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Elsevier

Books in Organic chemistry

This collection offers extensive coverage of organic synthesis, reaction mechanisms, and functional group chemistry. Showcasing innovative research, green chemistry approaches, and industrial applications, it supports chemists, students, and researchers in designing new molecules and materials. Addressing drug discovery, polymers, and sustainable processes, these titles foster creativity and technical excellence in advancing organic chemistry for societal benefit.

  • Bioactive Natural Products (Part C)

    V22
    • 1st Edition
    • Atta-ur Rahman
    • English
    Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.

  • Annual Reports in Organic Synthesis, 2000

    • 1st Edition
    • English
    This organized, annual serial provides a general review of structure/activity information for each synthetic compound discussed, clearly illustrates structures of compounds in every feasible synthetic pathway, and provides references to the primary literature for each reaction discussed.

  • Chemistry and Biology

    • 1st Edition
    • Volume 55
    • English
    Akaloids are a major group of natural products derived from a wide variety of organisms and are widely used as medicinal and biological agents. This series is world-renowned as the leading compilation of current reviews of this vast field.Internationall... acclaimed for more than 40 years, The Alkaloids, founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • The Handbook of Organic Compounds, Three-Volume Set

    NIR, IR, R, and UV-Vis Spectra Featuring Polymers and Surfactants
    • 1st Edition
    • Jerry Workman Jr.
    • English
    The Handbook of Organic Compounds: NIR, IR, Raman, and UV-Vis Spectra Featuring Polymers and Surfactants represents a compendium of practical spectroscopic methodology, comprehensive reviews, and basic information for organic materials, surfactants, and polymer spectra covering the Ultraviolet, Visible, Near Infrared, Infrared, Raman and Dielectric measurement techniques. This set represents a complementary organic compound handbook to the Nyquist inorganic handbook, published in 1996. This set comprises the first comprehensive multi-volume handbook to provide basic coverage for UV-Vis, 4th overtone NIR, 3rd overtone NIR, NIR, Infrared, Raman spectra, and Dielectric data for common organic compounds, polymers, surfactants, contaminants, and inorganic materials commonly encountered in the laboratory. The text includes a description and reviews of interpretive and chemometric techniques used for spectral data analysis. The spectra included within the atlas are useful for identification purposes as well as pedagogical for the instruction of the various interpretive and data processing methods discussed. This work is designed to be of help to students and vibrational spectroscopists in their efforts of daily spectral interpretation and data processing of organic spectra, polymers, and surfactants. All spectra are presented in wavenumber and transmittance, with the addition of ultraviolet, visible, 4th overtone NIR, 3rd overtone NIR, and NIR spectra also represented in nanometers and absorbance space. In addition, some Horizontal infrared ATR spectra are presented in wavenumber and absorbance space. All spectra are shown with essential peaks labeled in their respective units. The material in this handbook was contributed to by several individuals, and comments were received from a variety of prominent workers in the field of molecular spectroscopy. This type of handbookproject is a daunting task. This Handbook can provide a valuable reference for the daily activities of students and professionals working in modern molecular spectroscopy laboratories.

  • Handbook of Heterocyclic Chemistry

    • 2nd Edition
    • Alan R. Katritzky + 4 more
    • English
    Heterocyclic chemistry is the largest of the classical divisions of organic chemistry. Heterocyclic compounds are widely distributed in Nature, playing a vital role in the metabolism of living cells. Their practical applications range from extensive clinical use to fields as diverse as agriculture, photography, biocide formulation and polymer science. The range of known compounds is enormous, encompassing the whole spectrum of physical, chemical and biological properties. This book provides a balanced, concise and informative account of heterocyclic chemistry that will be suitable for graduate or advanced undergraduate students and a convenient reference book for research workers, for both specialists int he field and those whose expertise lies in other areas but who nevertheless need information on heterocylic chemistry. The Handbook of Heterocyclic Chemistry is illustrated throughout with thousands of clearly drawn chemical structures. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 35
    • English
    Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 35
    • English
    Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a fast developing one, with results and methodologies finding application from biology to solid state physics. The previous volumes in this serial constitute a lasting record of this field and will continue to do so as they are widely used and cited. The serial has maintained high levels of quality and utility over the years.Volume 35, devoted to the study of carbocations and free radicals, includes contributions on excess acidities, the relationship between structure and organic reactivity, electron transfer, bond-breaking and formation, donor/acceptor organizations, and the electron-transfer paradigm for organic reactivity. Readers will also benefit from the comprehensive subject and citation index.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 77
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Chemistry and Biology

