Contents
Preface
Acknowledgments
The Seventh Arne Tiselius Memorial Lecture
Are Circulating Immune Complexes The Key To Immunopathology?
Section A. Immune Complexes
A.1. Detection Methods and Reagents
Pitfalls in the Use of Biologic Reagents For the Detection of Immune Complexes
Preparation of Stabilized Human IgG Aggregates of Known Size and Their Reactivity in Immune Complex Assays
Automated Determination of Circulating Immune Complexes by Pacia
A Semi-Automated System Permitting Analysis of Immune Complex Components
A New Solid Phase Assay System For Immune Complexes Using Fc-Fragments of Human IgG (Spaif)
The Use of Bovine Conglutinin As A Reagent For Detecting Immune Complexes
Detection of Circulating Immune Complexes by Radioimmunoassay with Monoclonal Rheumatoid Factor: Comparison with Clq Binding and Raji Cell Radioassays in Cancer
Rheumatoid Factor Radioimmunoassay For Immune Complexes
Detection of Immune Complexes in Human Renal Transplantation by Using Anti-Antibody
Measurements of Immune Complex Formation by Difference Turbidity
A Titration Method For Rf and Immune Complexes
A.2. Theory of Antigen-Antibody Reaction
Antibody Structures and Effector Functions: Immunoglobulin Carbohydrates Revisited
The Alternative Pathway of Complement Activation: Initiation, Amplification and Control
Functional Differentiation of Immunoglobulin G
The Precipitin Reaction: The Importance of The Fc-Portion of IgG
Calculation of Immune Complex Distributions
Computer Modeling of Precipitin Reactions
Modification of The Interaction Between Platelets and Immune Complexes by Cl Subcomponents (First Component of Complement)
Light Scattering by Growing Antigen-Antibody Complexes
A.3. Isolation of Immune Complexes
Immunologie Properties of Aggregated Human IgG: Column Fractionation of Thermal Aggregates
Comparison of Raji Cells and Protein A-Sepharose For Isolation of Soluble Immune Complexes From Serum
Isolation of Soluble Immune Complexes by Affinity Chromatography Using Staphylococcal Protein-A Sepharose As Substrate
Purification of Soluble Immune Complexes From Serum Using Solid-Phase Conglutinin and Clq
A.4. Nature of Antigen in Immune Complexes
Are Immune Complexes Immunoglobulin Aggregates?
A Multi-Faceted Approach To Characterization and Isolation of Immune Complexes
Milk Precipitins and Circulating Immune Complexes in Selective IgG Deficiency
Soluble Immune Complexes in Subjects with Selective Iga Deficiency
Immunoglobulin-Alkaline Phosphatase Complexes in Human Serum
A.5. Fate of Immune Complexes
Transport of Immune Complexes To Germinal Centers
Structural Determinants For the Circulating Life-Times of Immunoglobulins and Immune Complexes
Clearance of Soluble Immune Complexes and Aggregates
A.6. Immune Complexes in Arthritis
Analysis of Immune Complexes in Rheumatoid Arthritis
Circulating Immune Complexes in Ankylosing Spondylitis
Clq Reactive Immune Complexes in Sjogren's Syndrome
Immune Complexes in Rheumatoid Arthritis : Correlations with Clinical Features and Effects of Gold
Thrombocyte Aggregation by Sera and Antiglobulin Complexes From Patients with Rheumatoid Arthritis
A.7. Immune Complexes in Viral, Bacterial, Parasitic Infections
A.7.1. Viral Infections
A.7.2. Bacterial Infections
A.7.3. Parasitic Infections
A.8. Immune Complexes in Systemic Lupus (SLE)
Activity of Systemic Lupus Erythematosus (SLE) Followed by Circulating Immune Complexes
The Heterogeneity of Immune Complexes in Disease
The Occurrence and Significance of Circulating Anti-ds-DNA And Free DNA in SLE
Detection of Immune Complexes in Connective Tissue Diseases: A Comparison of Three Radioassays
The Occurrence of Immune Complexes in Patients with Multiple Sclerosis
A.9. Immune Complexes in Nephritis
Immune Complexes in Human Glomerulonephritis. A Study of 99 Cases Using A Clq Binding Assay
