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Elsevier

Books in Life sciences

  • The Science of Grapevines

    Anatomy and Physiology
    • 2nd Edition
    • Markus Keller
    • English
    The Science of Grapevines: Anatomy and Physiology is an introduction to the physical structure of the grapevine, its various organs, their functions and their interactions with the environment. Beginning with a brief overview of the botanical classification (including an introduction to the concepts of species, cultivars, clones, and rootstocks), plant morphology and anatomy, and growth cycles of grapevines, The Science of Grapevines covers the basic concepts in growth and development, water relations, photosynthesis and respiration, mineral uptake and utilization, and carbon partitioning. These concepts are put to use to understand plant-environment interactions including canopy dynamics, yield formation, and fruit composition, and concludes with an introduction to stress physiology, including water stress (drought and flooding), nutrient deficiency and excess, extreme temperatures (heat and cold), and the impact and response to of other organisms. Based on the author’s years of teaching grapevine anatomy as well as his research experience with grapevines and practical experience growing grapes, this book provides an important guide to understanding the entire plant.

  • Biophysical Methods in Cell Biology

    • 1st Edition
    • Volume 125
    • English
    This new volume of Methods in Cell Biology looks at methods for analyzing of biophysical methods in cell biology. Chapters cover such topics as AFM, traction force microscopy, digital holographic microscopy, single molecule imaging, video force microscopy and 3D multicolor super-resolution screening

  • Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A

    • 1st Edition
    • Volume 72
    • English
    This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development.

  • Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

    • 1st Edition
    • Pierfausto Seneci
    • English
    This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents.

  • Riboswitches as Targets and Tools

    • 1st Edition
    • Volume 550
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitches as targets and tools and contains sections on such topics as constructing and optimizing artificial riboswitches, live cell imaging and intracellular sensors with artificial riboswitches, conditional control of gene expression with artificial riboswitches, using artificial riboswitches for protein evolution and pathway optimization, and anti-riboswitch drug screens.

  • Dynamic Systems Biology Modeling and Simulation

    • 1st Edition
    • Joseph DiStefano III
    • English
    Dynamic Systems Biology Modeling and Simuation consolidates and unifies classical and contemporary multiscale methodologies for mathematical modeling and computer simulation of dynamic biological systems – from molecular/cellular, organ-system, on up to population levels. The book pedagogy is developed as a well-annotated, systematic tutorial – with clearly spelled-out and unified nomenclature – derived from the author’s own modeling efforts, publications and teaching over half a century. Ambiguities in some concepts and tools are clarified and others are rendered more accessible and practical. The latter include novel qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory; and analyzing structural and measurement (data) models for quantification feasibility. The level is basic-to-intermediat... with much emphasis on biomodeling from real biodata, for use in real applications.

  • Crash Course Cell Biology and Genetics Updated Print + eBook edition

    • 4th Edition
    • Matthew Stubbs + 1 more
    • Paul Simons
    • English
    The (printed) ‘Updated Edition’ now comes with added value access to the complete, downloadable eBook version via Student Consult. Search, read and revise whilst on the move and use the interactive self-assessment to test your understanding. Crash Course - a more flexible, practical learning package than ever before.Crash Course – your effective everyday study companion PLUS the perfect antidote for exam stress! Save time and be assured you have all the core information you need in one place to excel on your course and achieve exam success.A winning formula now for over 15 years, each series volume has been fine-tuned and fully updated, with an improved layout tailored to make your life easier. Specially written by senior medical students or recent graduates – those who have just been in the exam situation – with all information thoroughly checked and quality assured by expert faculty advisors, the result is books which exactly meet your needs and you know you can trust.The subject of cell biology and genetics has never been more essential to the medical curriculum and to modern medicine – yet is widely feared by students. This fully revised edition aims to make it as easy to understand and remember as possible, to ensure a solid grounding in the essential underlying principles and how they relate to clinical practice. It incorporates the latest developments in this fascinating and fast-moving field – including the human genome project and spin-offs such as the thousand genome project – as well as discussion of important ethical issues. Emerging molecular tools and laboratory techniques are explained so that you can appreciate where new treatments for genetic disease and screening technologies have arisen. An updated self-assessment section matching the latest exam formats then allows you to assess your progress and test your performance.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 314
    • English
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2013: 4.522.

