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Elsevier

Books in Life sciences

  • Animal Cognition in Nature

    The Convergence of Psychology and Biology in Laboratory and Field
    • 1st Edition
    • Russell P. Balda + 2 more
    • English
    In this book, the editors bring together results from studies on all kinds of animals to show how thinking on many behaviors as truly cognitive processes can help us to understand the biology involved. Taking ideas and observations from the while range of research into animal behavior leads to unexpected and stimulating ideas. A space is created where the work of field ecologists, evolutionary ecologists and experimental psychologists can interact and contribute to a greater understanding of complex animal behavior, and to the development of a new and coherent field of study.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 61
    • English

  • Laboratory Methods in Food Microbiology

    • 3rd Edition
    • Wilkie F. Harrigan
    • English
    Laboratory Methods in Food Microbiology describes a wide range of methods for use in the microbiological analysis of foods, including approaches to counting and detection procedures for microorganisms, identification of bacteria, yeasts and fungi, microbiological analysis for the main food commodity groups, and safety in the food microbiology laboratory. The book also discusses specific food poisoning outbreaks in the United States.

  • Advances in Immunology

    • 1st Edition
    • Volume 70
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • International Review of Cytology

    A Survey of Cell Biology
    • 1st Edition
    • Volume 185
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 34
    • English
    This volume of Advances in Marine Biology contains four eclectic reviews on topics ranging from marine mollusc mucus to deep-sea hydrothermal vent fauna.Advances in Marine Biology contains up-to-date reviews of all areas of marine science, including fisheries science and macro/micro fauna. Each volume contains peer-reviewed papers detailing the ecology of marine regions.

  • Energetics of Biological Macromolecules, Part B

    • 1st Edition
    • Volume 295
    • John N. Abelson + 1 more
    • English
    General Description of the Volume:The very existence of biological structures and their functional interactions are dictated by energetic relationships. Thus the central theme of this volume is that thermodynamic methods, i.e. techniques that probe the energetics of biological macromolecules, now comprise a powerful and practical family of tools for research in modern biology. The application of thermodynamics and statistical thermodynamics to biochemical and biophysical systems is presented. This volume supplements Methods in Enzymology, Volume 259.General Description of the Series:The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Breast Cancer

    • 1st Edition
    • Volume 2
    • W.P. Peters + 1 more
    • English
    Breast cancer research has never been in such an exciting and hopeful phase as today. From a clinical perspective, the discovery of genetic markers of risk in a proportion of familial breast cancer cases has opened up new vistas for understanding and ultimately preventing this disease. On the other hand, aggressive - even daring - therapies are being proven to be effective against advanced breast cancer. For the breast cancer experimentalist, this is also a time of great advance. Although animal and cell culture breast cancer models have proven to be of great use, there are now increasing opportunities to test the concepts developed in these models in actual clinical samples and cases. It is gratifying to see how well these concepts "translate" into the clinical setting. A very active area of research that is linking the laboratory to the clinic is the dissection of the biology and elucidation of the significance of proliferate breast disease and the identification of true, "high risk" or "preneoplastic" legions within the previously ill-defined spectrum of fibrocystic or benign breast disease. One anticipates that discoveries made here will also lead to earlier detection, intervention and prevention of life-threatening cancer.Even, however, as we look with optimism to the eventual eradication of breast cancer, we are once again forced to face the reality that we have not yet achieved our goal. Thus, we are saddened by the much too premature death of Dr. Helene Smith from breast cancer. Helena's work was at the forefront of efforts to understand the biology of human breast cancer at the molecular level. Her insight, open-mindedness, and refusal to sacrifice relevance for convenience will continue to set the standard for all breast cancer researchers. This volume is dedicated to her memory.

  • Cell Polarity

    • 1st Edition
    • Volume 26
    • J.R. Bartles
    • English
    Few cells conform to the stereotype of the spherical blob hastily scribbled on chalkboards and, regrettably, sometimes even displayed prominently in textbooks. Instead, real cells display a remarkable degree of structural and functional asymmetry. In modern cell biological parlance, this asymmetry has come to be lumped under the general heading of "cell polarity". Cell polarity is by no means restricted to the cells of tissues and organs, but can also be displayed by cells that lead a more solitary existence. The amazing extent to which cell morphology is correlated with function has long been a source of inspiration for biologists. Today the fascination continues unabated in the field of cell polarity, where it is fueled by an ever-deepening appreciation for the ways that fundamental cellular processes, such as membrane trafficking and cytoskeleton assembly, contribute to the establishment and maintenance of cell polarity. In the ensuing chapters, a collection of experts will summarize and interpret the findings obtained from basic research on cell polarity in a diverse array of experimental systems.

