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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • NGF and Related Molecules in Health and Disease

    • 1st Edition
    • Volume 146
    • L. Aloe + 1 more
    • English
    The book highlights different aspects of current understanding of neurotrophin-recepto... signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-asso... activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.

  • Non-Neuronal Cells of the Nervous System: Function and Dysfunction

    Part I: Structure, Organization, Development and Regeneration: Part II: Biochemistry, Physiology and Pharmacology: Part III: Pathological Conditions
    • 1st Edition
    • Volume 31
    • L. Hertz
    • English
    The brain, and the rest of the nervous system, consists of nerve cells (neurons) and non-neuronal cells (glial cells), which by far outnumber the neurons, but in the past have received much less attention. This began to change about 30 years ago with the realization that glial cells carry out very important functions, generally in collaboration with the nerve cells. Evidence is now starting to accumulate that glial cells, especially astrocytes and microglia, may be major (in some cases the main) players in a multitude of neurological and mental diseases, and that different types of glial cells interact not only with nerve cells but also with each other and with cells lining brain tissue and controlling exchange of nutrients and other compounds between the brain and the rest of the body. Understanding of these interactions during normal function and in disease states is hampered by the fact that general knowledge of cellular interactions during brain function is limited. These books present an attempt to remedy this situation. In the first two volumes, basic information about cell types and biochemical and physiological interactions between these cells is provided by leading experts in the field, and in the last part emerging evidence of the importance of such cellular interactions in several of the most important neurological and mental diseases is presented by leading researchers working actively in the field in question.

  • Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear

    • 1st Edition
    • Volume 57
    • Raymond Romand + 1 more
    • English
    Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike.

  • Blood-Spinal Cord and Brain Barriers in Health and Disease

    • 1st Edition
    • Hari Shanker Sharma
    • Hari Shanker Sharma
    • English
    Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma.

  • Advances in Insect Physiology

    • 1st Edition
    • Volume 31
    • English
    Advances in Insect Physiology publishes eclectic volumes containing important, comprehensive and in-depth reviews on all aspects of insect physiology. It is an essential reference source for invertebrate physiologists and neurobiologists, entomologists, zoologists and insect biochemists. First published in 1963, the serial is now edited by Steve Simpson (Oxford University, UK). In 2002, the Institute for Scientific Information released figures showing that Advances in Insect Physiology has an Impact Factor of 3, placing it 2nd in the highly competitive category of Entomology. Volume 31 contains four timely reviews, including an important contribution on insect neurobiology.

  • From Molecules to Networks

    An Introduction to Cellular and Molecular Neuroscience
    • 1st Edition
    • John H. Byrne + 3 more
    • English
    An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.

  • Brain Maps

    Structure of the Rat Brain
    • 3rd Edition
    • Larry Swanson
    • English
    For neuroscientists, particularly those studying neuroanatomy, neurophysiology, and molecular biology, a detailed atlas of the rat brain is essential for any laboratory. This updated edition of Brain Maps: Structure of the Rat Brain provides atlas maps aligned in 3-dimensional space and created using color photomicrographs of histological sections based on a single rat brain. Where other atlases use multiple brains as models, the use of a single brain allows for true 3-D reconstruction. The atlas employs color coding of the major parts of the brain and extends this coding system to the atlas levels, flatmaps, and nomenclature tables for easier reference. With systematic nomenclature tables, references to the primary research literature for all of the structures, and coverage of the neuroanatomical methods and mapping, this is a reference every laboratory should have on-hand.

  • The Roots of Visual Awareness

    • 1st Edition
    • Volume 144
    • C.A. Heywood + 2 more
    • English
    The present volume was assembled in honor of Professor Alan Cowey FRS, and attempts to embrace his wide range of research interests in visual neuroscience. It is divided into four sections. The first contains a group of papers dealing with different fundamental aspects of the visual system, including the control and monitoring of eye movements. The second is concerned with the functional organization of cortical visual areas and their role in visual perception and visually guided action. The third addresses issues concerning color and motion perception, along with broader questions of visual attention; and the effects of selective brain damage on these different aspects of visual experience. The fourth and final section of the volume deals explicitly with questions relating to visual awareness, with particular emphasis on 'blindsight', a topic on which Alan Cowey has worked extensively in recent years, both in humans and in monkeys.

