Eukaryotic DNA Recombination is a collection of papers that discusses advances in eukaryotic genetic recombination. Papers address issues in eukaryotic genetic recombination, particularly DNA integration in mammalian genomes, genetic recombination in Drosophila or Caenorhabditis; the manipulation of the mouse genome; genome organization; and genetic recombination in protozoa. One paper discusses chromatid interactions during intrachromosomal recombination in mammalian cells, namely, intrachromatid and sister chromatid. Another paper analyzes the implication for chromosomal recombination and gene targeting; results on extrachromosomal recombination show that circles are inefficient substrates for recombination even if only one of two substrates in an intermolecular reaction is circular. One author discusses the genetics and molecular biology of recombination, citing the work of Watson and Crick, stating that crossing-over occurs between genes (not within them). He also explains that the formation and resolution of recombination intermediaries depend on enzyme or other proteins. This book will prove invaluable to cellular biologists, microbiologists, and researchers engaged in genetics and general biology.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 10
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 10 is a six-chapter text that is devoted to several special areas of lipid research, including significant progress in established areas of interest in the field. The introductory chapter surveys the application of electron microscopic techniques to the analysis of plasma lipoproteins. The subsequent chapter deals with the possible modification of reticuloendothelial functions by lipids and the role of lipids in cellular, humoral, and immune responses. These topics are followed by discussions of the microsomal enzymes of sterol biosynthesis and the enzymatic synthesis and degradation of glycerol lipids, which contain ether bonds. The remaining chapters focus on lipid neurochemistry. These chapters specifically examine particular brain lipids, such as fatty acids, phospholipids, sphingolipids, galatosyl lipids, and sterols. A discussion of lipids of the entire nervous system and their variation with age is also included. This book will prove useful to lipids chemists, biochemists, and organic chemists.

  • The Third World Congress on Biosensors Abstracts

    1-3 June 1994, New Orleans, USA
    • 1st Edition
    • Abstracts
    • English
    Biosensors 94: The Third World Congress on Biosensors Abstracts focuses on the progress in the field of biosensors, including immuno-absorbent 'catch' system, surface plasmon resonance, and chemiluminescence. The selection first offers information on the development of a commercial multichannel clinical sensor chip; commercial development and application of biosensors; amperometric biosensors based on dehydrogenase/NAD and heterocyclic quinones; and enzyme-epoxy membrane based semi-automated glucose analyzing system. The text then takes a look at the orientation of antibody fragments to increase TIRF immunosensor efficiency and the development of latex-technology for specific DNA detection with surface plasmon resonance. The book elaborates on gas-phase biosensor for the determination of ethanol vapor; novel electrochemical gas phase biosensors for the detection of phenolic vapors; and the development of an immuno-absorbent 'catch' system for the detection of pesticides and pesticide analogues. The book also ponders on the kinetics of binding of immobilized antibodies under nonequilibrium, flow conditions; flow injection thin-layer cell immunosensor with chemiluminescent detection of peroxidase label; and new optical fiber sensor for detecting chemiluminescence and its application to immunoassay. The selection is a valuable source of data for researchers interested in biosensors.

  • Multiple Equilibria in Proteins

    • 1st Edition
    • Jacinto Steinhardt + 1 more
    • Bernard Horecker + 2 more
    • English
    Multiple Equilibria in Proteins covers the multiple interactions between small ions and molecules and a protein molecule. The book also deals with the physicochemical mechanisms of this interaction and the information about protein structure and the forces stabilizing that structure. The text discusses the mathematical description of complex formation, the thermodynamic analysis of binding data, and various theoretical models which can be used to describe the phenomena of small molecule-macromolecu... interactions. The measurement of complex formation; the binding of neutral molecules; and hydrogen-ion equilibria are also considered. The book further tackles metal-ion binding; the binding of organic ions by proteins; as well as protein-protein interaction. Chemists and biochemists will find the book useful.

