Conformation in Biology and Drug Design
The Peptides: Analysis, Synthesis, Biology, Vol. 7
- 1st Edition - November 26, 1985
- Imprint: Academic Press
- Editors: Sidney Udenfriend, Johannes Meienhofer, Victor J. Hruby
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 4 5 7 - 4
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 8 0 0 - 7
The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in… Read more
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Request a sales quoteThe Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.
Contributors
Preface
Nomenclature and Abbreviations
Chapter 1 A Perspective on the Application of Physical Methods to Peptide Conformational-Biological Activity Studies
I Introduction
II Some Biological Considerations
III Historical Development of Peptide Conformational Studies in Solution
IV Theoretical Methods for Examining Peptide Conformations
V Application of Conformational and Dynamic Studies of Peptides to Their Biological Activities
References
Chapter 2 Circular Dichroism of Peptides
I Introduction
II General Aspects of Peptide CD
III Specific Systems
References
Chapter 3 Application of Fluorescence Techniques in Studies of Peptide Conformations and Interactions
I Introductory Remarks
II Fluorophores in Peptides
III Fluorescence Quantum Yield and Lifetime Measurements
IV Fluorescence Polarization Studies
V Measurement of Intramolecular Distances by Singlet-Singlet Resonance Energy Transfer Experiments
VI Fluorescence Studies of Peptide Interactions with Macromolecular Systems
VII Concluding Remarks
References
Chapter 4 Theoretical Methods in the Analysis of Peptide Conformation
I Introduction
II Definitions and Conventions
III Methodology
IV Results
References
Chapter 5 Theoretical Simulation of Conformation, Energetics, and Dynamics of Peptides
I Introduction
II Techniques and Methodology
III Applications
IV Summary and Future Directions
References
Chapter 6 Paramagnetic Metal Ions as Nuclear Magnetic Resonance Probes of Peptide Conformation in Solution
I Introduction
II Paramagnetic Metal Ion-Induced Shifts and Relaxation Enhancements
III Conclusions
References
Chapter 7 Nuclear Magnetic Resonance Studies of Peptide-Macromolecule Interactions
I Introduction
II Nuclear Magnetic Resonance Techniques
III Peptide-Protein Interaction
IV Peptide-Lipid Interaction
V Peptide-Nucleic Acid Interactions
VI Conclusions and Prospects
References
Chapter 8 Solid-State Nuclear Magnetic Resonance of Peptides
I Introduction
II Methods
III Applications
IV Prospects
References
Chapter 9 Modern Nuclear Magnetic Resonance Spectroscopy of Peptides
I Introduction
II Conformational Homogeneity
III General Strategy for Nuclear Magnetic Resonance Investigation of Peptides
IV Assignment of Proton Nuclear Magnetic Resonance Signals
V Heteronuclear Techniques
VI Sequence Analysis
VII Quantitative Evaluation of Nuclear Magnetic Resonance Spectra
VIII Conclusions
References
Index
- Edition: 1
- Published: November 26, 1985
- Imprint: Academic Press
- No. of pages: 516
- Language: English
- Paperback ISBN: 9781483204574
- eBook ISBN: 9781483218007
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