  • Acetylcholine in the Cerebral Cortex

    • 1st Edition
    • Volume 145
    • L. Descarries + 2 more
    • English
    Comprehensive exposé, by leading neuroscientists, of current knowledge on the neurotransmitter acetylcholine in the cerebral cortex. All aspects of the subject are covered, from its most elementary, at the molecular and cellular levels, to its systemic and holistic implications, including its role in cognition and involvement in human diseases and therapeutics. The twenty-two chapters are grouped under four main headings : I. Functional Morphology of the Acetylcholine Innervation in Cerebral Cortex (Including Hippocampus); II. Modes of Action of Acetylcholine in the Cerebral Cortex; III. Cortical Properties and Functions Modulated by Acetylcholine, and IV. Clinical, Pathological and Therapeutic Implications. This broad perspective updates the reader on recent advances and future trends in the study of a major neuromodulatory system in brain.

  • Brain Mechanisms for the Integration of Posture and Movement

    • 1st Edition
    • Volume 143
    • English

  • Mechanisms of Memory

    • 1st Edition
    • J. David Sweatt
    • J. David Sweatt
    • English
    This book stands as the first unified overview of the cellular and molecular mechanisms underlying higher-order learning and memory. It integrates modern discoveries concerning learning and memory disorders such as mental retardation syndromes and Alzheimer's Disease, while also emphasizing the results gained from the cutting-edge research methodologies of genetic engineering, complex behavioral characterization, proteomics, and molecular biology. This book provides a foundation of experimental design that will be useful to all students pursuing an interest in laboratory research. This book is an enlightening and invaluable resource for anyone concerned with memory mechanisms.

  • Visions: Artists Living with Epilepsy

    • 1st Edition
    • Steven C. Schachter
    • English
    Visions: Artists Living with Epilepsy is the art of epilepsy, captured in a book. You will discover beautiful, insightful, haunting images that reveal the souls of artists touched by epilepsy.

  • Concepts and Challenges in Retinal Biology

    • 1st Edition
    • Volume 131
    • H. Kolb + 2 more
    • English
    In August 2000 a Festschrift was held at the Marine Biological Laboratory, Woods Hole, Massachusetts to celebrate the career of Professor John E. Dowling on the occasion of his 65th birthday. Containing contributions from more than 50 of John's colleagues, representing a Who's Who of the vision research community, this work not only provides a memento of the occasion, but will hopefully serve as a basic reference for future researchers in retinal biology.The volume is divided somewhat arbitrarily into seven areas of retinal research containing chapters that present in some cases a broad overview of a particular topic, and in others an account of current research and studies in progress. These chapters exemplify the richness, diversity, and excitement of contemporary retinal research. They also remind us of how much more needs to be done before we understand fully the interrelationship between retinal neurons, the complex interactions between neurons and glial cells, and the mechanisms that govern retinal development.A final chapter contributed by John Dowling provides an overview of past accomplishments, and offers some future perspectives on retinal research in the 21st century.

  • Viral Vectors for Treating Diseases of the Nervous System

    • 1st Edition
    • Volume 55
    • David S. Latchman
    • English
    Gene therapy offers considerable potential for the treatment of various incurable diseases of the nervous system. Viral Vectors for Treating Disease of the Nervous System describes a number of different viral vectors developed for achieving high efficiency gene delivery to the brain. Vectors described include those based on adenovirus, adeno-associated virus, Herpes Simplex Virus, lentivirus, and other retroviruses. It also discusses the potential application of such viruses in treating brain tumors, Parkinson's disease, and other diseases of the nervous system.