  • Advances in Immunology

    • 1st Edition
    • Volume 125
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • Surface Modification of Magnesium and its Alloys for Biomedical Applications

    Biological Interactions, Mechanical Properties and Testing
    • 1st Edition
    • T.S.N. Sankara Narayanan + 2 more
    • English
    Surface modification of magnesium and its alloys for biomedical applications: Biological interactions, mechanical properties and testing, the first of two volumes, is an essential guide on the use of magnesium as a degradable implant material. Due to their excellent biocompatibility and biodegradability, magnesium based degradable implants provide a viable option for the permanent metallic implants. This volume focuses on the fundamental concepts of surface modification of magnesium, its biological interactions, mechanical properties and, in vitro and in vivo testing. The contents of volume 1 is organized and presented in three parts. Part 1 reviews the fundamental aspects of surface modification of magnesium, including surface design, opportunities, challenges and its role in revolutionizing biodegradable biomaterials. Part 2 addresses the biological and mechanical properties covering an in vivo approach to the bioabsorbable behavior of magnesium alloys, mechanical integrity and, the effects of amino acids and proteins on the performance of surface modified magnesium. Part 3 delves in to testing and characterization, exploring the biocompatibility and effects on fatigue life alongside the primary characteristics of surface modified magnesium. All chapters are written by experts, this two volume series provides systematic and thorough coverage of all major modification technologies and coating types of magnesium and its alloys for biomedical applications.

  • Nonviral Vectors for Gene Therapy

    Physical Methods and Medical Translation
    • 1st Edition
    • Volume 89
    • English
    The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 90
    • English
    A compilation of up to date reviews of topics in biotechnology and medical field.

  • Control of Plant Virus Diseases

    Vegetatively-Propagated Crops
    • 1st Edition
    • Volume 91
    • English
    The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field. The series of eclectic volumes are valuable resources to virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers. Volume 91 features articles on control of plant virus diseases.

  • The Molecular Basis of Viral Infection

    • 1st Edition
    • Volume 129
    • English
    Virology is in a sense both one of the most important precursors and one of the most significant beneficiaries of structural and cellular molecular biology. Numerous breakthroughs in our understanding of the molecular interactions of viruses with host cells are ready for translation into medically important applications such as the prevention and treatment of viral infections. This book collects a wide variety of examples of frontline research into molecular aspects of viral infections from virological, immunological, cell- and molecular-biological... structural, and theoretical perspectives.

  • The Management of Scientific Integrity within Academic Medical Centers

    • 1st Edition
    • Peter Snyder + 2 more
    • English
    The Management of Scientific Integrity within Academic Medical Centers discusses the impact scientific misconduct has in eight complex case studies. Authors look at multifaceted mixtures of improper behavior, poor communication, cultural issues, adverse medical/health issues, interpersonal problems and misunderstandings to illustrate the challenge of identifying and managing what went wrong and how current policies have led to the establishment of quasi legal processes within academic institutions. The book reviews the current global regulations and concludes with a section authored by a US federal court judge who provides his perspective on the adequacy of current regulations and policies.

  • Advances in Agronomy

    • 1st Edition
    • Volume 129
    • English
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial. Six volumes are published yearly which ensures that authors’ contributions are disseminated to the readership in a timely manner.

