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The Biology of Animal Viruses
- 2nd Edition - January 1, 1974
- Authors: Frank J. Fenner, B. R. McAuslan, C. A. Mims
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 2 5 3 0 4 0 - 1
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 7 1 8 8 - 0
The Biology of Animal Viruses, Second Edition deals with animal viruses focusing on molecular biology and tumor virology. The book reviews the nature, chemical composition,… Read more
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Request a sales quoteThe Biology of Animal Viruses, Second Edition deals with animal viruses focusing on molecular biology and tumor virology. The book reviews the nature, chemical composition, structure, and classification of animal viruses. The text also describes the methods of isolating animal viruses, how these are grown in the laboratory, assayed, purified, and used in biochemical experiments. The book also describes the structure and chemistry of many known viruses such as the papovaviridae, herpes virus, poxvirus, coronavirus, or the Bunyamwera supergroup. The book then explains the structure and function of the animal cell including the cytoplasmic organelles, the nucleus, inhibitors of cell function, and viral multiplication. Other papers discuss in detail the multiplication of the DNA and RNA viruses, whose mechanisms of multiplication differ from those of other viruses. Other papers discuss the known prevention and treatment methods of viral diseases, as well as the epidemiology and evolution of viral diseases resulting from human's disturbance of the biosphere and from medical and experimental innovations. The text can prove useful for immunologists, veterinarians, virologists, molecular researchers, students, and academicians in the field of cellular microbiology and virology.
Preface
Preface to First Edition
Acknowledgments
1 The Nature and Classification of Animal Viruses
Introduction
The Nature of Viruses
The Chemical Composition of Animal Viruses
The Structure of Animal Viruses
Classification and Nomenclature in Biology
Previous Classifications of Viruses
A Classification of Animal Viruses
Short Descriptions of the Major Groups of DNA Viruses
Short Descriptions of the Major Groups of RNA Viruses
Unclassified Viruses
The Origins of Viruses
2 Cultivation, Assay, and Analysis of Viruses
Introduction
Cell Culture
Embryonated Eggs
Laboratory Animals
Assay of Viral Infectivity
Assay of Other Properties of Virions
Purification and Separation of Virions and Their Components
Electron Microscopy of Viruses
Nucleic Acid Hybridization
Examination of an Unknown Virus
Measurement of Antibodies and Antigens
3 The Structure and Chemistry of the Virion: A Systematic Survey
Introduction
Papovaviridae
Adenovirus
Herpesvirus
Iridovirus
Poxvirus
Parvovirus
Picornaviridae
Togaviridae
Orthomyxovirus
Paramyxovirus
Coronavirus
Arenavirus
Bunyamwera Supergroup
Rhabdovirus
Leukovirus
Reovirus
Orbivirus
Unclassified Viruses
General Observations
4 Structure and Function of the Animal Cell
Introduction
Structure of an Undifferentiated Animal Cell
The Cytoplasmic Membrane
Cytoplasmic Organelles
The Nucleus
The Cell Cycle
Molecular Biology of Animal Cells
Inhibitors of Cell Function and Viral Multiplication
5 The Multiplication of DNA Viruses
Introduction
The Multiplication Cycle
The Essential Steps in Multiplication
A Systematic Survey
Parvovirus
Papovaviridae
Adenovirus
Herpesvirus
Iridovirus
Poxvirus
6 The Multiplication of RNA Viruses
Introduction
The Essential Steps in Multiplication
A Systematic Survey
Picornaviridae
Togaviridae
Orthomyxovirus
Paramyxovirus
Coronavirus
Arenavirus
Bunyamwera Supergroup
Rhabdovirus
Leukovirus
Reovirus
Orbivirus
7 Viral Genetics
Introduction
Numbers of Genes in Viruses
Technical Methods
Host-Controlled Modification
Mutation
Kinds of Mutants of Animal Viruses
Interactions between Viruses
Genetic Recombination
Interactions of Viral Nucleic Acid and Cellular DNA
Genetic Reactivation
Host-Cell Reactivation and Photoreactivation
Complementation
Adenoviruses and SV40
Phenotypic Mixing
Heterozygosis and Polyploidy
Mapping by Serial Inactivation and Direct Biochemical Analysis
Adaptation to New Hosts
8 Interference and Interferon
Introduction
Virus-Attachment Interference
Homologous Interference
Heterologous Interference
Interferon-Mediated Interference
Biological Properties of Interferons