  • The Immune-Neuroendocrine Circuitry

    History and Progress
    • 1st Edition
    • Volume 3
    • I. Berczi + 1 more
    • English
    The book summarises the current understanding of the Nervous -, Endocrine and Immune systems with emphasis on shared mediators and receptors and functional interaction. In addition to the fundamental physiological and pathophysiological mechanisms, which are presented in detail, some clinically relevant subjects are also presented, such as inflammation, asthma and allergy, autoimmune disease, immunodeficiency and the acute phase response. • A comprehensive presentation of neuroimmune biology• Introduces the subject matter to the uninformed reader• Contains basic information, theoretical considerations and up-to-date clinical chapters• The clinical chapters will be helpful to practising physicians

  • The Science of Color

    • 2nd Edition
    • Steven K. Shevell
    • English
    The Science of Color focuses on the principles and observations that are foundations of modern color science. Written for a general scientific audience, the book broadly covers essential topics in the interdisciplinary field of color, drawing from physics, physiology and psychology. This book comprises eight chapters and begins by tracing scientific thinking about color since the seventeenth century. This historical perspective provides an introduction to the fundamental questions in color science, by following advances as well as misconceptions over more than 300 years. The next chapters then discuss the relationship between light, the retinal image, and photoreceptors, followed by a focus on concepts such as color matching and color discrimination; color appearance and color difference specification; the physiology of color vision; the 15 mechanisms of the physics and chemistry of color; and digital color reproduction. Each chapter begins with a short outline that summarizes the organization and breadth of its material. The outlines are valuable guides to chapter structure, and worth scanning even by readers who may not care to go through a chapter from start to finish. This book will be of interest to scientists, artists, manufacturers, and students.

  • Neurons: Methods and Applications for the Cell Biologist

    • 1st Edition
    • Volume 71
    • English
    Neurons: Methods and Applications for the Cell Biologist lays out numerous simple techniques for growing and carrying out experiments with many varieties of neurons. Subjects include peripheral and central neurons from vertebrate and invertebrate sources, as well as neuron-like cell lines. It also explains recent advances in our ability to introduce exogenous proteins and genes to neurons in culture. Procedures for successful protein infiltration, biolistic transfection, electroporation, and viral transgenic methods in neurons are also presented.

  • Psychology of Learning and Motivation

    • 1st Edition
    • Volume 43
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work.

  • Cognitive Vision

    Psychology of Learning and Motivation
    • 1st Edition
    • Volume 42
    • English
    Use of visual information is used to augment our knowledge, decide on our actions, and keep track of our environment. Even with eyes closed, people can remember visual and spatial representations, manipulate them, and make decisions about them. The chapters in Volume 42 of Psychology of Learning and Motivation discuss the ways cognition interacts with visual processes and visual representations, with coverage of figure-ground assignment, spatial and visual working memory, object identification and visual search, spatial navigation, and visual attention.

  • Encyclopedia of the Neurological Sciences

    • 1st Edition
    • Robert B. Daroff + 3 more
    • English
    The Encyclopedia of the Neurological Sciences explores all areas of the discipline in its 1000+ focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The concise entries are all written at a level of comprehension not previously seen in existing literature by contributing authors representing an eclectic and diverse view of all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. The easy-to-use "encyclopedic-dictio... format features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes for compelling reading by everyone from the academic researcher to students, to the curious lay person. An online version of the Encyclopedia of the Neurological Sciences will be available on ScienceDirect in 2004. Visit http://info.scienced... for contact and subscription information. Access options are available even if you're not an existing ScienceDirect customer!

