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Clinical Immunobiology
1st Edition - January 1, 1972
Editors: Fritz H. Bach, Robert A. Good
eBook ISBN:9781483216324
9 7 8 - 1 - 4 8 3 2 - 1 6 3 2 - 4
Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional… Read more
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Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional development, as well as the molecular and cellular nature of the immune apparatus. The subsequent chapters deal with the relation of structure to function in the lymphoid system and its molecules. These topics are followed by discussions of the fundamental issues of tolerance, inflammation, immunological mediators and amplifiers, and immunogenetics. The remaining chapters explore the immunobiological aspects of transplantation, allergy, tumor immunity, autoimmunity, immunodeficiency, and immunosuppression. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.
List of Contributors
Preface
Structure-Function Relations in the Lymphoid System
I. Introduction
II. The Two-Component Concept
III. Development of B and T Cells
IV. Major Function of T Cells
V. Location and Nature of T Cells
VI. Distribution of T Cells
VII. The Nature and Distribution of B Cells
VIII. Development and Structure of the Thymus
IX. Functions of the Thymus
X. T-Cell Markers
XI. B-Cell Markers
XII. Structure and Function of the Bursa
XIII. The Bursal Equivalent
XIV. T-Cell-B-Cell Interactions
XV. Involution of the Immunological Systems
XVI. Immunodeficiency Diseases of Man in Light of the Differentiation of T and B Cells
XVII. The Crucial Experiments of Nature
References
The Immunoglobulins
I. Introduction
II. Methods of Study
III. Problems of Heterogeneity
IV. Nomenclature
V. Antigenic Markers
VI. Gross Structural Relations
VII. Metabolism and Distribution of the Immunoglobulins
VIII. Function of Immunoglobulins and Structure-Function Relationships
IX. Cell Surface Immunoglobulins and Receptors
X. Phylogeny and Ontogeny
XI. Conclusion
Cellular Immunity
I. Introduction
II. Some Definitions and the Ingredients of the Reaction
III. Cellular Immunity—A Basis for Immunological Homeostasis
IV. Immunological Surveillance and Tumor Espionage
V. Microbial Parasitism and Self + χ Linkage—An Invitation to Autoimmunity
VI. Mechanisms of Cellular Immunity—in Vivo Expressions
VII. In Vitro Correlates of Cellular Immunity and Their Mediators
VIII. In Vivo Realities—The Scope of Cellular Immunity
IX. Immunological Amnesia—The Price of Immunosuppression
X. Deciphering the Language of Cells
XI. Cellular Ecology—Waste Disposal and the Loss of Immunological Virginity
XII. Cries of Relevance and Immunological Reconstitution
XIII. Conclusion
References
Transplantation Immunology
I. Introduction
II. Mechanisms of Rejection
III. Physiological Consequences of Classic Rejection
IV. Immunosuppression
V. Changing Host-Graft Relationships
VI. Graft Pretreatment
VII. Histocompatibility Typing in Patients
VIII. Is Clinical Organ Transplantation Practical?
References
Immunological Tolerance
I. Introduction
II. Relevance to Medicine
III. T and B Lymphocytes
IV. Antibody Affinity
V. Protein Antigens
VI. Pneumococcal Polysaccharide
VII. Antigen-Binding Cells in Tolerant Animals
VIII. In Vitro Tests for Cell-Mediated Cytotoxicity
IX. Blocking and Unblocking Serum Factors
X. Induced Tolerance to Allogeneic Cells
XI. Chimerism
XII. Transplanted Organs
XIII. Viruses and Virus-Induced Tumors
XIV. Tolerance to Foreign Red Blood Cells
XV. Tolerance to Skin Sensitizers
XVI. T-Cell Control
XVII. Ontogeny of Immune Responsiveness
XVIII. Development of Autoimmunity
XIX. In Vitro Studies of Tolerance and Underlying Mechanisms
References
Inflammation
I. Introduction
II. Vascular Phase
III. Cellular Phase
IV. Lymphatics
V. Mediators
VI. Control of Inflammation
VII. Chronic Inflammation
VIII. Conclusion
References
Fundamental Immunogenetics—Their Application to Histocompatibility
I. Introduction
II. Basic Genetics
III. Genes and Antigens
IV. Transplantation Genetics in the Mouse
V. Histocompatibility in Man
VI. Addendum
Humoral Amplification Systems in Inflammation
I. Introduction
II. Complement
III. Kinin-Generating System
IV. Concluding Comments
References
Immunosuppression
Introduction
I. Agents or Methods That Do Not Discriminate for Lymphocytes
II. Agents That Discriminate for Lymphocytes
III. Agents That Discriminate for Macrophages
IV. Agents That Discriminate between Lymphocyte Subpopulations
V. Agents That Discriminate for Specific Reactive Lymphocyte Clones
Miscellaneous Comments
References
Tumor Immunology
I. Introduction
II. Critical Demonstration of Specific Defense Reactions against Experimental Tumors
III. Tumor-Associated Antigens in Virus-Induced Experimental Neoplasms
IV. In Vitro Approaches
V. Escapes
VI. Studies on Human Tumors
VII. Etiological Clues
References
Allergy
I. Introduction
II. The Target Cells
III. The Antibodies
IV. The Allergens
V. Mediators
VI. The Interaction between Cell-Bound IgE and Allergen
VII. Mechanism of Mediator Release by the IgE-Allergen Interaction
VIII. The Relation of Intrinsic Asthma to the Allergic Response
IX. The Clinical Diagnosis of Allergic Diseases
X. The Pharmacological Therapy of Allergic Diseases
XI. The Immunological Therapy of Allergic Diseases
References
Immunological Deficiency Disease
I. Introduction
II. Severe Combined Immunodeficiency
III. Infantile X-Linked Agammaglobulinemia
IV. Transient Hypogammaglobulinemia of Infancy
V. Selective Immunoglobulin Deficiencies
VI. X-Linked Immunodeficiency wity Hyper-IgM
VII. Congenital Thymic Aplasia (DiGeorge’s Syndrome)
VIII. Episodic Lymphopenia with Lymphocytotoxin
IX. Wiskott-Aldrich Syndrome
X. Hereditary Ataxia-Telangiectasia
XI. Immunodeficiency with Normal or Hyperimmunoglobulinemia
XII. Immunodeficiency with Short-Limbed Dwarfism
XIII. Immunodeficiency with Thymona
XIV. Common, Variable, Unclassifiable Immunodeficiency