Bioenergetics

General Preface

Preface to Section V

Chapter I Quantum Biochemistry


1. Introduction

a. The Methods and the Scope of Quantum Biochemistry

b. Present Status of the Calculations


2. Aspects of the Electronic Structure of the Nucleic Acids

a. Overall Results

b. The Significance of Resonance Energy

c. Van der Waals-London Interactions

d. Chemical Reactivity


3. Electron-Donor and -Acceptor Properties of Biomolecules and Charge-Transfer Complexes


4 The Structure of Proteins (and their Constituents) and the Problem of Semiconductivity in Biopolymers


5. The Origin of the "Energy Wealth" in the Energy-Rich Phosphates


6. The Mechanism of Enzyme and Coenzyme Activity


7. The Mechanism of Chemical Carcinogenesis

a. Structure-Activity Correlations in Aromatic Hydrocarbons

b. Interactions Between the Carcinogens and Possible Cellular Receptors


8. Conclusions

References

Chapter II. Mechanisms of Energy Transfer


1. Introduction


2. Theory of Excitation Transfer

a. Classifications

b. Strong Coupling

c. Weak Coupling

d. Very Weak Coupling

e. Long Range Dipole-Dipole Transfer


3. Experimental Investigations

a. Methods

b. Delocalization

c. Single-Step Transfer

d. Multi-Step Transfer


4. Applications to Biological Systems

References

Chapter III. Charge Transfer in Biology

Section A. Donor-Acceptor Complexes in Solution


1. Introduction


2. Energetics


3. Characteristics of the Charge-Transfer Absorption Band


4. Paramagnetic Complexes and Electron-Transfer Reactions


5. Equilibrium Constants


6. Contact Charge Transfer


7. Solvent Effects


8. Other Useful Physical Methods for the Study of Complex Formation

a. Infrared Spectroscopy

b. Nuclear Magnetic Resonance Spectroscopy

c. Polarography

d. Fluorescence and Phosphorescence

e. Temperature-Jump Relaxation and Flash Techniques


9. Effect of Complex Formation on Reaction Rates


10. Complexes of Biological Materials

a. Flavins

b. Pyridine Nucleotides

c. Other Complexes


11. Complexes of Metal Cations

References

Chapter III. Charge Transfer in Biology

Section b. Transfer of Charge in the Organic Solid State


1. Transfer of Charge by Semiconduction


2. Photoconductivity


3. Donor-Acceptor Complexes


4. Models of Lamellar Systems


5. Dye-Sensitized Photoconductivity

References

Chapter IV. Active Transport and Ion Accumulation


1. Introduction

a. Some Relationships Between Chemical Reaction and Transport

b. Chemiosmotic Processes


2. Translocation Catalysis

a. The Facilitation of Solute Diffusion by Catalytic Carriers

b. Group Translocation

c. Classification of Translocation Reactions


3. Translocation Catalysis through Lipoprotein Membranes


4. The General Mechanisms of Translocation Catalysis

a. Mobile Versus Fixed Carriers

b. The Carrier Centre


5. Secondary Translocation

a. Non-Coupled Solute Translocation: Uniport

b. Anti-Coupled Solute Translocation: Antiport

c. Sym-Coupled Solute Translocation: Symport

d. Proton-Coupled Solute Translocation


6. Primary Translocation

a. The Na+/K+-Antiporter-ATPase

b. The H+-Translocator-ATPase

c. The H+-Translocator Oxido-Reductases


7. The Coupling of Primary and Secondary Translocation


8. Postcript

Acknowledgements

References

Subject Index