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Elsevier

Books in Life sciences

  • Innovations and Human Factors Challenges in Healthcare Product Design

    • 1st Edition
    • Kamalpreet Sandhu + 3 more
    • English
    Innovations and Human Factors Challenges in Healthcare Product Design covers best practices and advanced design methods to capture, document, and validate various challenges at the early stage of the design process, also delving into how to mitigate design strategies to address those challenges without compromising the cost, effort, safety, and quality of the device. The book provides a comprehensive collection of technical notes, research designs, design methods and processes, case studies, comprehensive literature on the industrial impact of design methods and processes, and applications of digital technologies for design, analysis, manufacturing, testing, and deployment. Readers will find multidisciplinary coverage of the application of technology and science for product design in healthcare sectors.

  • The Journey from Cocoa to Chocolate

    Preserving Flavor and Bioactive Compounds
    • 1st Edition
    • Ravi Pandiselvam + 1 more
    • English
    The Journey from Cocoa to Chocolate: Preserving Flavor and Bioactive Compounds provides an end-to-end review of different pre-processing and processing methods and their effects on the nutritional, physiochemical, sensorial properties, and health benefits of cocoa. Readers will explore the journey from cocoa beans to chocolate, including recent advances in processing techniques and the utilization of cocoa by-products for improved sustainability and waste reduction. The book emphasizes cocoa's beneficial components, also including retention processing techniques that do not sacrifice sensorial properties. Readers from academia, research, food science, and the chocolate industry will benefit from this new resource.Cocoa beans contain huge sources of phytochemicals that act as both flavor agents and bioactive compounds. Care must be taken in the processing of cocoa into chocolate in order to maintain cocoa's natural health benefits while enhancing flavor to create the sweet treat we know and love.

  • Wearable Smart Sensing Devices for Sustainable Healthcare

    Techniques, Fabrication, Data Collection and Analysis
    • 1st Edition
    • Arpana Parihar + 2 more
    • English
    Wearable Smart Sensing Devices for Sustainable Healthcare: Techniques, Fabrication, Data Collection and Analysis presents a complete overview of the techniques for developing integrated wearable sensors, the systems that power them, and the fabrication issues involved in making them. The book bridges the gap between theory and practice, offering scientific knowledge and practical insights. Written by renowned researchers and industry experts, this book provides valuable understanding and insights into the design, data processing, analysis, and fabrication of wearable sensors that is ideal for academic engineering and scientific researchers, industry engineers, and scientists interested in developing wearable sensor devices.

  • Moving Toward Nonanimal Approaches in Medical Research and Testing

    • 1st Edition
    • Gail A. Van Norman + 1 more
    • English
    Moving Toward Nonanimal Approaches in Medical Research and Testing pioneers a single-source guide for researchers regarding nonanimal research tools and methodologies and their many advantages and applications in place of animals. This book is presented in three parts: historical, ethical, legislative, and scientific contexts on the need to shift away from animal-based research and testing; the latest advances in nonanimal tools and methods for biomedical research and testing of human therapeutics and other compounds, including microphysiological systems, bioprinting, biobanks, and artificial intelligence; and achieving a practical shift toward these powerful approaches, including advocacy for legal, regulatory, and policy change, securing funding for nonanimal studies, and how to overcome bias against nonanimal methods. This book, primarily directed to researchers in biomedicine, human medical therapeutics, and toxicology, will also appeal to researchers in industry, providing overview and insights about the latest applications of nonanimal research tools and methods for product development and testing. Clinicians who wish to understand the reliability of testing therapeutics with nonanimal versus animal methods, as well as advocacy groups seeking an up-to-date understanding of ethical, economic, political, and scientific considerations in moving toward nonanimal approaches, will also find significant value in this text. Finally, legislators and those involved in regulatory review and oversight will benefit from this single comprehensive source for developing a basic understanding of nonanimal research and human safety.

  • Radiation Biology

    Molecular Foundations and Clinical Applications
    • 1st Edition
    • Barry S. Rosenstein + 1 more
    • English
    Radiation Biology: Molecular Foundations and Clinical Applications is a comprehensive exploration of the effects of radiation on living organisms, delving into the molecular mechanisms underlying cellular responses. This book examines critical topics such as radiation-induced DNA damage, repair processes, and molecular signaling pathways. It provides a detailed look at how cells respond to radiation, addressing cell cycle control, apoptosis, and the effects of radiation on immune system functionality. As a resource for researchers, it bridges the gap between molecular biology and clinical oncology, offering insights into radiation's role in both therapeutic contexts and its broader impact on human biology.In addition to its focus on molecular responses, the book covers topics like tumor microenvironment and metabolism, the role of epigenetics in radiation biology, and the hallmarks of cancer relevant to radiation therapy. It also provides discussions on chemotherapeutic agents, radiation carcinogenesis, and the complex interplay between radiation and cancer biology. The later sections extend the scope to tissue, organ, and systemic effects of radiation, making it an invaluable reference for professionals in molecular biology, oncology, and related fields striving to push the boundaries of radiation research.

  • Nutritional Strategies, Predictive Models, and Sustainable Policies

    • 1st Edition
    • Sandeep K. Panda + 2 more
    • English
    Nutritional Strategies, Predictive Models, and Sustainable Policies brings together scientists, professors, and policymakers from over 10 countries to cover strategies and approaches to improve human health by focusing on the nutritional needs of children, pregnant women, and patients from around the world. Sections cover existing policies in specific geographical areas, critical reviews on the scientific updates of maternal, pediatric, and geriatric nutrition and how the Pandemic disrupted nutritional strategies, review predictive models on different nutrition categories for certain diseases and cancers, and highlight international and regional policies related to nutrition in war affected countries.

