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Elsevier

Books in Life sciences

  • Sea Otter Conservation

    • 1st Edition
    • Shawn Larson + 2 more
    • English
    Sea otters are good indicators of ocean health. In addition, they are a keystone species, offering a stabilizing effect on ecosystem, controlling sea urchin populations that would otherwise inflict damage to kelp forest ecosystems. The kelp forest ecosystem is crucial for marine organisms and contains coastal erosion. With the concerns about the imperiled status of sea otter populations in California, Aleutian Archipelago and coastal areas of Russia and Japan, the last several years have shown growth of interest culturally and politically in the status and preservation of sea otter populations. Sea Otter Conservation brings together the vast knowledge of well-respected leaders in the field, offering insight into the more than 100 years of conservation and research that have resulted in recovery from near extinction. This publication assesses the issues influencing prospects for continued conservation and recovery of the sea otter populations and provides insight into how to handle future global changes.

  • Bones and Cartilage

    Developmental and Evolutionary Skeletal Biology
    • 2nd Edition
    • Brian K. Hall
    • English
    Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail. The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research.

  • Cognitive Enhancement

    Pharmacologic, Environmental and Genetic Factors
    • 1st Edition
    • Shira Knafo + 1 more
    • English
    Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance. The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals.

  • Re-Engineering Clinical Trials

    Best Practices for Streamlining the Development Process
    • 1st Edition
    • Peter Schueler + 1 more
    • English
    The pharmaceutical industry is currently operating under a business model that is not sustainable for the future. Given the high costs associated with drug development, there is a vital need to reform this process in order to provide safe and effective drugs while still securing a profit. Re-Engineering Clinical Trials evaluates the trends and challenges associated with the current drug development process and presents solutions that integrate the use of modern communication technologies, innovations and novel enrichment designs. This book focuses on the need to simplify drug development and offers you well-established methodologies and best practices based on real-world experiences from expert authors across industry and academia. Written for all those involved in clinical research, development and clinical trial design, this book provides a unique and valuable resource for streamlining the process, containing costs and increasing drug safety and effectiveness.

  • Switchable and Responsive Surfaces and Materials for Biomedical Applications

    • 1st Edition
    • Johnathan Zhang
    • English
    Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors.

  • Tissue Engineering

    • 2nd Edition
    • Clemens van Blitterswijk + 1 more
    • English
    Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface.

  • Lipids, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 43-4
    • Donald A. Smith
    • English
    This issue of Endocrinology and Metabolism Clinics, devoted to Lipids, is edited by Dr. Donald A. Smith. Articles in this issue include: Advanced Lipoprotein Testing; Improving Cardiovascular Risk Assessment: Coronary calcium scor and CT coronary imaging; Understanding HDL; Statin Strategies for Maximizing Public Health: benefits and harms; Cellular Cholesterol Regulation: SREBP and miRNA; Mediterranean Diet – the best diet for CV protection?; Pediatric Lipidology: An Earlier Approach; Newer LDL-lowering Therapies; and Statin Combination Therapies.

  • Controlled Drug Delivery

    The Role of Self-Assembling Multi-Task Excipients
    • 1st Edition
    • M A Mateescu + 2 more
    • English
    In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in this comprehensive book include: the concept of self-assembling; starch and derivatives as pharmaceutical excipients; and chitosan and derivatives as biomaterials and as pharmaceutical excipients. Later chapters discuss polyelectrolyte complexes as excipients for oral administration; and natural semi-synthetic and synthetic materials. Closing chapters cover protein-protein associative interactions and their involvement in bioformulations; self-assembling materials, implants and xenografts; and provide conclusions and perspectives.