    • 1st Edition
    • Volume 54
    • English
    Alkaloids are a major group of natural products derived from a wide variety of organisms, which are widely used as medicinal and biological agents. This series is world-renowned as the leading compilation of current reviews of this vast field.Internationall... acclaimed for more than forty years, The Alkaloids , founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • Bioactive Natural Products (Part B)

    V21
    • 1st Edition
    • Atta-ur Rahman
    • English
    Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.

  • Alkaloids: Chemical and Biological Perspectives

    • 1st Edition
    • Volume 14
    • S.W. Pelletier
    • English
    Volume 14 of this series presents three interesting reviews of research on alkaloids. Chapter 1, by Paul L. Schiff, Jr., is a monumental effort, presenting a selective, comprehensive tabular review of research on the bisbenzylisoquinolin... alkaloids, with an analysis of the respective alkaloid types. The chapter should serve as a very useful tool for the bench research scientist who is involved in the isolation and elucidation of structures of bisbenzylisoquinolin... alkaloids. Moreover, the data in these tables provides the botanical distribution and occurrence (family, genus, species) of the various classes of these alkaloids. The alkaloids are also categorized by their molecular weights and structural types. Chapter 2, by Toh-Seok Kam, is a review of alkaloids derived from Malaysian flora. Malaysia's position near the Equator confers on it a tropical climate characterized by high temperatures, humidity, and rainfall, conditions favorable for plant life that has resulted in a rich flora of about 15,000 species of higher plants. This review concentrates on work published during the past twenty years and where appropriate compares the occurrence of alkaloids with studies of similar plants from countries neighboring to Malaysia, especially Thailand and Indonesia. Chapter 3, by Jie Jack Li, presents a collection of very interesting total syntheses of naturally occurring indole alkaloids where palladium chemistry plays a central role in the syntheses. Five different types of palladium-mediated reactions are treated: (1) oxidative cyclization reactions promoted by palladium (II) species; (2) transmetallation reactions with organoboranes, organostannanes, and organozinc reagents; (3) inter- and intramolecular Heck reactions; (4) reactions with &pgr;-allylpalla... as the intermediate; and (5) reactions using C-N bond formation as the key step for the synthesis.

  • The Chemistry and Technology of Furfural and its Many By-Products

    • 1st Edition
    • Volume 13
    • K.J. Zeitsch
    • English
    This book is a "world first", since the furfural industry has been traditionally secretive to the point of appearing shrouded in clouds of mystery. Even renowned encyclopedic works have published but scant and often erroneous information on the subject. Striking a healthy balance between theory and practice, the book leads the reader from reaction mechanisms and kinetics to the technology of making furfural by various old and new processes, using conventional raw materials or sulfite waste liquor. Detailed discussions of means of increasing the yield are of great chemical and technological interest as well as of immense economic importance.From furfural proper, the treatise shifts to the fascinating field of wanted and unwanted by-products ranging from largely unutilized carboxylic acids to troublesome impurities such as 5-methyl furfural and 2-furyl methyl ketone, and then to extremely valuable serendipitous flavor compounds such as diacetyl and 2,3-pentanedione. A wide variety of derivatives are discussed; considerable space is devoted to polytetrahydrofuran, an important building block of stretchable synthetic fibers, while furan resins from both furfural and furfuryl alcohol are given the attention commensurate with their industrial importance. Notable supplementary chapters cover the in-line measurement of furfural, the treatment of furfural waste water, and various aspects of corrosion. A chapter on the applications of furfural elaborates not only traditional uses in extracting petroleum and vegetable oils but also the sensational discovery that furfural is a highly effective "indirect nematocide". Without becoming toxic, it changes the microflora of the soil by stimulating bacteria antagonistic to nematodes, thereby reducing the nematode population to zero, at an unprecedented low price. It is believed that this application will be the principal outlet for furfural in the future.A comprehensive list of physical properties, some never published before, make the book an indispensable companion for producers, users and researchers alike.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 55
    • English
    Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Bioactive Natural Products (Part E)

    V24
    • 1st Edition
    • Atta-ur Rahman
    • English
    Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.

