Limited Offer
Frontiers in Catecholamine Research
Proceedings of the Third International Catecholamine Symposium Held at the University of Strasbourg, Strasbourg, France May 20–25, 1973
- 1st Edition - May 18, 2014
- Editors: Earl Usdin, Solomon H. Snyder
- Language: English
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 5 5 8 6 - 9
Frontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg,… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteFrontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg, France, on May 20-25, 1973. This book is organized into nine parts encompassing 205 chapters. The text begins with a discussion on clinically and experimentally used drugs that have been developed or whose mechanism of action has been clarified through monoamine research. Parts II and III deal with enzymes related to catecholamine studies, their properties, regulation, genetics, mechanism of action, and localization. Parts IV and V examine the concepts of synaptic dynamics of brain regulators and the isolation, characterization, methods of analysis, and mechanism of action of catecholamines. Part VI focuses on the complexities that surround the extrapolation of catecholamine function into the realms of electrophysiology and behavior. Part VII discusses the metabolism, behavioral, neurological, and physiological effects of amphetamine and other drugs of abuse. The concluding parts describe the role of catecholamine and its metabolism in neurologic diseases, such as schizophrenia.
Foreword
Historical
Acknowledgments
Participants
Abbreviations
I. Keynote Address
The Impact of Monoamine Research on Drug Development
II. Enzymes
Two Mechanisms of Catecholamine storage in Adrenal Chromaffin Granules
Properties of Tyrosine Hydroxylase
Cofactors of Tyrosine Hydroxylase
Characterization of dopa decarboxylase
Characterization, Localization and Regulation of Catecholamine Synthesizing Enzymes
Immunological Localisation of Dopamine-β-Hydroxylase on the Chromaffin Granule Membrane
New Inhibitors of Microbial Origin for Dopamine-β-Hydroxylase
Picolinic Acid Derivatives as Inhibitors of Dopamine β-Hydroxylase In Vivo; their Effects on Blood Pressure and Stress Ulcer
The Innervation of Cerebral Blood Vessels by Central Noradrenergic Neurons
Comparative Studies on Bovine and Guinea Pig Tyrosine Hydroxylase
Regulation of Phenylethanolamine N-Methyltransferase
Catechol-O-Methyltransferase
The cellular Localization and Physiological Role of Catechol-O-Methyltransferase in the Body
Immunological Characterization of Catechol-O-Methyltransferase
New Concepts on the N-Methylation Reactions of Biogenic Amines in Adrenal Medulla and Brain
Ring Dehydroxylation of N-Methylation of Noradrenaline and Dopamine in the Intact Rat Brain
Degradation of the Transmitter Amines by Specific Types of Monoamine Oxidases
The Importance of the 'Hydroxylamine Metabolic Route' in Pharmacology, Toxicology and Pharmacokinetics
Some Characteristics of Rat Liver Mitochrondrial Monoamine Oxidases
The Nature of the Electrophoretically Separable Forms of Monoamine Oxidase
Transformation of Monoamine Oxidases and Deamination of Fattyaromatic Monoamines
On the Mechanism of Inhibition of Monoamine Oxidase
Selective Localization of Monoamine oxidase Forms in Rat Mesenteric Artery
Oxidative-Reductive Pathways for Metabolism of Biogenic Aldehydes
Sulfate Conjugates in the Brain
Reporter's Notes
