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Perspectives in Virology
Antiviral Mechanisms
- 1st Edition, Volume 9 - June 28, 2014
- Editor: Morris Pollard
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 4 4 8 6 - 0
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 6 9 7 1 - 9
Perspectives in Virology IX: Antiviral Mechanisms is a collection of scientific papers presented at the Ninth Gustav Stern Symposium on Perspectives in Virology: Antiviral… Read more
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Request a sales quotePerspectives in Virology IX: Antiviral Mechanisms is a collection of scientific papers presented at the Ninth Gustav Stern Symposium on Perspectives in Virology: Antiviral Mechanisms, held at Notre Dame, Indiana in February 1974. The majority of the papers in this volume concentrate on the different ways the human body defends itself against viral attack. Others deal with artificial means of interfering with the life cycle of viruses. Topics covered in this compendium include defective interfering (DI) particles as antiviral agents; detection and identification by immune electron microscopy of fastidious agents associated with respiratory illness, acute nonbacterial gastroenteritis, and hepatitis A; and synthetic vaccines. Cellular immune response in viral infections; transfer factor and cellular immunity to viral infection; and studies on adenine rabinoside are presented as well. Virologists, microbiologists, pathologists, pharmacologists, and researchers in the fields of medicine and pathology will find the book insightful and informative.
List Of Invited Participants
Foreword In Honor of Sir Christopher Howard Andrewes
Preface
Welcome
Chapter 1 Perspectives in Virology: Vaccinations
Text
References
Chapter 2 Detection and Identification by Immune Electron Microscopy of Fastidious Agents Associated with Respiratory Illness, Acute Nonbacterial Gastroenteritis, and Hepatitis A
I. Introduction
II. Detection of Rhinoviruses
III. Detection of Coronavirus Strain
IV. Identification of an Agent Associated with Acute Nonbacterial Gastroenteritis
V. Identification of an Agent Associated with Hepatitis A
VI. Conclusion
References
Discussion
Chapter 3 Current Understanding of Hepatitis B Virus Infection and Its Implications For Immunoprophylaxis
I. Introduction
II. Nomenclature
III. Tests for HBS Ag and anti-HBs
IV. Epidemiology
V. Antigenic Diversity of HBS Ag
VI. Nature of Hepatitis B Antigens
VII. Studies of Hepatitis Type B in Nonhuman Primates
VIII. Prospects for Immunization Against Hepatitis B
IX. Conclusion
References
Discussion
Chapter 4 Defective Interfering Particles As Antiviral Agents
I. Introduction
II. Continuous Infection of Cells by Vesicular Stomatitis Virus
III. Nucleocapsid Accumulation
IV. Molecular Basis of Interference
V. Discussion
References
Discussion
Chapter 5 Synthetic Vaccines of the Future
I. Introduction
II. Specificity Determinants
III. Antigenic Competition
IV. Synthetic Antigens and Role of Conformation
V. Synthetic Antigens Cross-Reactive with Natural Products
VI. Genetic Control of Immune Response
VII. Built-in Adjuvanticity
VIII. Vaccine Specificities?
IX. Concluding Remarks
References
Chapter 6 Inhibition of Viral Neuraminidase As a New Approach to the Prevention of Influenza
I. Introduction
II. Comparison of Antihemagglutinin and Antineuraminidase Immunization
III. Mechanisms of Influenza Virus Suppression
References
Discussion
Chapter 7 Cellular Immune Response in Viral Infections
I. Introduction
II. Different Routes of Spread of Virus Infection
III. Immune Mechanisms Preventing Type II Spread
IV. Conclusion
References
Discussion
Chapter 8 Transfer Factor and Cellular Immunity to Viral Infection
I. Introduction
II. Transfer Factor in the Initiation and Augmentation of CMI
III. Immunotherapy with Transfer Factor (TFD)
References
Discussion
Chapter 9 Immunological Evidence for a Viral Etiology of Certain Human Malignant Tumors
I. Introduction
II. Role of Lymphocytes in Immunology
III. Relation of T-Cell Deficiency to Cancer and Autoimmunity
IV. Clinical Tests of Transfer Factor
V. Combined Effect of Immunodeficiency and Oncogenic Viruses in Cancer
References
Discussion
Chapter 10 Genetic Transmission of RNA Tumor Viruses
I. Introduction
II. Replication of RNA Tumor Viruses
III. Congenital Infection and Genetic Transmission
IV. Evidence for Genetic Transmission
V. Vertical Transmission and Host Antiviral Mechanisms
VI. Genetic Control of Endogenous Virus Expression
VII. Xenotropic Viruses
VIII. Inheritance of Acquired Genes
IX. Epilogue
References
Discussion
Chapter 11 Type C Virus Inhibitor Associated with Cells Cultivated from New Zealand Black Mice
I. Introduction
II. Biological and Physico-Chemical Properties of the Inhibitor
References
Discussion
Chapter 12 Inhibition of Rous Sarcoma Virus Replication by Inhibitors of Cell Replication
I. Introduction
II. Absence of Viral Antigens in Rous Sarcoma Virus-Infected Stationary Chicken Embryo Fibroblasts
III. Experimental Systems
IV. Appearance of Virus RNA in Rous Sarcoma Virus-Infected Stationary Chicken Embryo Fibroblasts After Stimulation with Serum
V. Rous Sarcoma Virus Production in Chicken Embryo Fibroblasts Made Stationary After Activation
VI. A Model for the Replication of Rous Sarcoma Virus
VII. Summary
References
Discussion
Chapter 13 Mechanism of Interferon-Induced Block in mRNA Translation
I. Introduction
II. Materials and Methods
III. Results
IV. Conclusions
References
Discussion
Chapter 14 Clinical Utilization of Exogenous Human Interferon
I. Introduction
II. Prior Studies with Exogenous Interferon in Man
III. Present Studies of Varicella Zoster Infections Treated with Interferon
IV. Perspectives for Exogenous Interferon
References
Discussion
Chapter 15 Interferon Cell Receptor Interactions
I. Cell Species Specificity of Interferon
II. Induction of Antiviral State by Interferon
III. Conclusion
References
Chapter 16 Inhibition of Enveloped Viruses in a Model of Virus-Induced Hyperlipemia
I. Introduction
II. The Phenomenon of Viral Lipemia
III. Specificity of Lipemia
IV. Mechanism of Lipemia
V. Antiviral Effects of Antilipemic Agents
VI. Implications and Discussion
VII. Summary
References
Discussion
Chapter 17 Photodynamic Inactivation of Herpesvirus
I. Introduction
II. Photosensitization of Virus with Dye
III. Dye-Light Therapy of Herpesvirus Infections
IV. References
Discussion
Chapter 18 Studies on Adenine Arabinoside—A Model for Antiviral Chemotherapeutics
I. Introduction
II. Early Investigations of Ara-A and Analogs
III. Treatment of Herpetic Infections with Ara-A
IV. Treatment of Cytomegalovirus with Ara-A
V. Therapeutic Potential of Ara-A
References
Discussion
Chapter 19 Epilogue
Text
Subject Index
- No. of pages: 376
- Language: English
- Edition: 1
- Volume: 9
- Published: June 28, 2014
- Imprint: Academic Press
- Paperback ISBN: 9781483244860
- eBook ISBN: 9781483269719