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Elsevier

Books in Life sciences

  • Molecular Mechanisms of Cancer Resistance

    Emerging Technologies and Therapeutic Strategies
    • 1st Edition
    • Ahmet Acar
    • English
    Molecular Mechanisms of Cancer Resistance: Emerging Technologies and Therapeutic Strategies explores innovative tools and strategies designed to address the critical issue of drug resistance in cancer treatment. This comprehensive volume is tailored for researchers, clinicians, and students, offering insights into the latest advancements and methodologies in the field. The book covers essential topics such as molecular mechanisms of drug resistance, the tumor microenvironment, and emerging technologies like single-cell analysis and computational modeling. Each chapter features contributions from leading experts, providing a multi-dimensional perspective on both foundational concepts and cutting-edge research.By engaging with this book, the academic audience gains access to groundbreaking research and therapeutic strategies that enhance understanding and practice. The knowledge acquired will inspire collaboration and innovation, ultimately contributing to more effective and personalized cancer treatment approaches.

  • The Brain Histaminergic System in Health and Disease

    • 1st Edition
    • Zhong Chen + 2 more
    • English
    Histamines in Neurology and Psychiatry summarizes histamines and their impact on neuroinflammation and brain development in key neural circuits. This book presents the latest research on the physiological regulation of a neuroendocrine responses and releases, broadly discussing histamine receptor modulators and histamine effects in neurology and psychiatry, and also including clinical applications that will be of interest to practitioners.

  • Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine

    • 1st Edition
    • Cheng Xue + 3 more
    • English
    Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine biomarkers, providing invaluable insights for clinicians, researchers, and healthcare professionals. From historical perspectives to cutting-edge technologies, this reference presents an updated understanding of urine biomarkers' role across diverse bodily systems. With sections devoted to fundamental concepts, molecular signatures, and clinical applications, readers gain a deep understanding of urine biomarkers' significance in disease diagnosis and personalized medicine.Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.

  • Pediatric Gastroenterological Diagnosis

    A Diagnostic Primer
    • 1st Edition
    • Richard Thomas Lee Couper
    • English
    Pediatric Gastroenterological Diagnosis: A Diagnostic Primer focuses on the theoretical aspects of diagnosing pediatric gastroenterology diseases, including historical and current information. Sections cover pediatric gastroenterology diseases and provide practical advice for quick and accurate diagnosis. In addition, the book provides multiple pediatric tables and references, as well as brief clinical vignettes that identify potential pitfalls clinicians may encounter. This is the perfect reference for clinicians who struggle with complex diagnosis and problem-solving, and will be ideal for pediatric gastroenterology trainees and pediatric gastroenterologists.

  • Nutritional Treatments for Liver Disease

    The Effects of Food and Plants
    • 1st Edition
    • Erika Ramos-Tovar + 1 more
    • English
    Nutritional Treatments for Liver Disease: The Effects of Food and Plants offers an essential, comprehensive guide to leveraging nutritional science in the prevention and treatment of liver diseases. Authored by leading research experts in the fields of experimental liver disease and the effects of herbal compounds, and the pathophysiology and pharmacology of liver diseases, this volume synthesizes cutting-edge research on the therapeutic efficacy of functional foods, medicinal plants, vitamins, and gut microbiota modulation for hepatic disorders. Liver diseases represent a significant global health burden with limited pharmacological options. Nutritional Treatments for Liver Disease: The Effects of Food and Plants addresses this gap by detailing the cellular and molecular mechanisms through which natural and synthetic nutritional compounds exert protective, anti-inflammatory, antifibrotic, and antiviral effects on the liver. Topics include the epidemiology of liver diseases, malnutrition complications, and the role of key bioactive compounds such as silymarin, curcumin, quercetin, coffee, and various vitamins. Designed for researchers, clinicians, nutritionists, and students alike, this authoritative resource combines scientific rigor with practical insights to foster advanced understanding and inspire novel therapeutic strategies in liver disease management.