  • International Review of Neurobiology

    • 1st Edition
    • Volume 54
    • Ronald J. Bradley + 2 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of chapters covering recent advances in the field of neurobiology. Chapters address anesthetic binding sites on the nicotinic acetylcholine receptors, NMDA receptor signal regulation, alcohol self-administration in rodents, and dopamine receptor mutations in mice.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 32
    • Peter J.B. Slater + 3 more
    • English
    The aim of Advances in the Study of Behavior remains as it has been since the series began: to serve the increasing number of scientists who are engaged in the study of animal behavior by presenting their theoretical ideas and research to their colleagues and to those in neighboring fields. We hope that the series will continue its "contribution to the development of the field", as its intended role was phrased in the Preface to the first volume in 1965. Since that time, traditional areas of animal behavior have achieved new vigor by the links they have formed with related fields and by the closer relationship that now exists between those studying animal and human subjects.

  • Neurological Disorders

    Course and Treatment
    • 2nd Edition
    • Thomas Brandt + 4 more
    • English
    This single-volume reference covers the natural course, treatment, and management of all neurological diseases affecting the brain, spinal cord nerves and muscles. This comprehensive text reference seeks to assist physicians with treatment by providing an easy-to-use compendium covering the treatment and management of all neurological diseases along with details on the natural course of these diseases. Organized for ease of use and quick reference, each chapter presents a neurological disorder or key symptoms and systematically discusses the clinical syndrome and differential diagnosis, natural course, principles of therapy, and practical management of each.

  • Mitochondrial Function and Dysfunction

    • 1st Edition
    • Volume 53
    • Anthony Schapira
    • English
    Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease.

  • Peptide Receptors, Part II

    • 1st Edition
    • Volume 20
    • A. Bjorklund + 2 more
    • English
    Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complementwith chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry.... derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-recepto... complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.

  • Neurobiology of the Immune System

    • 1st Edition
    • Volume 52
    • Angela Clow + 1 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Gonadotropin-Releasing Hormone: Molecules and Receptors

    • 1st Edition
    • Volume 141
    • I.S. Parhar
    • English
    This volume summarizes the evolution and physiology of GnRH molecules and receptors, and provides insight as to how social behavior influences cellular and molecular events in the brain from a comparative perspective.The chapters in this volume are divided into three major sections: Development and Cell Migration, GnRH Receptors, Physiology and Regulation. The review papers arose primarily from presentations made at the Second International Symposium on the Comparative Biology of GnRH, held in Penang, Malaysia, June 2-4, 2001; a satellite symposium in conjunction with the XIV International Congress of Comparative Endocrinology, Sorrento, Italy. In addition, leading neuroscientists doing cutting-edge research in the field of GnRH were invited as authors to make this volume a valuable reference.

  • The Brain's Eye

    Neurobiological and Clinical Aspects of Oculomotor Research
    • 1st Edition
    • Volume 140
    • J. Hyönä + 3 more
    • English
    The book comprises selected papers presented at the 11th European Conference on Eye Movements (Turku, Finland, 2001). The conference series brings together researchers from various disciplines with an interest to study behavioral, neurobiological and clinical aspects of eye movements. This volume consists of five sections: I. Saccadic eye movements. II. Change blindness and transsaccadic integration. III. Smooth pursuit eye movements. IV. Eye-hand coordination. V. Clinical aspects of eye movement research. Each section ends with a commentary chapter written by a distinguished scholar. These commentaries discuss and integrate the contributions in the section and provide an expert view on the most significant present and future developments in the respective areas. The book is a reference volume including a large body of new empirical work but also principal theoretical viewpoints of leading research groups in the field. Among the topics discussed in this book are the role of cortical and subcortical brain areas in the control of saccadic eye movements, attentional mechanisms in guiding smooth pursuit eye movements, neural mechanisms related to eye-hand coordination, oculomotor deficits in psychiatric disorders, Parkinson's disease, head injury, and cannabis abusers, integration of visual information across saccadic movements, and blindness to abrupt changes in the visual environment. The book addresses a wide audience including readers with an interest in neurophysiology and neuropsychology of vision, clinical research, attention and performance, and visual cognition.

  • Fundamental Neuroscience

    • 2nd Edition
    • Larry Squire + 9 more
    • English
    With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates.The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities.

