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Elsevier

Books in Life sciences

  • The Prefrontal Cortex

    • 5th Edition
    • Joaquin Fuster
    • English
    The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain. The book offers a unifying, interdisciplinary perspective that is lacking in other volumes written about the frontal lobes, and is, once again, written by the award-winning author who discovered "memory cells," the physiological substrate of working memory. The fifth edition constitutes a comprehensive update, including all the major advances made on the physiology and cognitive neuroscience of the region since publication in 2008. All chapters have been fully revised, and the overview of prefrontal functions now interprets experimental data within the theoretical framework of the new paradigm of cortical structure and dynamics (the Cognit Paradigm), addressing the accompanying social, economic, and cultural implications.

  • Lipid Domains

    • 1st Edition
    • Volume 75
    • English
    Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains.

  • Foods, Nutrients and Food Ingredients with Authorised EU Health Claims

    Volume 2
    • 1st Edition
    • Michele Sadler
    • English
    The second volume of Foods, nutrients and food ingredients with authorised EU health claims continues from Volume 1, which provided a comprehensive overview of many of the permitted health claims for foods and nutrients approved under European Regulation EC 1924/2006. This new volume discusses more of the health claims authorised to date for use in the EU. The chapters cover details of various permitted claims, such as the approved wording, conditions of use, the target group for the claims, the evidence for the claimed health benefits, and where appropriate details of other relevant legislation, consumer-related issues and future trends. The book opens with an overview of regulatory developments relating to health claims. Part One reviews authorised disease risk reduction claims and proprietary claims. The second part investigates ingredients with permitted ‘general function’ claims, with chapters examining ingredients such as red yeast rice, glucomannan and guar gum. The final section of the book explores foods and nutrients with permitted health claims, including chapters on authorised EU health claims for prunes, foods with low or reduced sodium or saturated fatty acids, and claims for essential and long chain polyunsaturated fatty acids.

  • Netter’s Cranial Nerve Collection

    • 1st Edition
    • Frank H. Netter
    • English
    Netter’s Cranial Nerve Collection brings together classic illustrations of these clinically important nerves by Frank H. Netter, MD, combined with illustrated cross-sections and dissection videos to provide clarity to this intricate and difficult area of anatomy.

  • Wildlife Toxicity Assessments for Chemicals of Military Concern

    • 1st Edition
    • Marc Williams + 3 more
    • English
    Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species.

  • Building a Cell from its Component Parts

    • 1st Edition
    • Volume 128
    • English
    The cell interior is another world that we are only beginning to explore. Although there are a number of approaches for examining the inner workings of the cell, the reductionist approach of building up complexity appeals to many with physical science and engineering backgrounds. This volume of Methods in Cell Biology spans a range of spatial scales from single protein molecules to vesicle and cell sized structures capable of complex behaviors. Contributions include; methods for combining different motors and cytoskeletal components in defined ways to produce more complex behaviors; methods to combine cytoskeletal assemblies with fabricated devices such as chambers or pillar arrays; reconstituting membrane fission and fusion; reconstituting important biological processes that normally take place on membrane surfaces; and methods for encapsulating protein machines within vesicles or droplets.

  • Advances in Parasitology

    • 1st Edition
    • Volume 89
    • English
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. The 2013 impact factor is 4.36

  • Direct Microbial Conversion of Biomass to Advanced Biofuels

    • 1st Edition
    • Michael E Himmel
    • English
    'Direct Microbial Conversion of Biomass to Advanced Biofuels' is a stylized text that is rich in both the basic and applied sciences. It provides a higher level summary of the most important aspects of the topic, addressing critical problems solved by deep science. Expert users will find new, critical methods that can be applied to their work, detailed experimental plans, important outcomes given for illustrative problems, and conclusions drawn for specific studies that address broad based issues. A broad range of readers will find this to be a comprehensive, informational text on the subject matter, including experimentalists and even CEOs deciding on new business directions.