  • Advances in Medicinal Chemistry

    • 1st Edition
    • Volume 5
    • A.B. Reitz + 1 more
    • English
    Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

  • High-Resolution NMR Techniques in Organic Chemistry

    • 1st Edition
    • Volume 19
    • T. Claridge
    • English
    From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology.In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.

  • Perspectives in Organopalladium Chemistry for the 21st Century

    • 1st Edition
    • J. Tsuji
    • English
    Perspectives in Organopalladium Chemistry for the 21st Century is a monograph on modern organopalladium chemistry, with an emphasis on the use of palladium in organic synthesis. The collection of articles is reprinted from a special issue of the Journal of Organometallic Chemistry.The field of organopalladium chemistry is evolving rapidly, building on a growing catalogue of reactions that employ palladium-containing catalysts. This book should hold particular interest for those who apply palladium reagents and catalysts to organic synthesis; in fact, palladium is considered by many to be the most useful transition element employed for organic syntheses. This selection of articles by leading scientists, published as "Perspectives in Organopalladium Chemistry for the 21st Century", provides an impressive overview of the field that every chemist who works with organometallic palladium catalysts should read.

  • Writing Reaction Mechanisms in Organic Chemistry

    • 2nd Edition
    • Philippa H. Solomon
    • English
    Writing Reaction Mechanisms in Organic Chemistry, Second Edition, is an invaluable guide to charting the movements of atoms and electrons in the reactions of organic molecules. Miller and Solomon illustrate that understanding organic reactions is based on applying general principles rather than the rote memorization of unrelated processes, and, in turn, emphasize that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions. Students and research chemists alike will find this book useful in providing a method of organizing and synthesizing an oftentimes overwhelming quantity of information into a set of general principles and guidelines for determining and describing organic reaction mechanisms.

  • The Porphyrin Handbook, Volume 10

    • 1st Edition
    • Karl Kadish + 2 more
    • English

  • Chemistry and Biology

    • 1st Edition
    • Volume 53
    • English
    Alkaloids are a major group of natural products derived from a wide variety of organisms, which are used as medicinal and biological agents. This series is world-renowned as the leading compilation of current reviews of this vast field.Internationall... acclaimed for more than forty years, The Alkaloids , founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • Advances in Physical Organic Chemistry

    Cumulative Subject and Author Indexes for Part 2
    • 1st Edition
    • Volume 34
    • English
    The objective of the serial is to present considered reviews on the quantitative study of organic compounds and their behavior--physical organic chemistry in its broadest sense--in a manner accessible to a general readership.

  • Advances in Physical Organic Chemistry

    Cumulative Subject and Author Indexes for Part 1
    • 1st Edition
    • Volume 33
    • English
    The objective of this serial is to present considered reviews on the quantitative study of organic compounds and their behavior--physical organic chemistry in its broadest sense--in a manner accessible to a general readership.

  • Annual Reports in Organic Synthesis 1999

    • 1st Edition
    • English
    One of the more difficult problems facing chemists today is that of "keeping up with the literature." Thus, an organized annual review of synthetically useful information would prove beneficial to nearly all organic chemists, both specialists and non-specialists in synthesis. Weintraub et al. are very successful in creating such an original review.