  • The Dual Role of Inflammation in Cancer

    • 1st Edition
    • Surajit Pathak + 1 more
    • English
    The Dual Role of Inflammation in Cancer Genesis and Therapy explores the pivotal role inflammation plays in the development and progression of cancer. The book delves into how chronic inflammation creates a microenvironment that supports tumor growth by promoting cellular proliferation, survival, and migration while suppressing immune responses. It traces historical observations, linking inflammation to cancer while also examining how inflammatory cells and mediators contribute to various stages of tumorigenesis. In addition, it discusses the implications of inflammation on cancer treatment, highlighting the potential of anti-inflammatory agents and immunotherapy in targeting the inflammatory tumor microenvironment.By elucidating on the intricate relationship between inflammation and cancer, the book aims to pave the way for more effective and personalized cancer treatment strategies. As such, it is a valuable resource for researchers in immunology and oncology.

  • Geriatric Neurosurgery in Clinical Practice

    • 1st Edition
    • Joe M. Das
    • English
    Geriatric Neurosurgery in Clinical Practice is an essential resource that provides a thorough and modern overview of geriatric neurosurgery. This volume compiles the latest research and clinical practice guidelines, offering practical advice for clinicians caring for elderly patients. It delves into a range of topics, including the management of common neurosurgical conditions in elderly patients, surgical techniques, postoperative care, and the integration of multidisciplinary approaches to enhance patient outcomes. Users will find this to be an invaluable reference for practicing neurosurgeons, neurosurgery residents, neurologists, geriatric physicians, and researchers seeking clear and concise information on current treatments and procedures for geriatric neurosurgery.

  • Model Validation and Uncertainty Quantification in Biomechanics

    From Soft Biological Tissue to Blood Flow
    • 1st Edition
    • Gerhard A. Holzapfel + 2 more
    • English
    Model Validation and Uncertainty Quantification in Biomechanics: From Soft Biological Tissue to Blood Flow provides a comprehensive overview of the latest technology in biomechanical modeling and analysis. Part I presents the foundational principles of modeling primary biomechanical systems, including the intricate workings of the cardiovascular system. This section also provides invaluable insights into essential topics such as sensitivity analysis, uncertainty quantification, machine learning, and surrogate modeling. In Part 2, the book transitions into an in-depth examination of the current state-of-the-art in model validation techniques across a diverse array of biomechanical disciplines, including the latest advancements and best practices. Part 3 introduces current and innovative approaches for quantifying uncertainties inherent in biomechanical modeling. Chapters range from established methodologies to emerging techniques, providing a comprehensive overview of the various strategies employed in addressing uncertainty in biomechanical studies. Finally, in Part 4, the book concludes with a focus on cutting-edge methods, specifically spotlighting the utilization of machine learning and surrogate modeling for both model validation and uncertainty quantification. Through real-world applications and case studies, this book provides an in-depth understanding of how these advanced techniques are reshaping the landscape of biomechanics research.

  • Politics, Practice, and Policy

    How to Get Things Done in Food and Nutrition, 10 Case Studies
    • 1st Edition
    • Eileen Kennedy
    • English
    Food and Nutrition Policy: 10 Case Studies for Developing Effective Policies and Programs explains how policy compromises are reached and then changed over time as new information becomes available. Derived from the authors’ experiences while serving as a political appointee in the federal government, participating in international committees and boards, and from materials from a graduate course which she teaches on global food and nutrition policy at Tufts University, the 10 case studies presented in this book provide real world learning examples on how contentious issues are resolved in the political process.While each of the ten chapters focuses on a specific topic, the book showcases an overriding theme of food and health justice, equity, and empowerment. Readers will deduce key factors to examine pivotal policy decisions while the author dissects polarizing topics such as examining the successes and failures of dietary guidelines, front label packaging approaches, implications of expanding personalized nutrition, the obesity epidemic and the role of GMO’s in agricultural production, and more.

  • Thin Film Photovoltaics

    Single-Junction and Tandem
    • 1st Edition
    • Jeyakumar Ramanujam + 1 more
    • English
    Thin Film Photovoltaics: Single-junction and Tandem provides a comprehensive introduction to thin film solar cells and the latest developments in this expanding field. The book includes detailed information on material properties required for solar cells, working principles, energy band structure, charge transport to the electrodes and approaches to improve efficiency. Front-end and back-end processes are discussed in detail. Current challenges to commercial translation and potential opportunities to overcome to those challenges are also covered, and factors limiting solar cells parameters are also considered. Emphasis is on new materials and state-of-the-art technologies used for fabrication and characterization.Thi... book is suitable for researchers in academia and R&D in the subject areas of materials science and engineering, energy, physics, and chemistry.

  • Nonthermal Extraction Technologies of Polysaccharides

    Principles, Techniques, Characterization, and Applications
    • 1st Edition
    • Seyed Mohammad Taghi Gharibzahedi
    • English
    Nonthermal Extraction Technologies of Polysaccharides: Principles, Techniques, Characterization, and Applications explores cutting-edge nonthermal extraction technologies, including ultrasound, microwave, high-pressure, pulsed electric field, enzymatic extraction methods, and cold plasma technology and their effects on polysaccharide biofunctionalities, such as antioxidant and antimicrobial properties and potential applications. With an examination of the therapeutic benefits associated with these compounds, including anti-cancer, antioxidant, antimicrobial, anti-inflammatory, and anti-obesity properties, this book aspires to highlight advanced techniques to significantly enhance polysaccharide yield, bioactivity, and purity when compared to traditional approaches.The initial chapters introduce the fundamental structures, sources, and importance of polysaccharides, thus setting the stage for a deeper understanding of their functionality and chemical characterization. By offering both theoretical frameworks and practical guidance, this book equips professionals with the knowledge required to effectively incorporate polysaccharides into health-promoting products for advancing research and applications in the evolving landscape of functional foods and biomedical innovation.