  • Spinal Cord Trauma

    Regeneration, Neural Repair and Functional Recovery
    • 1st Edition
    • Volume 137
    • L. McKerracher + 2 more
    • English
    This book covers, in a broad perspective, research on spinal cord injury, beginning with human spinal cord injury to experimental studies in animals, to molecular mechanisms of injury and regeneration.Every year 12,000 will suffer spinal cord injury leading to permanent disability. In the last five years enormous progress has been made in the understanding of spinal cord injury, and in ways to elicit repair in animal models of spinal cord injury. The scope includes animal models of spinal cord injury, strategies for neuroprotection and regeneration, and possible roles of axon guidance molecules in injury and regeneration. Topical reviews are presented as well as new data on timely issues in spinal cord injury research.

  • Sensory Systems

    Anatomy, Physiology and Pathophysiology
    • 1st Edition
    • Aage R. Moller
    • English
    Sensory Systems: Anatomy, Physiology and Pathophysiology provides a comprehensive description of how human sensory systems function, with comparisons of the five senses and detailed descriptions of the functions of each of them. In addition to describing anatomy and function, the book also provides insight as to how sensory information is processed in the brain to provide the basis for communication and for our perception of our surroundings. The information is presented in a way that is suitable for individuals from diverse disciplines and educational backgrounds. It gives the clinician an understanding of the function of normal and diseased sensory systems and provides a convenient, up-to-date source of information relevant to individuals in the fields of communication and communication disorders. This book is ideal for scientists, clinical researchers, and students in neurology and neuroscience.

  • Vasopressin and Oxytocin: From Genes to Clinical Applications

    • 1st Edition
    • Volume 139
    • D. Poulain + 2 more
    • English
    The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohyp... system. Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.

  • Plasticity in the Adult Brain: From Genes to Neurotherapy

    • 1st Edition
    • Volume 138
    • M.A. Hofman + 5 more
    • English
    In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience.

  • Glucose Metabolism in the Brain

    • 1st Edition
    • Volume 51
    • English
    Regulation of glucose at the biochemical level affects every area of the brain, and has impact from cellular to behavioral brain function. It plays an important role in diseases such as diabetes, stroke, schizophrenia and drug abuse as well as in normal and dysfunctional memory and cognition. This volume represents a thorough examination of all the major issues that are relevant to glucose metabolism by brain cells in relation to disease, combining basic research and clinical findings in a single, indispensable reference.

  • Genetics of Movement Disorders

    • 1st Edition
    • Stefan M. Pulst
    • English
    Hereditary or genetic diseases featuring involuntary movements constitute a major aspect of the practice of neurology, functional neurosurgery, genetics, and many areas of basic and applied neuroscience research. Describing the current knowledge on these disorders, Genetics of Movement Disorders brings together information essential for clinicians, geneticists, and neuroscientists in one source. Utilizing a convenient and accessible format, the book is designed to allow easy identification of relevant information, with the overall organization of topics following established phenotypic classifications of movement disorders such as Parkinsonian syndromes, chorea, ataxia, and major categories of diseases grouped by gene locus. This book broadly appeals to neurologists, neuroscientists, geneticists, as well as cell and molecular biologists and hematologists.

  • The Cognitive Electrophysiology of Mind and Brain

    • 1st Edition
    • Alberto Zani + 1 more
    • English
    Cognitive electrophysiology is a very well established field utilizing new technologies such as bioelectric events-related potentials (ERP) and magnetic (ERF) recordings to pursue the investigation of mind and brain. Current research focuses on reviewing ERP/ERF findings in the areas of attention, language, memory, visual and auditory perceptual processing, emotions, development, and neuropsychological clinical damages. The goal of such research is basically to provide correlations between the structures of the brain and their complex cognitive functions.This book reviews the latest findings in the areas of attention, language, memory, visual and auditory perception, and brain damage research based primarily on research conducted using ERP recordings. Beyond just compiling the knowledge gained from ongoing research, the authors also identify outstanding problems in the field and predict future developments.

