Neuro-psychopharmacology

Volume 1

List of CINP Committees

Acknowledgements

Preface

Opening Session of the Tenth Congress

Opening of the Congress

Welcome by the Dean of the Faculty of Medicine

Opening Remarks

Comments on the Scientific Program

Presidential Address

Scientific Sessions

Symposium 1 Geriatric Neuro-Psychopharmacology

Summary of the Session

The Aging Brain: Current Theories and Psychopharmacological Possibilities

Assessment Modalities of Cognitive Functions of the Aged Patient

Clinical Assessments in Psychogeriatry

A Selected Review of Anxiolytics, Neuroleptics and Antidepressants in Psychogeriatrics

Aging, Hormones and Mental Functioning

Cerebral Protectors in Psychogeriatrics

The Pharmacology of Nootropic Drugs: Geropsychiatric Implications

Some Clinical Studies with Piracetam - A “Nootropic” Substance

Symposium 2 Parameters and Methods in the Measurement of Therapeutic Response

Summary of the Session

Prevention and Treatment of Depression in General Practice. (A Clinical Center as a New Channel)

The Effect of Drug Treatment on Interpersonal Styles of Manic Patients

Validity Problems in Psychiatric Rating Scales as a Function of the Severity of Disturbance

New Statistical and Computer Techniques to Measure Psychopathological Changes

A Criterion-Refined Measure of Depressed Mood

Symposium 3 International Standards in Psychopharmacology

Summary of the Session

Brief Review of the Work of the Ad Hoc Committee for the Clinical Assessment of Psychotropic Medication

Evaluation of Anti-Anxiety Drugs

International Standards for Controlled Clinical Trials of Antidepressants

Standards for the Clinical Study of Antipsychotic Substances

Revue des Critères Nationaux pour l'étude Clinique des Substances Antipsychotiques. Discussion

A Review of National Standards for the Clinical Study of Toxic Consequences of Psychotropic Medication

Symposium 4 Training Models in Psychopharmacology

Summary of the Session

International Training Courses in Psychopharmacology for Teachers in Medical Schools

Training Models in Psychopharmacology: Present Activities and Future Plans

Preclinical Psychopharmacology and Therapeutics: A Pharmacologist's Point of View

Discussion

Training Models in Psychopharmacology: The Psychiatrist's Point of View

Discussion

Clinical Experimentation and Therapeutic Models

Problèmes de Mise en Application des Modèles de Formation en Psychopharmacologie

Programme of Post-Graduate Instruction in the Treatment of Depression

Symposium 5 A Critical Study on Psychostimulant Drugs

Summary of the Session

Introduction

Testing Psychostimulants in Animals

Comments on the Report by P. Simon

Pharmacokinetics of New Psychostimulants. Critical Considerations

Physiological and Electroclinical Correlations of some New Psychostimulant Drugs

A Critical Study of the New Psychostimulating Drugs: Clinical Aspects

Symposium 6 Treatment of Drug Dependence: Problems and Perspectives

Summary of the Session

Clinical Management of Drug Dependence: Pharmacotherapeutic Aspects

Rapid Drug Detoxification: Further Observations

Behavior Therapies in the Treatment of Drug Dependence: Methodological Aspects and Basic Advantages and Disadvantages

Acupuncture in Narcotic Withdrawal: A Preliminary Report on Biochemical Changes in the Blood and Urine of Heroin Addicts

Experimental "Auricular Electroacupuncture" in Morphine-Dependent Rats: Behavioral and Biochemical Observations

Effectiveness of Butyrophenones and Related Drugs in Narcotic Withdrawal

Symposium 7 Therapy Resistant Patients and Safety Margin Problems

Summary of the Session

Individual Reactivity to Psychotropic Drugs in Animals

Some Examples of Resistance to Psychotropic Drugs in Animals and Man

Acute Pharmacological Effects of Chlorpromazine in Neuroleptic Therapy-Resistant Chronic Schizophrenic Patients

Therapeutic Dilemma in Neuroleptic-Resistant Psychotic Disorders

Treatment of Therapy-Resistant Affective Disorders

The Anxiolytic Agents and their Limitations

Symposium 8 Synaptic Receptors and Psychotropic Drugs

Symposium 9 Role of Cations in Synaptic Function and in the Mechanism of Action of Neuro-Psychotropic Drugs

Summary of the Session

The Role of Calcium in Neurosecretion

Role of Cations in the Transport Mechanism of Amino Acid Precursors and Neurotransmitters

Activation of Brain Adenylate Cyclase via Ca++ Receptors

Relationships Between Cyclic Nucleotides and Divalent Cations in Neuroblastoma Cells. Modifications by Putative Neurotransmitters and Neuropsychotropic Drugs

