Molecular Aspects of Animal Development

Contributors to Volume III

Preface

Contents of Previous Volumes

Chapter 1 Molecular Events During Oocyte Maturation

I. Introduction

II. The Induction of Maturation

III. Morphological Events of Maturation and Their Relationship to Early Development

IV. Macromolecular Synthesis during Maturation

V. Characterization of Hormone-Oocyte Interactions in the Induction of Maturation

VI. Concluding Comments

References

Chapter 2 Transcriptional Patterns in Early Mammalian Development

I. General Introduction

II. Onset of Gene Activity in Preimplantation Mammalian Embryos

III. RNA Containing Poly(A) Sequences in Preimplantation Rabbit Embryos

IV. Complexity of Transcription in Developing Mammals

V. Mechanisms of Transcriptional Control

VI. Relationship of Transcriptional Changes to the General Biochemistry of the Preimplantation Embryo

VII. Concluding Remarks

References

Chapter 3 Occurrence and Developmental Significance of Gene Amplification

I. Introduction

II. Gene Amplification Versus Gene Reiteration

III. Occurrence of Gene Amplification

IV. Visualization of Gene Amplification

V. Possible Mechanisms of Gene Amplification

VI. Theories on Developmental Significance

VII. Summary and Concluding Remarks

References

Chapter 4 The Injection of RNA into Living Cells: The Use of Frog Oocytes for the Assay of mRNA and the Study of the Control of Gene Expression

I. Introduction

II. The Translation and Assay of mRNA's

III. Quantitative Studies: The Efficiency of Translation of Injected mRNA

IV. The Fidelity of Translation of Injected mRNA's

V. The Specificity of the Translational Machinery of the Oocyte

VI. The Post-Translational Modification of Messenger Products

VII. mRNA Injection as a Means for Analyzing the Translational Systems of the Living Cell

VIII. Translation of mRNA-Precursor Molecules

References

Chapter 5 Post-Transcriptional Control of Protein Synthesis

I. Introduction

II. Evidence for Translational Control of Protein Synthesis in Bacteria

III. Evidence for Post-Transcriptional Control of Protein Synthesis in Animal Cells

IV. Concluding Remarks

References

Chapter 6 The Control of Isoenzyme Patterns in Development

I. Introduction

II. Isoenzyme Biochemistry: A General Introduction

III. Isoenzyme Distribution

IV. Mechanisms of Control of Isoenzyme Expression During Development

V. Concluding Remarks

References

Chapter 7 Substances with Morphogenetic Activity in Differentiation of Vertebrates

I. Introduction

II. Determination, Differentiation, and Competence

III. Evidence for the Existence of Special Morphogenetic Factors

IV. Chemical Properties, Biological Activity, and Mechanism of Action of Morphogenetic Substances Effective in Early Embryogenesis

V. Induction and Determination in Normogenesis of Amphibian Embryos

VI. Stimulation of Hematopoiesis

VII. Nerve Growth Stimulating and Epithelial Growth Stimulating Factors

VIII. Concluding Remarks

References

Chapter 8 Protein Nutrition in Growth Regulation during Early Development

I. Introduction

II. The Requirement of Embryos for Nutrient Protein

III. The Requirement of Embryos for Specific Nutrient Proteins

IV. Nutrient Protein Complementation

V. Quantitative Analysis of Protein Utilization

VI. Protein Deprivation during Early Development

References

Chapter 9 Mitochondrial Differentiation during Animal Development

I. Introduction

II. Structure of Mitochondria

III. Enzyme Content of Mitochondria

IV. Mitochondrial Differentiation

V. Concluding Statement

References

Chapter 10 Occurrence and Possible Functions of Mitochondrial DNA in Animal Development

I. Introduction

II. Cytoplasmic DNA

III. Replication and Stability of mt DNA

IV. Transcription of mt DNA

V. Mitochondrial Protein Synthesis

VI. The Possible Results of Interfering with the Mammalian Mitochondrial Genome

VII. Concluding Remarks

References

Author Index

Index to Genus and Species Names

Subject Index