  • Molecular Biology of Plant Tumors

    • 1st Edition
    • Günter Kahl + 1 more
    • English
    Molecular Biology of Plant Tumors provides an opportunity to learn in detail about the latest insights into the mechanism of transformation of plant cells by Agrobacterium tumefaciens. The study of the molecular mechanism responsible for the crown gall phenomenon (induced by Agrobacterium tumefaciens) illustrates the point that the fundamental study of the cause(s) and mechanism(s) of abnormal growth might be one of the most efficient ways to understand cellular differentiation and the molecular basis of gene expression. The book is organized into three parts that contain research on abnormal plant growth, crown gall tumors, and potential vectors for genetic engineering in agriculture. The genetic structure responsible for the neoplasmic transformation of plant cells in crown galls is a bacterial plasmid (called Ti for tumor-inducing). Research described in this volume demonstrates that these Ti plasmids were designed by evolution as natural gene vectors with which some bacteria can introduce active genes into plants. These transferred genes are maintained by integration in the plant genome and their expression is directly or indirectly responsible for the tumorous growth pattern.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 18
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 18 is a seven-chapter text that brings together significant research studies on atherosclerosis. The opening chapter describes the pathological techniques in atherosclerosis research. The succeeding chapters deal with the influence of lipid-lowering drugs on bile acid metabolism and the cholesterol metabolism in ovarian tissue. Other chapters examine the principal role of sulfolipids and the influence of dietary linoleic acids on blood pressure regulation in rats. The closing chapters review the influence of nonnutritive fiber on lipid metabolism and the influence of fiber on lipid-associated diseases. These chapters also consider the techniques for polar lipid analysis. This book will be of great value to lipid chemists, biochemists, and researchers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 12
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 12 is a seven-chapter text that focuses on the significant progress in lipid metabolism. The opening chapter reviews the relationships between plasma and tissue lipids and atherosclerosis. Understanding the dynamics of exchange of plasma lipoproteins with aortic tissue is the basis of understanding the etiology of this disease and the approaches to therapy. The succeeding chapters describe the phases of lipid metabolism in cultured cells and the influences of various dietary components on the specific enzymes of fatty acid and cholesterol biogenesis. Other chapters discuss the role of phospholipids in transport and enzymic reactions, membrane fluidity, aspects of lipid-protein interactions, and the physiologic role of thyroid lipids. The closing chapters explore the chemistry and biological function of glycosyl glycerides, as well as the physiopathology of the biguanidines, a class of oral hypoglycemic agents. This book will prove useful to lipid chemists, biochemists, and researchers.

  • Microbial Iron Metabolism

    A Comprehensive Treatise
    • 1st Edition
    • J. B. Neilands
    • English
    Microbial Iron Metabolism: A Comprehensive Treatise provides a comprehensive treatment of microbial iron metabolism. It aims to contribute to an increased understanding of the path of iron in microbial species and, eventually, in the plant and animal. The book is organized into five parts. Part I describes some features of iron and its function in the microbial world. These include a historical sketch of the recognition of the importance of iron in cellular physiology; a description of certain physical properties of ferrous and ferric ions; and a list of various known biocoordination derivatives grouped by ligand atom. Metabolism under iron-limited conditions is also examined. Part II presents studies on iron transport, biosynthesis, and storage in microorganisms. Part III examines iron enzymes and proteins, including ferredoxin, rubredoxin, nitrogenase, and hydrogenase. Part IV deals with reactions of inorganic substrates. Part V presents a study on the role of bacterial iron metabolism in infection and immunity.

  • Molecular Approaches to Neurobiology

    • 1st Edition
    • Ian R. Brown
    • English
    Molecular Approaches to Neurobiology deals with molecular approaches to the analysis of the nervous system. This book surveys the current state of knowledge in a number of areas of molecular neurobiology that includes the subcellular level of chromatin structure, complexity of RNA synthesis, role of hormones in cell differentiation, and molecular correlates between neuropeptides and behavior. A comprehensive review of procedures for the isolation of specific brain cells and their experimental use is also provided at the end of this text. This publication is useful to those working in the field of neurochemistry and those engaged in morphological and physiological approaches to the analysis of the nervous system, as well as molecular biologists and biochemists working with non-neural tissues.