  • Progress in Heterocyclic Chemistry

    A Critical Review of the 1998 Literature Preceded by Two Chapters on Current Heterocyclic Topics
    • 1st Edition
    • Volume 11
    • G.W. Gribble + 1 more
    • English
    This volume of Progress in Heterocyclic Chemistry (PHC) is the eleventh annual review of the literature, covering the work published on most of the important heterocyclic ring systems during 1998, with inclusions of earlier materials as appropriate. In addition, this year there are three specialized reviews. Martine Demeunynck and Arnaud Tatibouët present recent chemistry of Tröger's Base in Chapter 1. Pedro Merino reviews the reactions of metalated heterocycles with carbonyl compounds in Chapter 2. John Joule summarizes the remarkable nucleophilic substitution chemistry on the indole five-membered ring in Chapter 3. The subsequent chapters deal with recent advances in the field of heterocyclic chemistry arranged by increasing ring size and with emphasis on synthesis and reactions. Due to the ever increasing amount of material to be surveyed, the authors were encouraged to provide selective and critical reviews of the more significant papers where space does not allow comprehensive coverage.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 74
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight to yield an understanding of how the chemistry drives the properties.Degenerat... ring transformations of heterocycles are classified as reactions in which a heterocyclic system is converted into the same heterocyclic system. This monograph covers an authoritative, comprehensive overview of a host of degenerate ring transformations in five- and six-membered heterocycles. It shows how by the use of 15N-labeled, 13C-labeled, or selectively substituted compounds these degenerate rign transformations can be discovered and how most of the results can be explained by the Addition Nucleophile, Ring Opening, and Ring Closure [ANRORC] mechanism. Another main topic of the monograph is the occurrence of degenerate ring transformations.

  • Heterogeneous Catalysis in Organic Chemistry

    • 1st Edition
    • Gerard V. Smith + 1 more
    • English
    The features of this book which will be of special interest to academic organic chemists are the introduction (Chapter 1), which presents a short course on the concepts and language of heterogeneous catalysis, covers organic reaction mechanisms of hydrogenation (Chapter 2), hydrogenolysis (Chapter 4), and oxidation (Chapter 6), a presents problems and solutions specific for running heterogeneous catalytic organic reactions in solution. These materials can supplement advanced chemistry courses. Most synthetic organic chemists use a variety of "protecting groups" which they attach to functional groups (reactive groups of atoms) while some reaction is being conducted on another part of the molecule. These protecting groups prevent reactions of the functional groups during other reactions and are removed later by a heterogeneous catalytic method called hydrogenolysis. One unique feature of this book, not found in other books on catalysis, is an exhaustive chapter (Chapter 4) on hydrogenolysis, which is dredged from the recent synthetic literature published by modern organic chemists. Academic organic chemists should find this chapter extremely useful and may wish to adopt the book as a supplement for advanced organic chemistry courses designed for seniors and for graduate students. It will also be useful for professors and their research groups engaged in synthetic organic chemistry. Many academic organic chemists are not aware of recent advances in heterogeneous enantioselective catalysis (Chapter 3) or in selective low temperature, liquid phase heterogeneous catalytic oxidations by hydrogen peroxide (Chapter 6). These specialty topics are timely and may be new to academic organic chemists and can be used to supplement their advanced courses. Several features of this book will also be of special interest to industrial chemists who are unfamiliar with heterogeneous catalysis. Many good organic chemists are hire by industry. They synthesize a new compound using standard organic synthetic techniques but are informed by their supervisor that they must convert some of their synthetic steps into heterogeneous catalytic steps. They may not have been exposed to heterogeneous catalysis and have few places to turn. This book offers them a crash course in heterogeneous catalysis as well as many examples of reactions and conditions with which they can start their search. Those industrial organic chemists already familiar with heterogeneous catalysis will find this book useful as a reference to many examples in the recent literature. They will find recent surface science discoveries correlated with heterogeneous catalysis or organic reactions and mechanistic suggestions designed to stimulate innovative nontraditional thinking about organic reactions on surfaces.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 32
    • English
    Volume 32 is proof again of the platform provided by Advances in Physical Organic Chemistry for some of the most interesting and diverse papers being produced today. Contributions by academic and industrial chemists give the volume a perspective useful to those working in both fields.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 73
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and most biological scientists. Written by established authorities in the field, the comprehensive review combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Alkaloids: Chemical and Biological Perspectives