  • Cell Injury

    • 1st Edition
    • Volume 13
    • Edward Bittar
    • English
    At no time since the introduction of cell pathology by Virchov more than a century ago has the outlook for pathology as an integrated discipline been brighter. It is surely clear that the revolution of molecular biology and biotechnology has wrought profound changes in the various basic medical sciences including pathology. But to say this is hardly enough, particularly since the burgeoning field of molecular pathology has been challenged and altered by a powerful concept, namely, programmed cell death. Called apoptosis, which in Greek means falling off, it is intimately connected with cell removal and regeneration; that is, with tissue homeostasis. Nowhere is this more dramatically illustrated as a physiological process than in the gut, endometrium, and embryo. Similarly, little doubt is left that clusters of apoptotic-induced genes are involved in the control of carcinogenesis. The evidence for this is already compelling; it is plain, for instance, that p53 triggers apoptosis whenever DNA repair is incomplete. The question now is, how quickly can the Genome project shed some light on the genetics underlying apoptosis?It is tolerably clear that there is no such thing as a general model of cell injury, but there are models, as it should be. One thing is already certain: cell stress during septicemia is the quintessential model. Death here requires the failure of at least three organs! We are told that oxidative stress plays a major role in the pathogenesis of the syndrome. This is not surprising. The whole subject of reactive oxygen species (ROS) is thus given much weight. By far, the most important mechanisms underlying membrane lesions, due to ROS, are those involving inactivation of several key enzymes among a host of enzymes, lipid peroxidation, and iron speeding up bydroxyl radical production. The stark fact is that evolutionary pressure has produced a fiasco by not endowing the cell with enough antioxidant power or reducing the ROS pool. In organs with high O2 consumption, mitochondrial leakage of O2 (the superoxide anion) could well be considerable. Thus our main point here is that caloric restriction gives us a way of tackling the problem for the time being. One has only to remember that it improves survival.Whether there has been a "breakthrough" is not yet quite certain, but oxidative stress combined with long-term overactivation of glutamate receptors may enable us to understand several neurodegenerative disorders including Parkinson's disease. This broad topic is touched upon in detail in the Neurobiology module (Volume 14).There is a vast literature relating to injury of heart muscle. Two chapters address this topic. Looking back, are we to conclude that a membrane lesion, which is essentially functional, does not exist? Consider, as an example, the NMR experiments in which a raised Pco2, leads very rapidly to a fall in heart muscle pH. We also venture whether it begs several fundamental questions relating to events that precede the onset of necrobiosis. A telling argument is that an early event could be as simple as the root of the problem in ischemia is not as simple as that of a leaky membrane. But the initiating event would seem to be a redox imbalance vix., changes in cytosolic and mitochondrial NAD+/NADH.We urge the student to go back to Volume 4 (Part II) and read, once more, the chapter on Cellular ATP by Harris. In Part IV, the chapter on the Human Heat Shock Response by Jurivich merits a second reading. Though the present volume is a veritable source of many unanswered questions, it has the distinct simplicity of telling us that molecular pathology, like molecular biology, represents a way of thinking.

  • Photosynthesis: Molecular Biology of Energy Capture

    • 1st Edition
    • Volume 297
    • John N. Abelson + 1 more
    • English
    General Description of the Volume:The articles in this Methods in Enzymology volume reflect the integration of molecular genetics with photosynthesis. They focus on the genetic engineering of the photosynthesis apparatus, new mechanisms for genetic selection of photosynthetic mutants, biophysical and biochemical analysis of Photosystem I and Photosystem II Mutations, and Photosynthetic Gene Expression.General Description of the Series:The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Molecular Motors and the Cytoskeleton, Part B

    • 1st Edition
    • Volume 298
    • John N. Abelson + 1 more
    • English
    This Methods in Enzymology volume continues the description (initiated in Volume 85) of the purification and assay of this diverse group of proteins involved in cytoplasmic organization. It discusses some of the more promising attempts to apply techniques of molecular biology genetics and molecular cytochemistry to these proteins. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Tropical Mariculture

    • 1st Edition
    • Sena S. De Silva
    • English
    Tropical Mariculture takes an in-depth look at developmental activities in a growing industry striving towards sustainability and environmental integrity. All of the contributors to this book have considerable experience and expertise in the field of tropical mariculture, and this is the first book to bring expert contributions together. The topics covered are wide and varied, ranging from general issues such as the impact of mariculture on coastal ecosystems to genetic improvement of cultured marine species, as well as the specifics of breeding selected marine species of current importance, such as groupers and sea bass. Significant coverage is also given to the problems of larval rearing in inland aquaculture as well as the demands of water- and land-based resources in a tropical environment. This book will be essential for everyone working in and researching tropical mariculture.