Alterations in Hypothalamic Ions: Influence on Limbic Function

Interactions Between Cations and Psychotropic Drugs

Studies of Sodium, Magnesium, and Lithium in Patients with Affective Illness

Lithium Action on Phosphate, Calcium and Magnesium

Symposium 10 Putative Neurotransmitters and Neuromodulators Other than Aromatic Amines: Their Role in Neuropharmacology

Summary of the Session

Methods to Evaluate in Vivo the Activity of GABA Receptor Agonists

The Turnover Rate of GABA in Brain Nuclei of Rats Injected with DA Receptor Antagonists and GABA Receptor Agonists

Studies on Endorphins in Man

Pharmacological Implications of Dopaminergic, Cholinergic and GABAergic Neurons in the Action of Antipsychotics and Narcotic Analgetics

Sodium-Dependent High Affinity Chlorine Uptake: Its Significance and Practical Use

Substance P and Enkephalin: Distribution in the Nervous System as Revealed with Immunohistochemistry

The Excitatory Action of Substance P and TRH on Spinal Motoneurons

Symposium 11 Interrelationships Between Various Neurotransmitter Systems

Summary of the Session

Hìstochemical and Micropunch Analysis of Aminergic and Cholinergic Pathways

Neurotransmitters of the Human Brain and their Relationships

Neurotransmitter Actions and Interactions

Influence of Different Putative Neurotransmitters on ACh Release from the Brain and Spinal Cord

Effects of GABAergic and Serotoninergic Drugs on the Activity of Cholinergic Interneurons in Rat Striatum

Importance of Interactions Between Transmitter Systems in Relation to Regulation of the Sleep-Waking Cycle

Humoral Mechanisms Underlying Hypothalamic and Mesodiencephalic Control of Appetitive Behavior and Thermoregulation

Multitransmitter Mechanisms Underlying Selected Function, Particularly Aggression, Learning and Sexual Behavior

Multitransmitter Mechanisms and Treatment of Affective Disease

Symposium 12 Indolamines and Precursors in Depressive State. Anti-Depressive Action of L-5-Hydroxy-Tryptophan

Summary of the Session

Norepinephrine and Serotonin Metabolism in the Rat Brain: Effects of Chronic Phenelzine Administration

Neuroendocrine and Behavioral Studies with Fluoxetine, an Inhibitor of Serotonin Uptake in Brain

A Pharmacotherapeutic Approach to Research into Depressive Illness

Action Anti-Dépressive du L-5-Hydroxytryptophane et Test au Probénécide

Treatment of Intention-Action Myoclonus by 5-Hydroxytryptophan

The Serotonergic Neurotransmitter System in the Affective Disorders. A Preliminary Evaluation of the Antidepressant and Antimanic Effects of Fenfluramine

Symposium 13 Neurotransmitters, Behavior and Brain Dysfunction

Summary of the Session

Neuropharmacology and Histopathology of Experimentally Induced Parkinsonism and Circling

Some Animal Models of Extrapyramidal Disorders

Aporphines, Somatostatin and Parkinson's Disease

Drug-Induced Extrapyramidal Reactions: Clinical Considerations

Motor Aspects of Basal Ganglia Disorders: The Example of Parkinson's Disease

Effects of Antipsychotic Drugs on Normal and Abnormal Animal Behavior

Cyclic Nucleotides, GABA and Dopamine in the Mechanism of Action of Antipsychotic Drugs

Four Dopamine Agonists: A Clinical Continuum

Correlation Between Clinical Effects of Various Antidepressant Treatments and their Effects on Monoaminergic Receptors in the Brain

Affective Symptoms in Dysthyroid States: Possible Relation to Altered Sensitivity at, or Beyond Central Catecholamine Receptors

New Evidence of Serotonin-Deficient Depressions

Exploration of Affective Illness

Symposium 14 Genetic Psychopharmacology

Summary of the Session

Neurochemical Correlates of Behaviour and Drug Responses Genetically Determined

Pharmacogenetic Approach of the Effect of Morphine and Alcohol in Mice

Behavioral, Genetic and Neurochemical Aspects of Alcohol Preference of Mice

A Pharmacogenetic Approach to Study Lithium Treatment in Manic-Depressive Illness

Symposium 15 Metabolism and Kinetics of Psychotropic Drugs

Summary of the Session

Drug Distribution in the Brain

Brain Distribution and Pharmacokinetics of Psychotropic Drugs: Desipramine

Metabolism and Pharmacokinetics of a Substituted Benzamide Sulpiride in Animals: Specific Localization and Neuro-Endocrinological Aspect