    • 1st Edition
    • Volume 13
    • S.W. Pelletier
    • English
    Volume 13 of this series presents five timely reviews of research on alkaloids such as new developments in the chemistry and biology of alkaloids from amphibian skins. It provides a synopsis and tabulation of the hundreds of alkaloids that have been detected, with an emphasis on occurrence, structure, dietary origins, and biological activity. Alkaloids containing the 1, 2, 3, 3a, 8, 8a - hexahydropyrrolo [2,3b] indole ring system and the cyclotryptamines are discussed. An exhaustive list of available structures is provided. The chemical and biological structures have been evaluated critically so as to identify existing errors and expose irregularities in appearance or biological function. In addition, attention is drawn to the possible implications of the accumulated knowledge related to the synthesis, occurrence, and biochemistry of this class of alkaloids.Recent work on alkaloids containing the comparatively non – basic pyrrole ring system is summarized. One of the chapters covers isolation, structure elucidation, biological activity, and selected chemical syntheses of certain pyrrole alkaloids.Recent developments in the chemistry of diterpenoid and norditerpenoid alkaloids occurring in Aconitum, Delphinium and Consolida genera of the Ranunculaceae family used in Chinese and Indian medicine are surveyed and the book ends with a focus on transition metal – catalyzed carbonylations as efficient and novel approaches to the construction of piperidine, izidine and quinazoline alkaloids, which occur in great numbers in nature.

  • Advances in Medicinal Chemistry

    • 1st Edition
    • Volume 4
    • B.E. Maryanoff + 1 more
    • English
    Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

  • Advances in Asymmetric Synthesis

    • 1st Edition
    • Volume 3
    • Alfred Hassner
    • English
    Enantioselective synthetic methods are not only in the forefront of chemical and pharmaceutical research but activity in this area is constantly increasing. It is stimulated by the urgency to obtain drugs or compounds of medicinal interest as single anantiomers, and the keeness to synthesize natural products in nonracemic form. This volume presents seven chapters from pioneers and authorities in this rapidly expanding field.

  • Blood Substitutes, Present and Future Perspectives

    • 1st Edition
    • E. Tsuchida
    • English
    This book contains the selected papers presented at the seventh International Symposium on Blood Substitutes (7th ISBS) held at the International Conference Center of Waseda University in Tokyo on 7-10 September 1997. In keeping with the scientific design of the 7th ISBS Symposium, chapters have been carefully selected and organized to showcase the advancements in recent research. This book includes up-to-date clinical results of leading companies which are manufacturing hemoglobin-based or fluorocarbon-based blood substitutes, and covers issues of hemoglobin toxicity and side effects such as vasoconstriction in more detail using carefully designed in vivo and ex vivo techniques. This book is also a collection of various new types of red cell substitutes such as recombinant Hbs, recombinant albumine-lipidheme complex, modified red blood cells, and perfluorochemicals using material science and molecular engineering.

  • Studies in Natural Products Chemistry

    Structure and Chemistry (Part F)
    • 1st Edition
    • Volume 20
    • Atta-ur Rahman
    • English
    Natural Products Chemistry continues to grow at an increasing pace and this growth is reflected in the present volume of Studies in Natural Products Chemistry, which is the 20th of this series. The first 20 volumes were largely devoted to structure and synthesis of various classes of natural products, irrespective of their bioactivity. Subsequent volumes of this series will however be devoted to the chemistry of bioactive natural products and will therefore a departure from the earlier volumes.The present volume contains contributions from a number of eminent scientists and covers interesting reviews on terpenes, alkaloids and other types of natural products reported from terrestrial and marine sources. Comprehensive indexes covering all the 20 volumes have been prepared which include a Cumulative General Subject Index along with more focused Cumulative Indices on Organic Synthesis, Pharmacological Activity and Biological Source. This comprehensive indexing of the volumes should make the entire series much more valuable and user-friendly.

