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Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Advanced Methodologies to Study and Enhance Cellular Cytotoxicity Against Cancer

    • 1st Edition
    • Volume 207
    • English
    Advanced Methodologies to Study and Enhance Cellular Cytotoxicity Against Cancer, provides a comprehensive overview of the latest techniques and strategies used to investigate and boost the cytotoxic activity of cells targeting cancer. Designed for researchers, clinicians, and students in oncology, immunology, and cellular biology, this volume brings together leading experts to discuss cutting-edge experimental models, analytical tools, and therapeutic approaches.

  • Neurogenetic Therapies

    Advancements in Treating Nervous System Disorders
    • 1st Edition
    • Ashutosh Pareek + 4 more
    • English
    Neurogenetic Therapies: Advancements in Treating Nervous System Disorders offers a comprehensive resource on the latest gene therapy techniques and their applications in treating neurological disorders. The book delves into various gene therapy methods, including genomic DNA-based therapies, vector-mediated delivery, and RNA interference-based gene silencing. It explores the use of these techniques in treating conditions such as Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, and Duchenne muscular dystrophy. Key topics include the molecular and genetic basis of nervous system disorders, the role of epigenetics, and the development of stem cell and genome editing therapies.With contributions from leading experts, the book also addresses regulatory and ethical considerations in gene therapy, providing a balanced perspective on the challenges and opportunities in this rapidly evolving field. Case studies and practical examples illustrate successful gene therapy treatments, offering valuable insights into translating research into clinical practice. This book is an essential resource for students, researchers, and scientists in neurogenetics, neurology, and molecular biology, as well as clinicians interested in the mechanisms and treatment of neurodegenerative diseases.

  • Chromatin Signaling and Diseases

    • 2nd Edition
    • Olivier Binda + 2 more
    • English
    Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.

  • Molecular Mechanisms of Spermatogenesis

    • 1st Edition
    • Volume 168
    • English
    Molecular Mechanisms of Spermatogenesis, Volume 168 provides a comprehensive overview of the molecular mechanisms that govern spermatogenesis, the complex process through which sperm cells are produced in the male testes. Sections in this new release include: From undifferentiated gonads to ovaries and testes, Molecular regulation of germ-somatic cell interactions: insights from spatial transcriptomics, All about the mammalian germline cyst, Stem cell competition, Genetic and epigenetic regulation of cell fate determination of human spermatogonial stem cells, A Sertoli Valve niche at the Terminal End of Seminiferous Tubules for Mammalian Spermatogenic Stem Cells, The formation and function of the synaptonemal complex, and more.Additional sections cover Meiotic crossover control: interplay between the recombination process and chromosome organization, Drosophila spermiogenesis, New Insights on the Biogenesis and Functional Importance of the Sperm Cytoplasmic Droplet, Asymmetric male meiosis in genetics and evolution, Current understanding of adult stem cells in Leydig cell biology, Unraveling the complexity of spermatogenesis from single-cell perspective, and much more.

  • Immunomodulators

    • 1st Edition
    • Volume 151
    • English
    Immodulators, Volume 151 explores the pivotal role immodulators play in regulating immune responses for health and disease management. The book provides an in-depth overview of various classes of immunomodulatory agents, including biologics, small molecules, natural compounds, and synthetic drugs, examining their mechanisms of action and therapeutic applications. Chapters in this new release include Marine-Derived Polysaccharides and Peptides as Next-Generation Immunomodulators: Molecular Mechanisms, Therapeutic Potential, and Translational Challenges, Advances in Immunomodulation: From Dietary Influence to Computational Precision, iPSC-derived immunotherapy for Tau and Alzheimer's disease, and much more.Additional sections cover Antibodies targeting amyloid-β and Tau oligomers in Alzheimer's Disease, Biosimilars: Antibody and Nanobody Based Therapeutic Approaches Towards Protein Misfolding Diseases, Immunomodulator drugs: mechanisms of action and systemic effects, Microbiome and microbial products as immunomodulators: implication for gastrointestinal cancers, Integration of Network pharmacology, docking, and dynamics analysis to investigate the immunomodulatory activity of Pongamia pinnata, Transcriptomic Insights into Epigenetic and Immunomodulatory Roles of Nuclear Histone Genes in Bladder Cancer: A bioinformatics Approach, Utilizing DREIMT Database for Drug Prioritization in Immunomodulatory Therapy for Psoriasis and Psoriatic Arthritis, and many additional topics.