  • A Dictionary of Pharmacology and Allied Topics

    • 2nd Edition
    • D.R. Laurence + 1 more
    • English
    This dictionary spans the practice of pharmacology, and of allied sciences insofar as they are related to it, with particular emphasis on the development, regulation and use of human medicine. It is offered to students as well as to professionals in pharmacology and allied sciences for reference and for browsing, and as a bedside book and travelling companion. Its size (approximately 2000 entries) is appropriate for these uses.Features of this dictionary:• Provides definitions of terms in pharmacology, both basic and clinical• Gives information on new medicine development and official regulations• Covers allied topics, including statistics, ethics, scientific miscounduct, authorship, publication and law.

  • Ion Channels, Part B

    • 1st Edition
    • Volume 293
    • John N. Abelson + 1 more
    • English
    This volume plus its companion, Volume 294, presents cutting edge techniques for the study of ion channels, ranging from the molecular to the physiological level. These volumes supplement Volume 207 of Methods inEnzymology

  • Advances in Genetics

    • 1st Edition
    • Volume 38
    • English
    This volume of Advances in Genetics furthers the serial's goal of presenting topics of interest to both human and molecular geneticists. Topics of interest in this volume include:Expression patterns of regulatory genes and the role they play in developmentHereditar... ataxias and specific disease states where the genetic defect has been identifiedMinute genes, their mutations, and their molecular function in DrosophilaThe genetics and molecular biology of rhythm mutants and clock moleculesDouble strand breaks in DNA and their repair mechanisms

  • Sperm Competition and Sexual Selection

    • 1st Edition
    • Tim R. Birkhead + 1 more
    • English
    Sperm Competition and Sexual Selection presents the intricate ways in which sperm compete to fertilize eggs and how this has prompted reinterpretations of breeding behavior. This book provides a theoretical framework for the study of sperm competition, which is a central part of sexual selection. It also discusses the roles of females and the relationships between paternal care in sperm competition. The chapters focusing on taxonomic development are diverse and cover all the major animal groups, both vertebrate and invertebrate, and plants. The final chapter provides an overview discussing the relationship between sperm competition and sexual selection in terms of both function and mechanism and how these translate into species fitness. This book will be of prime interest to behaviorists, ecologists and evolutionary biologists, suggesting new avenues of research and new ways of approaching old problems.

  • International Review of Cytology

    • 1st Edition
    • Volume 184
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 33
    • James A. Bristol + 5 more
    • English
    Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.

  • Human Aggression

    Theories, Research, and Implications for Social Policy
    • 1st Edition
    • Russell G. Geen + 1 more
    • English
    For centuries, scholars have debated the causes of aggression and the means to reduce its occurrence. Human Aggression brings together internationally recognized experts discussing the most current psychological research on the causes and prevention of aggression. Scholars, policy makers, practitioners, and those generally concerned with the growing issue of aggression find this a much needed reference work. Topics include how aggression is related to the usage of drugs, how temperature affects aggression, the effect of the mass media on aggression, violence by men against women, and the treatment of anger/aggression in clinical settings. The book also provides a comprehensive review of theory and methodology in the study of aggression.

