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Mechanisms in Bioenergetics
- 1st Edition - May 10, 2014
- Imprint: Academic Press
- Author: Efraim Racker
- Editor: Anthony San Pietro
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 5 7 4 6 6 2 - 5
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 6 8 9 3 - 4
Advanced Biochemistry: Mechanisms in Bioenergetics provides information pertinent to the fundamental aspects of the mechanisms in bioenergetics. This book covers a variety of… Read more
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Advanced Biochemistry: Mechanisms in Bioenergetics provides information pertinent to the fundamental aspects of the mechanisms in bioenergetics. This book covers a variety of topics, including the enzymatic mechanism of ATP formation and the regulatory mechanisms that control its metabolic utilization. Organized into three parts encompassing 18 lectures, this book begins with an overview of the process of converting nutrients into forms of useful energy, which is the essence of energy metabolism. This text then explores the properties that have a specific bearing on the problem of oxidative phosphorylation. Other lectures consider the phosphoroclastic reaction with pyruvate, which plays a curious and apparently specific role in nitrogen fixation. This book discusses as well the operation of control mechanisms of energy metabolism in intact cells. The final lecture analyzes the rate-limiting steps in carbohydrate metabolism of various cells and some of the metabolic factors that govern them. This book is a valuable resource for graduate students.
PrefaceAbbreviationsReference AbbreviationsPart I Formation of Adenosine Triphosphate in Soluble Systems Lecture 1 General Considerations of Energy Production Substrate Level Oxidative Phosphorylation Phosphoroclastic Reactions Dehydration of 2-Phosphoglycerate Catalyzed by Enolase Oxidative Phosphorylation and Photophosphorylation Lecture 2 Substrate Level Oxidative Phosphorylation (A) Oxidation of Glyceraldehyde 3-Phosphate Lecture 3 Substrate Level Oxidative Phosphorylation (B) Oxidation of Glyceraldehyde 3-Phosphate Lecture 4 Substrate Level Oxidative Phosphorylation (C) Oxidation of Acetaldehyde in Bacteria Aspartic Semialdehyde Dehydrogenase Oxidation of α-Ketoglutarate and Pyruvate Other Variants Lecture 5 Phosphoroclastic Reactions: Phosphoketolase Phosphoketolase Lecture 6 Other Phosphoroclastic Reactions Reactions with Pyruvate Phosphorolysis of a C—N Bond Phosphorolysis of Thiol Esters Dehydration of 2-Phosphoglycerate Catalyzed by EnolasePart II Formation of Adenosine Triphosphate in Particulate Systems Lecture 7 Oxidative Phosphorylation in Mitochondria Stages of Discovery Mitochondrial Enzymes Lecture 8 The Respiratory Chain Cytochromes 𝒂 and 𝒂3 Cytochrome 𝒄 Cytochrome 𝒄1 Cytochrome 𝒃 Flavoproteins Pyridine Nucleotides Ubiquinone-Coenzyme 𝑄 Phospholipids Structural Protein Electron Carriers Lecture 9 Localization of Phosphorylation Sites in Mitochondria The Crossover Point Measurements of the Three Phosphorylation Sites Thermodynamic Considerations Lecture 10 Exchange Reactions in Oxidative Phosphorylation The Pi32-ATP Exchange Quantitative Evaluation The ADP-ATP Exchange The H2O18-Pi and H2O18-ATP Exchanges Lecture 11 Partial Reactions of Oxidative Phosphorylation ATPase Reversal of Electron Transport Lecture 12 Uncouplers and Inhibitors of Oxidative Phosphorylation True Uncouplers of Oxidative Phosphorylation Inhibitory Uncouplers Inhibitors of Oxidative Phosphorylation Inhibitors of Oxidation Lecture 13 Soluble Factors and Intermediates of Oxidative Phosphorylation Nonprotein Factors Protein Coupling Factors Lecture 14 Theories and Speculations TextPart III Regulation of Adenosine Triphosphate Utilization in Multi-Enzyme Systems Lecture 15 Studies of Reconstructed Multi-Enzyme Systems Text Lecture 16 Approaches to The Metabolism of Intact Cells and to The Rate-Limiting Factors in Ascites Tumor Cells Rate-Limiting Factors in Ascites Tumor Cells Lecture 17 Metabolism of Intact Cells Rate-Limiting Factors in HeLa Cells Rate-Limiting Factors in Leukocytes and Brain Rate-Limiting Factors in Muscle Lecture 18 Induced Changes in Energy Metabolism TextSubject Index
- Edition: 1
- Published: May 10, 2014
- Imprint: Academic Press
- Language: English
AS
Anthony San Pietro
Affiliations and expertise
Indiana University, Bloomington, Indiana, U.S.A.Read Mechanisms in Bioenergetics on ScienceDirect