  • Advances in Agronomy

    • 1st Edition
    • Volume 132
    • English
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

  • Enzyme Nanoparticles

    Preparation, Characterisation, Properties and Applications
    • 1st Edition
    • Chandra S. Pundir
    • English
    This book is the first book in English on nanotechnology and nanomaterials integrating with enzymatic systems, with a focus on nanoparticles and biological applications. It covers comprehensively the relevant topics to understand the development of enzyme nanoparticles as it relates to the complicated structures of enzyme nanoparticles and their functionalization and immobilization on to various supports. The preparation of enzyme nanoparticles, their kinetic properties and applications after immobilization of the immobilized enzyme nanoparticles is described. The use of colour images in all formats of the book will improve the understanding of the topics covered. The book offers an integration of Enzymology and Nanotechnology and provides the latest information on preparation of enzyme nanoparticles, their characterization, their functionalization and immobilization on to various supports and thereafter their kinetic properties and applications in various industries with special reference to Biosensor Technology.

  • Animal Behavior

    • 2nd Edition
    • Michael D. Breed + 1 more
    • English
    Animal Behavior, Second Edition, covers the broad sweep of animal behavior from its neurological underpinnings to the importance of behavior in conservation. The authors, Michael Breed and Janice Moore, bring almost 60 years of combined experience as university professors to this textbook, much of that teaching animal behavior. An entire chapter is devoted to the vibrant new field of behavior and conservation, including topics such as social behavior and the relationship between parasites, pathogens, and behavior. Thoughtful coverage has also been given to foraging behavior, mating and parenting behavior, anti-predator behavior, and learning. This text addresses the physiological foundations of behavior in a way that is both accessible and inviting, with each chapter beginning with learning objectives and ending with thought-provoking questions. Additionally, special terms and definitions are highlighted throughout. Animal Behavior provides a rich resource for students (and professors) from a wide range of life science disciplines.

  • Sugarcane

    Agricultural Production, Bioenergy and Ethanol
    • 1st Edition
    • Fernando Santos + 2 more
    • English
    Sugarcane: Agricultural Production, Bioenergy and Ethanol explores this vital source for "green" biofuel from the breeding and care of the plant all the way through to its effective and efficient transformation into bioenergy. The book explores sugarcane's 40 year history as a fuel for cars, along with its impressive leaps in production and productivity that have created a robust global market. In addition, new prospects for the future are discussed as promising applications in agroenergy, whether for biofuels or bioelectricity, or for bagasse pellets as an alternative to firewood for home heating purposes are explored. Experts from around the world address these topics in this timely book as global warming continues to represent a major concern for both crop and green energy production.

  • Biotechnology

    • 2nd Edition
    • David P. Clark + 1 more
    • English
    Biotechnology, Second Edition approaches modern biotechnology from a molecular basis, which has grown out of increasing biochemical understanding of genetics and physiology. Using straightforward, less-technical jargon, Clark and Pazdernik introduce each chapter with basic concepts that develop into more specific and detailed applications. This up-to-date text covers a wide realm of topics including forensics, bioethics, and nanobiotechnology using colorful illustrations and concise applications. In addition, the book integrates recent, relevant primary research articles for each chapter, which are presented on an accompanying website. The articles demonstrate key concepts or applications of the concepts presented in the chapter, which allows the reader to see how the foundational knowledge in this textbook bridges into primary research. This book helps readers understand what molecular biotechnology actually is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future.

  • Neurology of Sexual and Bladder Disorders

    • 1st Edition
    • Volume 130
    • David B. Vodusek + 1 more
    • English
    The neurology of sex and bladder disorders requires specialized knowledge and represents a challenge for clinical neurologists focused on the neurological condition. Sex and bladder disorders are often related to more general neurological disorders like Parkinson’s disease and multiple sclerosis, and often the sex and bladder disorders are passed to specialists in urology. Neurology of Sexual and Bladder Disorders: Handbook of Clinical Neurology is a focused, yet comprehensive overview that provides complete tutorial reference to the science, diagnosis and treatment of sex and bladder disorders from a neurologic perspective.

  • Feed and Feeding Practices in Aquaculture

    • 1st Edition
    • English
    Feed and fertilizer are significant costs in aquaculture operations and play an important role in the successful production of fish and other seafood for human consumption. This book reviews the key properties of feeds, advances in feed formulation and ingredient choices and the practicalities of feeding systems and strategies. Feed and Feeding Practices in Aquaculture provides an authoritative and comprehensive coverage of the topic and is an essential guide for nutritionists, farm owners and technicians in aquaculture, as well as those working in R&D in the feed production industry and academics/postgradua... students with an interest in the area.