  • Cell Death Part B

    • 1st Edition
    • Volume 206
    • English
    Cell Death Part B continues the comprehensive exploration of cellular mechanisms governing the fate of cells in health and disease. This volume delves deeper into the molecular pathways, regulatory networks, and biological consequences of various cell death modalities, including apoptosis, necrosis, autophagy, ferroptosis, pyroptosis, and other emerging forms.

  • Fundamentals of Molecular Structural Biology

    • 2nd Edition
    • Subrata Pal
    • English
    Fundamentals of Molecular Structural Biology, Second Edition reviews the mathematical and physical foundations of molecular structural biology, covering the latest advancements. The book begins with historical perspectives before exploring mathematical concepts, physical aspects of chemistry, the chemical basis of biology, structural analysis, visualization, protein folding, transcription, RNA processing, cell signaling, and computational molecular biology. Additionally, this new edition delves into AI fundamentals and applications, including AlphaFold and RoseTTAFold. This fully updated edition provides a detailed overview of the fundamental concepts across molecular structural biology and acts as an ideal guide for researchers and advanced students.Given the increasingly interdisciplinary nature of this subject, this book provides early career researchers and those shifting into an adjacent field a "fundamentals" resource to get them up-to-speed on the foundations of a particular field.

  • Profiles of Drug Substances, Excipients, and Related Methodology

    • 1st Edition
    • Volume 51
    • English
    Profiles of Drug Substances, Excipients, and Related Methodology, Volume 51 provides comprehensive profiles of four pharmaceutical compounds: Vortioxetine, Rosuvastatin Calcium, Perindopril, and Ferulic Acid. In addition, it includes a review article concerning Drugs and Polymer Based Local Delivery Systems in the Treatment of Periodontal Diseases. Chapters in this new release include Vortioxetine: A Comprehensive Profile, Rosuvastatin Calcium: A Comprehensive Profile, Ferulic Acid: A Comprehensive Profile, Perindopril: A Comprehensive Profile, Drugs and Polymer Based Local Delivery Systems in the Treatment of Periodontal Diseases, Kinetic Exclusion Assay Technology: Theory, Experimental Aspects, and Applications in Concentration Measurements Across Diverse Fields, and more.No other book series provides this essential information as promptly and pertinently. Sections provide review articles and database compilations categorized into five primary domains: Physical Profiles of Drug Substances and Excipients; Analytical Profiles of Drug Substances and Excipients; ADME Profiles of Drug Substances and Excipients; Methodology Pertaining to the Characterization of Drug Substances and Excipients; and Methods of Chemical Synthesis.

  • Innovative Nanotechnology: Transforming Skin Cancer Diagnosis and Treatment

    • 1st Edition
    • Volume 169
    • English
    Innovative Nanotechnology: Transforming Skin Cancer Diagnosis and Treatment, Volume 169 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include an Introduction to Nanotechnology in Dermatology, Basics of Skin Cancer: Types, Diagnosis, and Current Challenges, Current Challenges in Skin Cancer Diagnosis and Treatment, Nanocarriers for Drug Delivery in Skin Cancer, Nanotechnology in Skin Cancer Diagnosis, Therapeutic Nanoparticles and Targeted Therapy, and much more.Additional chapters cover Nanotechnology in Photodynamic and Photothermal Therapy for Skin Cancer, Challenges in Translating Nanotechnology from Research to Clinical Practice, Nanotechnology and Immunotherapy Synergies in Skin Cancer, Patient-Centric Approaches and Personalized Nanomedicine in Skin Cancer, The Role of Theranostics and Nanotheranostics in Skin Cancer Management, Preclinical and Clinical Trials in Nanotech Skin Cancer Treatment, Safety, Ethical, and Regulatory Considerations in Nanotechnology for Skin Cancer, and many more interesting chapters on topics of current interest.

  • Cell Death Part A

    • 1st Edition
    • Volume 205
    • English
    This comprehensive volume explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. The book brings together leading experts to discuss both established and emerging approaches for studying cell death, with a strong emphasis on practical laboratory techniques and their applications in disease research and drug discovery.

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