  • 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine

    • 1st Edition
    • Lijie Grace Zhang + 2 more
    • English
    3D Bioprinting and Nanotechnology in Tissue Engineering provides an in depth introduction to these two technologies and their industrial applications. Stem cells in tissue regeneration are covered, along with nanobiomaterials. Commercialization, legal and regulatory considerations are also discussed in order to help you translate nanotechnology and 3D printing-based products to the marketplace and the clinic. Dr. Zhang’s and Dr. Fishers’ team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application.The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs, and this book provides an overview of these technologies and their integration. It shows how nanotechnology can increase the clinical efficiency of prosthesis or artificial tissues made by bioprinting or biofabrication. Students and professionals will receive a balanced assessment of relevant technology with theoretical foundation, while still learning about the newest printing techniques.

  • Essential Clinical Anatomy of the Nervous System

    • 1st Edition
    • Paul Rea
    • English
    Essential Clinical Anatomy of the Nervous System is designed to combine the salient points of anatomy with typical pathologies affecting each of the major pathways that are directly applicable in the clinical environment. In addition, this book highlights the relevant clinical examinations to perform when examining a patient’s neurological system, to demonstrate pathology of a certain pathway or tract. Essential Clinical Anatomy of the Nervous System enables the reader to easily access the key features of the anatomy of the brain and main pathways which are relevant at the bedside or clinic. It also highlights the typical pathologies and reasoning behind clinical findings to enable the reader to aid deduction of not only what is wrong with the patient, but where in the nervous system that the pathology is.

  • The Sea Cucumber Apostichopus japonicus

    History, Biology and Aquaculture
    • 1st Edition
    • Volume 39
    • Hongsheng Yang + 2 more
    • English
    While sea cucumber is one of China's and Asia’s most prized seafoods, and aquaculture programs are being developed on a huge commercial scale, Chinese expertise and knowledge in this area has not been well disseminated worldwide. The Sea Cucumber Apostichopus japonicus is the first book to bridge this gap by compiling key information related to hatchery and aquaculture techniques, nutritional and medical values, markets, and trade flow of the number one sea cucumber species. It summarizes the historical and most recent developments in the trade and aquaculture of Apostichopus japonicus, as well as important aspects of its anatomy, population dynamics, reproduction, development, physiology, and biochemistry. With sea cucumber harvest and aquaculture booming worldwide, comprehensive knowledge of China’s technological breakthroughs in this rapidly expanding field is key. The Sea Cucumber Apostichopus japonicus is essential to understanding the cultural underpinnings of the insatiable market demands for sea cucumber and what drives sea cucumber trade. It also provides biological information and aquaculture techniques that can be adapted to other species, making it a valuable resource for researchers and practitioners involved in sea cucumber harvesting, aquaculture, and conservation.

  • Tortillas: Wheat Flour and Corn Products

    • 1st Edition
    • LW Rooney + 1 more
    • English
    Corn and wheat are among the most important cereals worldwide, representing many of the calories and proteins consumed. Tortillas and tortilla-related products are among the fastest-growing segments of the food industry and represent a sizeable portion of those calories. Tortillas: Wheat Flour and Corn Products answers the food industry’s need to meet the growing demand for high-quality tortillas and tortilla-based foods. This book will guide food scientists, product developers, and nutritionists through the fascinating science and technology behind the production of corn and wheat flour tortillas. This title is the most comprehensive English-language book of its kind. It fully describes the technology, nutritional value, and quality control measures of corn and wheat flour tortillas, tortilla chips, and related products. It accomplishes this through 300 pages of quality text, complemented by easy-to-understand facts, figures, tables, and summaries that seamlessly guide users to an understanding of the fundamental underlying principles that optimize tortilla production and guide product development. Tortillas: Wheat Flour and Corn Products is ideal for academics and industry professionals, including food science and nutrition students; people working in the tortilla and snack food industries; industry staff interested in the quality control/assurance aspects of tortillas; and professionals interested in cereal processing and product development. Edited by the renowned food science educators in tortilla production, this book provides high-quality training at both the academic and corporate levels