  • Brain Lipids in Synaptic Function and Neurological Disease

    Clues to Innovative Therapeutic Strategies for Brain Disorders
    • 1st Edition
    • Jacques Fantini + 1 more
    • English
    Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.

  • Spiders, Scorpions, Centipedes and Mites

    The Commonwealth and International Library: Biology Division
    • 1st Edition
    • J. L. Cloudsley-Thompson
    • G.L. Watt
    • English
    Spiders, Scorpions, Centipedes and Mites provides information pertinent to different species of insects, including woodlice, millipedes, centipedes, scorpions, and spiders. This book presents the complexity of factors influencing the distribution and ecology of animals. Organized into 11 chapters, this book starts with an overview of the characteristics and different adaptation to life on land of woodlice. This text then provides information on the structural characteristics of the different orders of millipedes, including Oniscomorpha, Limacomorpha, and Colobognatha. Other chapters consider the biology of centipedes wherein the body is divided into a variable number of somites, each of which is provided with a pair of limbs used for locomotion. This book discusses as well the large pedipalp furnished with stout chelae, which is the most striking feature of spiders. The final chapter deals with the stages in the development of mites. This book is a valuable resource for zoologists, upper school biology teachers, and university students.

  • Basic Pharmacology

    • 3rd Edition
    • R W Foster
    • English
    Basic Pharmacology, Third Edition aims to present accounts of drug actions and their mechanisms in a compact, inexpensive, and updated form, and explain the basis of the therapeutic exploitation of drugs. This book is divided into sections that follow a particular theme and is introduced by the relevant pharmacological general principles. In each section, the major groups of drugs related to the theme are discussed with detailed expositions of the important “type” substances. Drugs of lesser importance are placed in proper context. A list of abbreviations that are referenced throughout the book is provided after the introduction. An index is also included at the end. This edition is designed to help students taking pharmacology, including medical students of subjects affiliated to medicine, to appreciate the rationale underlying the uses of drugs in therapeutics.

  • Food Science and Human Nutrition

    • 1st Edition
    • Volume 29
    • G. Charalambous
    • English
    This volume brings together 63 papers dealing with chemical, biochemical, sensory, microbiological, nutritional, technological and analytical aspects of foods for human consumption. The information presented is of considerable interest to all researchers, analysts, nutritionists, manufacturers, packagers, etc., involved in the perennial effort to gain more insight into the correlation between food science and human nutrition. (Limitation of space allows only a selection of papers to be mentioned).

  • Family Caregiving in the New Normal

    • 1st Edition
    • Joseph E. Gaugler + 1 more
    • English
    Family Caregiving in the New Normal discusses how the drastic economic changes that have occurred over the past few years have precipitated a new conversation on how family care for older adults will evolve in the future. This text summarizes the challenges and potential solutions scientists, policy makers, and clinical providers must address as they grapple with these changes, with a primary focus given to the elements that may impact how family caregiving is organized and addressed in subsequent decades, including sociodemographic trends like divorce, increased participation of women in the workforce, geographic mobility, fewer children in post-baby boom families, chronic illness trends, economic stressors, and the current policy environment. A section on the support of caregivers includes technology-based solutions that examine existing models, personal health records, and mobile applications, big data issues, decision-making support, person-centered approaches, crowd-sourced caregiving such as blogs and personal websites that have galvanized caregivers, and new methods to combine paid and unpaid forms of care.

  • Advanced Mass Spectrometry for Food Safety and Quality

    • 1st Edition
    • Volume 68
    • English
    Advanced Mass Spectrometry for Food Safety and Quality provides information on recent advancements made in mass spectrometry-based techniques and their applications in food safety and quality, also covering the major challenges associated with implementing these technologies for more effective identification of unknown compounds, food profiling, or candidate biomarker discovery. Recent advances in mass spectrometry technologies have uncovered tremendous opportunities for a range of food-related applications. However, the distinctive characteristics of food, such as the wide range of the different components and their extreme complexity present enormous challenges. This text brings together the most recent data on the topic, providing an important resource towards greater food safety and quality.

  • Streptococcus Pneumoniae

    Molecular Mechanisms of Host-Pathogen Interactions
    • 1st Edition
    • Jeremy Brown + 2 more
    • English
    Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases.

