Opioid Peptides: Biology, Chemistry, and Genetics
The Peptides: Analysis, Synthesis, Biology, Vol. 6
- 1st Edition - May 10, 2014
- Imprint: Academic Press
- Editors: Sidney Udenfriend, Johannes Meienhofer
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 4 5 6 - 7
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 7 9 9 - 4
The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into… Read more
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Request a sales quoteThe Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activity relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.
Contributors
Preface
Introduction
Nomenclature and Abbreviations
Structures of Opiates and Related Nonpeptide Receptor Ligands Discussed in the Text
Opioid Peptides with Special Names
Contents of Previous Volumes
Chapter 1 Opioid Peptide Precursors and Their Genes
I Introduction
II Cloning of cDNAs for Opioid Peptide Precursors
III Nucleotide Sequences of mRNAs Encoding Opioid Peptide Precursors and Assignment of Protein Sequences
IV Cloning and Structural Analysis of Opioid Peptide Precursor Genes
V Regulation of Gene Expression
VI Biological Significance of Multihormone Precursors
VII Concluding Remarks
References
Chapter 2 Proenkephalin and the Products of Its Processing: Chemistry and Biology
I Introduction
II Methodology
III Isolation and Characterization of Enkephalin-Containing Peptides
IV Conclusions from Peptide and Protein Chemistry
V Molecular Biology
VI Evidence for Posttranslational Modifications
VII Distributions of Proenkephalin and Its Products
VIII Biological Considerations
IX Regulation of Proenkephalin Biosynthesis
X Processing of Proenkephalin
XI Concluding Remarks
References
Chapter 3 Pro-opiomelanocortin: A Polyprotein at the Interface of Endocrine and Nervous Systems
I Introduction
II Structure of the Pro-opiomelanocortin (POMC) Polypeptide Precursor and Its Corresponding Gene
III Regulation of Pro-opiomelanocortin-Derived Peptide Production
IV Posttranslation Regulation of Production of Pro-opiomelanocortin-Derived Peptide
V Conclusion
References
Chapter 4 Biology and Chemistry of the Dynorphin Peptides
I History
II Distribution
III The Dynorphin (Kappa Opioid) Receptor
IV Possible Physiologic Functions
V Prospects
References
Chapter 5 Opioid Receptors
I Introduction
II Heterogeneity of Opioid Receptors
III Endogenous Opioid Peptides
IV Isolation of Opioid Receptors
V Conclusions
References
Chapter 6 ß-Endorphin: Structure and Activity
I Introduction
II Synthesis of ß-Endorphin and Its Analogs
III Biological Characterization
IV Structure-Activity Relationships in ß-Endorphins
V Concluding Remarks
References
Chapter 7 Conformational Analysis of Enkephalin and Conformation-Activity Relationships
I Introductory Remarks
II Conformational Models of Enkephalin Based on Structural Comparison with Opiates
III Theoretical Energy Calculations
IV Crystal Structure Determinations
V Conformational Studies in Solution
VI Conformationally Restricted Enkephalin Analogs
VII Conclusion
References
Chapter 8 Structure-Activity Relationships in Enkephalin Peptides
I Introduction
II Structure-Activity Relationships
III Conclusion
References
Chapter 9 Opioid Peptides in Humans and Their Clinical Significance
I Introduction
II Strategies Used in the Study of the Clinical Significance of Endogenous Opioid Peptides
III Distribution of Opioid Peptides in Humans
IV Possible Physiological and Pathophysiological Roles of Opioid Peptides
V Conclusion and Future Prospects
References
Index
- Edition: 1
- Published: May 10, 2014
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9781483204567
- eBook ISBN: 9781483217994
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