  • Advances in Parasitology

    • 1st Edition
    • Volume 41
    • English
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • Intracellular Protein Degradation

    • 1st Edition
    • Volume 27
    • A.J. Rivett
    • English
    This volume brings together a set of reviews that provide a summary of our current knowledge of the proteolytic machinery and of the pathways of protein breakdown of prokaryotic and eukaryotic cells. Intracellular protein degradation is much more than just a mechanism for the removal of incorrectly folded or damaged proteins. Since many short-lived proteins have important regulatory functions, proteolysis makes a significant contribution to many cellular processes including cell cycle regulation and transciptional control. In addition, limited proteolytic cleavage can provide a rapid and efficient mechanism of enzyme activation or inactivation in eukaryotic cells.In the first chapter, Maurizi provides an introduction to intracellular protein degradation, describes the structure and functions of bacterial ATP-dependent proteases, and explores the relationship between chaperone functions and protein degradation. Many of the principles also apply to eukaryotic cells, although the proteases involved are often not the same. Interestingly, homologues of one of the bacterial proteases, Ion protease, have been found in mitochondria in yeast and mammals, and homologues of proteasomes, which are found in all eukaryotic cells (see below), have been discovered in some eubacteria. Studies of proteolysis in yeast have contributed greatly to the elucidation of both lysosomal (vacuolar) and nonlysosomal proteolytic pathways in eukaryotic cells. Thumm and Wolf (chapter 2) describe studies that have elucidated the functions of proteasomes in nonlysosomal proteolysis and the contributions of lysosomal proteases to intracellular protein breakdown. Proteins can be selected for degradation by a variety of differen mechanisms. The ubiquitin system is one complex and highly regulated mechanism by which eukaryotic proteins are targetted for degradation by proteosomes. In chapter 3, Wilkinson reviews the components and functions of the ubiquitin system and considers some of the known substrates for this pathway which include cell cycle and transcriptional regulators. The structure and functions of proteosomes and their regulatory components are described in the two subsequent chapters by Tanaka and Tanahashi and by Dubiel and Rechsteiner. Proteasomes were the first known example of threonine proteases. They are multisubunit complexes that, in addition to being responsible for the turnover of most short-lived nuclear and cytoplasmic protein, are also involved in antigen processing for presentation by the MHC class I pathway. Recent studies reviewed by McCracken and colleagues (chapter 6) lead to the exciting conclusion that some ER-associated proteins are degraded by cytosolic proteasomes. Lysosomes are responsible for the degradation of long-lived proteins and for the enhanced protein degradation observed under starvation conditions. In chapter 7 Knecht and colleagues review the lysosomal proteases and describe studies of the roles of lysosomes and the mechanisms for protein uptake into lysosomes. Methods of measuring the relative contribution of different proteolytic systems (e.g., ubiquitin-proteasome pathway, calcium-dependent proteases, lysosomes) to muscle protein degradation, and the conclusions from such studies, are reviewed by Attai and Taillinder in the following chapter. Finally, proteases play an important role in signaling apoptosis by catalyzing the limited cleavage of enzymes. Mason and Beyette review the role of the major players, caspases, which are both activated by and catalyze limite proteolysis, and also consider the involvement of other protoelytic enzymes in this pathway leading cell death.

  • Advances in Agronomy

    • 1st Edition
    • Volume 64
    • English
    Volume 64 contains six comprehensive reviews covering key contemporary topics on crop and soil sciences. As always, the topics are varied and exemplary of the array of subject matter covered by this long-running serial. With this latest volume, Advances in Agronomy continues to be recognized as a leading reference and as a first-rate source of the latest research in agronomy, crop science, and soil science.

  • More Landmarks in Biochemistry

    • 1st Edition
    • Volume 4
    • L.A. Stocken + 1 more
    • English
    This fourth volume in the series on biochemistry looks at foundations in modern biochemistry. Topics covered include: the genetic solution; the genetic basis of development; DNA repair; evolution in an RNA world; nitrogen fixation; solute channels; viruses; biochemistry in retrospect and propspect.

  • Advances in Structural Biology

    • 1st Edition
    • Volume 5
    • S.K. Malhotra + 1 more
    • English
    Volume 5 in the series Advances in Structural Biology is based upon a selection of articles presented at the Workshop on Molecular Bio-physics of the Cytoskeleton: Microtubule Formation, Structure, Function, and Interactions (August 18-22 1997 at the Banff Conference Centre in Banff, Alberta, Canada). Its main objective was to review the state-of-the-art of the field and stimulate a multidisciplinary investigation into the molecular biology of the cytoskeleton, which is amply manifested in the articles selected and published in this volume.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 75
    • English
    Volume 75 of Advances in Cancer Research continues the series' goal of publishing timely and authoritative reviews in the broad field of cancer research. Graves and Petersen begin the volume with a review of ets proteins and their role in biological specificity. Chapter 2 by Boshoff and Weiss discusses Kaposi's sarcoma and its associated herpesviruses. Chapter 3 by Taipale and colleagues discusses the ways in which the effects of TGF-B can be targeted through its deposition to the extracellular matrix in a latent form. Petersen and colleagues present their research on breast cancer from the phenotypic differentiation standpoint in Chapter 4. The clinical, pathological, and genetic characteristics of hereditary renal carcinoma are reviewed by Zbar and Lerman in Chapter 5. In Chapter 6, Ellem and co-workers discuss the numerous ways in which metastatic cells escape immune killing. Chapter 7 by Kramer et al. Concludes the volume with a discussion on the role of apoptosis via CD95 in liver, colon, and hematopoetic cells.