  • An Introduction to Biotechnology

    The Science, Technology and Medical Applications
    • 1st Edition
    • W.T. Godbey
    • English
    An Introduction to Biotechnology is a biotechnology textbook aimed at undergraduates. It covers the basics of cell biology, biochemistry and molecular biology, and introduces laboratory techniques specific to the technologies addressed in the book; it addresses specific biotechnologies at both the theoretical and application levels.Biotechnology is a field that encompasses both basic science and engineering. There are currently few, if any, biotechnology textbooks that adequately address both areas. Engineering books are equation-heavy and are written in a manner that is very difficult for the non-engineer to understand. Numerous other attempts to present biotechnology are written in a flowery manner with little substance. The author holds one of the first PhDs granted in both biosciences and bioengineering. He is more than an author enamoured with the wow-factor associated with biotechnology; he is a practicing researcher in gene therapy, cell/tissue engineering, and other areas and has been involved with emerging technologies for over a decade. Having made the assertion that there is no acceptable text for teaching a course to introduce biotechnology to both scientists and engineers, the author committed himself to resolving the issue by writing his own.

  • Navigating Academia: A Guide for Women and Minority STEM Faculty

    • 1st Edition
    • Pauline Mosley + 1 more
    • English
    Navigating Academia: A Guide for Women and Minority STEM Faculty explores the infrastructure of the academy and provides a systematic account of where and why women and minorities fall behind men in the preparation for and development of their academic careers. This book offers useful strategies for recruiting, retaining, and advancing women and minorities. Chapters include testimonials from faculty and administrators about how they made their ascent within the academy. Navigating Academia: A Guide for Women and Minority STEM Faculty also discusses how to modify and expand faculty recruiting programs, how to diversify search committees, how to encourage intervention by deans, and how to assess past hiring efforts. This guide is an important resource for women and minorities seeking success in the academy as well as for administrators focused on faculty and professional development.

  • Planning a Career in Biomedical and Life Sciences

    Making Informed Choices
    • 1st Edition
    • Avrum I. Gotlieb
    • English
    Planning a Career in Biomedical and Life Sciences presents useful information, insights, and tips to those pursuing a career in the biomedical and life sciences. The book focuses on making educated choices during schooling, training, and job searching in both the academic and non-academic sectors. The premise of Planning a Career in Biomedical and Life Sciences is that by understanding the full path of a career in either the biomedical or life science fields, you can proactively plan your career, recognize any opportunities that present themselves, and be well prepared to address important aspects of your own professional development. Topics include choosing your training path, selecting the best supervisor/mentor, and negotiating a job offer.

  • Biomarkers and Biosensors

    Detection and Binding to Biosensor Surfaces and Biomarkers Applications
    • 1st Edition
    • Ajit Sadana + 1 more
    • English
    Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market.

  • Personalized Cancer Chemotherapy

    An Effective Way of Enhancing Outcomes in Clinics
    • 1st Edition
    • Da Yong Lu
    • English
    Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations. A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed. This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes.

  • Inflammation in Heart Failure

    • 1st Edition
    • Matthijs Blankesteijn + 1 more
    • English
    Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students.

  • Oral Delivery of Insulin

    • 1st Edition
    • T.A. Sonia + 1 more
    • English
    Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.

  • Advances in Software Science and Technology

    • 1st Edition
    • Volume 5
    • Tsutomu Kamimura
    • English
    This serial is a translation of the original works within the Japan Society of Software Science and Technology. A key source of information for computer scientists in the U.S., the serial explores the major areas of research in software and technology in Japan. These volumes are intended to promote worldwide exchange of ideas among professionals.This volume includes original research contributions in such areas as Augmented Language Logic (ALL), distributed C language, Smalltalk 80, and TAMPOPO-an evolutionary learning machine based on the principles of Realtime Minimum Skyline Detection.

  • Cord Blood Stem Cells Medicine

    • 1st Edition
    • Catherine Stavropoulos-Giokas + 2 more
    • English
    Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy.

  • A Complete Course in Canning and Related Processes

    Volume 2: Microbiology, Packaging, HACCP and Ingredients
    • 14th Edition
    • Susan Featherstone
    • English
    A Complete Course in Canning is firmly established as a unique and essential guide to canning and related processes. Professionals in the canning industry and students have benefited from successive editions of the book for over 100 years. This major new edition continues that reputation, with extensively revised and expanded coverage. The three-title set is designed to cover all planning, processing, storage and quality control phases undertaken by the canning industry in a detailed, yet accessible fashion. Major changes for the new edition include new chapters on regulation and labelling that contrast the situation in different regions worldwide, updated information on containers for canned foods and new information on validation and optimization of canning processes, among many others.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 71
    • English
    Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Human Chorionic Gonadotropin (hCG)

    • 2nd Edition
    • Laurence A. Cole
    • English
    Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.