Physicochemical Properties of Interferons
Methods of Assay of Interferons
Induction of Interferon
Viruses and Nucleic Acid as Inducers of Interferon
Mechanism of Interferon Action
Enhancement
9 Pathogenesis: The Spread of Viruses through the Body
Introduction
Mechanisms of Cell Damage
Cell Damage in the Infected Animal
Infections of the Skin
Infections of the Respiratory Tract
Infections of the Alimentary Tract
Systemic infections
Generalized Infections with Rashes
Infections of the Nervous System
Congenital Infections
Infections of Lymphoid Tissues
Infections of Miscellaneous Organs
The Incubation Period and Its Significance in Pathogenesis
Virulence at the Level of Organism
10 Pathogenesis: The Immune Response
Introduction
The Immunoglobulins
Complement
Cell-Mediated Immunity
Cells and Tissues Involved in the Immune Response
The Immune Response in Mature Animals
Immunological Tolerance
Immunity in the Fetus and Newborn
The Immune Response to Viral Infection
Neutralization of Viruses by Antibody
Secretory Antibodies on Mucosal Surfaces
Passive Immunity
The Duration of Active Immunity
Changes in the Reactivity of Antibodies after Multiple Infections
Recovery from Viral Infection
The Immune Response as a Cause of Pathological Changes
Immunosuppression by Viruses
Immunological Tolerance in Viral Infection
Immunological Aspects of Infections with Oncogenic Viruses
Novel Antigens on the Surface of Cells Undergoing Cytocidal Infections
11 Pathogenesis: Nonimmunological Factors and Genetic Resistance
Introduction
Interference and Interferon in the Intact Animal
Other Nonimmunological Factors in Resistance
The Influence of Age on Resistance to Viral Infections
Genetic Resistance
12 Persistent Infections
Introduction
Persistent Infections of Cultured Cells
Persistent Infections in Intact Animals
Latent Infections
Chronic Infections
Slow Infections
Factors in the Pathogenesis of Persistent Infections
13 Viral Oncogenesis: DNA Viruses
Introduction
Tumors Produced under Natural Conditions
Tumor Production by Adenoviruses
Transformation of Cultured Cells by Adenoviruses
Tumor Production by Polyoma Virus and SV40
Interactions of Polyoma Virus and SV40 with Cultured Cells
Events during Nonproductive Infection with Polyoma Virus and SV40
Properties of Transformed Cells
Adenovirus-SV40 Hybrid Viruses
14 Viral Oncogenesis: RNA Viruses
Introduction
Avian RNA Tumor Viruses in Chickens
Rous Sarcoma Virus in Mammals
Interactions of Avian Tumor Viruses with Cultured Avian Cells
Properties of Cells Transformed by Avian Tumor Viruses
Transformation of Cultured Mammalian Cells by Avian Tumor Viruses
Mechanism of Transformation by Avian Tumor Viruses
Murine Leukoviruses : Subgenus A
Pathogenesis of Murine Leukemia
Murine Sarcoma Viruses
Mammary Tumor Virus : Leukovirus Subgenus B
Human Tumor Viruses
Other RNA Tumor Viruses
Induction of Mammalian Leukoviruses, Oncogenes, Protoviruses, Provirus
Epilogue
15 Prevention and Treatment of Viral Diseases
Introduction
Efficacy of Viral Vaccines
Safety of Viral Vaccines
Live Vaccines
Inactivated Vaccines
Passive Immunization
The Psychology of Immunization
Medical and Veterinary Vaccines
Human Viral Vaccines
Prospects for New Vaccines
Antiviral Chemotherapy and Chemoprophylaxis
Interferon
Synthetic Polynucleotides and Other Interferon Inducers
Idoxuridine and Other Halogenated Nucleosides
Thiosemicarbazones
Amantadine and Derivatives
Some Other Compounds of Potential Value
16 The Epidemiology of Viral Infections
Introduction
Routes of Entry and Exit
The Respiratory Tract
The Alimentary Tract
The Eye and the Genitourinary Tract
Vertical Transmission
The Epidemiological Importance of Immunity
Multiple-Host Infections : The Viral Zoonoses
Seasons and Weather
Overwintering of Arboviruses
The Epidemiological Importance of Inapparent Infections
Epidemiological Research
17 Evolutionary Aspects of Viral Diseases
Introduction
The Antiquity of Some Viruses
Changes of Virus and Host in Myxomatosis
Influenza in Man
Antigenic Drift with Other Viruses
New Viruses and New Viral Diseases
The Eradication of Viral Diseases
Bibliography
Index
- No. of pages: 850
- Language: English
- Edition: 2
- Published: January 1, 1974
- Imprint: Academic Press
- Hardback ISBN: 9780122530401
- eBook ISBN: 9781483271880
FF
Frank J. Fenner
Affiliations and expertise
The Australian National University Canberra, ACT, AustraliaRead The Biology of Animal Viruses on ScienceDirect