  • Remote Sensing for Vegetation Monitoring

    Technologies, Applications and Models
    • 1st Edition
    • Prem Chandra Pandey + 3 more
    • English
    Remote Sensing for Vegetation Monitoring: Technologies, Applications and Models provides insight on the pivotal role that remote sensing plays in vegetation monitoring. As traditional field assessments face challenges due to inaccessible study sites and lengthy data collection, this book offers a comprehensive view of remote sensing applications for monitoring various vegetation ecosystems, including forests, grasslands, mangroves, and agriculture. The book presents a coherent and consistent structure, across five sections that build upon prior knowledge and detail the quantitative and qualitative assessments made possible through remote sensing technologies. Remote Sensing for Vegetation Monitoring: Technologies, Applications and Models caters to a diverse audience, including researchers and practitioners seeking to navigate the evolving landscape of vegetation monitoring through case studies, new algorithms and state-of-the-art methods.

  • Agricultural Pollination

    The Role of Beneficial Insects in Food Security and Sustainability
    • 1st Edition
    • Habib Ali
    • English
    Agricultural Pollination: The Role of Beneficial Insects in Food Security and Sustainability delves into the intricate relationship between farming and pollinators, as well as other beneficial insects, examining the ways in which their ecological roles can improve crop health and yield, ultimately bolstering food security without environmentally harmful chemical interventions. The book begins with coverage of foundational topics, such as types of key pollinators and their behaviors, and moves into more practical topics, such as creating pollinator-friendly landscapes and emerging technologies in pollination services.Taking a multidisciplinary approach, the book also covers conservation strategies, economic impacts of pollinators, policy recommendations, and community engagement. This timely reference will offer invaluable insights for researchers, students, agricultural industry professionals, and policymakers alike, contributing to the advancement of environmentally-frie... and economically viable agricultural practices.

  • Mitochondrial Intoxication

    • 2nd Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication, Second Edition, offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication, and challenges of mitochondrial profiling during pre-clinical studies. The book then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication.The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides, and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, this new release offers cutting-edge insights on mitochondrial toxicity, serving as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

  • Epigenetic Mechanisms in Brain Physiology and Disorders

    • 1st Edition
    • Volume 219
    • Moshe Szyf + 1 more
    • English
    Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.

  • Thiamine, thiamine pyrophosphate and thiamine pyrophosphate-dependent enzymes Part B

    • 1st Edition
    • Volume 736
    • English
    Thiamine Pyrophosphate (TPP)-Dependent Enzymes, Volume 736 in the Methods in Enzymology series covers this diverse group of ubiquitous enzymes with timely chapters on Methods for Studying ThDP-dependent Mycobacterial MenDs (SEPHCHC Synthases), Mammalian 2-hydroxyacyl-CoA lyases, discovery and assays, Anti-infective target 1-deoxy-d-xylulose-5... synthase (DXS) and drug design for enzyme inhibition, Expression, Purification, and Mechanistic Studies of DXP synthases from Deinococcus radiodurans, Plasmodium falciparum, and Plasmodium vivax, Comparison of the catalysis of ThPP-dependent enzymes AHAS, ALS, and DXS, and much more.Additional sections cover Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis, Biochemical and Structural characterization of novel ‘split-gene’ archeal transketolases, 4-Hydroxybenzoylform... decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5: characterization and involvement in bacterial lignin degradation, Engineering of phosphoketolase from Bifidobacterium adolescentis for increased activity on non-phosphorylated substrates and application in a cell-free reaction system for ATP regeneration, Repurposing TPP-dependent enzymes with anodic oxidation for the conversion of aldehydes to enantioenriched carboxylic acids, and much more.

  • miRNA in Human Disease

    From Biomarkers to Therapeutics
    • 1st Edition
    • Parul Gupta + 6 more
    • English
    miRNA in Human Disease: From Biomarkers to Therapeutics explores the critical role of microRNAs (miRNAs) in the development and progression of various diseases, emphasizing their significance as biomarkers and therapeutic targets. Sections provide a comprehensive overview of the biogenesis, function, and regulation of miRNAs, offering insights into how these small noncoding RNA molecules influence gene expression and contribute to disease development and progression. The book covers traditional and advanced methods for miRNA extraction, the role of miRNAs in infectious diseases, cancer, neurological disorders, cardiovascular disease, hemoglobinopathies, pregnancy complications, and metabolic disorders.Sections also discuss the latest research on miRNA-based therapies, including the design and delivery of miRNA mimics and inhibitors and their potential applications in personalized medicine. With a strong focus on practical implementation, the book includes detailed case studies and real-world examples that demonstrate the clinical relevance of miRNA research. It addresses the challenges and future directions in the field, providing a roadmap for researchers, clinicians, and industry professionals to harness the potential of miRNAs for disease diagnosis, treatment, and prevention.