  • Chromatin

    Structure & Function
    • 3rd Edition
    • Alan P. Wolffe
    • English
    The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization... DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. This book consistently interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes, and will be essential reading for students and molecular biologists who want to really understand how DNA works.

  • Reproductive Endocrinology and Biology

    • 1st Edition
    • Volume 12
    • Edward Bittar
    • English
    We have now reached the mid-point of our editorial task of putting together the compendium, Principles of Medical Biology, which is supposed to be composed of twenty-five modules. The present single-volume module on reproductive endocrinology and biology is in more than one respect a continuation of Module 10 (in two volumes) dealing with molecular and cellular endocrinology. In addition, it intersects, as it should, with various parts of obstetrics and gynaecology, both of which are abetted by technology. One has only to recall that the practical benefits of ultrasound in perinatal medicine and in vitro fertilisation are the outcome of the technological revolution in biomedicine. Whether we are approaching a new era in reproductive biology following the invention of animal cloning is still hard to tell. For some people, it remains an article of faith that cloning of the human being is highly probable. For others, asexual reproduction is anathema. It should surely be obvious to us all that somatic cell nuclear transfer technology (SCNTT) is going to be at its strongest in dealing with husbandry. Whether this and several social forces will alter our modern outlook, there can be little doubt.As in diverse clinical and basic research, so in obstetrics, animals are used as a model. The data thus obtained is extrapolated, if valid, to the mother and foetus. The success of this approach is exemplified in studies carried out on sheep as a model. On the whole, it is also quite apparent that progress in the field of reproductive biology is to a large extent ascribable to the discovery in other disciplines of new hormones, as well as the introduction of new tools and recent improvements in laboratory methods including measurement of hormones.

  • Nonhuman Primates in Biomedical Research

    Diseases
    • 1st Edition
    • English
    This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.

  • Biotechnology Annual Review

    • 1st Edition
    • Volume 4
    • M.R. El-Gewely
    • English
    Progress in the applications of biotechnology depends on a wide base of basic as well as applied sciences. The output of biotechnology has already proved itself in many different fields, from health to biomining, and from agriculture to enzyme "breeding".The objectives of the Biotechnology Annual Review series is to provide readers with the needed in-depth knowledge by reviewing specific topics in each volume. In this way, it is easier for scientists to keep in touch with progress and applications in biotechnology.Up-to-... topics are reviewed that are related to regulatory affairs, social impact, biodiversity and patent issues, as well as production and technology.

  • Monitoring Vertebrate Populations

    • 1st Edition
    • William L. Thompson + 2 more
    • English
    This book is written to serve as a general reference for biologists and resource managers with relatively little statistical training. It focuses on both basic concepts and practical applications to provide professionals with the tools needed to assess monitoring methods that can detect trends in populations. It combines classical finite population sampling designs with population enumeration procedures in a unified approach for obtaining abundance estimates for species of interest. The statistical information is presented in practical, easy-to-understand terminology.

  • Medical Applications of Liposomes

    • 1st Edition
    • D.D. Lasic + 1 more
    • English
    The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 1960's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises. Following the original optimism in the 70's and early 80's, a period of severe skepticism ensued at the end of the 80's and beginning of the 90's, culminating in a moderate but real optimism in the mid 90's, as a result of a successful launch of the first products in the US and Europe.In this collection of papers, the editors have gathered the most promising ideas, approaches, applications and commercial developments, thereby presenting an up-to-date compilation of the present status of the field. This includes such broad areas as anti-cancer chemotherapy immune stimulation and infectious diseases. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such as DNA plasmids (genes), antisense oligonucleotides or ribozymes. Other future developments may be in topical delivery, vaccination and in diagnostics.Features of this book:• Contributions from almost all the leading labs in the field• Up-to-date, critical reviews bridged by editors' introductions• Organized into a logical framework.