  • Side Effects of Drugs Annual

    A worldwide yearly survey of new data in adverse drug reactions
    • 1st Edition
    • Volume 36
    • English
    The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

  • Malaria Control and Elimination Program in the People’s Republic of China

    • 1st Edition
    • Volume 86
    • English
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. The 2012 impact factor is 3.778.

  • Best Synthetic Methods

    Organophosphorus (V) Chemistry
    • 1st Edition
    • Chris Timperley
    • English
    Best Synthetic Methods: Organophosphorus (V) Chemistry provides systematic coverage of the most common classes of pentavalent organophosphorus compounds and reagents (including phosphonyl, phosphoryl, and organophosphates), and allows researchers an easy point of entry into this complex and economically important field. The book follows the Best Synthetic Methods format, containing practical methods, synthetic tips, and shortcuts. Where relevant, articles include toxicity data and historical context for the reactions. Typical analytical and spectroscopic data are also presented to enable scientists to identify key compound characteristics. The book is a valuable companion to research chemists in both academia and industry, summarizing the best practical methods (often originating in difficult-to-access, foreign-language primary literature) in one place. It is ideally suited for those working on industrial applications of these compounds, including insecticides, herbicides, flame retardants, and plasticizers.

  • Reference Module in Biomedical Research

    • 1st Edition
    • Michael J. Caplan
    • English

  • Translational Regenerative Medicine

    • 1st Edition
    • Anthony Atala + 1 more
    • English
    Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being.

  • Metabolomics as a Tool in Nutrition Research

    • 1st Edition
    • J-L Sebedio + 1 more
    • English
    Metabolomics is a multidisciplinary science used to understand the ways in which nutrients from food are used in the body and how this can be optimised and targeted at specific nutritional needs. Metabolomics as a Tool in Nutrition Research provides a review of the uses of metabolomics in nutritional research. Chapters cover the most important aspects of the topic such as analysis techniques, bioinformatics and integration with other ‘omic’ sciences such as proteomics and genomics. The final chapters look at the impact of exercise on metabolomic profiles and future trends in metabolomics for nutrition research.

  • Molecular Genetics Medicine

    • 1st Edition
    • Volume 4
    • Theodore Friedmann
    • English
    Continuing to keep pace with progress in human molecular genetics, Volume 4 of Molecular Genetic Medicine reviews five new areas of critical importance. Chapter 1 reviews the molecular mechanisms that have beenunraveled in the pathogenesis of eye diseases. The second chapter explains the remarkable new principle if genomic imprinting, or epigenetic modification imposed by parental history. Chapter 3 describes the etiology of amyotrophic lateral sclerosis, or Lou Gehrig's Disease, as effected by superdioxide dismutase function and neuron degeneration. The fourth chapter covers the normal and aberrant functions of peroxisomes, now implicated in many diseases, most notably adrenoleukodystrophy... publicized widelyby the"cure"called Lorenzo's oil. The final chapter summarizes recombination techniques that permit functional new genetic material to be introduced into, and subsequently transmitted through, the germ line of mammalian cells. These amazing methods arehaving profound impacts on medicine and on concepts of the study of normal human development and disease.

  • Molecular Basis of Mitochondrial Pathology

    • 1st Edition
    • Volume 17
    • C. P. Lee
    • English
    The field of mitochondrial diseases is currently one of the rapidly growing fields of research in cell and molecular biology. This volume encompasses the latest development in this field of research. The chapters cover topics in a wide range of disciplines including biophysics, biochemistry, cell and molecular biology, molecular genetics, and clinical medicine.