  • Heat Transfer and Fluid Flow in Biological Processes

    • 1st Edition
    • Sid M. Becker + 1 more
    • English
    Heat Transfer and Fluid Flow in Biological Processes covers emerging areas in fluid flow and heat transfer relevant to biosystems and medical technology. This book uses an interdisciplinary approach to provide a comprehensive prospective on biofluid mechanics and heat transfer advances and includes reviews of the most recent methods in modeling of flows in biological media, such as CFD. Written by internationally recognized researchers in the field, each chapter provides a strong introductory section that is useful to both readers currently in the field and readers interested in learning more about these areas. Heat Transfer and Fluid Flow in Biological Processes is an indispensable reference for professors, graduate students, professionals, and clinical researchers in the fields of biology, biomedical engineering, chemistry and medicine working on applications of fluid flow, heat transfer, and transport phenomena in biomedical technology.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 6- Regulation of Autophagy and Selective Autophagy
    • 1st Edition
    • M. A. Hayat
    • English
    Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus. The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored. This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

  • Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

    • 1st Edition
    • Manmohan Singh + 1 more
    • English
    Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies.

  • Brain Metastases from Primary Tumors, Volume 2

    Epidemiology, Biology, and Therapy
    • 1st Edition
    • M. A. Hayat
    • English
    Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors fills that gap, serving as the first two-part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age- and gender-related trends are also discussed, as is the use of biomarkers for early detection.

  • Cellular and Molecular Neurophysiology

    • 4th Edition
    • Constance Hammond
    • English
    Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology.

  • Bark Beetles

    Biology and Ecology of Native and Invasive Species
    • 1st Edition
    • Fernando E. Vega + 1 more
    • English
    Bark Beetles: Biology and Ecology of Native and Invasive Species provides a thorough discussion of these economically important pests of coniferous and broadleaf trees and their importance in agriculture. It is the first book in the market solely dedicated to this important group of insects, and contains 15 chapters on natural history and ecology, morphology, taxonomy and phylogenetics, evolution and diversity, population dynamics, resistance, symbiotic associations, natural enemies, climate change, management strategies, economics, and politics, with some chapters exclusively devoted to some of the most economically important bark beetle genera, including Dendroctonus, Ips, Tomicus, Hypothenemus, and Scolytus. This text is ideal for entomology and forestry courses, and is aimed at scientists, faculty members, forest managers, practitioners of biological control of insect pests, mycologists interested in bark beetle-fungal associations, and students in the disciplines of entomology, ecology, and forestry.

  • Estrogen Effects on Traumatic Brain Injury

    Mechanisms of Neuroprotection and Repair
    • 1st Edition
    • Kelli A Duncan
    • English
    This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury.

  • Handbook of Arsenic Toxicology

    • 1st Edition
    • Swaran Jeet Singh Flora
    • English
    Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention.

  • Craniopharyngiomas

    Comprehensive Diagnosis, Treatment and Outcome
    • 1st Edition
    • James J. Evans + 1 more
    • English
    Craniopharyngiomas: A Comprehensive Guide to Diagnosis, Treatment and Outcome is a comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas, rare brain tumors that grow near the pituitary gland. Even though these tumors are generally benign, due to the location, prognosis was often bleak. This reference provides a resource for specialists requiring a comprehensive overview of this rare form of tumor, outlining new diagnostic, imaging and surgical techniques, including endoscopic endonasal cranial base surgery, which enable successful neurosurgical intervention. With a better prognosis, patients require multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology.

  • Bones and Cartilage

    Developmental and Evolutionary Skeletal Biology
    • 2nd Edition
    • Brian K. Hall
    • English
    Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail. The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research.

  • Sea Otter Conservation

    • 1st Edition
    • Shawn Larson + 2 more
    • English
    Sea otters are good indicators of ocean health. In addition, they are a keystone species, offering a stabilizing effect on ecosystem, controlling sea urchin populations that would otherwise inflict damage to kelp forest ecosystems. The kelp forest ecosystem is crucial for marine organisms and contains coastal erosion. With the concerns about the imperiled status of sea otter populations in California, Aleutian Archipelago and coastal areas of Russia and Japan, the last several years have shown growth of interest culturally and politically in the status and preservation of sea otter populations. Sea Otter Conservation brings together the vast knowledge of well-respected leaders in the field, offering insight into the more than 100 years of conservation and research that have resulted in recovery from near extinction. This publication assesses the issues influencing prospects for continued conservation and recovery of the sea otter populations and provides insight into how to handle future global changes.