  • Progress in Heterocyclic Chemistry

    A Critical Review of the 1997 Literature Preceded by Two Chapters on Current Heterocyclic Topics
    • 1st Edition
    • Volume 10
    • G.W. Gribble + 1 more
    • English
    Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). The volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of interest to heterocyclic chemists.The highlight chapters in Volume 10 are all written by leading researchers in their field and these chapters constitute a systematic survey of the important original material reported in the literature on heterocyclic chemistry in 1997. Additional articles in this volume also review "The Synthesis of Chlorins, Bacteriochlorins, Isobacteriochlorins" and "Higher Reduced Porphyrins and Heterocyclic ortho-Quinodimethane... with previous volumes in the series, Volume 10 will enable academic and industrial chemistry and advanced students to keep abreast of developments in heterocyclic chemistry in an effortless way.

  • Designer Drugs Directory

    • 1st Edition
    • K. Valter + 1 more
    • J-C. Landry
    • English
    This book is intended to serve as quick reference handbook on so-called designer drugs. These new, mainly synthetic compounds are also often referred to as analogues of controlled substances. This new work provides a unique directory of 104 designer drugs. This class of drugs is rapidly growing in variety and number of compounds. Although identification, toxicology and other properties have been thoroughly investigated, their analogues and derivatives remain poorly documented. This book fills the gap.Data which is available is often contradictory and confused. This directory provides a critical treatment of the subject which is thoroughly indexed including both the subject index and an index listing more that 230 street names of the described designer drugs.Divided into two parts; the first section describes aspects of designer drug manufacture, new abuse trends, sources of information and terminology. The second, descriptive part, classifies the drugs into ten main categories according to their chemical structure and prevalent pharmacological action. A separate chapter is devoted to each category, followed by a set of corresponding data sheets, street names and eventual synonyms, Toxicological data, short notes on the history of drugs as well as the most pertinent bibliographic references are included.

  • Ligand Coupling Reactions with Heteroatomic Compounds

    • 1st Edition
    • Volume 18
    • English
    The whole field of ligand coupling has only emerged in the last decade as a basis for new synthetic transformations. As Professor Finet shows in this comprehensive survey, the recent clarification of reaction mechanisms of ligand coupling process around heteroatom centres, now provides an understanding of these reactions which are certain to permit their application in organic synthesis, thereby achieving transformations which are quite difficult to achieve by other methods. This book provides in a thorough and scholarly way, a balanced coverage of the whole field.

  • Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries

    • 1st Edition
    • Volume 17
    • D. Obrecht + 1 more
    • English
    The words "Combinatorial Chemistry" have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, and even inorganic solids. All of these activities have in common an attempt to expand the diversity of structure available to the chemist as well as the access to this diversity, permitting the discovery of new and valuable biological acid material properties. In this outstanding survey of combinatorial organic chemistry, the authors, Obrecht who has established a new combinatorial chemistry company called Polyphor, and Villalgardo have brought together the literature, including that from 1998, and have concisely analysed the applications and achievements of this new field. This work will be of value to all chemists engaged in preparative work, both in industry and academe.

  • Brassinosteroids

    A New Class of Plant Hormones
    • 1st Edition
    • V. A. Khripach + 2 more
    • English
    Plants possess the ability to biosynthesize a large variety of steroids, but it was not until 1979 that a hormonal function was demonstrated in plants. Today, about 40 structurally and functionally related steroids, known as brassinosteroids, have been isolated from natural sources. Brassinosteroids demonstrate various kinds of regulatory activities in the growth and development of plants. This book is based on a 1990 Russian monograph, but includes all important subsequent literature and developments, including unpublished data from the authors' laboratories.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 72
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Chemistry and Biology

    • 1st Edition
    • Volume 52
    • English
    Alkaloids are a major group of natural products derived from a variety of organisms, which are widely used as medicinal and biological agents. This Series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 33
    • David Robertson + 5 more
    • English
    Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 31
    • English
    The objective of the serial is to present considered reviews on the quantitative study of organic compounds and their behavior--physical organic chemistry in its broadest sense--in a manner accessible to a general readership.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 53
    • English
    This volume is one of a series providing critical articles by research specialists in the industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology.