  • Biocatalysis in Non-Conventional Media

    Proceedings of an International Symposium, Noordwijkerhout, 26-29 April 1992
    • 1st Edition
    • Volume 8
    • M.H. Vermuë + 3 more
    • English
    The international symposium "Fundamentals of Biocatalysis in Non-Conventional Media" was organized under auspices of the working party Applied Biocatalysis of the European Federation of Biotechnology. Among the topics discussed at the symposium were physical-chemical aspects such as pH, water-activity, viscosity, dielectric constants, polarity etc. in relation to biocatalysis in non-conventional media. New measuring techniques were introduced.For people working in the field of biocatalysis in non-conventional media this book will give an excellent overview of the gain in understanding over the last five years of the fundamental aspects of biocatalysis in non-conventional media.

  • Essays in Biochemistry

    • 1st Edition
    • K. F. Tipton
    • English
    Essays in Biochemistry, Volume 25 provides information on the developments in the continually changing field of biochemistry. Each chapter of the book is written by an expert on the area of research. The volume contains contributions that deal with such topics as intracellular protein degradation; the metabolic heterogeneity of liver parenchymal cells; and the biochemistry of ethanol metabolism and the pathogenesis of alcoholic liver disease (ALD). Biochemistry and neurochemistry in the 1800 and their origins in comparative animal chemistry is discussed extensively in the final chapter. Biochemists will find the book very informative.

  • Protides of the Biological Fluids

    Proceedings of the Thirty-Second Colloquium, 1984
    • 1st Edition
    • Volume 32
    • H. Peeters
    • English
    An International Review Series Devoted to Proteins and Related Studies, Volume 32: Protides of the Biological Fluids documents the proceedings of the 32nd Colloquium held in 1984. This compilation is organized into three parts. Part I begins with an introduction to the defense mechanism of immunoglobulins, followed by a description of enzymes and proteins, such as lactoperoxidase and lactoferrin. The secretions that include CSF, colostrum, milk, female and male genital secretions, saliva, gastrointestinal juice, nasal and bronchoalveolar secretions, tears and synovial fluid are also elaborated. The tumor markers, which include ferritin, CEA, and TPA are dealt with in Part II. The immunotoxins, tumor imaging, and lymphoid malignancies are also covered. Part III is devoted to the advances in the separation of protides, including the staining procedure for protein detection, two-dimensional electrophoresis, and HPLC and affinity chromatography. This book is valuable to biology students and clinicians of disciplines related to advances in the protein field.

  • Drug Design

    • 1st Edition
    • Volume 9
    • BAREHAM BAREHAM J
    • English
    Drug Design, Volume IX examines various aspects of drug design and covers topics ranging from the consequences of the Hansch paradigm for the pharmaceutical industry to the Masca model of pharmacochemistry. A physicochemical basis for the design of orally active prodrugs is also considered, along with the use of interactive graphics in medicinal chemistry. Comprised of seven chapters, this volume begins with a discussion on efforts to avoid toxicity, not only of drugs, pesticides, and food additives but also of chemicals in general. The reader is then introduced to various aspects of the development of bioactive agents, including the optimization of existing agents by the design of more efficient prodrugs. Other chapters focus on Hansch's paradigm and its application to industrial practice; the application of multivariate statistics to pharmacochemistry; a logico-structural approach to computer-assisted drug design; and spatial arrangements in bioactive molecules. This book will be of interest to pharmacologists, chemists, and those involved in drug design.

  • Protides of the Biological Fluids

    Proceedings of the Thirty-Third Colloquium, 1985
    • 1st Edition
    • Volume 33
    • H. Peeters
    • English
    An International Review Series Devoted to Proteins and Related Studies, Volume 33: Protides of the Biological Fluids documents the proceedings of the 33rd Colloquium held in 1985. This book is divided into three sections. Section A focuses on the plasma protein genes that includes the location of genes on the chromosome, pathology and variance of several genes, and gene expression. The proteins of the nucleus and detection of antibodies, such as antinuclear antibodies (ANA), to nuclear constituents are deliberated in Section B. Section C is devoted to the technical advances in the field of protein chemistry. This book is a good reference for students, researchers, and medical practitioners conducting work on the protides of biological fluids.