  • Nutrient Metabolism

    Structures, Functions, and Genes
    • 2nd Edition
    • Martin Kohlmeier
    • English
    Nutrient Metabolism, Second Edition, provides a comprehensive overview of the supply and use of nutrients in the human body and how the body regulates intake. Chapters detail the principles determining digestion and absorption of food ingredients and how these compounds and their metabolites get into the brain, cross the placenta and pass through the kidneys. Each nutrient’s coverage contains a nutritional summary that describes its function, its food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. This handbook contains the latest information on the scope of structures, processes, genes and cofactors involved in maintaining a healthy balance of nutrient supplies. Of interest to a wide range of professionals because nutrient issues connect to so many audiences, the book contains a useful link to dietary supplements.

  • Industrial Biorefineries and White Biotechnology

    • 1st Edition
    • Ashok Pandey + 4 more
    • English
    Industrial Biorefineries and White Biotechnology provides a comprehensive look at the increasing focus on developing the processes and technologies needed for the conversion of biomass to liquid and gaseous fuels and chemicals, in particular, the development of low-cost technologies. During the last 3-4 years, there have been scientific and technological developments in the area; this book represents the most updated information and technological perspective on the topic.

  • Spinal Infections, An Issue of Neuroimaging Clinics

    • 1st Edition
    • Volume 25-2
    • E. Turgut Tali
    • English
    Spinal Infections is explored in this important Neuroimaging Clinics issue. Articles include: Pathologic approach to spinal cord infections; Pediatric spinal infection and inflammation; Pediatric and adult spinal Tb: imaging and pathophysiology; Pyogenic spinal infections; Spinal brucellosis; Viral infection of the spinal cord and roots; Parasitic and rare spinal infections; Overview of complications and sequeala in spinal infections; Neurosurgical approach to spinal infections; Image guided interventions in spinal infections; Pathological basis of pyogenic, nonpyogenic, and other spondylitis and discitis, and more!

  • Image-Guided Neurosurgery

    • 1st Edition
    • Alexandra J. Golby
    • English
    Image-Guided Neurosurgery provides readers with an update on the revolutionary improvements in imaging and visualization relating to neurosurgery. From the development of the pneumoencephalogram, to the operating microscope, to cross sectional imaging with CT and later MRI, to stereotaxy and neuronavigation, the ability to visualize the pathology and surrounding neural structures has been the driving factor leading surgical innovation and improved outcomes. The book provides a comprehensive reference on the application of contemporary imaging technologies used in neurosurgery. Specific techniques discussed include brain biopsies, brain tumor resection, deep brain stimulation, and more. The book is ideal for neurosurgeons, interventional radiologists, neurologists, psychiatrists, and radiologists, as well as technical experts in imaging, image analysis, computer science, and biomedical engineering.

  • Handbook of Marine Microalgae

    Biotechnology Advances
    • 1st Edition
    • Se-Kwon Kim
    • English
    Handbook of Microalgae: Biotechnology Advances offers complete coverage of marine microalgae, including biology, production techniques, biotechnological applications, economic perspectives of applications, and environmental effects of marine microalgae blooms. With contributions from world experts, Handbook of Microalgae: Biotechnology Advances focuses on microalgae from an organism perspective to offer a complete picture from evolution to biofuel.

  • Membrane Proteins – Engineering, Purification and Crystallization

    • 1st Edition
    • Volume 557
    • English
    Membrane Proteins – Engineering, Purification and Crystallization, a volume of Methods In Enzymology, encompasses chapters from the leading experts in the area of membrane protein biology. The chapters provide a brief overview of the topics covered and also outline step-by-step protocol for the interested audience. Illustrations and case example images are included wherever appropriate to help the readers understand the schematics and general experimental outlines.

  • Health of HIV Infected People

    Food, Nutrition and Lifestyle with Antiretroviral Drugs
    • 1st Edition
    • Ronald Ross Watson
    • English
    Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs provides basic and applied knowledge on the supportive roles of bioactive foods, exercise, and dietary supplements on HIV/AIDS patients receiving antiretroviral drugs. Approaches include the application of traditional herbs and foods aiming to define both the risks and benefits of such practices. Readers will learn how to treat or ameliorate the effects of chronic retroviral disease using readily available, cheap foods, dietary supplements, and lifestyle changes with specific attention to the needs of patients receiving antiretroviral drugs. This work provides the most current, concise, scientific appraisal of the efficacy (or lack thereof) of key foods, nutrients, dietary plants, and behavioral shifts in preventing and improving the quality of life of HIV infected infants and adults, while also giving the needed attention to these complex and important side effects.