  • Horizons of Bioenergetics

    Proceedings of a Symposium held at Bloomington, Indiana October 12-15, 1970
    • 1st Edition
    • Anthony San Pietro + 1 more
    • English
    Horizons of Bioenergetics provides information pertinent to the fundamental aspects of bioenergetics. This book covers a variety of topics, including oxidative phosphorylation, energy conservation, ATP formation, metabolic regulation, glycolysis, and photosynthesis efficiency. Organized into five sessions encompassing 23 chapters, this book begins with an overview of the major landmarks in biochemical evolution that are most relevant to the discussion on bioenergetics. This text then reviews the knowledge about ATP generation by substrate level phosphorylation by anaerobic bacteria that ferment organic compounds. Other chapters consider the resolution and reconstitution of oxidative phosphorylation. This book discusses as well another energy-requiring activity associated with electron transport in mitochondria that may take primacy over oxidative phosphorylation. The final chapter deals with the possibility that conformational change can induce major shifts in electro-chemical potential and provide a mechanism for energy storage and conversion. This book is a valuable resource for biochemists, scientists, and research workers.

  • Hydrolytic Reactions

    Cobamide and Biotin Coenzymes
    • 1st Edition
    • Volume 16
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 16: Hydrolytic Reactions; Cobamide and Biotin Coenzymes treats both the chemistry and function of the coenzymes. This book discusses the thermodynamic and kinetic aspects of enzyme catalysis, hydrolytic enzymes displaying “active center” characteristics, chelation and stereochemical considerations in enzyme catalysis, and biological oxidation mechanisms. The recommendations of the Enzyme Commission of the International Union of Biochemistry and classified list of enzymes are also covered. This publication likewise elaborates the spectral characteristics of the cobamide coenzymes and mode of binding of biotin. Other topics include the classification of carboxyl esterases, structure and reactivity of phosphorylated metabolites, and mechanism of action of chymotrypsin. This volume is a good reference for biochemists and specialists concerned with enzymes.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 22
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 22 provides information pertinent to the fundamental aspects of lipid research. This book covers a variety of topics, including lipid secretion, lipids in platelet function, lipid transfer proteins, serum cholesterol, and cholesterol metabolism. Organized into five chapters, this volume begins with an overview of the lipid secretion of the meibomian glands, with emphasis on its chemical composition and physical properties. This text then explains the influence of lipids in platelet function and considers the metabolism of arachidonic acid in disease states, such as diabetes, nephrosis, and atherosclerosis. Other chapters examine the manner in which dietary cholesterol contributes to regulation of cholesterol metabolism. This book discusses as well the identification, isolation, and metabolism of sterol carrier proteins and lipid transfer proteins. The final chapter deals with the underlying problems that militate against a simple dose–response relationship. This book is a valuable resource for biologist, biochemists, and clinicians.

  • Methods in Virology

    Volume VIII
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume VIII focuses on the methods used in virology, including microscopy, hybridization, viruses, and fingerprint analysis. The selection first offers information on the hybridization of viral nucleic acids; applications of oligonucleotide fingerprinting to the identification of viruses; and immunosorbent electron microscopy in plant virus studies. Discussions focus on the detection of double-stranded RNA, principles and mechanisms of fingerprint analysis, preparation of labeled nucleic acid probes, and basic methods of nucleic acid hybridization. The text then elaborates on quantitative transmission electron microscopy for the determination of mass-molecular weight of viruses and use of thin sectioning for visualization and identification of plant viruses. Topics include technical procedures for processing plant tissues, cytological modifications of diagnostic value, procedure and treatment of data to obtain the average mass of virus particles, and applications in virology. The book takes a look at the detection of genome-linked proteins of plant and animal viruses; methods for assay, purification, and characterization of prions; and the use of mosquitoes to detect and propagate viruses. The selection is a valuable source of information for researchers interested in the methods employed in virology.