  • Brain Mapping: The Methods

    • 2nd Edition
    • Arthur W. Toga + 1 more
    • English
    Investigation of the functional architecture of the human brain using modern noninvasive imaging techniques is a rapidly expanding area of research. A proper knowledge of methodology is needed to appreciate the burgeoning literature in the field. This timely publication provides an excellent catalogue of the main techniques. The authors offer an invaluable analysis of mapping strategies and techniques, providing everything from the foundations to the major pitfalls and practical applications of the modern techniques used in neuroimaging. Contains over 1000 full color pages with more than 200 color figures.

  • Milestones in Neurotoxicity and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu

    • 1st Edition
    • M. Naoi + 4 more
    • English
    This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences.The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.

  • Neurophysiology in Neurosurgery

    A Modern Intraoperative Approach
    • 1st Edition
    • Vedran Deletis + 1 more
    • Vedran Deletis
    • English
    Through real-time assessments of how the patient's nervous system is functioning throughout a surgical procedure, Neurophysiology in Neurosurgery presents vital techniques to guide surgeons in their efforts to minimize the risks of unintentional damage to healthy nervous tissue. This book provides a comprehensive overview of the most up-to-date intraoperative neurophysiological techniques and guidelines for the managment of neuroanesthesia during MEP monitoring. Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example.

  • Neurobiology of Diabetic Neuropathy

    • 1st Edition
    • Volume 50
    • English
    This volume of International Review of Neurobiology defines primary biochemical causation of diabetic complications, identifies cellular glucose transducers, balancing roles of protein kinase C and MAP kinases, and sets in context the role of apoptosis and the interactive roles of neurons and Schwann cells. It also defines the cell biology of autonomic neuropathy, considers the balanced needs of science, clinical practice, and economics in clinical trial design, provides the definitive evaluation of aldose reductase inhibitors, and explains the failure of nerve growth factor.

  • In Situ Hybridization Protocols for the Brain

    • 2nd Edition
    • Volume 47
    • English
    This volume of the International Review of Neurobiology was written to assist researchers without any previous experience with in situ hybridization, allowing them to follow the protocols and expect good results. It contains all the information required for newcomers to achieve successful in situ hybridization results, and methods for improving the technique of those already utilizing it. Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

    • 1st Edition
    • Volume 19
    • L. Kaczmarek + 1 more
    • English
    That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration.Th... single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning. This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

  • Encyclopedia of the Human Brain

    • 1st Edition
    • Vilayanur S. Ramachandran
    • English
    In the past decade, enormous strides have been made in understanding the human brain. The advent of sophisticated new imaging techniques (e.g. PET, MRI, MEG, etc.) and new behavioral testing procedures have revolutionized our understanding of the brain, and we now know more about the anatomy, functions, and development of this organ than ever before. However, much of this knowledge is scattered across scientific journals and books in a diverse group of specialties: psychology, neuroscience, medicine, etc. The Encyclopedia of the Human Brain places all information in a single source and contains clearly written summaries on what is known of the human brain. Covering anatomy, physiology, neuropsychology, clinical neurology, neuropharmacology, evolutionary biology, genetics, and behavioral science, this four-volume encyclopedia contains over 200 peer reviewed signed articles from experts around the world. The Encyclopedia articles range in size from 5-30 printed pages each, and contain a definition paragraph, glossary, outline, and suggested readings, in addition to the body of the article. Lavishly illustrated, the Encyclopedia includes over 1000 figures, many in full color. Managing both breadth and depth, the Encyclopedia is a must-have reference work for life science libraries and researchers investigating the human brain.

  • Hormones, Brain and Behavior

    • 1st Edition
    • Donald W. Pfaff
    • English
    Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 41
    • Brian H. Ross
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 41 includes in its coverage chapters on multimedia learning, brain imaging, and memory, among others.