  • Protides of the Biological Fluids

    Proceedings of the Thirty-First Colloquium, 1983
    • 1st Edition
    • Volume 31
    • H. Peeters
    • English
    Protides of the Biological Fluids: Metal Binding Proteins, Tumor Markers, Monoclonal Antibodies covers the proceedings of the 31st Colloquium by the same title, held in Brussels, Belgium in 1983. This work is composed of three sections encompassing 245 chapters. The first section describes first the structure, physiological function, and physiopathology of metal binding proteins. This section also considers the metal binding mechanism and a series of iron binding and copper binding proteins, as well as hemopexin proteins. The second section is concerned with the physiopathology, screening, monitoring, tumor localization, and biomarkers of tumor. This section also explores the field of immunohistochemistry of biomarkers for tumor monitoring. The third section discusses drug targeting, immunohistochemistry... the identification of lymphocytes and other antigens. Considerable chapters are devoted to clinical assays of monoclonal antibodies. This book will prove useful to oncologists, protein scientists, clinicians, and researchers.

  • MicroRNA in Regenerative Medicine

    • 1st Edition
    • Chandan K. Sen
    • English
    This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering

  • Protides of the BIological Fluids

    Proceedings of the Thirtieth Colloquium, 1982
    • 1st Edition
    • Volume 30
    • H. Peeters
    • English
    Protides of the Biological Fluids: Proceedings of the 30th Colloquium, 1982 is a collection of manuscripts presented at the 30th Colloquium, held in Brussels, Belgium in 1982. This text is organized into three sections encompassing 160 chapters. The first section highlights the mechanisms of the normal and abnormal mental function through evaluation of neuroproteins or the so-called “think-proteins”. This section describes the manifestations, clinical features, diagnosis, and therapeutic options of nervous system diseases. The second section tackles monoclonal proteins as a reagent to detect antigens. This section deals with the significant progress in cancer therapy and the binding of cytotoxic drugs to monoclonal antibodies. The third section considers the potential of isodalt electrophoresis and high-pressure liquid chromatography, with particular emphasis on their application to protein analysis in biological fluids. This book will be of great value to biochemists, clinical chemists, and clinicians.

  • Human Physiology in Extreme Environments

    • 1st Edition
    • Hanns-Christian Gunga
    • English
    Human Physiology in Extreme Environments is the one publication that offers how human biology and physiology is affected by extreme environments while highlighting technological innovations that allow us to adapt and regulate environments. Covering a broad range of extreme environments, including high altitude, underwater, tropical climates, and desert and arctic climates as well as space travel, this book will include case studies for practical application. Graduate students, medical students and researchers will find Human Physiology in Extreme Environments an interesting, informative and useful resource for human physiology, environmental physiology and medical studies.

  • Current Topics in Bioenergetics

    Volume 1
    • 1st Edition
    • D. R. Sanadi
    • English
    Current Topics in Bioenergetics, Volume I presents the molecular basis of biological energy transduction. This book focuses on photosynthetic reactions. Organized into seven chapters, this volume begins with an overview of the second photosystem that evolves oxygen from water. This text then presents a brief historical background of fluorescence in relation to the development of the two-pigment-system concept of photosynthesis and indicates the significance of fluorescence measurements in the study of photosynthesis. Other chapters consider mitochondrial ion transport, its relation to active transport in cells, and its possible effects on muscle contraction. This book discusses as well the concept of uncoupling in oxidative phosphorylation. The reader is also introduced to the biochemical basis of luminescence, which has been investigated in several organisms. The final chapter deals with the study of mitochondrial cations and of the cation transport. This book is a valuable resource for biochemists, molecular biologists, scientists, and research workers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 5
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 5 presents information pertinent to the chemistry, biochemistry, and physiology of lipids. This book discusses the metabolism of myelin lipids and explains the factors affecting brain cholesterol. Organized into nine chapters, this volume begins with an overview of the biosynthesis of fatty acids. This text then discusses the physiology of adipose tissue in which aspects of adipose tissue physiology of a number of animal species are compared. Other chapters consider the physiological, biochemical, and morphological changes observed in ethionine-induced fatty liver. This book discusses as well the metabolism of lipids by macrophages and the relationship of this phenomenon to atherosclerosis. The final chapter deals with the phase diagrams of glyceride mixtures, a subject that is more physicochemical in nature and suggests another area of investigation to biologists. This book is a valuable resource for biologists, biochemists, neurochemists, scientists, and research workers.