  • Rapid Virus Diagnosis

    Application of Immunofluorescence
    • 2nd Edition
    • P. S. Gardner + 1 more
    • English
    Rapid Virus Diagnosis: Application of Immunofluorescence presents developments in immunofluorescence as a technique for the diagnosis of virus infections. It discusses the effective and rapid methods for the diagnosis of virus infections. It addresses the application of fluorescent antibody techniques to the diagnosis and the investigation of virus infections and the assessment of their value both to the clinician and to the virologist. Some of the topics covered in the book are the fluorescence microscopy; nature of fluorescence; filter systems; transmitted light microscopy; interference filters for transmitted light microscopy; lamp centration and alignment of microscope; contrast-fluorescenc... condensers; photomicrography; and choice of microscope. The culture of viruses for production of antiserum is fully covered. The selection of cell lines or tissues for virus culture is discussed in detail. The text describes in depth the fluorescent antibody staining techniques. The preparation of specimens from respiratory infections is presented completely. A chapter is devoted to the respiratory syncytial virus. Another section focuses on the analysis influenza virus, paramyxoviruses, and picornaviruses. The book can provide useful information to doctors, virologists, students, and researchers.

  • Cholinergic Ligand Interactions

    • 1st Edition
    • D. J. Triggle + 2 more
    • English
    Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholinesterase and its isozymes in muscle disease. The volume contains nine chapters and begins with a study on possible conformational changes in acetylcholinesterase... This is followed by separate chapters on the subunits of acetylcholinesterase... in vitro studies with the cholinergic receptor of the eel electroplax; identification and isolation of acetylcholine receptors; assay and properties of essential (junctional) cholinesterases of the rat diaphragm; and structural variations in cholinergic ligands. Subsequent chapters deal with ligand interactions at the muscarinic receptors and changes in cholinesterases isozymes during normal and dystrophic muscle development.

  • Clinical Oral Microbiology

    • 1st Edition
    • T. Wallace MacFarlane + 1 more
    • English
    Clinical Oral Microbiology describes the significant models of monomicrobial and polymicrobial mechanisms of pathogenicity to appreciate the multifactorial nature of many infections. This book provides an understanding in the development of the science and practice of clinical oral microbiology. Organized into five parts encompassing 17 chapters, this book begins with an overview of the various types of oral and dental infections. This text then describes the different environmental characteristics of the human mouth, which consists of a complex mixture of microbial species of bacteria, fungi, mycoplasma, and protozoa. Other chapters consider the relative proportions of oral microorganisms in health. This book discusses as well the interplay of the etiological factors in dental caries. The final chapter deals with the transmission of infectious agents among patients and staff within a hospital environment, which is commonly called as cross-infection. This book is a valuable resource for microbiologists, dentists, oral pathologists, clinicians, and practitioners.

  • Prehistoric Hunter-Gatherers

    The Emergence of Cultural Complexity
    • 1st Edition
    • RABIGER
    • English
    Prehistoric Hunters–Gatherers: The Emergence of Cultural Complexity focuses on the emergence of cultural complexity among hunter–gatherers. This book presents the demographic, ecological, and social perspectives that add to the understanding of the emergence of more elaborate organization. Organized into four parts encompassing 17 chapters, this book begins with an overview of previous perspectives on cultural complexity and suggests directions in the study of change. This text then proposes a synthesis of both ecological and social approaches as a more powerful interpretative framework for the study of complexity. Other chapters consider the relationship between population and social complexity in an elaboration of major argument regarding demographic pressure and cultural change. This book provides as well an intriguing look at the regional consequences of their focus on whaling. The final chapter characterizes approaches to hunter–gatherer complexity and reiterates the significance of change in human society prior to the adoption of domesticated animals and plants. This book is a valuable resource for archeologists and anthropologists.