  • Epilepsy, Infantile Spasms, and Developmental Encephalopathy

    • 1st Edition
    • Volume 49
    • English
    Epilepsy, Infantile Spasms, and Developmental Encephalopathy explores the nature and bases of infantile spasms - a major representative of the catastrophic developmental seizure disorders seen in early childhood. Although this topic has received considerable attention as a clinical disorder, the underlying pathogenesis of infantile spasms remains poorly understood. The aim is not simply to describe and label the clinical phenomenology associated with infantile spasms, but rather to work toward an understanding of the underlying mechanisms and of effective treatment strategies. The result is a volume with a high density of exciting ideas that can be taken to the bedside or to the laboratory for further study.Approaching the subject from an interdisciplinary perspective, this book integrates clinical and basic science in its discussion of infantile spasms as representative of a common developmental brain disorder. It also provides experimentally testable hypotheses to direct further research, and presents reviews of the literature associated with suggested underlying mechanisms.

  • Do Seizures Damage The Brain

    • 1st Edition
    • Volume 135
    • T. Sutula + 1 more
    • English
    What are the consequences, if any, of repeated brief seizures that are the defining feature of epilepsy? A firm answer to this question has been surprisingly elusive for a variety of reasons. Clearly there is a subset of patients who appear to tolerate seizures with relatively limited long-term consequences, and not all patients are destined to progress to intractability with frequent seizures and disability. This variability and individual susceptibility has made it difficult to make statements that fairly apply to the full range of people with epileptic disorders, whose disorders span a broad spectrum from mild with excellent control and few limitations, to severe with multiple daily seizures and pronounced disability that affects employment, educational performance, an personal life.This volume seeks to explore the spectrum of severe to more subtle damage that may be a consequence of seizures. The contributing authors have addressed these questions and related issues using a variety of methods in experimental models and in patients with epilepsy.

  • Changing Views of Cajal's Neuron

    • 1st Edition
    • Volume 136
    • E.C. Azmitia + 4 more
    • English
    Cajal is the Father of Neuroscience and his personal view of the Neuron has dominated the field for over 100 years. No single person has been able to challenge his global perspective of the neuron gained by Cajal's work in neuroanatomy, development, physiology, evolution and medicine. However, over 30 neuroscientists from around the world have accepted the challenge of writing a review article on "Changing Views of Cajal's Neuron". Many of these experts admitted they could only add to Cajal's theory and they carefully provided their new findings based on modern methods of microscopy, molecular biology or neurobiology. Other experts recognized specific areas where Cajal's ideas of neurons needed to be altered and refined. Key knowledge necessary to understand plasticity or development is now available and permits a changed view. A few of the authors directly challenged some of the most widely accepted and cherished theories of Cajal: the neuron as an isolated unit, function of dendrites, the direction of electrical conductivity and the importance of plasticity in the adult brain. In total, the collection of articles provides a fascinating perspective to the enormous force of Cajal's genius in the 21st Century view of the neuron.

  • Universes in Delicate Balance: Chemokines and the Nervous System

    • 1st Edition
    • R.M. Ransohoff + 4 more
    • English
    It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development.Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue.This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts.The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis.Underst... human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.

  • Growth and Lactogenic Hormones

    • 1st Edition
    • Volume 2
    • L. Matera + 1 more
    • English
    For more than seventy years evidence has accumulated documenting the existence of a bi-directional communication network between growth hormone and the immune system. In the past twenty years there has been a tremendous proliferation of information detailing the workings of the growth hormone and insulin-like growth factor axis. A multitude of growth factors and binding proteins have been identified. More and more evidence supporting the important role of the growth hormone IGF network in the well functioning of the normal immune system has been documented. Clearly the challenge today is not to prove, but to understand, the neuroimmune regulatory role of GLH in its entire complexity.The ultimate goal of this volume and of all the other volumes of this series is to promote the understanding of the science and to ease human suffering.

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