  • Cognitive Enhancement

    Pharmacologic, Environmental and Genetic Factors
    • 1st Edition
    • Shira Knafo + 1 more
    • English
    Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance. The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals.

  • Re-Engineering Clinical Trials

    Best Practices for Streamlining the Development Process
    • 1st Edition
    • Peter Schueler + 1 more
    • English
    The pharmaceutical industry is currently operating under a business model that is not sustainable for the future. Given the high costs associated with drug development, there is a vital need to reform this process in order to provide safe and effective drugs while still securing a profit. Re-Engineering Clinical Trials evaluates the trends and challenges associated with the current drug development process and presents solutions that integrate the use of modern communication technologies, innovations and novel enrichment designs. This book focuses on the need to simplify drug development and offers you well-established methodologies and best practices based on real-world experiences from expert authors across industry and academia. Written for all those involved in clinical research, development and clinical trial design, this book provides a unique and valuable resource for streamlining the process, containing costs and increasing drug safety and effectiveness.

  • Switchable and Responsive Surfaces and Materials for Biomedical Applications

    • 1st Edition
    • Johnathan Zhang
    • English
    Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors.

  • Lipids, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 43-4
    • Donald A. Smith
    • English
    This issue of Endocrinology and Metabolism Clinics, devoted to Lipids, is edited by Dr. Donald A. Smith. Articles in this issue include: Advanced Lipoprotein Testing; Improving Cardiovascular Risk Assessment: Coronary calcium scor and CT coronary imaging; Understanding HDL; Statin Strategies for Maximizing Public Health: benefits and harms; Cellular Cholesterol Regulation: SREBP and miRNA; Mediterranean Diet – the best diet for CV protection?; Pediatric Lipidology: An Earlier Approach; Newer LDL-lowering Therapies; and Statin Combination Therapies.

  • Controlled Drug Delivery

    The Role of Self-Assembling Multi-Task Excipients
    • 1st Edition
    • M A Mateescu + 2 more
    • English
    In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in this comprehensive book include: the concept of self-assembling; starch and derivatives as pharmaceutical excipients; and chitosan and derivatives as biomaterials and as pharmaceutical excipients. Later chapters discuss polyelectrolyte complexes as excipients for oral administration; and natural semi-synthetic and synthetic materials. Closing chapters cover protein-protein associative interactions and their involvement in bioformulations; self-assembling materials, implants and xenografts; and provide conclusions and perspectives.

  • Planning a Career in Biomedical and Life Sciences

    Making Informed Choices
    • 1st Edition
    • Avrum I. Gotlieb
    • English
    Planning a Career in Biomedical and Life Sciences presents useful information, insights, and tips to those pursuing a career in the biomedical and life sciences. The book focuses on making educated choices during schooling, training, and job searching in both the academic and non-academic sectors. The premise of Planning a Career in Biomedical and Life Sciences is that by understanding the full path of a career in either the biomedical or life science fields, you can proactively plan your career, recognize any opportunities that present themselves, and be well prepared to address important aspects of your own professional development. Topics include choosing your training path, selecting the best supervisor/mentor, and negotiating a job offer.

  • Navigating Academia: A Guide for Women and Minority STEM Faculty

    • 1st Edition
    • Pauline Mosley + 1 more
    • English
    Navigating Academia: A Guide for Women and Minority STEM Faculty explores the infrastructure of the academy and provides a systematic account of where and why women and minorities fall behind men in the preparation for and development of their academic careers. This book offers useful strategies for recruiting, retaining, and advancing women and minorities. Chapters include testimonials from faculty and administrators about how they made their ascent within the academy. Navigating Academia: A Guide for Women and Minority STEM Faculty also discusses how to modify and expand faculty recruiting programs, how to diversify search committees, how to encourage intervention by deans, and how to assess past hiring efforts. This guide is an important resource for women and minorities seeking success in the academy as well as for administrators focused on faculty and professional development.

