Penicillins and Cephalosporins

Contributors

Preface

Introduction

Contents of Other Volumes


1. The Chemistry of Penicillin Sulfoxide

I. Introduction

II. Penicillin Sulfoxide

III. Reactions of Azetidinone Sulfenic Acids withHalogenating Reagents

IV. Conjugate Addition Reactions of Azetidinone Sulfenic Acids

V. Reactions of Azetidinone Sulfenic Acids with Enol Ethers

VI. Reactions of Azetidinone Sulfenic Acids with Phosphorus Reagents

VII. Reactions of Thiazoline Azetidinones

VIII. Miscellaneous Reactions of Penicillin Sulfoxide

IX. Cephalosporin Chemistry

References


2. Cephalosporin Antibiotics Prepared by Modifications at the C-3 Position

I. Introduction

II. 3-Heteroatom-Substituted Cephalosporins (CI, 0, S, N)

III. Other Cephalosporins Modified at the C-3 Position

References


3. Cephamycin Antibiotics

I. Introduction

II. Natural Products

III. Chemical Procedures for the Introduction of Functionality into C-7 of Cephalosporins and C-6 of Penicillins

IV. Effect of the 7-Methoxy Group on the Chemistry of Cephamycins

V. Structure-Activity Relationships of 6-Substituted Penicillins and 7-Substituted Cephalosporins

References


4. Antimicrobial and Pharmacokinetic Properties of Newer Penicillins and Cephalosporins

I. Microbiological Activity: The Quest for an Expanded Gram-Negative Spectrum

II. Pharmacokinetics: The Quest for Better Absorption and Longer Half-Life

III. Summary and Conclusions

References


5. Theoretical and Physicochemical Studies on ß-Lactam Antibiotics

I. Traditional Views of Structure-Activity Relationships

II. Applicable Theoretical Methods

III. Computational Studies on the Mode of Action of Cephalosporins

IV. Other Computational Investigations

V. Other Physiochemical Studies of ß-Lactams and Relevant Structures

VI. Conclusions

References

Index