Clearance and Glomerular Deposition of Circulating Immune Complexes
Protein Transport in Glomeruli with Immune Complexes
Clearance and Glomerular Localization of Well Defined Immune ComplexesEs
Circulating Immune Complexes in Acute Rheumatic Fever and Acute Poststreptococcal Glomerulonephritis
Role of HBsAg Immune Complexes in Glomerulonephritis of Essential Mixed Cryoglobulinemia (EMC)
Detection of Circulating Immune Complexes with Clq Binding Test in Glomerulonephritis and Complement Profiles
Immune Complex Binding To Human Glomerular Complement Receptors
Clq Binding Activity of Sera From Renal Transplanted Patients Treated with Anti-Lymphocyte Globulins
Clq Binding Immune Complexes and C3 Nephritic Factor (C3nef) in Hypocomplementemic Human Glomerulonephritis
Occurrence of Iga in Tissues of Patients with Alcoholic Hepatic Disease, Anaphylactoid Purpura and Recurrent - Often Benign - Hematuria
Application of Solid Phase Clq Assay in Sera From Nephropathic Patients
Immune Complex Type Glomerulonephritis in Rabbit Induced by A Streptococcal Antigen
Circulating Immune Complexes in Renal Transplant Recipients
A. 10. Immune Complexes in Cancer
Relevance of Circulating Immune Complexes in Cancer Sera
Evaluation of Prognosis and Tumor Extent in Cancer Patients by Detecting Circulating Immune Complexes with The 125i-Clq-Binding Assay
Serial Testing For Immune Complexes in Malignant Melanoma
Detection, Isolation and Characterization of Immune Complexes in Malignant Melanoma
Demonstration of Circulating Immune Complexes in Melanoma Patients by Means of A Granulocyte Fagocytosis Test
Clinical Implications of Elevated Levels of Circulating Immune Complexes in Patients with Malignant Melanoma
Circulating Immune Complexes in Nasopharyngeal Carcinoma Patients and Their Household Contacts
Circulating Immune Complexes in Sera of Patients with Lung Cancer
Studies On Identification of Antigens in Immune Complexes of Lung Cancer Patients
Circulating Immune Complexes in Multiple Myeloma
A.II. Clinical Screening For Immune Complexes
Detection of Circulating Immune Complexes by The Ciq Binding Activity CLQBA) in Liver Diseases with Or Without HBsAg
The Clq Deviation Test For the Detection of Circulating Immune Complexes, A 2-Year? Survey in A University Medical Center
Clinical Value of Immune Complex Assays
Methods of De-Complementation and The Detection of IC
Cryoglobulins As Immune Complexes: An Immunochemical Study of Cryoprecipitates
Thyroglobulin and Anti-Thyroglobulin Immune Complexes in Human Sera
Serial Measurement of Circulating Immune Complexes in Leukemia
A. 12. Therapy of Immune Complex Syndromes
Intensive Plasmapheresis in Idiopathic Thrombocytopenic Purpura
Monitoring of Plasmapheresis in Sle by Immune Complex Assays
Plasmapheresis in the Management of Systemic Lupus Erythematosus: The Relevance of Tests For Circulating Immune Complexes
The Effect of Plasmapheresis On Circulating Immune Complexes Measured by Raji-Cell and Indirect Granulocyte Phagocytosis Text (IGPT)
Cryoglobulin-Associated Immune Complex Disease: Treatment with Ant Venom
A.13. Immune Complexes Under Experimental Conditions
Evidence For Immunopathology in Primate Pregnancies
Effect of Anti-Proteoglycan Sera On Metabolic Functions of Calf Cartilage Cells in Vitro
Immunologie Arterial Injury in Swine
Clq Binding Immune Complexes in Genetically Selected Thymus Deficient Swan Mice Or Athymic Mice
Localization of Immune Complexes Induced by Mercuric Chloride in the Rat. A Study of Various Organs
Section B. Cytoskeletal Proteins
B.1. Cytoskeletal Protein Systems
B.1.1. The Cytoskeleton
B.1.2. Actin, Profilin
B.1.3. Tubulin
B.2. The Role of The Cytoskeletal Proteins
The Role of Contractile Filaments in Platelet Activation
Are Microfilaments Involved in Secretion?
