Glycobiology of the Immune System and Disease
- 1st Edition - October 1, 2026
- Latest edition
- Author: Shyamasree Ghosh
- Language: English
Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans a… Read more
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Description
Description
Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, it is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.
Key features
Key features
- Provides the first book on the glycobiology of the immune system
- Gives insights on the glycobiology of the epidemic and pandemic causing virus H1N1/H5N1, Coronavirus and COVID-19
- Highlights the importance of glycobiology and its probable role in generating therapy for viral infections
- Provides up-to-date and accessible information for beginners in glycoimmunology and for readers with an interest in infectious diseases and host response
Readership
Readership
Table of contents
Table of contents
1.1 Immune system
1.2 Glycans
1.3 Glycosylation
1.4 Glycan-binding proteins (GBPs) or lectins
2. C-type lectin in host-pathogen interactions
2.1 Structure
2.2 C-type lectin receptors and infection biology
3. Galectins
3.1 Introduction
3.2 Role in infection
4. Siglecs and the immune system
4.1 Sialic acid recognition by siglecs and cis interactions with endogenous glycans
4.2 Sialoadhesin and cellular interactions in the immune system
5. CD22 and B cell signalling
6. New CD33-related Siglecs in the innate immune system
7. Modulation of immune tolerance by Siglec-sialic acid interaction
8. Siglecs and immune regulation
8.1 Pathogen internalization by innate immune cells: phagocytosis and endocytosis by Siglec
9. Siglecs and the attenuation of inflammatory responses
9.1 Immune evasion by pathogens via Siglec ligation
9.2 Attenuation of DAMP-mediated inflammation by Siglecs
10. The regulation of the life span of myeloid cells in the context of inflammation by Siglec-8, Siglec-9, and Siglec-F
10.1 Regulation of natural killer cell function by Siglec-7
11. Siglecs, dendritic cells, and T cell activation
11.1 Siglecs and the regulation of plasmacytoid dendritic cell function
11.2 Siglecs in conventional dendritic cells and the regulation of T cell activation and polarization
11.3 A direct role for Siglecs in T cells
11.4 Siglecs in B cell biology and the maintenance of immunological tolerance
12. Glycobiology of autoimmunity and chronic inflammation
13. Immune response and glycobiology
13.1 Glycobiology of pathogens
13.2 Role of glycan-binding proteins
14. Glycobiology of fungus and infection
14.1 Pathogenic fungi
14.2 Candida albicans: glycans are central in host interactions
14.3 Aspergillus fumigatus
14.4 Cryptococcus neoformans and its capsule
14.5 Fungal glycans and drug targets
15. Glycobiology of virus and infection
15.1 Zika virus
15.2 Coronavirus and COVID-19
15.3 Lassa
15.4 Mumps
15.5 Chlorella
15.6 Varicella zoster
15.7 Avian coronavirus
15.8 Influenza A virus
15.9 Chikungunya virus
15.10 Semliki Forest virus
15.11 Herpes simplex virus (HSV)
15.12 Rabies virus
15.13 Rotavirus
15.14 Ross river virus
15.15 H1N1/H5N1 virus
15.16 New Castle disease virus
16. Glycans as antibody epitopes
17. Glycobiology of bacteria and infection
17.1 Bacterial surface glycans as virulence factors
17.1.1 Polysaccharide capsules
17.1.2 Lipopolysaccharide (LPS)
17.2 Mechanisms of colonization and invasion
17.2.1 Adhesins and receptors
17.2.2 Invasion factors
17.3 Bacterial toxins as glycosyltransferases
17.4 Glycan-based interaction of host and gut microflora: commensals and pathogens
18. Glycobiology of tumour and immunity
18.1 Glycosylation in cancer
18.1.1 Altered branching and fucosylation of N-glycans
18.1.2 Increased mucins and truncated O-glycans
18.1.3 Increased and aberrant sialic acid expression
18.1.4 Increased selectin ligand expression
18.2 Altered expression of blood groups
18.3 Altered expression of glycosphingolipids
18.4 Loss of GPI-anchor expression
18.5 Altered hyaluronan
18.6 Alterations in sulfated glycosaminoglycans
18.7 Altered cytoplasmic and nuclear O-GlcNAc
18.8 Mechanisms of altered glycan expression
18.9 Glycan changes in cancer stem cells and during EMT
18.10 Clinical significance
19. Therapeutic strategies based on microorganism and virus protein-glycan interactions
19.1 Structure–function considerations of glycans
19.2 Pharmacological driving force: protein–GAG interactions and the glycan-protein network (GPN)
19.3 Identification of protein-specific GAG sequences
19.4 Therapeutic approaches
Product details
Product details
- Edition: 1
- Latest edition
- Published: October 1, 2026
- Language: English
About the author
About the author
SG