Clinical Significance of Measuring Plasma Levels of Psychotropic Drugs: Phenothiazines

Clinical Significance of Measuring Plasma Levels of Antidepressants

Clinical Significance of Monitoring Plasma Levels of Benzodiazepine Tranquilizers and Antiepileptic Drugs

Symposium 16 New Trends in the Mechanisms of Action of Minor Tranquilizers

Psychopharmacological Characterization of Anxioiytics (Minor Tranquilizers)

Behavioral Approaches to Study Mechanisms of Actions of Minor Tranquilizers

Interaction of Minor Tranquillizers with Synaptic Processes Mediated by GABA

Action of Diazepam, Haloperidol, Morphine and Muscimol on the cGMP Content of Cerebellum

Modification of Excitatory and Inhibitory Synaptic Mechanisms by Minor Tranquilizers

Volume 2

Plenary Session 1 Psychotropic Drugs and Neuroendocrinology

Summary of the Session

Monoaminergic Regulation of the Neuroendocrine Transducer which Controls ACTH Secretion

Stimulation of Growth Hormone and Prolactin Release by Morphine and Opiate-Like Peptides

Psychotropic Drugs and Neuroendocrine Function in Psychopathological Conditions

Psychotropic Drugs and Sexual Behavior

Interaction of Psychotropic Drugs with Brain Oligopeptides

Pituitary-Adrenal System Hormones and Behavior

Hormones in the Treatment of Nervous and Mental Disease: Present Status and Development

Plenary Session 2 Ten CINP Congresses. Retrospective and Prospective

Summary of the Session

Psychopharmacology Research: An Attempt at an Overview

Clinical Pharmacology and Pharmacotherapy

Drug Evaluation

Alcohol and Drug-Related Problems

Round Table 1 Interaction of Psychotropic Drugs

Summary of the Session

Effects of Neuroleptics on the Metabolism of Tricyclic Antidepressants

Tricyclics and MAO Inhibitors: Rational Polypharmacy in Treatment-Resistant Depressions

Interaction Between Lithium and Other Psychotropic Drugs

Drug Interactions in the Course of Maintenance Therapy with Neuroleptics

Interaction of Neuroleptics Clozapine and Haloperidol

Round Table 2 Biochemical and Pharmacological Typology of Depression

The Effect of Lithium in Depressive Subtypes

Lithium-Responsive Depressive Illness: Clinical and Biological Characteristics

Lymphocyte and Erythrocyte Antigens in Manic-Melancholic Mode

Clinical Paradoxes from Typologies of Depression

Round Table 3 Quantitative Electroencephalography in Psychopharmacology

Summary of the Session

EEG Statistical Spectral Analysis and New Trends of Quantitative EEG

Methodological Considerations in Quantitative Pharmaco-Electroencephalography

Quantitative EEG of "Classical" Psychoactive Drugs

Quantitative Electroencephalography in Psychiatric Research

Quantitative Pharmaco-Electroencephalography in the Discovery of Psychotropic Properties of Drugs

Clinical Significance and Methodological Problems of Quantitative EEG in the Discovery and the Prediction of Psychotropic Properties of a Newly Developed Substance

EEG Measures for Pharmacodynamic Analysis of Psychoactive Drugs in Man

Quantitative EEG of Circulatory Psychotropic Drugs

Computer EEG Findings with Lisuride

Round Table 4 Contemporary Drug Abuse and Pharmacopsychosis. Pattern of Illicit and Licit Abuse (Polydrug Use)

Summary of the Session

Experimental Pharmacodependence. Opiate and Amphetamine Intravenous Self-Administration Animal Models

Psychoses and Other Adverse Psychiatric Reactions Associated with Marihuana

Les Pharmacopsychoses Comme Modèle d'étude des Psychoses en Psychiatrie Biologique

Licit and Illicit Drugs: Patterns of Use

Patterns of Drug Abuse in Canada

Round Table 5 Mechanism of Drug Dependence

Summary of the Session

Opiate Receptor Binding Studies in Rat Brain During Morphine Primary Dependence and Early Abstinence

Dependence Liability of Opiate-Like Peptides

Conformational States of the Opiate Receptor

Characteristics of Opioid Peptides from Brain and Pituitary

Mechanism of Opiate Dependence Elucidated by Analysis of the Interaction Between Opiates and Methylxanthines

Effect of Calcium and Lanthanum in Morphine Analgesia and Tolerance

Round Table 6 Neuropsychotropic Drugs and Immature Brain

Summary of the Session

Development of Monoamine Neurons and Effects of Psychotropic Drugs

Changing Relationships Among Neurotransmitter Systems in Developing Striatum: Implications for Neuro-Psychopharmacology

