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Development and Function of Myeloid Subsets
- 1st Edition, Volume 120 - September 23, 2013
- Editors: Kenneth Murphy, Miriam Merad
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 1 7 0 2 8 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 1 7 1 1 7 - 6
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wi… Read more
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Request a sales quoteAdvances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
- Informs and updates on all the latest developments in the field
- Contributions from leading authorities and industry experts
Immunologists and infectious disease specialists, cell biologists and hematologists.
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Contributors
Chapter One. Ontogeny and Functional Specialization of Dendritic Cells in Human and Mouse
Abstract
1 Introduction
2 History of DC Identification and Characterization
3 Recent Advances in Mouse DC Immunobiology: Lessons from a Rodent
4 Recent Advances in Human DC Immunobiology
5 Humanized Mice
6 Matching Mice and Men
7 The Relationship of DCs to Monocytes and Macrophages
8 Next Steps Ahead
9 Disclosure Statement
Acknowledgments
References
Chapter Two. Dendritic Cell Migration Through the Lymphatic Vasculature to Lymph Nodes
Abstract
1 Structure and Function of the Lymphatic Vasculature
2 DC Migration into Lymphatics and the Requirement for Specialized Lymphatic Capillaries
3 DC Mobilization to LNs: The Role of CCR7
4 DC Mobilization to LNs: The Machinery for Locomotion
5 Lymphangiogenesis and DC Trafficking During Inflammation
6 Concluding Remarks
References
Chapter Three. A Close Encounter of the Third Kind: Monocyte-Derived Cells
Abstract
1 Dendritic Cell and Macrophages
2 Monocytes, the Mononuclear Phagocytes of the Blood Compartment
3 Monocytes, as Precursors of Tissue Mononuclear Phagocytes
4 Monocyte-Derived Cells in the Inflamed Peritoneum
5 Monocyte-Derived Cells in the Inflamed Brain
6 Monocyte-Derived Cells in the Intestine
7 Development of Monocyte-Derived Cells
8 Perspective
Acknowledgment
References
Chapter Four. Plasmacytoid Dendritic Cell Development
Abstract
1 Background
2 Markers for pDC Identification
3 Cytokines Promoting pDC Development
4 Transcription Factors Determining pDC Development
5 Early Investigation of the Myeloid Versus Lymphoid Origin of pDC
6 Markers of pDC of Lymphoid Origin?
7 CDP and the Consensus Myeloid Pathway to pDC
8 Reassessment of the Lymphoid Pathway to pDC
9 Implications of RAG-1 Expression and IgH Gene Rearrangements in pDC
10 Extension of the CDP Definition to Include New pDC Precursors
11 A Different Non-pDC but pDC-Like Product of the Myeloid Pathway
12 Tracking pDC Development Using Cellular “Barcoding”
13 Some Conclusions
References
Chapter Five. Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases
Abstract
1 The Mononuclear Phagocyte System
2 The DC Lineage
3 Origin and Regulation of DC Differentiation
4 DC Heterogeneity
5 Batf–IRF8–ID2-Dependent DC Lineage
6 Batf3–ID2–IRF8-Independent DC Lineage
7 Monocyte-Derived DCs and Inflammatory DCs
8 The LC Exception
9 The Human DC Lineage
10 Human Histiocytoses as a Result of Dysregulated Differentiation of the Human Myeloid Compartment
11 Conclusion and Perspective
Acknowledgments
References
Chapter Six. Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity
Abstract
1 Introduction
2 Activation, Priming, and Tolerance as Adaptive Responses of Macrophages (Fig. 6.1)
3 Polarized Activation
4 Molecular Mechanisms Underlying Macrophage Polarization
5 Epigenetic Regulation of Macrophage Polarization
6 Posttanscriptional Regulation in Macrophage Activation and Polarization
7 Concluding Remarks
Acknowledgments
References
Chapter Seven. Terminal Differentiation of Dendritic Cells
Abstract
1 Introduction
2 Dendritic Cell Subsets
3 Transcriptional Regulation of Early DC Development: Cellular Differentiation and Some of the Key Regulatory Molecules
4 Transcriptional Regulation of Late DC Development at Steady State
5 Alternative DC Generation: Emergency Hematopoiesis
6 Perspectives
Acknowledgments
References
Chapter Eight. Diversity of Pathogen Sensors in Dendritic Cells
Abstract
1 Introduction
2 Diversity of Pathogen Sensors in DCs
3 Interactions and Effectors
4 Perspectives
Acknowledgments
References
Chapter Nine. Transcriptional Control of Dendritic Cell Development
Abstract
1 Dendritic Cells Comprise Functionally Heterogeneous Subsets
2 DC Development
3 ZBTB46 and CDCS
4 Ongoing Issues in DC Development
Acknowledgments
References
Chapter Ten. Transcriptional Control of Macrophage Identity, Self-Renewal, and Function
Abstract
1 Creating Macrophage Identity
2 Controlling Macrophage Numbers and Proliferation
3 Transcriptional Control of Macrophage Specialization and Functional Activation States
4 Concluding Remarks
Acknowledgments
References
Index
Contents of Recent Volumes
- No. of pages: 318
- Language: English
- Edition: 1
- Volume: 120
- Published: September 23, 2013
- Imprint: Academic Press
- Hardback ISBN: 9780124170285
- eBook ISBN: 9780124171176
KM
Kenneth Murphy
Kenneth M. Murphy works in Washington University School of Medecine, USA.
Affiliations and expertise
Washington University School of Medecine, USAMM
Miriam Merad
Affiliations and expertise
Icahn Medical Institute, New York, USARead Development and Function of Myeloid Subsets on ScienceDirect