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Microbial Transformations of Steroids
1st Edition - January 1, 1967
Authors: William Charney, Hershel L. Herzog
9 7 8 - 1 - 4 8 3 2 - 6 1 5 5 - 3
Microbial Transformations of Steroids: A Handbook aims to provide those who wish to use microbial transformations of steroids with a single source book starting from 1937 to the… Read more
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Microbial Transformations of Steroids: A Handbook aims to provide those who wish to use microbial transformations of steroids with a single source book starting from 1937 to the present. The handbook first offers information on the history of the microbial transformations of organic compounds, including earliest works on the study of nonsteroids and steroids; significance of discovery of anti-inflammatory action of cortisone; first hydroxylations and dehydrogenations; manufacture of natural and synthetic corticosteroids; and trends in research. The text then ponders on chemical classification of microbial transformations of steroids, as well as the role of enzymes in microbial transformations and the classes of reactions. The publication elaborates on the construction and use of the table. Topics include order of the table, nomenclature, description of the transformation leading to the product, yield, organism, and constants. The book also focuses on taxonomy and use of the table, including system of classification, specific notes on divisions of the table, and source of cultures. The handbook is a valuable source of data for readers interested in the microbial transformations of steroids.
PrefaceChapter I Introduction Earliest Work - Nonsteroid Earliest Work - Steroid Significance of Discovery of Antiinflammatory Action of Cortisone First Hydroxylations First Dehydrogenations Manufacture of Natural and Synthetic Corticosteroids New Trends in ResearchChapter II Chemical Classification of Microbial Transformations of Steroids The Role of Enzymes in Microbial Transformations Practical Implications The Classes of Chemical Reactions Oxidation Reduction Esterification of Steroid Alcohols Isomerization of Double Bonds Miscellaneous Addition, Rearrangement, and Elimination Processes Resolution of Steroids from Total SynthesisChapter III The Construction and Use of Table I Order of the Table Nomenclature Description of the Transformation Leading to the Product Yield Organism Constants References Table I: Transformations by ProductChapter IV Taxonomy System of Classification Classes and Major Orders of Fungi and Bacteria (Reported to Transform Steroids) Hydroxylation - Taxonomic Distribution According to Order Hydroxylation - Taxonomic Distribution According to Genus Δ1-Dehydrogenation - Taxonomic Distribution According to Genus Table II: Taxonomy to SpeciesChapter V The Construction and Use of Table III - Transformations by Genus Order of the Table Specific Notes on Divisions of the Table Genera Species Sources Substrates Reactions References Culture Collections (Source of Cultures) Table III: Transformations by GenusChapter VI BibliographyChapter VII Bibliographical Appendix