  • Current Topics in Bioenergetics

    Volume 3
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 3 provides information pertinent to the phenomena associated with biological energy transduction at different levels of sophistication. This book discusses the energy-linked processes in mitochondria. Organized into seven chapters, this volume begins with an overview of the core of the mechanism of oxidative phosphorylation. This text then explains the basic features of artificial membranes model system and its usefulness in probing membrane phenomena. Other chapters consider the thermodynamic and kinetic aspects of active transport of ions and attempt to relate photoreception with the subsequent electrophysiological events. This book discusses as well the regulation of respiration by muscular activity and on energy transduction in phototropism and phototaxis. The final chapter deals with the mechanism of phototaxis in microorganisms and explains the phenomenon as a translational response of a freely moving organism to a light stimulus. This book is a valuable resource for biochemists, cell biologists, and physiologists.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 2
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 2 provides a discussion of theories of triglyceride structure and presents a provocative comparison of in vitro versus in vivo lipid biosynthesis. This book covers brain phosphoinositide research, synthesis of phosphoglycerides, and the chemistry of lapoamino acids and phosphatidylglycerol... Organized into eight chapters, this volume begins with an overview of the procedure for calculating the percentages of the individual triglycerides as well as for triglyceride families. This text then examines the complex field of bacterial lipids. Other chapters consider the two aspects of the relationship between lipid metabolism and atherosclerosis. This book discusses as well the lipolytic and esterolytic activity of various tissues in connection with lipid transport and its relevancy to the development of atherosclerosis. The final chapter deals with the methods best adopted for in vitro and in vivo investigations of lipid biosynthesis. This book is a valuable resource for phospholipid chemists, biochemists, and scientists.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 3
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 3 presents the analysis of human serum lipoproteins and emphasizes the possibilities inherent in the application of computer methods to such analyses. This book discusses the effects of various drugs on the other important component of the serum lipids, the phospholipids. Organized into six chapters, this volume begins with an overview of the possibility of a dehydrogenation toward the methyl group. This text then presents a detailed discussion of lipoprotein structure, metabolism, and catabolism. Other chapters consider some potentially significant revisions in lipoprotein procedure, including additions to the technology of lipoprotein analysis. This book discusses as well the chemistry and metabolism of plasma lipoprotein as related to physiological and disease states. The final chapter deals with the advances in methods of purification and studies of the properties and mode of action of lipases. This book is a valuable resource for organic chemists, neurochemists, and biochemists.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 4
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 4 provides information pertinent to the actions of catecholamines to lipid metabolism. This book discusses lipid metabolism in microorganisms wherein one relates specifically to the fatty acids of microorganisms and the other to general aspects of lipid metabolism in microorganisms. Organized into seven chapters, this volume begins with an overview of some of the contributions of lipid research to the understanding of the clotting mechanism. This text then examines the extent to which dietary carbohydrate interferes in lipid metabolism. Other chapters consider the lipid-mobilizing effects of adrenomimetic agents, which are highly specific for the depot type of adipose tissue. This book discusses as well a number of areas of bacterial lipid biochemistry that are under investigation. The final chapter deals with the procedures for assessing the purity of labeled lipids by organic synthesis, biosynthesis, and isotope exchange techniques. This book is a valuable resource for biochemists, scientists, and research workers.

