The Antigens

List of Contributors

Preface

Contents of Other Volumes

Chapter 1 Ir Genes: Antigen-Specific Genetic Regulation of the Immune Response

I. Introduction/Definitions

II. Developing Concepts

III. The Role of Genetic Restriction of Cell Interactions in Ir Gene Function

IV. Levels of Imposition of Genetic Restriction; Role of the Thymic Environment; Studies in Chimeras

V. Ia Antigens as Ir Gene Products

VI. Non-MHC-Linked Ir Genes

VII. The Role of Suppressor Cells in Ir Gene Control

VIII. The T Cell Repertoire Model

IX. The Antigen Presentation Model

X. T Cell Influences on Antibody Specificity

XI. Epilogue

References

Chapter 2 Molecular Genetics of Class II (Ia) Antigens

I. Introduction

II. Immunogenetics

III. Genomic Organization of the I Region

IV. Correlation of Immunogenetic and Molecular Genetic Maps

V. Gene Organization

VI. Polymorphism of Class II Antigens

VII. Correlation Between Structure and Function of Class II Antigens

VIII. Regulation of Ia Expression

IX. Conclusion

References

Chapter 3 Antigen-Specific T Cell Clones and T Cell Factors

I. Introduction

II. Functional T Cell Hybridomas and Their Soluble Products

III. Antigen-Specific Virus-Transformed Functional T Cell Lines

IV. T Cell Continuous Lines and Clones

V. The T Cell Receptor

VI. Concluding Remarks

References

Chapter 4 Infection and Autoimmunity

I. Introduction

II. Molecular Mimicry Between Microbial and Host Antigens

III. Autoantibodies Produced by Patients with Infections

IV. Altered Self

V. Polyclonal Activation

VI. The Role of Infection in the Expression of HLA Class II Antigens in Self Tissues

VII. The Anti-Idiotypic Network

VIII. Specific Therapy of Autoimmune Disease

References

Index