Physiological Aspects of Rat Central Nervous System Maturation

The Ontogenetic Development of the Opiate Receptor and Enkephalin in Rat Brain

Molecular Correlates of Brain Development: tRNA as a Possible Intermediate in the Formation of Neuroactive Substances

Behavioral Consequences of Very Early Developmental Exposure to Chlorpromazine in Rats

Round Table 7 New Aspects in Neuro-Psychopharmacology

Cerebral Trace Amines: Their Function and Relevance

Negative Reinforcing Properties of Psychotropic Drugs

Desensitization of β-Adrenergic Receptors and β-Adrenergic Agonists

Workshop 1 Control of Catecholamine Biosynthesis

Noradrenergic Neurons: Post-Stimulation Increase in Catecholamine Biosynthesis

Mode of Regulation of Tyrosine Hydroxylase: Induction and Activation

Regulation of Tyrosine Hydroxylase in Superior Cervical Ganglia

Workshop 2 Behavioural and Pharmacological Methods of Modifying Drug-Reinforced Responding

Summary of the Session

Pharmacological Modification of Cocaine and Apomorphine Self-Administration in the Squirrel Monkey

Chlorpromazine- and Haloperidol-Induced Changes in some Behavioral Effects of Cocaine and Amphetamine

Comparison of the Effects of the Intravenous and Intracerebral Routes of Naloxone and Diallylnormorphine Administration in the Morphine-Dependent Rhesus Monkey

Discrete-Trial Control of Morphine Self-Injection Behaviour in Squirrel Monkeys: Effects of Naloxone and Chlorpromazine Pre-Treatments

Suppression of Intravenous Drug Self-Administration by Punishment in Monkeys: Selected Observations

Discussion of the Session Topic

Workshop 3 The Whole Patient in Response to Pharmacotherapy

Summary of the Session

Pharmacotherapy as an Aid to More Effective Psychotherapy

The "Total Patient" in Relation to Psychopharmacology

Total Treatment of the Patient

Workshop 4 Translations of the AMP System

Summary of the Session

Pregnancy and Infancy of the German—Swiss AMP System

Introductory Remarks on the Revision of the AMP System Manual

First Translation of the AMP System: The Croatian One

Experiences with the Russian and Esthonian Translations of the AMP Psychopathology Scale in Depression and Schizophrenia

The AMP System: Progress in the Spanish Translation

The AMP System in English

The Implications of the AMP System in Canadian Psychiatry

Conceptual and Semantic Problems Raised by the French Translation of the AMP Psychopathology Scale

Workshop 5 Human Brain Bank

Introduction

The NINCDS/NIMH Human Neurospecimen Bank

Methodological Aspects of Post-Mortem Investigations of Human Brain, with Special Reference to Monoamines and Related Enzymes

Mass Fragmentographic Determination of Free and Conjugated Monoamine Metabolites in Human Brain Tissue Obtained at Autopsy

Brain Banks from the Point of View of the Psychiatrist

Workshop 6 Models in Geriatric Neuro-Psychopharmacology

Summary of the Session

Molecular Biological Models in Geriatric Neurobiology

Central Hypoxia Models and Correlations with Aging Brain

Neuronal Lipofuscin and Learning Deficits in Aging Mammals

Biochemical Changes in Central Catecholaminergic Neurons of the Senescent Rats

Brain Cholinergic Deficits in Senescent Animals

Discussion

Thermoregulation as a Model in Geriatric Neuro-Psychopharmacology

Disturbed Vigilance Regulation as a Model of Geriatric Neuro-Psychopharmacology

Tricyclic Drug Treatment in the Elderly Patient

Evaluation of Two Geriatric Behavioral Rating Scales

Perspectives in Geriatric Neuro-Psychopharmacology

Workshop 7 Communications in Neuro-Psychopharmacology

Summary of the Session

Communications in Neuro-Psychopharmacology: Viewpoint from the World Health Organization

Information Dissemination in Neuro-Psychopharmacology: Viewpoint from the WHO International Reference Center for Psychotropic Drugs

Communication in Neuro-Psychopharmacology: Viewpoint from a WHO Regional Reference Centre for Psychotropic Drugs

Collaborative Reference Center: Role and Functions

Communication Through Publications

Computer and Audio-Visual Communication Channels of Drug Information

Communication Needs in Neuro-Psychopharmacology from the Teacher's Point of View

The Future of Communications in Neuro-Psychopharmacology

Plenary Session 3 Chairman's Summaries of the Special Sessions

Closing Session of the Tenth CINP Congress

Subject Index