First Session
Second Session
III. Regulation
Trans-synaptic Regulation of Tyrosine Hydroxylase
Modulation of Adrenal Tyrosine Hydroxylase Induction by Serotonin Nerve Function
Role of Catecholamines in Induction of Adrenal Tyrosine Hydroxylase
Dopamine-β-Hydroxylase and the Regulation of Catecholamine Biosynthesis
Retrograde Axonal Transport of Dopamine-β-Hydroxylase
Growth and Development of a Sympathetic Ganglion In Vivo
Studies on the Mechanism of Regulation of Tyrosine Hydroxylase Activity during Nerve Stimulation
Transsynaptic and Humoral Regulation of Adrenal Catecholamine Synthesis in Stress
Transsynaptic Regulation of Tyrosine Hydroxylasein Adrenal Medulla: Possible Role of Cyclic Nucleotides
Comment—Cholinergic Regulation of Tyrosine Hydroxylase
Sympathetic Ganglia in Culture
Lack of Relationship between Noradrenaline Content and Tyrosine Hydroxylase Activity in Cultured Sympathetic Ganglia
Induction of Tyrosine Hydroxylase in Superior Cervical Ganglion by Cold Exposure: Effects of Decentralization and Mecamylamine
Regulation of Catechol Synthesis in an Adrenergic Clone of Mouse Neuroblastoma
Development of the Central Catecholaminergic Neurons of the Rat
Interaction between the Nerve Growth Factor (NGF) and Adrenergic Blocking Agents in Sympathetic Neurons
Neuroblastoma Cells as a Tool for Neuronal Molecular Biology
Reporter's Notes
IV. Synaptic Dynamics of Receptors
The classification of Adrenergic Receptors
Antagonism of Propranolol to Isoproterenol in Guinea-Pig Trachea: Some Cautionary Findings
Regulation of Cyclic AMP Levels in Brain
Regulation of Adenosine 3',5'-Cyclic Monophosphate Metabolism in Hybrid Somatic Cells
Ontogenetic Development of the Catecholamine-Sensitive Adenyl Cyclase Activity of Rat Cerebral Cortex
Role of β-Adrenergic Receptor in the Control of Serotonin N-Acetyltransferase in Rat Pineal
Beta-Adrenergic Regulation of Indole Metabolism in the Pineal Gland
Selective Regulation of the Multiple Molecular form of Cyclic Nucleotide Phosphodiesterase by Norepinephrine and Other Agents
StereoiSomers of Catecholamines
Effects of Catecholamines and Prostaglandins on Cyclic AMP Levels in Brain In Vivo
Development of Antibodies against Catecholamines
Metabolic Responses of Cardiac, Skeletal Muscle, and Fat Cells to Catecholamines
Methods of Approach for the Isolation of β-Adrenergic Receptors
Toward Isolation of a β-Adrenergic Binding Protein
Recent Advances in the Active site Chemistry of the Adrenergic Alpha-Receptor
Operation of Two Epinephrine Receptors and an Acetylcholine Receptor in the Exocrine Cell of the Rat Parotid Gland
Dopamine-, Octopamine- and Serotonin-Sensitive Adenylate Cyclases: Possible Receptors in Aminergic Neurotransmission
Comparison of the Excitatory Action of Acetylcholine and Noradrenaiine on the Guinea-Pig Myometrium
Possible Mechanism of the Action of Catecholamines on Smooth Muscle
Reporter's Notes
V Synaptic Dynamics
Chairman's remarks
Catecholamine Release and Mobilization of Protein
Neuronal and Extraneuronal Catecholamine Uptake Mechanisms
The Possible Importance of Young (large) Amine Storage Granules for Adrenergic Nerve Terminal Function
Conformational Aspects of the Inhibition of Neuronal Uptake of Noradrenaiine by Tricyclic Antidepressants
Composition and Molecular Organization of Chromaffin Granules
A Large Second Pool of Norepinephrine in the Highly Purified Vesicle Fraction from Bovine Splenic Nerve