  • Fundamentals and Functional Advancements of Fungal Enzymes in Biorefinery and Bioproducts Development

    Volume 1
    • 1st Edition
    • Manikant Tripathi + 1 more
    • English
    Fundamental and Functional Advancements of Fungal Enzymes in Biorefinery and Bioproducts Development offers highlights the fundamental aspects of fungal enzymes which include their structure, function, chemical composition, and their functional importance for biorefinery and bioproducts development. This is the first of two volumes that provides a comprehensive overview of the utilization of fungal enzymes for biorefinery and bioproduct development. Volume 1 introduces various types of fungal enzymes and offers a better understanding of the basic science of fungal enzymes, their structure, their fundamental functions and limitations in biochemical development. This book also explores the processes involved in improving the enhanced production, efficiency, and efficacy of fungal enzymes for application. It also examines biofuel and bioproducts production using fungal enzymes. In combination with Volume 2, this book offers a holistic view of the potential and challenges of engineered fungal enzymes for researchers, scientists, and industry professionals seeking to deepen their knowledge of fungal enzymes and their role in biochemical advances.

  • Advances in Brain Tumor Therapy

    From Molecular Mechanisms to Clinical Practice
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Advances in Brain Tumor Therapy: From Molecular Mechanisms to Clinical Practice explores the evolving landscape of brain tumor treatment, addressing challenges posed by these rare yet impactful malignancies. The book highlights significant improvements in patient prognoses due to advances in targeted therapies and immunotherapies while also recognizing the limitations of current treatment options. The content examines brain tumor epidemiology, incidence, risk factors, and survival rates followed by an extensive overview of existing therapeutic approaches, including clinical trials, targeted treatments, immunotherapies, and systemic therapies. It also delves into the critical signaling pathways that drive tumor biology and implications for future strategies.This book serves as an essential resource for healthcare professionals, clinical researchers, medical students, and scientists, bridging the gap between basic science and clinical practice. By providing insights into the latest advancements and emerging technologies, it equips readers with the knowledge necessary to navigate the complexities of brain tumor therapy and prepare for future innovations.

  • Artificial Intelligence and the Water-Energy-Food Nexus

    Innovations for Sustainable Resource Management
    • 1st Edition
    • Ali Fares
    • English
    Artificial Intelligence and the Water-Energy-Food Nexus: Innovations for Sustainable Resource Management is a groundbreaking exploration on how AI transforms the management of our planet's most vital resources. Specific topics include enhancing poultry production and the predictions of crop yields and post-harvest processing, while also dealing with FEW security in sub-Saharan Africa. Additionally, the book covers various topics that showcase AI's potential to boost agricultural productivity, mitigate climate change, and promote food security. This book's content covers ethical considerations, interdisciplinary collaboration, and the integration of AI into real-world practices.Readers will find an in-depth analysis of the intersections of AI and the FEW Nexus, including the critical need for sustainable farming practices, water conservation, and energy efficiency. Contributing authors are experts from around the globe who offer practical solutions, case studies, and cutting-edge technologies like digital twins, machine learning, and hyperspectral imaging to optimize resource management.

  • Perianal Crohn’s Disease

    Diagnosis and Treatment
    • 1st Edition
    • Bolin Yang + 2 more
    • English
    Perianal Crohn’s Disease: Diagnosis and Treatment includes the latest knowledge, concepts, first-hand theoretical views, and clinical experience of clinical frontline experts in the field of inflammatory bowel disease. The book systematically describes disease phenotypes, clinical features, examination methods, diagnoses, and treatments. It takes a scientific, practical, and systematic account of both common and rare conditions associated with Perianal Crohn’s Disease, offering informative content, clinical case information, cutting-edge viewpoints, and current, authoritative research findings. The book contains a depth of current clinical experience, including the use of photographs to support examples of conditions, methods, and techniques. In addition, it provides clear ideas and a wealth of clinical information for the clinical diagnosis and management of perianal Crohn's disease.

  • Neuroscience-Informed Psychoeducation (NIPE) for Brain and Mental Health

    Part B
    • 1st Edition
    • Volume 303
    • English
    Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Fundamentals of Absorption Spectroscopy

    • 1st Edition
    • Imtaiyaz Hassan
    • English
    Fundamentals of Absorption Spectroscopy offers a clear and comprehensive introduction to the principles, instrumentation, and applications of absorption spectroscopy across UV-Visible, IR, and other spectral regions. Designed for students, researchers, and industry professionals, this book bridges theory and practice with practical illustrations and real-world case studies, providing a solid foundation in both fundamental concepts and contemporary applications in chemistry, biology, medicine, environmental monitoring, and materials science. It fills the gap between overly advanced and overly simplified texts by combining fundamental theory with practical insights, particularly from biological perspectives. This book addresses the need for an updated, student-friendly, and application-oriented resource in absorption spectroscopy. Readers will benefit from structured guidance that connects theoretical principles with experimental data, explains instrumentation and its limitations, and demonstrates applications across diverse fields such as pharmaceuticals, environmental analysis, and biomolecular sciences. The inclusion of case studies and recent advances in spectroscopic technology ensures relevance for both academic study and professional practice.