  • Molecules, Cells, and Parasites in Immunology

    • 1st Edition
    • Carlos Larralde + 2 more
    • English
    Molecules, Cells, and Parasites in Immunology contains the proceedings of a symposium on immunology held in Mexico City in the fall of 1979 under the auspices of the National University of Mexico (UNAM). This volume brings together prominent foreign scientists and Mexican investigators to discuss the areas of immunology that being developed at UNAM. Either in the form of reviews or of original presentations, the various authors proffer observations and ideas that generally relate to the regulation of the immune response at the molecular and cellular levels. The topic of Molecules encompasses the effect of molecular aggregation upon the triggering of physiological events, cooperative binding, and the expression of immunoglobulins during the lymphocyte differentiation process. Under the heading of Cells, there are contributions dealing with the physiological and pathological roles of interiorized antibodies; the mechanisms of antigen recognition by T cells; and the synthesis of membrane proteins by myeloma cells which somehow protect them from killer T cells. The section on Parasites includes some unique contributions on the immunology of human and animal cysticercosis and amebiasis, complemented by a general discussion of host-parasite relationships.

  • Lymphocyte Differentiation, Recognition, and Regulation

    • 1st Edition
    • David H. Katz
    • F. J. Dixon + 1 more
    • English
    Lymphocyte Differentiation, Recognition, and Regulation provides an overview of the state of knowledge on cellular immunology. The focus is on animal work than on studies in man, although in certain areas human lymphocyte biology has been discussed in some detail. The book attempts to integrate information from diverse areas of cellular immunology, immunogenetics, and immunochemistry to form some cohesive concepts that can be perhaps utilized as a working foundation for students and investigators in various areas of immunology. The book begins with a general description of some of techniques and principles underlying the systems frequently employed in cellular immunology. This is followed by detailed analyses of lymphocyte differentiation, receptor function, and regulatory processes. The main points that emerge from such analyses are that the immune system is an infinitely complex and finely tuned network of cells, receptors, and molecules which interact with one another in a genetically controlled manner that is manifested ultimately in the process known as differentiation.

  • Antigens, Lymphoid Cells and the Immune Response

    • 1st Edition
    • G. J. V. Nossal + 1 more
    • F. J. Dixon + 1 more
    • English
    Antigens, Lymphoid Cells, and the Immune Response deals with the nature and properties of antigens and with the functional anatomy and cell physiology of the mammalian lymphoid system which responds to antigens. The book discusses the central questions in cellular immunology; the antigens and the afferent limb of the immune response; and antibodies and the afferent limb of the immune response. The text also describes the organ distribution of antigens; the functional anatomy of the lymphoid system; and the behavior patterns of lymphoid cells. The microscopic and electron microscopic distribution of antigen in lymphoid organs; the interaction of antigens with cells of the reticuloendothelial system; and the interaction of antigen with lymphoid cells are also considered. The book further tackles the role of antigen in immunological tolerance; antibody production and tolerance dissociated; and antigen and lymphoid cells.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 2
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 2 covers the advances in the field being made to apply bone marrow transplantation to the treatment of several diseases. This volume is divided into 11 chapters and begins with surveys of the clinical considerations of bone marrow transplantation. Considerable chapters are devoted to the application of this transplantation to the treatment of various diseases, including aplastic anemia, aregenerative pancytopenia, leukemia, uniformly fatal severe combined immunodeficiency diseases, and Wiskott-Aldrich syndrome. Other chapters examine the cellular engineering in the form of bone marrow and thymus transplantation. The remaining chapters consider the effects of exposure to excessive amounts of radiation or cytotoxic chemicals, as well as the hematopoietic failure based on malfunction of the complex process of normal hematological development and maintenance. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

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