  • Health of HIV Infected People

    Food, Nutrition and Lifestyle without Antiretroviral Drugs
    • 1st Edition
    • Ronald Ross Watson
    • English
    Health of HIV Infected People: Food, Nutrition and Lifestyle Without Antiretroviral Drugs defines the supportive roles of bioactive foods, exercise, and dietary supplements on the health of HIV infected people who do not have access to resources or those who choose not to utilize antiretroviral drugs. Approaches such as the application of traditional herbs and foods are given careful definition by experts who define the risks and benefits of such practices within this important context. Readers learn how to treat or ameliorate the effects of chronic retroviral disease using readily available, cheap foods, and dietary supplements. Ultimately, this work delivers a current, concise, scientific appraisal of the efficacy of key foods, nutrients, dietary plants, and behavioral changes in preventing and improving the quality of life of HIV infected infants and adults who are not undergoing antiretroviral therapy.

  • Personalized Epigenetics

    • 1st Edition
    • Trygve O. Tollefsbol
    • English
    Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

  • Medicinal Chemistry of Anticancer Drugs

    • 2nd Edition
    • Carmen Avendaño + 1 more
    • English
    Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.

  • Waking and the Reticular Activating System in Health and Disease

    • 1st Edition
    • Edgar Garcia-Rill
    • English
    Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating” properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders.

  • Handbook of Fertility

    Nutrition, Diet, Lifestyle and Reproductive Health
    • 1st Edition
    • Ronald Ross Watson
    • English
    Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health focuses on the ways in which food, dietary supplements, and toxic agents, including alcohol and nicotine affect the reproductive health of both women and men. Researchers in nutrition, diet, epidemiology, and endocrinology will find this comprehensive resource invaluable in their long-term goal of understanding and improving reproductive health. This book brings together a broad range of experts researching the different aspects of foods and dietary supplements that promote or detract from reproductive health. Section One contains several overview chapters on fertility, how it is assessed, and how it can be affected by different metabolic states, nutritional habits, dietary supplements, the action of antioxidants, and lifestyle choices. Sections Two and Three consider how male and female fertility are affected by obesity, metabolic syndrome, hormonal imbalance, and even bariatric surgery. Section Four explores the ways diet, nutrition, and lifestyle support or retard the success of in vitro fertilization, while Section Five explores how alcohol and other drugs of abuse lower fertility in both women and men.

  • Basic Principles of Drug Discovery and Development

    • 1st Edition
    • Benjamin E. Blass
    • English
    Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 69
    • English
    Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 91
    • English
    A compilation of up to date reviews of topics in biotechnology and the medical field.

  • Essentials of Medical Biochemistry

    With Clinical Cases
    • 2nd Edition
    • Chung Eun Ha + 1 more
    • English
    Essentials of Medical Biochemistry, Second Edition: With Clinical Cases is the most condensed, yet detailed biochemistry overview available on the topic. It presents contemporary coverage of the fundamentals of biochemistry, emphasizing relevant physiologic and pathophysiologic biochemical concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find basic and fundamental concepts that will aid students and professionals in biochemistry, medicine, and other healthcare disciplines. the text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 46
    • English
    Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 46 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry.

  • The Science and Ethics of Antipsychotic Use in Children

    • 1st Edition
    • Nina Di Pietro + 1 more
    • English
    The Science and Ethics of Antipsychotic Use in Children reviews the latest findings for the safety and efficacy of the rapidly rising incidence of antipsychotic use in children and examines tensions that are created by off-label use, both in clinical psychiatric practice and research.In the past ten years, the number of antipsychotics prescribed to children with psychiatric disorders has skyrocketed. Despite this rapid growth, most medications have been inadequately studied in children for safety or efficacy and many have serious adverse health. Measures are needed to ensure that the health and safety of children are being protected, and debates have emerged over whether or not clinical trials in this population should be conducted.