  • The Hormonal Treatment of Endometriosis and Adenomyosis

    A Comprehensive Review of the Role of Hormonal Treatments in the Management of Pain and Infertility in Patients with Endometriosis and Adenomyosis
    • 1st Edition
    • Antonio Simone Laganà + 1 more
    • English
    The Hormonal Treatment of Endometriosis and Adenomyosis: A Comprehensive Review of the Role of Hormonal Treatments in the Management of Pain and Infertility in Patients with Endometriosis and Adenomyosis is a comprehensive and practical reference on the effects of various hormonal treatments on endometriosis and adenomyosis lesions. The book summarizes the latest evidence regarding the safety and efficacy of these treatments in managing pain associated with these conditions. Additionally, the book explores the evidence-based benefits of hormonal therapies in improving fertility chances for patients, both through natural conception and assisted reproductive technologies.The book helps readers grasp the generalizability of current research findings and identifies existing research gaps, shedding light on new perspectives for future investigation. Through this comprehensive approach, the book serves as an invaluable resource for healthcare professionals, researchers, and patients alike.

  • Challenges and Trends in Food Safety

    Contamination, Public Health, and Control Measures
    • 1st Edition
    • João Miguel Rocha + 3 more
    • English
    Challenges and Trends in Food Safety: Contamination, Public Health, and Control Measures provides a comprehensive review of the most recent available knowledge about microbiological, chemical and physical risks associated with food consumption. The book also provides a useful future outlook of new trends, and advanced and novel technologies for ensuring food safety and food security. Divided into five sections, the title covers the systems leading to food contamination, food science in service of food security and public health in the first section. Biological hazards and threats for food safety and effective control measures are covered in the second section, while the third one discusses the chemical hazards of food and effective control measures. The fourth section covers physical hazards of food and effective control measures and the final section brings practical solutions, future trends and advanced technologies for ensuring food safety. Edited by a team of experts in the field of Food Safety, Microbilogy and Defense, this book is an ultimate reference, serving as a guide to elaborate on food contamination from various aspects.

  • Real-World Research to Improve Dementia Care

    Embedding Pragmatic Trials of Non-Drug Interventions
    • 1st Edition
    • Jill Harrison + 1 more
    • English
    Real-World Research to Improve Dementia Care: Embedding Pragmatic Trials of Non-Drug Interventions addresses the urgent need for effective care strategies for the over 50 million individuals living with Alzheimer's disease and related dementias. This insightful book introduces embedded, pragmatic trials as a way to bridge the gap between clinical research and everyday practice, emphasizing collaboration among healthcare systems, researchers, and communities. Through a series of chapters, the book explores partnership strategies, ethical considerations, and the selection of meaningful outcome measures, all aimed at enhancing dementia care. The authors present case studies that showcase successful interventions and innovative practices across care settings.By highlighting both the challenges and solutions in dementia care, this book serves as a vital resource for healthcare professionals and researchers. It advocates for a compassionate approach that values the voices of individuals living with dementia, ultimately aiming to improve their quality of life.

  • Medicines Safety and Pharmacovigilance

    Introduction, Concepts, and Applications
    • 1st Edition
    • Rabia Hussain
    • English
    Medicines Safety and Pharmacovigilance: Introduction, Concepts, and Applications provides a comprehensive guide for pharmaceutical professionals navigating the complex landscape of medicine safety and vigilance. Designed to support strategic decision-making, this reference draws on industry expertise to uphold the highest standards of patient care. The book addresses essential regulatory requirements, reporting obligations, and ethical considerations, offering practical guidance for implementing effective pharmacovigilance systems. Covering the latest technological advancements, it ensures readers are equipped to meet the modern challenges faced by healthcare and pharmaceutical sectors in monitoring the safety and efficacy of medicines for diverse populations worldwide.Beyond the foundational concepts, the book presents detailed insights into signal detection, risk management plans, and the real-world application of pharmacovigilance through case studies from both high- and low-middle-income countries. It examines the pivotal role of pharmacists and the importance of tailored approaches for special populations, while emphasizing effective communication of medicines safety.

  • Clinician’s Guide to Headache

    Head, Neck, and Face Pain Syndromes
    • 1st Edition
    • Pravin Thomas
    • English
    Clinician’s Guide to Headache: Head, Neck, and Face Pain Syndromes is a clinically focused, case-based reference for neurologists, headache specialists, pain physicians, trainees, and allied clinicians caring for patients with head, neck, and facial pain. Rather than relying only on conventional disease-based descriptions, it reflects the realities of everyday practice: complex and overlapping syndromes, diagnostic uncertainty, secondary causes, comorbidities, and rapidly changing therapeutic options. Organized around real clinical scenarios, the book covers the full breadth of headache medicine, from classification, anatomy, history taking, examination, and pathophysiology to migraine, trigeminal autonomic cephalalgias, cranial neuralgias, CSF pressure disorders, neurovascular and inflammatory diseases, infections, metabolic causes, epilepsy-related headache, sleep-related disorders, ophthalmic presentations, pediatric headache, neck pain, and facial pain. Foundational sciences, such as anatomy, neuroradiology, pharmacology, and pathophysiology, are presented in a practical, case-oriented manner to support bedside decision-making. The text also addresses the important frontiers in modern headache care, biologics, percutaneous interventions, implantable and noninvasive neuromodulation, and integrative strategies, such as yoga, meditation, and nutrition.With contributions from an international faculty, this volume provides a pragmatic, modern, and multidisciplinary approach to one of the most challenging areas in clinical neuroscience

  • Advanced MR Techniques for Neurodegenerative Diseases

    • 1st Edition
    • Volume 14
    • Kannie Wy Chan + 3 more
    • English
    Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.