Effect of Electrolytes on Amine Transport and Release Mechanisms in Nerve Endings
Small Intensely Fluorescent (SIF) Cells In Vivo and In Vitro
Neuronal Catecholamine Storage Vesicles
Secretion and Recovery of Catecholamines by the Adrenal Medulla
New Aspects of the Localization of Catecholamines in Adrenergic Neurons
Plastic Changes of Central Noradrenaline Neurons after 6-Hydroxydopamine
Characterization of Cortical Noradrenergic Axon Terminals with High Resolution Radioautography
Matrix Phase Organization in the Adrenal Chromaffin Granule
Release of Amines from Sympathetic Nerves
Mechanisms of Exocytosis
Immunological Studies of Dopamine β-Hydroxylase as a Marker for Adrenergic Synaptic Vesicles
Mechanisms of Catecholamine Secretion: Dual Feedback Control of Sympathetic Neurotransmitter Secretion; Role of Calcium
The Effect of Transmitter Release on the Dopamine β-Hydroxylase Content of Sympathetic Nerve Terminals
Phospholipids of the Chromaffin Granule Membrane and Catecholamine
Exocytosis at Sympathetic Nerve Terminals
On the Dynamics of Catecholamines Storage Structures in Sympathetic Neurons of the Rat as Studied by Radioautography
New Investigations of the Cardiovascular Actions of Dopamine
Drug Actions on α-Methyl-m-Tyramine, a False Dopaminergic Transmitter in the Rat Striatum
Extraneuronal Uptake of Catecholamines
Regulation of Catecholamine Release
Regulation of Catecholamine Release: The Muscarinic Inhibitory Mechanism
The Regulation of Transmitter Release Elicited by Nerve Stimulation through a Presynaptic Feed-back Mechanism
The Neurogenic Short-term Control of Catecholamine Synthesis and Release in the Sympatho-Adrenal System, as Reflected in the Levels of Endogenous Dopamine and β-Hydroxylated Catecholamines
In Vivo Release of 3H-DA from the Cat Caudate Nucleus
Regulation of Catecholamine Release: α-Receptor Mediated Feed-back Control in Peripheral and Central Neurones
Effect of Impulse Flow on the Release and Synthesis of Dopamine in the Rat Striatum
Effectiveness of Adrenergic Transmitter Concentrations in Synaptic Clefts of Differing Dimensions
Pulse-to-Pulse Modulation of Noradrenaline Release through a Prejunctional α-Receptor Auto-inhibitory Mechanism
Aspects on Prostaglandin and α-Receptor Mediated Control of Transmitter Release from Adrenergic Nerves
Catecholamine Release and Receptors in Brain Slices
Receptor Regulation Studies: Significance of Central Catecholamine Receptors in Cardiovascular Control
Receptor Regulation of Dopamine Turnover
Regulation of DA Synthesis in the Nigro Neostriatal System
Synthesis and Preferential Release of Newly Formed Norepinephrine during Increased Sympathetic Activity
Decentralization Increases Noradrenaline Release from Field-Stimulated Rat Irides
Effect of Acetylcholine on the Release of 3H-Norepinephrine by Nicotine and Potassium Chloride from Rat Brain Slices
Reporter's Notes
First session
Second Session
VI. Catecholamines in Central Nervous System
Introductory Remarks: Regional Economy and Families of Neuroregulatory Substances
Chairman's Introductory Remarks
Central Catecholamines and Hypertension
Norepinephrine as a Central Synaptic Transmitter
Central Dopaminergic Neurons: Neurophysiological Identification and Responses to Drugs
Existence of Dopaminergic Nerve Terminals in the Rat cortex
Excitatory Effects of Catecholamines in the C.N.S.