  • An Introduction to Biotechnology

    The Science, Technology and Medical Applications
    • 1st Edition
    • W.T. Godbey
    • English
    An Introduction to Biotechnology is a biotechnology textbook aimed at undergraduates. It covers the basics of cell biology, biochemistry and molecular biology, and introduces laboratory techniques specific to the technologies addressed in the book; it addresses specific biotechnologies at both the theoretical and application levels.Biotechnology is a field that encompasses both basic science and engineering. There are currently few, if any, biotechnology textbooks that adequately address both areas. Engineering books are equation-heavy and are written in a manner that is very difficult for the non-engineer to understand. Numerous other attempts to present biotechnology are written in a flowery manner with little substance. The author holds one of the first PhDs granted in both biosciences and bioengineering. He is more than an author enamoured with the wow-factor associated with biotechnology; he is a practicing researcher in gene therapy, cell/tissue engineering, and other areas and has been involved with emerging technologies for over a decade. Having made the assertion that there is no acceptable text for teaching a course to introduce biotechnology to both scientists and engineers, the author committed himself to resolving the issue by writing his own.

  • Biomarkers and Biosensors

    Detection and Binding to Biosensor Surfaces and Biomarkers Applications
    • 1st Edition
    • Ajit Sadana + 1 more
    • English
    Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market.

  • Inflammation in Heart Failure

    • 1st Edition
    • Matthijs Blankesteijn + 1 more
    • English
    Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students.

  • Personalized Cancer Chemotherapy

    An Effective Way of Enhancing Outcomes in Clinics
    • 1st Edition
    • Da Yong Lu
    • English
    Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations. A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed. This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes.

  • Oral Delivery of Insulin

    • 1st Edition
    • T.A. Sonia + 1 more
    • English
    Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.

  • Cord Blood Stem Cells Medicine

    • 1st Edition
    • Catherine Stavropoulos-Giokas + 2 more
    • English
    Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy.

  • A Complete Course in Canning and Related Processes

    Volume 2: Microbiology, Packaging, HACCP and Ingredients
    • 14th Edition
    • Susan Featherstone
    • English
    A Complete Course in Canning is firmly established as a unique and essential guide to canning and related processes. Professionals in the canning industry and students have benefited from successive editions of the book for over 100 years. This major new edition continues that reputation, with extensively revised and expanded coverage. The three-title set is designed to cover all planning, processing, storage and quality control phases undertaken by the canning industry in a detailed, yet accessible fashion. Major changes for the new edition include new chapters on regulation and labelling that contrast the situation in different regions worldwide, updated information on containers for canned foods and new information on validation and optimization of canning processes, among many others.

  • Advances in Software Science and Technology

    • 1st Edition
    • Volume 5
    • Tsutomu Kamimura
    • English
    This serial is a translation of the original works within the Japan Society of Software Science and Technology. A key source of information for computer scientists in the U.S., the serial explores the major areas of research in software and technology in Japan. These volumes are intended to promote worldwide exchange of ideas among professionals.This volume includes original research contributions in such areas as Augmented Language Logic (ALL), distributed C language, Smalltalk 80, and TAMPOPO-an evolutionary learning machine based on the principles of Realtime Minimum Skyline Detection.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 71
    • English
    Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Human Chorionic Gonadotropin (hCG)

    • 2nd Edition
    • Laurence A. Cole
    • English
    Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.

  • Side Effects of Drugs Annual

    A worldwide yearly survey of new data in adverse drug reactions
    • 1st Edition
    • Volume 36
    • English
    The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

  • Reference Module in Biomedical Research

    • 1st Edition
    • Michael J. Caplan
    • English

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