  • Regenerative Engineering of Musculoskeletal Tissues and Interfaces

    • 1st Edition
    • Syam Nukavarapu + 2 more
    • English
    Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces.

  • Monoclonal Antibodies

    Meeting the Challenges in Manufacturing, Formulation, Delivery and Stability of Final Drug Product
    • 1st Edition
    • Steven Shire
    • English
    Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies.

  • Modeling Food Processing Operations

    • 1st Edition
    • Serafim Bakalis + 2 more
    • English
    Computational modeling is an important tool for understanding and improving food processing and manufacturing. It is used for many different purposes, including process design and process optimization. However, modeling goes beyond the process and can include applications to understand and optimize food storage and the food supply chain, and to perform a life cycle analysis. Modeling Food Processing Operations provides a comprehensive overview of the various applications of modeling in conventional food processing. The needs of industry, current practices, and state-of-the-art technologies are examined, and case studies are provided. Part One provides an introduction to the topic, with a particular focus on modeling and simulation strategies in food processing operations. Part Two reviews the modeling of various food processes involving heating and cooling. These processes include: thermal inactivation; sterilization and pasteurization; drying; baking; frying; and chilled and frozen food processing, storage and display. Part Three examines the modeling of multiphase unit operations such as membrane separation, extrusion processes and food digestion, and reviews models used to optimize food distribution.

  • Advances in Parasitology

    • 1st Edition
    • Volume 88
    • English
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. The 2013 impact factor is 4.36

  • Grapevine Breeding Programs for the Wine Industry

    • 1st Edition
    • Andrew G. Reynolds
    • English
    Grapevine Breeding Programs for the Wine Industry: Traditional and Molecular Techniques summarizes recent trends in grapevine breeding, both in terms of research and practical programs. The first group of chapters covers the challenges faced by breeders and existing and emerging techniques used to combat them. Two further groups of chapters focus on grapevine breeding programs in different wine-producing countries around the world. With authoritative contributions from experts across the world’s winemaking regions, this book will be an essential reference for all those involved in viticulture and oeneology wanting to explore new methods, understand different approaches and refine existing practices.

  • Advances in Agronomy

    • 1st Edition
    • Volume 131
    • English
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. Five volumes are published yearly which ensures that authors’ contributions are disseminated to the readership in a timely manner. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

  • The Protective Arm of the Renin Angiotensin System (RAS)

    Functional Aspects and Therapeutic Implications
    • 1st Edition
    • Thomas Unger + 2 more
    • English
    The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications.

  • Antimicrobial Resistance and Food Safety

    Methods and Techniques
    • 1st Edition
    • Chin-Yi Chen + 2 more
    • English
    Antimicrobial Resistance and Food Safety: Methods and Techniques introduces antimicrobial resistant food-borne pathogens, their surveillance and epidemiology, emerging resistance and resistant pathogens. This analysis is followed by a systematic presentation of currently applied methodology and technology, including advanced technologies for detection, intervention, and information technologies. This reference can be used as a practical guide for scientists, food engineers, and regulatory personnel as well as students in food safety, food microbiology, or food science.

  • Sunflower

    Chemistry, Production, Processing, and Utilization
    • 1st Edition
    • Enrique Martínez-Force + 2 more
    • English
    This comprehensive reference delivers key information on all aspects of sunflower. With over 20 chapters, this book provides an extensive review of the latest developments in sunflower genetics, breeding, processing, quality, and utilization; including food, energy and industrial bioproduct applications. World-renowned experts in this field review U.S. and international practices, production, and processing aspects of sunflower.

  • Olive and Olive Oil Bioactive Constituents

    • 1st Edition
    • Dimitrios Boskou
    • English
    The market is flooded with products posing as elixirs, supplements, functional foods, and olive oil alternatives containing phenols obtained from multiple olive sources. This technically-oriented book will be of value to nutritionists and researchers in the biosciences. It unravels the body of science pertaining to olive minor constituents in relation to new chemical knowledge, technological innovations, and novel methods of recovery, parallel to toxicology, pharmacology, efficacy, doses, claims, and regulation. Topics include: the biological importance of bioactive compounds present in olive products; developments and innovations to preserve the level of bioactives in table olives and olive oil; and importance of variety, maturity, processing of olives, storage, debittering of olives and table olives as a valuable source of bioactive compounds.

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