Genetic Factors in the Control of Brain Levels of Biogenic Amines and Brain Excitability
Catecholamine Receptor Mechanisms in Vertebrates
Excitatory Effects of Dopamine on Molluscan Neurones
Analysis of Dopamine Specific, Excitatory and Inhibitory Neurons of the Snail
Dopaminergic Transmission in Relation to Mechanisms Underlying Stereotyped Behavior
Histochemical Demonstration of Monoamine Neuron Systems in the Human Fetal
Glyoxylic Acid Condensation: A new Fluorescence Histochemical Method for Sensitive and Detailed Tracing of Central Catecholamine Neurons
Behavioral-Anatomical Correlates of Central Catecholamine Neurons
Behavioral Pharmacology of 6-Hydroxydopamine
Biochemical and Behavioral Alterations following 6-Hydroxydopamine Administration into Brain
Inhibition of the Blood Pressure Response to α-Methyldopa in Unanesthetised Renal Hypertensive Rats by Neonatal 6-Hydroxydopamine (6-OHDA) Treatment
Biogenic Amines and Their Metabolism in the Study of Aggressive Behavior in Rats
Brain Norepinephrine and Ingestive Behavior
Effects on Feeding Behavior after Intrahypothalamic Injections of 6-Hydroxydopamine in Rats
Brain Stem Norepinephrine: Behavioral and Biochemical Differentiation of Responses to Foot Shock in Rats
The Coerulo-Cortical Norepinephrine System and Learning
Electrical Self-stimulation in the Locus Coeruleus and Norepinephrine Turnover in Cerebral Cortex
Effects of 6-Hydroxydopa
Cholinergic-Dopaminergic Relation in Different Brain Structures
Changes in Striatal DA Metabolism Induced by Cholinergic and Anticholinergic Nigral Stimulation in the Rat
Role of Catecholamines in the Control of the Sleep-Waking Cycle
Catecholamine Mechanisms: Their Presumptive Role in the Generation of REM Sleep PGO Waves
Effects on Precise Motor Responding of Bilateral 6-Hydroxydopamine Infusion into the Substantia Nigra
Telencephalic Distribution of Terminals of Brainstem Norepinephrine Neurons
Biochemical Evidence for Interaction Phenomena between Noradrenergic and Serotoninergic Systems in the Cat Brain
NE-Neuronsand Phasic Sleep Phenomena
Dopamine and Acetylcholine Neurones in Striatal and Limbic Structures: Effect of Neuroleptic Drugs
Role of Catecholamines in Neuroendocrine Function
Recent Morphological and Functional Studies on Hypothalamic Dopaminergic and Noradrenergic Mechanisms
Effect of Pregnancy and Sex Hormones on the Transmitter Level in Uterine Short Adrenergic Neurons
Catecholamines in Sexual Hormone Regulation: Forebrain Influence on Tubero-Infundibular Dopamine Neurons and Interaction with Cholinergic Systems
Effects of Catecholamines on Supraoptic Nucleus Neurones in Organ Culture
Catecholamines in Non-neural Cells of the CNS: A Possibility
Catecholamines and the Secretion of Renin, ActH and Growth Hormone
L-DOPA and Pancreatic Secretion
Catecholamine Biosynthetic Enzymes in Pancreatic Islet Cells
Brain Monoamines Participation in the Control of Growth Hormone Secretion in Different Animal Species
Effects of L-DOPA on Prolactin Secretion in Humans
Hypothalamic Catecholamines (CA) and the Secretion of Gonadotropins and Gonadotropin Releasing Hormones
Role of Sympathetic Fibers and of Adrenal Medulla in the Maintenance of Cardiovascular Homeostasis in Normotensive and Hypertensive Rats
Sodium and Catecholamine Excretion
Hypertension, Antihypertensive Drugs, and Norepinephrine in Blood Vessels
Intracisternal 6-Hydroxydopamine (6-OHDA) and 5,6-Dihydroxytryptamine (5,6-DHT) in Experimental Hypertension
Central Adrenergic Neurons and the Control of Blood Pressure
The Central Neural Regulation by Baroreceptors of Peripheral Catecholaminergic Mechanisms
Genetic Variation of the Catecholamine Biosynthetic Enzyme Activities in Various Strains of Rats Including the Spontaneously Hypertensive Rat
Norepinephrine Synthesis and Turnover in the Brain: Acceleration by Physostigmine
Aminoacyl Derivatives of Dopamine as Orally Effective Renal Vasodilators