  • Analytics and Laboratory Testing Protocols for Halal Food and Non-Food Products

    • 1st Edition
    • Syed Ghulam Musharraf
    • English
    Analytics and Laboratory Testing Protocols for Halal Food and Non-Food Products is a comprehensive exploration of the diverse field of Halal research and laboratory testing that dives into the scientific advancements necessary for ensuring compliance with Halal standards. The book introduces readers to methodologies and technologies used in laboratory testing, equipping them with the knowledge needed to adopt best practices and ensure compliance with Halal standards. It offers guidance on quality assurance measures and testing protocols, enabling readers to uphold the highest standards of Halal authenticity and enhance consumer confidence and brand reputation.This is an essential resource for graduate students and researchers in food sciences, analytical chemistry, and pharmaceutical sciences who want to check non-Halal ingredients and stay up-to-date with the latest developments in Halal assurance and quality control.

  • Antimicrobial Resistance, Sepsis, and the Invisible Threats to Women’s Health

    • 1st Edition
    • Uzma Syed + 1 more
    • English
    Antimicrobial Resistance, Sepsis, and the Invisible Threats to Women’s Health focuses on the burden of antimicrobial resistance (AMR) and sepsis on women's health, providing the latest information to educate both global researchers and healthcare professionals. The book begins by introducing the fundamental concepts of antimicrobial resistance and sepsis, setting the stage for a deeper exploration of their impact on women's health. It examines the epidemiology of sepsis and antimicrobial resistance in women, highlighting key risk factors, research gaps, reproductive health, antimicrobial resistance, and sepsis in detail, and further emphasizing their disproportionate impact on women's health.Additional coverage includes strategies for recruiting women in clinical trials and research studies, exploring the One Health approach integrating women's health into the broader context of AMR and sepsis and the role of artificial intelligence and technology in combating AMR and sepsis. The book concludes with case studies of female patients and their families affected by AMR and sepsis.

  • Surgical and Non-Surgical Advances in Stroke Management and Therapeutics

    • 1st Edition
    • Creed M. Stary + 2 more
    • English
    Surgical and Non-Surgical Advances in Stroke Management and Therapeutics offers a comprehensive exploration of contemporary stroke care. This essential resource synthesizes the latest research and clinical innovations, providing in-depth insights into advanced surgical techniques, emerging therapies, and interdisciplinary approaches to stroke treatment. Readers will gain a thorough understanding of both acute and chronic stroke management, enriched by expert commentary from leading clinicians and researchers. Covering everything from pioneering non-invasive interventions to state-of-the-art surgical strategies, this book delivers a critical framework for healthcare professionals dedicated to optimizing patient outcomes and rehabilitation.

  • Beer and Brewing

    Current Advances and Future Outlook
    • 1st Edition
    • Charles W. Bamforth
    • English
    Beer and Brewing: Current Advances and Future Outlook addresses key changes and challenges facing breweries today, and with an eye to the future. The book offers the latest in scientific research and technology for novel methods and ingredients, such as genetically modified yeasts. In response to the climate crisis and consumer demand for sustainable products, information on brewing process changes for lower waste and reduced impact will also be covered. Due to shifting consumer preferences, new product types such as spiked cider, low-alcohol, and alcohol-free beers will be discussed in addition to traditional beer.Edited by a true pillar of the field, the book approaches brewing on the basis of driving forces that are impacting the industry now and into the future. Researchers interested in applied brewing science, skilled small-scale brewers and other industry stakeholders will gain invaluable insight from Dr. Bamforth's latest work.

  • Signaling Pathways in Breast Cancer

    Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance
    • 1st Edition
    • Sumel Ashique + 3 more
    • English
    Signaling Pathways in Breast Cancer: Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance provides an in-depth exploration of the complex molecular mechanisms that drive breast cancer progression. The book focuses on critical signaling pathways, including PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, Wnt/β-catenin, and Notch, elucidating their roles in tumor development, survival, and therapeutic resistance. The content offers a comprehensive overview of these pathways, detailing their dysregulation in breast cancer and implications for targeted therapeutic strategies. It discusses FDA-approved treatments, emerging therapies, and the mechanisms behind drug resistance, integrating recent research findings to highlight novel molecular targets and biomarker discovery. This book serves as a valuable resource for researchers, clinicians, and students, bridging the gap between basic molecular biology and clinical applications. By providing structured insights into complex signaling networks and therapeutic interventions, it equips readers with essential knowledge for developing innovative approaches to breast cancer management and improving patient outcomes.

  • Pediatric Pulmonology

    A Global Handbook for Clinical Care Providers
    • 1st Edition
    • Allen J. Dozor
    • English
    Pediatric Pulmonology: A Global Handbook for Clinical Care Providers provides an in-depth exploration of pediatric respiratory diseases, offering a detailed examination of various conditions, diagnostic techniques, and treatment protocols. The book covers a wide range of topics, from the assessment of children with respiratory diseases to specific conditions such as asthma, cystic fibrosis, and bronchopulmonary dysplasia. Each chapter is contributed to by leading experts in the field, ensuring that the content is both authoritative and up-to-date. These crucial, practical skills are essential when a pediatric patient's first point-of-care is not a respiratory specialist.This is especially true of medical treatment in resource-poor areas. The book includes "how to guides" on vital procedures such as spirometry, chest imaging, and the management of respiratory emergencies. It also addresses respiratory diseases in newborns, the impact of environmental factors on children's respiratory health, and the unique challenges faced by children with neurologic and neuromuscular diseases. This comprehensive approach ensures that non-specialists gain a holistic understanding of pediatric respiratory diseases and their management.

