Regulatory Mechanisms of Carbohydrate Metabolism

General Introduction to the Proceedings

Foreword

Session 1. General Session

Metabolism of Pyruvate in Animals

Control of Hepatic Gluconeogenesis and Glucose Output by Glucagon and Insulin

Mapping the Regulatory Pathways of Glycogen Metabolism in Mammalian Skeletal Muscle

Mechanism of Insulin Secretion

Session 2. The Role of Pyruvate in the Regulation of Carbohydrate Metabolism

Regulation of Liver Pyruvate Kinase by Phosphorylation-Dephosphorylation Reactions

Pyruvate Transport across Mitochondrial and Plasmamembranes

Regulation of Heart Muscle Pyruvate Dehydrogenase by Phosphorylation/Dephosphorylation Reactions

Session 3. The Regulation of Gluconeogenesis

Hormonal Regulation of Phosphoenolpyruvate Carboxykinase (GTP) Synthesis

Regulation of Phosphopyruvate Synthesis in Normal and Pathological States

Session 4. Control of Muscle Glycogen Metabolism by Protein Kinases and Phosphates

Control of Rabbit Muscle Phosphorylase Phosphatase Activity

The Role of Calcium Dependent Protein Kinase in the Regulation of Muscle Glycogen Metabolism

The Role of Glycogen Synthase Kinase 2 in the Regulation of Glycogen Synthase

Specificities of Synthase Kinases and Phosphatase for the Phosphorylatable Sites in Glycogen Synthase

Session 5. Ketogenesis and Carbohydrate Metabolism

Interactions between Ketogenesis and Carbohydrate Metabolism in Rat Liver

Regulation of Partition of Free Fatty Acids between Triglyceride Synthesis and β-Oxidation in Liver

Interaction between Ketone-Body and Carbohydrate Metabolism in Peripheral Tissue

Session 6. Structure and Function of Phosphorylase

The Crystal Structure of Glycogen Phosphorylase b

Pyridoxal Phosphate Analogs and Coenzyme Function in Glycogen Phosphorylase

The Role of Pyridoxalphosphate in Glycogen Phosphorylases

Session 7. Regulatory Mechanisms in the Secretion of Pancreatic Hormones

Factors Controlling Glucagon Secretion

The Use of Glucose Analogues in the Elucidation of the Mechanisms of Insulin Release and Biosynthesis

Starvation: A Model for the Impaired Stimulus Recognition and Stimulus-Secretion-Coupling in Pancreatic ß-Cells

Metabolic and Secretory Characteristics of Cultured Human Islets of Langerhans

Session 8. Energy Homeostasis and the Regulation of Carbohydrate Metabolism

Regulation of Hepatic Glycolysis and Gluconeogenesis at the Step of Phosphofructokinase/FDPase

Substrate Cycles in the Control of Energy Metabolism in the Intact Animal

Phosphorus Nuclear Magnetic Resonance Studies on Perfused Heart

Session 9. Control of Glycogen Metabolism in Liver

The Glycoprotein Nature of Liver Glycogen

cAMP-Mediated and Non-cAMP-Mediated Hormonal Control of Liver Glycogenolysis

Properties and Regulation of Liver Protein Phosphatases

Release of Gluconeogenic Precursors from Skeletal Muscle

Index