Reporter's Notes
First session
Second session
VII. Amphetamines and Other Drugs of Abuse
Clinical Pharmocological Study and EEG changes of Delta-9-Tetrahydrocannabinol Effects in Human Volunteers
Amphetamine and Cocaine on Amine Turnover
Comparative Metabolism of Some Amphetamines in Various Species
Behavioral Pharmacology of D-Amphetamine: Some Metabolic and Pharmacological Considerations
Catecholamine Metabolism and Amphetamine Effects on Sensitive and Insensitive Mice
Effects of d-Amphetamine on Body Temperature and on Behavioral Thermoregulation in Rats
The Metabolism and Excretion of 'Amphetamines' in Man
The Postsynaptic Effect of Amphetamine on Striatal Dopamine-sensitive Neurones
Electrophysiological Effects of Amphetamine on Dopaminergic Neurons
Amphetamine and Noradrenergic Reward Pathways
Operant Behavioral Demonstration of Qualitative Differences between the d- and l-ISomers of Amphetamine
Dissociation of Amphetamine-Induced Release of Norepinephrine from Inhibition of Neuronal Uptake in Isolated Brain Tissue
Amphetamine and Methylphenidate Psychosis
Amphetamine Metabolism in Amphetamine-Induced Psychosis
On Amphetamine Tolerance and Abstinence in Rats
Behavioral and Biochemical Effects of L-DOPA in Psychiatric Patients
Halogen Substitution of Amphetamine Biochemical and Pharmacological Consequences
Narcotic Analgesics and the Regulation of Neuronal Catecholamine Stores
Effect of Methadone on Brain Dopamine Metabolism
Effects of Some Tetrahydrocannabinols on the Biosynthesis and Utilization of Catecholamines in the Rat Brain
Alcohol and Catecholamine Disposition: A Role for Tetrahydroisoquinoline Alkaloids
On the Possible Interrelationship in Mechanism of Action between Morphine, Amphetamine and Neuroleptic Drugs
Importance of Brain Dopamine for the Stimulant Actions of Amphetamine
p-Hydroxynorephedrine: Its Selective Distribution in Different Rat Brain Areas
The Effect of Morphine on Rat Brain Catecholamines: Turnover In Vivo and Uptake in Isolated SynaptoSomes
Psychopharmacological Profile of Cocaine
Reporter's Notes
VIII. Catecholamines in Man
Catecholamine Metabolites in CSF
Metabolites of Catecholamines in the Cerebrospinal Fluid
Selective Depletion of Brain Regional Noradrenaline by Systemic 6-Hydroxydopamine in Newborn Rats
VMA in Spinal Fluid: Evaluation of the Pathways of Cerebral Catecholamine Metabolism in Man
Oxygen-18 in Measurement of Dopamine Turnover in Rat Brain
Technical Strategies for the Study of Catecholamines in Man
Cyclic AMP and a Possible Animal Model of Receptor Supersensitivity
Application of Mass Fragmentography to the Quantitation of Endogenous Catecholamines
The Identification of Depressed Patients who have a Disorder of NE Metabolism and/or Disposition
Monoamine Neuron Systems in the Normal and Schizophrenic Human Brain: Fluorescence Histochemistry of Fetal, Neurosurgical and Post Mortem Material
Metabolism of Dopamine and L-DOPA in Human Brain
Changes in Human Serum Dopamine-β-Hydroxylase Activity in various Physiological and Pathological States
Dopamine-β-Hydroxylase Activity in Serum
Plasma Dopamine-β-Hydroxylase in Identical Twins Discordant for Schizophrenia
Catecholamine Metabolism and Neurologic Disease
Amines in Schizophrenia
Implications of Feedback Control in Catecholamine Neuronal Systems
Increased Serum Dopamine-β-Hydroxylase Activity during Neurogenic Hypertension in Quadriplegia
Hypothalamic Releasing Hormones and Catecholamines: A New Interface
Affective Disorders: The Catecholamine Hypothesis Revisited
Catecholamine Metabolism and Affective Disorders: Studies of MHPG Excretion
Collaborative Psychopharmacologic Studies Exploring Catecholamine Metabolism in Psychiatric Disorders
Reporter's Notes
IX. Closing Remarks
Index
- No. of pages: 1236
- Language: English
- Edition: 1
- Published: May 18, 2014
- Imprint: Pergamon
- eBook ISBN: 9781483155869