Development and Function of Myeloid Subsets

Series Page

Contributors

Chapter One. Ontogeny and Functional Specialization of Dendritic Cells in Human and Mouse

Abstract

1 Introduction

2 History of DC Identification and Characterization

3 Recent Advances in Mouse DC Immunobiology: Lessons from a Rodent

4 Recent Advances in Human DC Immunobiology

5 Humanized Mice

6 Matching Mice and Men

7 The Relationship of DCs to Monocytes and Macrophages

8 Next Steps Ahead

9 Disclosure Statement

Acknowledgments

References

Chapter Two. Dendritic Cell Migration Through the Lymphatic Vasculature to Lymph Nodes

Abstract

1 Structure and Function of the Lymphatic Vasculature

2 DC Migration into Lymphatics and the Requirement for Specialized Lymphatic Capillaries

3 DC Mobilization to LNs: The Role of CCR7

4 DC Mobilization to LNs: The Machinery for Locomotion

5 Lymphangiogenesis and DC Trafficking During Inflammation

6 Concluding Remarks

References

Chapter Three. A Close Encounter of the Third Kind: Monocyte-Derived Cells

Abstract

1 Dendritic Cell and Macrophages

2 Monocytes, the Mononuclear Phagocytes of the Blood Compartment

3 Monocytes, as Precursors of Tissue Mononuclear Phagocytes

4 Monocyte-Derived Cells in the Inflamed Peritoneum

5 Monocyte-Derived Cells in the Inflamed Brain

6 Monocyte-Derived Cells in the Intestine

7 Development of Monocyte-Derived Cells

8 Perspective

Acknowledgment

References

Chapter Four. Plasmacytoid Dendritic Cell Development

Abstract

1 Background

2 Markers for pDC Identification

3 Cytokines Promoting pDC Development

4 Transcription Factors Determining pDC Development

5 Early Investigation of the Myeloid Versus Lymphoid Origin of pDC

6 Markers of pDC of Lymphoid Origin?

7 CDP and the Consensus Myeloid Pathway to pDC

8 Reassessment of the Lymphoid Pathway to pDC

9 Implications of RAG-1 Expression and IgH Gene Rearrangements in pDC

10 Extension of the CDP Definition to Include New pDC Precursors

11 A Different Non-pDC but pDC-Like Product of the Myeloid Pathway

12 Tracking pDC Development Using Cellular “Barcoding”

13 Some Conclusions

References

Chapter Five. Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases

Abstract

1 The Mononuclear Phagocyte System

2 The DC Lineage

3 Origin and Regulation of DC Differentiation

4 DC Heterogeneity

5 Batf–IRF8–ID2-Dependent DC Lineage

6 Batf3–ID2–IRF8-Independent DC Lineage

7 Monocyte-Derived DCs and Inflammatory DCs

8 The LC Exception

9 The Human DC Lineage

10 Human Histiocytoses as a Result of Dysregulated Differentiation of the Human Myeloid Compartment

11 Conclusion and Perspective

Acknowledgments

References

Chapter Six. Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity

Abstract

1 Introduction

2 Activation, Priming, and Tolerance as Adaptive Responses of Macrophages (Fig. 6.1)

3 Polarized Activation

4 Molecular Mechanisms Underlying Macrophage Polarization

5 Epigenetic Regulation of Macrophage Polarization

6 Posttanscriptional Regulation in Macrophage Activation and Polarization

7 Concluding Remarks

Acknowledgments

References

Chapter Seven. Terminal Differentiation of Dendritic Cells

Abstract

1 Introduction

2 Dendritic Cell Subsets

3 Transcriptional Regulation of Early DC Development: Cellular Differentiation and Some of the Key Regulatory Molecules

4 Transcriptional Regulation of Late DC Development at Steady State

5 Alternative DC Generation: Emergency Hematopoiesis

6 Perspectives

Acknowledgments

References

Chapter Eight. Diversity of Pathogen Sensors in Dendritic Cells

Abstract

1 Introduction

2 Diversity of Pathogen Sensors in DCs

3 Interactions and Effectors

4 Perspectives

Acknowledgments

References

Chapter Nine. Transcriptional Control of Dendritic Cell Development

Abstract

1 Dendritic Cells Comprise Functionally Heterogeneous Subsets

2 DC Development

3 ZBTB46 and CDCS

4 Ongoing Issues in DC Development

Acknowledgments

References

Chapter Ten. Transcriptional Control of Macrophage Identity, Self-Renewal, and Function

Abstract

1 Creating Macrophage Identity

2 Controlling Macrophage Numbers and Proliferation

3 Transcriptional Control of Macrophage Specialization and Functional Activation States

4 Concluding Remarks

Acknowledgments

References

Index

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