The Role of Contractile and Cytoskeletal Proteins During Wound Healing and Tumor Cell Invasion
Ac Tin, Tubulin and Á-Actinin Cocap with Surface Immunoglobulins In Mouse B-Lymphocytes
Microfilamentous-Microtubular System, Motile Events and Insulin Release in the Pancreatic B-Cell
Studies of The Induction and Maintenance of A Generalized Polarization of Plasma Membrane Components
Cellular Dynamics of Neuronal Cells. The Organization of CSK in Neuroblastoma Cells
Cytoskeletal Proteins and Their Function in Pulmonary Alveolar Interstitial Cells
Fibrin Clot Rectractile Activity of Cultured Human Fibroblasts: Physiopathological Implications
B.3. Regulation of Cytoskeletal Protein Systems
Reaction of The Contractile Apparatus in Physarum to Injected Ca++, ATP, ADP and 5'AMP
Dynamics of Calcium Movements in Pancreatic Islets: Their Relevance to the Mechanics of Insulin Release
Analysis of Inner Face Plasma Membrane Proteins Involved in the Sensitivity of Na+/K+ Atpase To Ouabain
B.4. Immunological Aspects of The Cytoskeleton
Antigenic Similarities Between Intracellular 10 Nm Filaments of Fibroblasts and Extracellular Microfibrils
Smooth Muscle Antibodies Reacting with Microtubular Antigens
Immunomicroscopy of Cytoskeletal Filaments by Use of Purkinje Fibre Antiskeletin
Antigens Common To Human Fibroblasts and Serum
Section C. Techniques
C.1. Assay Methods
The Bioluminescent Determination of Substrates Using NAD-dependent Oxidoreductase Enzymes
Labeling of Tryptophan Residues in Peptides
Purification of Proteins by Subtraction Affinity Chromâtography
Control of Unwanted Fluorescence in Immunohistology
Kinetics of Multivalent Alkane-Protein Interactions On Hydrophobie Agaroses and Implications For the Multivalent Effector-Receptor Model
Immobilised Enzymes As Laboratory Reagents: Modification of the ph Optimum of Immobilised Glucose Oxidase
Effect of Polyethylene Glycol (Peg) On The Formation of Immune Complexes in the Region of Antibody Excess Measured by Nephelometric and Turbidimetric Methods
An Investigation Into the Distribution of Radial Immunodiffusion Quality Control Data
M.L. Salkie
Continuous-Crossed-Line Immunoelectrophoresis. A Methodological Modification For Comparison of Reference Patterns in Crossed Immunoelectrophoresis
C.2. Individual Protein Assays
A 2-Site Immunoradiometric Assay For the Determination of A-Albumin
Determination of Á-Albumin (GFA) in Cerebrospinal Fluid
A Solid Phase Enzyme Immuno-Assay of Ferritin in the Evaluation of Leukemia Patients
Microheterogeneity of Human Isoferritins Using Iron-59 Labeling. A New Purification Procedure
Antibody Labeling by Means of 125I-Protem A
Estimation of Immunoglobulin Concentrations in Serum Using Kinetic Measurements of The Immunoprecipitin Reaction
IgG Subclasses in Pepsin Resistant Normal Human IgG
Comparative Studies of Serum Immunoglobulins and Enzyme Activities For the Diagnosis of Liver Fibrosis
Author Index
Subject Index