  • Calcium Regulation of Cellular Function

    • 1st Edition
    • Volume 30
    • English
    Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves through cells, how it interacts with its many binding proteins, and how calcium and its intracellular receptor, calmodulin, control vital cellular processes. Coverage includes a detailed analysis of the mechanisms by which calcium bound to calmodulin regulates contractile proteins in smooth muscle cells. Close attention is given to the roles of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic signal transduction, protein synthesis, gene expression, programmed cell death, activation of T-lymphocytes, and control of cell division cycles. Other chapters discuss studies using genetically manipulable nonmammalian organisms to further proble the functions of calcium and calmodulin.

  • Handbook of the Aging Brain

    • 1st Edition
    • Eugenia Wang + 1 more
    • English
    Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition.

  • Molecular & Cellular Mechanisms of Neurotransmitter Release

    • 1st Edition
    • Volume 29
    • English
    This volume reviews recent findings on the regulation of exocytotic release of neurotransmitters from nerve terminals. Leading international investigators examine the properties and composition of the vesicles that store neurotransmitters and the molecular and cellular mechanisms that cause a vesicle to release transmitters in response to a nerve impulse.Coverage includes detailed analyses of quantal release of transmitters in the central and peripheral nervous systems. These studies shed new light on the questions of whether different transmitters are released together in fixed amounts and proportions, and whether and why effectors respond to such "transmitter quanta" in a quantal fashion. The book also highlights the relevance of research on neurotransmitter release to the study of various forms of synaptic plasticity, including higher functions such as learning and memory.

  • Starch: Basic Science to Biotechnology

    • 1st Edition
    • Volume 41
    • English
    This volume presents the physiological and biochemical aspects of storage carbohydrates, or starch granules, in plants. This up-to-date and thorough resource carefully integrates fundamental knowledge with the most recent information on the starch granule. It discusses the chemistry of the starch granule and the biochemistry, molecular biology, plant physiology, and genetics of plant starch synthesis. The books also describes the implications of these studies for theseed, biotechnology, and modified starch industries.

  • Eye Guidance in Reading and Scene Perception

    • 1st Edition
    • G. Underwood
    • English
    The distinguished contributors to this volume have been set the problem of describing how we know where to move our eyes. There is a great deal of current interest in the use of eye movement recordings to investigate various mental processes. The common theme is that variations in eye movements indicate variations in the processing of what is being perceived, whether in reading, driving or scene perception. However, a number of problems of interpretation are now emerging, and this edited volume sets out to address these problems. The book investigates controversies concerning the variations in eye movements associated with reading ability, concerning the extent to which text is used by the guidance mechanism while reading, concerning the relationship between eye movements and the control of other body movements, the relationship between what is inspected and what is perceived, and concerning the role of visual control attention in the acquisition of complex perceptual-motor skills, in addition to the nature of the guidance mechanism itself.The origins of the volume are in discussions held at a meeting of the European Society for Cognitive Psychology (ESCOP) that was held in Wurzburg in September 1996. The discussions concerned the landing effect in reading, an effect, that if substantiated, would provide evidence of the use of parafoveal information in eye guidance, and these discussions were explored in more detail at a small meeting in Chamonix, in February 1997. Many of the contributors to this volume were present at the meeting, but the arguments were not resolved in Chamonix either. Other leaders in the field were invited to contribute to the discussion, and this volume is the product. The argument remains unresolved, but the problem is certainly clearer.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 38
    • English
    @from:General Description of the SeriesThe Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. @from:General Description of the VolumeVolume 38 covers emotional memory, metacomprehension of text, and intertemporal choice.

  • Neural Aspects of Tactile Sensation

    • 1st Edition
    • Volume 127
    • J.W. Morley
    • English
    The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.Individua... chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

  • Handbook of Developmental Neurotoxicology

    • 1st Edition
    • William Slikker Jr. + 1 more
    • English
    The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. The book is written by internationally recognized experts on developmental neurotoxicology, covering subjects from basic neuro-development to toxic syndromes induced by various chemicals. It is an important text for both students and professionals who are interested in developmental neurobiology and neurotoxicology.

  • Fish Respiration

    • 1st Edition
    • Volume 17
    • Steve F. Perry + 1 more
    • English
    Fish Respiration synthesizes classical literature and highlights recent developments pertaining to the respiratory physiology of fishes. Compiled by a team of international researchers, this comprehensive and authoritative review of the respiratory physiology of fishes will appeal to any comparative physiologist interested in this subject.