  • Cryo-EM Methods and Management

    • 1st Edition
    • Edward T. Eng + 2 more
    • English
    Cryo-EM Methods and Management provides a detailed introduction to the latest advances of cryo-EM, from technical innovations to the logistical challenges of maintaining a modern cryo-EM facility. The book consists of four parts, beginning with an overview of cryo-EM. It then moves on to discuss Cryo-EM workflows, with chapters focusing on sample handling and preparation, data collection and hardware, and data procession and visualization. The third part centers on aspects of cryo-EM infrastructure and community building, considering facility set-up and management, monitoring facility performance, instrumentation monitoring , data sharing and standards, and training and development standards. The book then closes with a section looking towards future prospects for cryo-EM. This is an ideal reference for cryo-EM facility and lab managers, providing guidance to the often-overlooked aspect of facility building and management. Additionally researchers working with cryo-EM across molecular biology, structural biology, cell biology and biochemistry will benefit from this book.

  • Digital Transformation in Healthcare

    Innovations in Hospital and Medical Services
    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    Digital Transformation in Healthcare: Innovations in Hospital and Medical Services explores the digital revolution in healthcare, addressing the challenges and opportunities faced by hospitals, medical faculties, and research institutions. The book highlights the role of advanced information technologies in providing innovative solutions for an ageing population's well-being. It covers critical areas such as hospital management, adapting medical education to digital advancements, and emerging IT tools in healthcare. The book features contributions from leading academics and practitioners worldwide, discussing topics like 5G, AI, big data, blockchain, and digital tools for citizen empowerment, supported by real-world case studies. This resource is invaluable for academics, offering new insights to shape innovative policies in healthcare, education, and information technologies. It fosters dialogue among managers, students, policymakers, and healthcare professionals, contributing to the global advancement of digital healthcare practices.

  • Neuroscience of Social Behavior

    Bridging the Mind and Society
    • 1st Edition
    • Mikhail Votinov
    • English
    Social behavior is fundamental to human experience, yet the neural mechanisms that govern how individuals perceive, interpret, and respond to one another are only beginning to be understood. Neuroscience of Social Behavior: Bridging the Mind and Society offers a rigorous and integrative examination of the biological foundations of social interaction, synthesizing current knowledge from neuroscience, psychology, sociology, and anthropology into a coherent framework.The book addresses the full scope of social neuroscience, from the evolutionary origins of the social brain to the challenges posed by digital communication and artificial intelligence. Core topics include social perception, language and communication, empathy, mentalizing, moral cognition, decision-making, and the neural basis of both prosocial and antisocial behavior. The text further explores how hormones and neurochemistry modulate social bonds, how social reward and pain systems shape motivation, and how clinical conditions disrupt social functioning. Computational and translational perspectives are integrated throughout, connecting laboratory findings to real-world implications.By bridging multiple levels of analysis, from neural circuits and neurochemistry to behavior and societal context, this volume equips readers with a comprehensive understanding of how the brain supports, and sometimes undermines, our capacity for social life.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 104
    • English
    Advances in Marine Biology, Volume 104, the latest release in this serial that highlights new advances in the field, includes comprehensive chapters written by an international board of authors. Chapters in this new release explore Integrative Fish Biomechanics and Advancing marine invertebrate biodiversity in South Africa: Addressing gaps in taxonomy and genetic knowledge.

  • Novel Approaches to Saturated Fat Replacement in Processed Foods

    • 1st Edition
    • Pintu Choudhary + 1 more
    • English
    Novel Approaches to Saturated Fat Replacement in Processed Foods covers strategies to reduce and replace saturated fat without altering the physicochemical, textural, and full-fat sensory attributes of a final product. Beginning by introducing novel replacement fats such as oleogles, designed lipids, and other plant-based fat mimics, the book demonstrate how these tailor-made oils and fats with improved physical and organoleptic properties can enhance the role of fats and oils in food and nutrition. The book highlights the value of healthier replacement fats in bakery, diary, meat, and frying applications while addressing the nutritional profile and health benefits. It concludes with safety aspects around the use of replacement fats, future trends and developments in the category, the impact ingredients high in saturated fats can have on the environment, and insights into the acceptance of plant-based fat alternatives.

  • Chromatin Signaling and Diseases

    • 2nd Edition
    • Olivier Binda + 2 more
    • English
    Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.

  • Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management

    • 1st Edition
    • Wael Mohamed
    • English
    Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management offers a comprehensive exploration of the latest innovations and multidisciplinary approaches in Parkinson’s Disease treatment. The volume is organized into sections covering genetic therapies, gut microbiota, artificial intelligence, virtual reality, neuroprotective strategies, polypharmacy, and combination therapies. It addresses the integration of personalized medicine, neuroprotective diets, natural products, cognitive enhancers, and ethical considerations. Additional chapters introduce traditional medicine, music therapy, and the synergy between pharmacotherapy and complementary modalities. The book equips readers with the knowledge to implement innovative therapies, navigate complex ethical landscapes, and integrate multidisciplinary and complementary approaches.This reference is essential for those seeking to advance clinical practice and research in Parkinson’s Disease through the adoption of cutting-edge strategies.

  • Clinical Genomics

    A Guide to Clinical Next Generation Sequencing
    • 2nd Edition
    • Shashikant Kulkarni + 1 more
    • English
    Clinical Genomics, Second Edition is a comprehensive, practical reference [AN1] designed specifically for laboratory directors, clinical medical directors, and genomic medicine professionals. Edited by renowned genomic pathology leaders Kulkarni and Roy, this updated edition offers clear guidance on the current technical, bioinformatic, clinical, regulatory, and reimbursement considerations involved in implementing next-generation sequencing technologies within clinical molecular diagnostic laboratories.Structu... for ease of reference, this book covers targeted gene sequencing methods, whole exome/genome approaches, emerging technologies such as long-read sequencing, and critical considerations for assay validation. Detailed sections address bioinformatics workflows, variant detection and interpretation methodologies, integration with clinical informatics systems, and essential IT infrastructure, including cloud-based solutions.This book also thoroughly addresses practical topics essential to laboratory management, such as regulatory compliance, ethical frameworks, billing strategies, and reimbursement paradigms, helping directors navigate the evolving landscape of genomic diagnostics.