  • Starch: Basic Science to Biotechnology

    • 1st Edition
    • Volume 41
    • English
    This volume presents the physiological and biochemical aspects of storage carbohydrates, or starch granules, in plants. This up-to-date and thorough resource carefully integrates fundamental knowledge with the most recent information on the starch granule. It discusses the chemistry of the starch granule and the biochemistry, molecular biology, plant physiology, and genetics of plant starch synthesis. The books also describes the implications of these studies for theseed, biotechnology, and modified starch industries.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 71
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

  • Advances in Carbene Chemistry, Volume 2

    • 1st Edition
    • U.H. Brinker
    • English
    Beginning as chemical curiosities, carbenes are now solidly established as reactive intermediates with fascinating and productive research areas of their own. Five decades of divalent carbon chemistry have provided us with a vast repertoire of new, unusual and surprising reactions. Some of those reactions, once classified as exotic, have become standard methods in organic synthesis. These highly reactive carbene species have been harnessed and put to work to achieve difficult synthetic tasks that other reactive intermediates cannot easily perform. The fruitful relationship between experiment and theory has pushed carbene chemistry further toward the direction of reaction control; that is, regio- and stereoselectivity in intra- and intermolecular addition and insertion reactions. The interplay between experiment and modern spectroscopy has led to the characterisation of many carbenes that are crucial to both an understanding and a further development of this field. Understanding of carbene chemistry has advanced dramatically, especially in the last decade, and new developments continue to emerge. Some of the recent exciting findings have been collected in the first volume of Advances in Carbene Chemistry. With this second volume, the series will continue to provide a periodic coverage of carbene chemistry in its broadest sense - leading into the next century.

  • Alkaloids: Chemical and Biological Perspectives

    • 1st Edition
    • Volume 12
    • S.W. Pelletier
    • English
    Acronycine, a potent antitumor agent, was discovered in the bark of the small Australian Rutaceous tree, Acronychia baueri Schott. This new work presents a comprehensive survey of the isolation, structure determination, methods of synthesis, and the biological properties of acronycine, as well as an account of natural and synthetic analogues of acronycine, and their biological properties.Solanum alkaloids were reviewed in 1990 and this book surveys the new developments (isolation procedures, structural elucidation methods) and critically updates earlier reviews. In addition it presents the interesting chemistry and synthesis of cyclopeptide alkaloids. These cyclopeptide alkaloids have been isolated from ascidians, sea hares, and cyanobacteria. Also included are reviews of the use of the functionalized lactam, pyroglutamic acid, as a chiral template for the synthesis of alkaloids. The second review examines the on-line coupling of capillary electrophoresis (CE) and mass spectrometry (MS) for the analysis of alkaloid mixtures. Finally a review of oxygenated analogs of the alkaloid Marcfortine for their potent antiparasitic activity is included at the end of this work. Each chapter in this volume has been reviewed by at least one expert in the field. Indexes for both subjects and organisms are provided.

  • Advances in Catalysis

    • 1st Edition
    • Volume 42
    • English
    Since 1948, this Series has filled the gap between the papers that report and the textbooks that teach in the diverse areas of catalysis research. The editors of and contributors to Advances in Catalysis are dedicated to recording progress in this area. Each volume of Advances in Catalysis contains articles covering a subject of broad interest.

  • Chemistry and Biology

    • 1st Edition
    • Volume 51
    • English
    Chemistry and Biology is a celebration of the outstanding contributions to the field by Professor R.H.F. Manske, who founded the series in 1950. This special volume demonstrates the dramatic changes in alkaloidchemistry since then. It also offers a unique overview of recent developments in major areas of alkaloid chemistry and biology and looks at how these areas will develop in the future. These fourteen contributions are written by many of the leading alkaloid chemists in the world, and thus comprise a unique view of alkaloids and their contributions to the health and well-being of humankind.

  • The Combinatorial Index

    • 1st Edition
    • Barry A. Bunin
    • English
    With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity.

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