  • Animal Cell Culture Methods

    • 1st Edition
    • Volume 57
    • English
    This volume provides complete and thorough coverage of the classical and state-of-the-art methods used in cell culture. It also includes basic principles used in the selection of cells for specific scientific study, as well as analytical and procedural techniques.

  • Food Flavors: Formation, Analysis and Packaging Influences

    • 1st Edition
    • Volume 40
    • E.T. Contis + 5 more
    • English
    The 9th International Flavor Conference: George Charalambous Memorial Symposium was held July 1-4, 1997 at the Porto Myrina Palace on the Island of Limnos, Greece. This conference was organized as a tribute to Dr. George Charalambous organizer of the previous eight conferences, who passed away in November of 1994.The symposium brought together a group of international experts in food science and human nutrition to discuss their latest findings in a broad area of food science. Particular emphasis was placed on state-of-the-art instrumentation and methods.The 9th Conference followed the format and traditions of the previous meetings. More than 90 papers/posters were presented by scientists from nineteen countries. Dr. Apostolos Grimanis, a radioanalytical chemist and retired Director of the Radioanalytical Laboratory at the National Center for Scientific Research "Demokritos" in Athens opened the meeting with a tribute to Dr. Charalambous.The Conference Committee announced that the Division of Agricultural and Food Chemistry (American Chemical Society) has agreed to sponsor a Fellowship in Dr. Charalambous' honor in recognition of his tremendous contributions to the Division over many years.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 35
    • English
    Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on bacterial resistance mechanisms serves to highlight an important area of unmet medical need requiring the attention of medicinal chemists. Five topical subjects are reviewed: the biosynthesis, metabolism and function of Vitamin D3 and the potential application of its analogues in bone disorders and immune-related diseases; the therapeutic potential of neurokinin antagonists; opioid receptor antagonists; the mechanisms of bacterial resistance; and a survey of recent advances in cannabinoid research. This volume will deservedly take its place in clinical and industrial pharmaceutical libraries, and will prove invaluable to medicinal chemists.

  • Current Topics in Developmental Biology

    • 1st Edition
    • Volume 40
    • English
    This Series provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. This year marks a major milestone for the Series as it completes its thirtieth year of publication, making it the longest-running forum for contemporary issues in developmental biology.

  • Gums and Stabilisers for the Food Industry 9

    • 1st Edition
    • Peter A. Williams + 1 more
    • English
    This work contains the proceedings of a conference on gums and stabilisers for the food industry. Contributions are concerned with the structure-function relationships of various polysaccharides and protein systems, as well as progress on mixed biopolymer systems.

  • Bacterial Pathogenesis

    • 1st Edition
    • Volume 27
    • English
    Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.

  • Neurobiology of Learning and Memory

    • 1st Edition
    • Joe L. Martinez Jr. + 1 more
    • English
    Neurobiology of Learning and Memory provides an excellent overview of current information on this fast-growing field of neurobiology. The contents have been structured for use as a course text or as a handy resource for researchers in neuro- and cognitive psychology. It discusses learning and memory from developmental, pharmacological, and psychobiological perspectives, as well as changes in learning and memory with age. Neurobiology of Learning and Memory also includes research on invertebrates and vertebrates, presenting basics in anatomy and development along with computational models. It is written in an easy-to-follow format with summaries at the end of each chapter.

  • International Review of Cytology

    • 1st Edition
    • Volume 183
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Marine Mammals and Noise

    • 1st Edition
    • W. John Richardson + 3 more
    • English
    Many marine mammals communicate by emitting sounds that pass through water. Such sounds can be received across great distances and can influence the behavior of these undersea creatures. In the past few decades, the oceans have become increasingly noisy, as underwater sounds from propellers, sonars, and other human activities make it difficult for marine mammals to communicate. This book discusses, among many other topics, just how well marine mammals hear, how noisy the oceans have become, and what effects these new sounds have on marine mammals. The baseline of ambient noise, the sounds produced by machines and mammals, the sensitivity of marine mammal hearing, and the reactions of marine mammals are also examined. An essential addition to any marine biologist's library, Marine Mammals and Noise will be especially appealing to marine mammalogists, researchers, policy makers and regulators, and marine biologists and oceanographers using sound in their research.

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