Hepatic Plasma Proteins

Preface


1· Physiological and Clinical Implications of Human Plasma Protein Abnormalities

I. Coagulation Factors

A. Fibrinogen (factor I)

B. Prothrombin, factors VII, IX, and X, protein C, and protein S

C. Factors V and VIII

D. Factors XI, XII, and XIII

II. Plasma Protease Inhibitors

A. Antithrombin III

B. Heparin cofactor II

C. Cl inhibitor (C1NH)

III. Complement Factors

A. Complement cascade and evolutionary groups

B. Inherited defects of complement components

IV. Apolipoproteins

A. Evolutionary groups of apolipoproteins

B. Inherited defects of apolipoproteins


2· Acute-Phase Reactants

I. The α1-Acid Glycoprotein

A. Protein structure and function

B. Genetic variations

C. Evolution

D. Anatomy of the AGP genes

E. Tissue specific expression

F. Modulation of AGP by the acute-phase reaction and hormones

G. Developmental expression

II. C-Reactive Protein

A. Structure of the CRP and gene

B. Transcriptional regulation

C. Human CRP genes in transgenic mice

III. Serum Amyloid Protein

A. SAP and gene structure

B. Tissue deposits of SAP

C. Gene expression

IV. Serum Amyloid A

A. Protein and gene structure

B. Acute-phase reaction, aging, and amyloid formation

C. Function

D. Expression and regulation

V. Complement3

A. C3 protein and gene structure

B. Evolution

C. Regulation of expression of C3

VI. α2-HS-Glycoprotein

A. Protein structure

B. AHSG homologies

C. Tissue specific expression

D. AHSG in bone and development

E. Negative acute-phase reactant

VII. Albumin

A. Protein and gene structure

B. Gene regulation and the acute-phase reaction

C. Human genetic variations


3· Plasma Proteinase Inhibitors

I. Variety of Human Plasma Proteinase Inhibitors

A. α1-Antichymotrypsin

B. α2-Macroglobulin

C. Inter-α trypsin inhibitor

II. α1-Antitrypsin

A. Protein structure and function

B. Genetic variation

C. Biological implications of α1-antitrypsin variants

D. Evolution

E. Anatomy of the PI gene

F. Tissue specific and developmental expression


4. Plasma Protein Vehicles

I. Transferrin

A. Protein structure, evolution, and function

B. Genetic variants

C. Anatomy of the gene

D. Gene expression

II. Ceruloplasmin

A. Protein structure and evolution

B. Function

C. Anatomy of the gene

D. Gene expression

III. Transthyretin and the Retinol Binding Protein

A. Structure of transthyretin and retinol binding proteins and their genes

B. Familial amyloidotic polyneuropathy mutations

C. Gene regulation

D. Tissue specific expression and expression in transgenic mice

IV. Haptoglobin

A. Protein structure

B. Haptoglobin gene structure

C. Expression of the HP gene

V. Hemopexin

A. Protein and gene structure

B. Gene expression

VI. Vitamin D Binding Protein

A. Protein and gene structure

B. Evolutionary studies

C. Gene expression


5. Biochemical Regulators: Cytokines and Transcription Factors

I. Cytokines Regulate Changes in Plasma Protein Synthesis

A. Interleukin-6

B. Interleukin-11

C. Leukemia inhibitory factor

D. Interleukin-1

E. Tumor necrosis factor

F. Transforming growth factor ß

G. Interferons

II. Transcription Factors in the Nucleus Regulate Plasma Protein Gene Expression by Binding to Specific DNA Sequences

A. Helix-turn-helix

B. Zinc finger

C. Leucine zipper

III. Transcription Factors Interact with DNA Sequences of Plasma Protein Genes

A. IL-6DBP (IL-6 NF; LAP; NF-6)

B. IL-6-RE-BP (class 2) (LIF-RE)

C. HNF1 (APF; LFB1; HP1; HS; AFP)

D. HNF2(LF-A1)

E. HNF3

F. HNF4

G. C/EBP

H. NF1/CTF

I. NF-BA1

J. NFKB

K. Sp1

L. AP-1

M. DBP

N.CREB


0. NF-Y (ACF)

References

Index