  • Current Topics in Bioenergetics

    Volume 2
    • 1st Edition
    • D. R. Sanadi
    • English
    Current Topics in Bioenergetics, Volume 2 provides information pertinent to biological energy transduction, both at the molecular level and in systems having a higher degree of organization. This book presents the contractile mechanisms in cilia and flagella. Organized into 10 chapters, this volume begins with an overview of the concept of the photosynthetic unit that has been deeply involved in all models of photosynthesis. This text then discusses the mechanisms of light-induced conformational changes in chloroplasts, mediated by ion transport. Other chapters consider the conservation and utilization of energy derived from the oxidation of organic substrates by plant mitochondria. This book discusses as well the role of ubiquinone, which has undergone the familiar difficulty in establishing whether a redox active component is an obligatory member of the electron transfer in the respiratory chain. The final chapter deals with the steady state potentials found in the inner ear of mammals. This book is a valuable resource for otolaryngologists and scientists.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 6
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 6 provides information pertinent to brain cholesterol and myelin lipids. This book reviews the various aspects of the physiology, chemistry, and biochemistry of lipids. Organized into seven chapters, this volume begins with an overview of the separation of lipoproteins and discusses lipid metabolism in microorganisms. This text then provides a discussion of lipid metabolism in mycoplasmas. Other chapters consider the various aspects of metabolism of the lipid quinones and explore the relationship between lipids and atherosclerosis as a continuing source of biochemical, medical, and nutritional interest. This book discusses as well a comparative aspect of the development of atherosclerosis and explains the chemistry of bile acids. The final chapter deals with the aspects of steroid separations as well as with regard to separation of other metabolites that may influence lipid metabolism. This book is a valuable resource for biologists, biochemists, scientists, and research workers.

  • Neuromuscular Disorders of Infancy, Childhood, and Adolescence

    A Clinician's Approach
    • 2nd Edition
    • Basil T. Darras + 3 more
    • English
    Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference.

  • Neurobiology of Brain Disorders

    Biological Basis of Neurological and Psychiatric Disorders
    • 1st Edition
    • Michael J. Zigmond + 2 more
    • English
    Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases.

  • Class 1 Devices

    Case Studies in Medical Devices Design
    • 1st Edition
    • Peter J. Ogrodnik
    • English
    The Case Studies in Medical Devices Design series consists of practical, applied case studies relating to medical device design in industry. These titles complement Ogrodnik’s Medical Device Design and will assist engineers with applying the theory in practice. The case studies presented directly relate to Class I, Class IIa, Class IIb and Class III medical devices. Designers and companies who wish to extend their knowledge in a specific discipline related to their respective class of operation will find any or all of these titles a great addition to their library. Class 1 Devices is a companion text to Medical Devices Design: Innovation from Concept to Market. The intention of this book, and its sister books in the series, is to support the concepts presented in Medical Devices Design through case studies. In the context of this book the case studies consider Class I (EU) and 510(k) exempt (FDA) . This book covers classifications, the conceptual and embodiment phase, plus design from idea to PDS.

  • New Approaches to Prokaryotic Systematics

    • 1st Edition
    • Volume 41
    • Michael Goodfellow + 2 more
    • English
    Volume 41 of Methods in Microbiology is a methods book designed to highlight procedures that will revitalize the purposes and practices of prokaryotic systematics.This volume will notably show that genomics and computational biology are pivotal to the new direction of travel and will emphasise that new developments need to be built upon historical good practices, notably the continued use of the nomenclatural type concept and the requirement to deposit type strains in at least two service culture collections in different countries.

  • Glucose Intake and Utilization in Pre-Diabetes and Diabetes

    Implications for Cardiovascular Disease
    • 1st Edition
    • Ronald Ross Watson + 1 more
    • English
    This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular disease. Since pre-diabetes and diabetes are important cardiovascular disease risk factors, and impaired glucose metabolism among cardiac patients is extremely prevalent, the importance of reviewing pre-diabetes and its involvement in CVD complications is vital as one applies food and glycemic control to slow progress to diabetes and heart disease. The book further focuses on glucose intake and utilization in diabetes, including coverage of diabetes in the development and pathology of cardiovascular disease, risks and epidemiology of cardiovascular problems promoted by diabetes, macrovascular effects and their safety in therapy of diabetics, beta cell biology and therapy of diabetes, and nutrition to modulate diabetes.

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