Antimetabolites in Biochemistry, Biology and Medicine
Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10-12, 1978
- 1st Edition - January 1, 1979
- Imprint: Pergamon
- Editors: J. Skoda, P. Langen
- Language: English
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 8 9 0 9 - 3
FEBS: Federation of European Biochemical Societies, Volume 57: Antimetabolites in Biochemistry, Biology, and Medicine is a collection of papers that presents that advancement in… Read more
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Request a sales quoteFEBS: Federation of European Biochemical Societies, Volume 57: Antimetabolites in Biochemistry, Biology, and Medicine is a collection of papers that presents that advancement in the field of antimetabolites research. The title first covers the use of antimetabolites in enzymology, and then proceeds to tackling the consequences of analog incorporation into nucleic acids. Next, the selection discusses the rational approach to the use of antimetabolite in commination cancer chemotherapy an in immunosuppression. The text also covers the aspects of selective antiviral action. In the last part, the selection details various compounds, along with their synthesis and mechanisms of action. The book will be of great use to researchers and practitioners of biochemistry, biology, and medicine.
Introductory Remarks
Anti-metabolites as Tools in Enzymology
Recent Studies on the Interaction of 5-Fluoro-2'-deoxyuridylate with Thymidylate Synthetase
The Site of Action of Fluorouracil in Relation to the Amino Acid Sequence of Thymidylate Synthetase
Pharmacology of 5-AZA-2'-Deoxycytidine
Inhibitors of Thymidylate Synthetase
The Development of α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones as Inhibitors of Ribonucleotide Reductase
Transformation and Incorporation of 5-aza-2'-Deoxycytidine in the Lymphatic System
Consequences of Analog Incorporation into Nucleic Acids
The Effect of 5-Fluoropyrimidines on the Processing of Ribonucleic Acids in Liver
The Interactions of BrdU-Substituted DNA with LAC Repressor and Histones
The Incorporation of Hydroxymethyldeoxyuridine into DNA of Ehrlich Ascites Carcinoma Cells and Some of its Consequences
The Effect of Substrate Modification on Transcription of DNA by DNA-dependent RNA Polymerase
Some Structural Aspects of Nucleoside Antimetabolites, with Particular Reference to Tautomerism and Conformation
Transition State Analogs as Antimetabolites
Rational Approach to the Use of Anti-metabolites in Combination Cancer Chemotherapy and in Immunosuppression
Antimetabolites in Cancer Chemotherapy: Past, Present and Future
Approaches to Improved Therapeutic Selectivity with Methotrexate
Rational Use of Antimetabolites of Specific Amino Acids in Combination Chemotherapy of Cancer
Selectivity of Anticancer Drug Action in the Modulation of the Immune Response
Synthesis, Antineoplastic Effect in Animals with Experimental Tumors, and Some Other Biological Properties of Compound 9777-VUFB (DAMVAR)
Localized Chemotherapy of Solid Experimental Tumors with Macromolecular Carriers Containing Antifolates
Rational Use of Antimetabolites in Cancer Chemotherapy with Special Reference to High Dose Methotrexate/Citrovorum Factor Rescue Therapy
Aspects of Selective Antiviral Action
Selective Inhibition of Oncornaviral Functions (a Molecular Approach)
Strategy for the Development of Selective Anti-Herpes Virus Agents based on the Unique Properties of Viral-induced Enzymes - Thymidine Kinase, DNase and DNA Polymerase
Comparative Study of the Potency and Selectivity of Anti-Herpes Compounds
Molecular Basis for Serendipitous Development of Antiviral and Anticancer Aminonucleosides
New Types of Compounds, their Synthesis and Mechanism of Action
Some Consequences of Inhibition of the de novo Pathway of Pyrimidine Biosynthesis
Manipulation of Purine Nucleotide Concentrations by Antimetabolites
Molecular Targets for Methotrexate
Rational Design of Anti-Herpes Virus Anti-Metabolites
Search for New Antimetabolites and New Latent Forms of Metabolites and Antimetabolites among the Nucleoside Alkylphosphonates
"3-Oxapyrimidines" (Derivatives of 2,3-Di-hydro-1,3-6H-Oxazine) - A New Category of Antimetabolites with a Short Half-life
Author Index
Subject Index
- Edition: 1
- Published: January 1, 1979
- No. of pages (eBook): 384
- Imprint: Pergamon
- Language: English
- eBook ISBN: 9781483189093
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