  • Bioplastics for Food Packaging

    Materials, Procedures, and Applications
    • 1st Edition
    • Mehran Ghasemlou + 1 more
    • English
    Bioplastics for Food Packaging: Materials, Procedures, and Applications offers a comprehensive overview of the fundamentals and recent developments in the field of bioplastics tailored specifically for food packaging applications. Covering critical topics such as the environmental impact of plastic waste and the regulatory landscape driving the adoption of bioplastics in the food industry, this book discusses the unique benefits and drawbacks associated with different types of bioplastics. It explores practical applications of bioplastic flexible films, containers, coatings, and more, and showcases real-world success stories and industry insights.This is a valuable reference for those looking to understand the application of bioplastics in the food industry and stay updated on the latest trends and innovations in bioplastics for food packaging purposes.

  • Marine Mercury Bioaccumulation

    • 1st Edition
    • Luiz Drude de Lacerda
    • English
    Marine Mercury Bioaccumulation presents state-of-the-art research on mercury bioaccumulation in marine life. Written by leading experts in marine toxicology, this book delivers the latest information on monitoring and modeling mercury biomagnification in key marine taxa. Early chapters introduce the basic biology and ecology of how mercury travels through marine organisms and accumulates within marine food webs. Central chapters discuss the current status and exposure risks of key taxa, including marine vegetation, invertebrates, fishes, mammals, and birds. The book concludes with an assessment of human exposure to mercury through seafood products and novel modeling tools to assess environmental exposure risks and bioaccumulation.User... will find this to be a great resource for a global assessment of mercury contamination in the ocean, including biological resources, monitoring and modeling, current tools, existing research gaps, and suggestions on how to improve our monitoring and policy tools for improved safety of marine life and human consumption. This is an indispensable tool for researchers, resource managers, fisheries stakeholders, and students alike.

  • Body-on-a-Chip

    Essentials and Applications
    • 1st Edition
    • Anthony Atala + 1 more
    • English
    Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects. With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time.

  • Diagnostic Reasoning

    Laboratory-Based Case Studies in Clinical Chemistry
    • 1st Edition
    • Ibrahim A. Hashim
    • English
    Training in clinical chemistry is acquired via different avenues that include didactic lectures on pathophysiology of disease, methodologies and practical aspects of testing, and through attendance of operations meetings, sign-out sessions, seminars and tutorials. There is little instruction on how to apply the vast amount of knowledge gained in the process to practice. In other branches of medicine, cases are regularly presented with clinical information and therapeutic interventions which form the basis of training. Diagnostic Reasoning: Laboratory-Based Case Studies in Clinical Chemistry fills this gap for clinical chemistry. The concise and practical approach of the book, including real-life scenarios, is an excellent resource for pathology trainees, clinical laboratory science students, clinical chemistry fellows, clinical laboratory professionals, and clinicians. These cases help professionals remain competent in the field and be successful in their board exams. The cases are stated as they present, often with no or few clinical details accompanying the sample request with only barcoded samples arriving into the laboratory. In a busy laboratory, thousands of these cases are received daily and it is impossible to review the clinical information associated with the specimens.

  • Threats to Pollinator Abundance and Diversity

    • 1st Edition
    • Scott A. Elias
    • English
    Threats to Pollinator Abundance and Diversity, the first release in the Pollinators in Peril series, covers the latest research on insect pollinators, the threats to their survival, declining populations, and what conservation actions should be taken. The book demonstrates that most threats to pollinators are either directly or indirectly human-caused, such as chemicals, land alteration, and habitat loss due to agricultural practices, as well as climate change and its many ripple effects. Covering everything from honeybee pathogens to butterfly range changes, this book covers concepts that are both crucial for researchers in entomology, upper-level students, governmental and non-governmental organizations, and adjacent fields.Pollinating insects are among the most crucial species groups on earth. Without them, much of the earth’s vegetation would not survive and the elaborate ecosystems they sustain would collapse. Today, pollinator declines have reached critical levels in most regions of the world.

  • Pharmacological Approaches in Cancer Treatment

    A Comprehensive Guide
    • 1st Edition
    • Sadhna Aggarwal + 1 more
    • English
    Pharmacological Approaches in Cancer Treatment: A Comprehensive Guide presents an in-depth exploration of pharmacological approaches utilized in cancer treatment. The book's overarching theme revolves around understanding the intricate mechanisms and applications of various therapies, ranging from targeted treatments to immunotherapies. Through examination and analysis, the content sheds light on emerging trends and breakthroughs in the field, providing a comprehensive overview of cancer pharmacology. Sections target therapies, chemotherapy agents, immunotherapy, personalized medicine, combination therapies, drug resistance, novel drug delivery systems, palliative care in oncology, adverse effects of cancer pharmacotherapy, and preclinical studies.Each chapter provides the nuances of its respective subject matter, providing readers with a thorough understanding of the scientific underpinnings and practical applications of cancer pharmacology. Designed to cater to both oncology professionals and patients, this book serves as a valuable resource for enhancing understanding and informing treatment decisions.

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