  • Current Advances in Cancer Stem Cells and Neoplasia Research

    • 1st Edition
    • Hirendra Banerjee
    • English
    "Cancer, Volume 8" in the "Stem Cell Innovation in Health and Disease" series explores the rapidly evolving role of stem cells in cancer treatment. As cancer continues to impose a heavy global health burden, stem cell therapies are being recognized for their regenerative potential and ability to enhance recovery following aggressive therapies. Hematopoietic stem cell (HSC) transplantation is already a standard, FDA-approved treatment for hematologic cancers such as leukemia, myeloma, and lymphoma. These cells help regenerate healthy blood cells post-treatment. In addition, mesenchymal stem cells (MSCs) and neural stem cells (NSCs) are showing promise in preclinical models as therapeutic carriers, capable of homing to tumor sites and delivering anti-cancer agents such as nanoparticles, siRNAs, and small-molecule drugs. Recent clinical advancements include differentiation therapy, where stem cells are used to induce cancer cells to become non-cancerous. Two completed phase I clinical trials have demonstrated innovative applications: one using NSCs to convert a prodrug into a toxic compound within tumors, and another using MSCs engineered with viral enzymes to activate cytotoxic drugs directly at the tumor site. MSCs have also helped reduce graft-versus-host disease (GVHD), a major complication of stem cell transplants. This volume is divided into two main sections: understanding stem cell roles in cancer biology, and translating stem cell innovations into clinical practice. It features cutting-edge research, including organoid models, genetic editing, and iPSC technologies. Together, these insights offer a timely review of the field’s progress and its real-world potential to reshape cancer therapy.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 136
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advanced and Sustainable Biotechnologies from Fungi

    Functional Foods and Nutraceutical Production
    • 1st Edition
    • Pragya Tiwari + 1 more
    • English
    Advanced and Sustainable Biotechnologies from Fungi: Functional Foods and Nutraceutical Production provides insights into existing and emerging fungal biotechnologies, along with advances in high-throughput technologies to enhance the sustainable production of bio-based functional foods and nutraceuticals of fungal origin. Focusing on the emerging, global concern of hunger and malnutrition, this book explains how fungi-based biotechnologies offer prospective solutions to address the global food shortage using functional foods and nutraceuticals. Chapters cover the major portion of novel sources and various biotechnological approaches used for the production of functional foods and nutraceuticals from microorganisms and mushrooms and their applications in the industry. In addition, the book includes the existing and emerging biotechnological trends and approaches in enhanced production of Functional food and Nutraceuticals of fungal origin, such as Omics-guided advances, computational strategies, and biotechnological tools. 3D printed fungal food products, and social, ethical, and regulatory aspects of functional food and nutraceutical products are also discussed. Authored by a team of experts in the field of fungi biotechnology, this book serves as a reference material for food microbiologists, food scientists, and pharmaceutical professionals for the development of new functional foods and nutraceuticals.

  • AI-Driven Plant Science

    Advancing Crop Performance Through Omics Integration and Physiology
    • 1st Edition
    • Osamah Shihab Albahrey + 1 more
    • English
    AI-Driven Plant Science: Advancing Crop Performance Through Omics Integration and Physiology offers cutting-edge insights into the rapidly evolving fields of precision agriculture, Artificial Intelligence, plant biotechnology and genetic engineering, and bioinformatics. With a strong focus on applications in smart agriculture, crop improvement, and environmental adaptation, it bridges the gap between advanced research and practical implementation. The rapid advancements in AI and biotechnology have created both opportunities and complexities for the agricultural sector. This book fills a critical gap in the existing literature by providing a multidisciplinary resource that integrates AI, biotechnology, and agricultural science. While there are numerous resources on plant biology and AI individually, few works explore their synergistic potential in depth. This book offers actionable insights into how AI can revolutionize crop physiology, stress tolerance, and plant-based research. It also highlights the challenges and ethical considerations of integrating AI into agricultural practices, ensuring a balanced and forward-thinking perspective. AI-Driven Plant Science: Advancing Crop Performance Through Omics Integration and Physiology provides a definitive guide for researchers, industry professionals, and students seeking to understand and apply AI in plant science and crop production.

  • Biomechanics of the Heart

    From Model to Patient
    • 1st Edition
    • Peter Bovendeerd + 3 more
    • English
    Biomechanics of the Heart: From Model to Patient provides readers with a comprehensive overview of the modeling and assessment of the heart’s biomechanics. The book addresses topics such as the physiology of normal and diseased hearts, cardiovascular imaging, modeling of myocardial tissue in the passive and active states, as well as state-of-the-art approaches for patient specific modeling of the heart’s mechanical function. This is all augmented by case studies and examples of exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases. Readers are introduced to modeling of the heart’s anatomical and muscular structure, a review of imaging techniques to analyze the geometry, content and dynamics of the heart, as well as an in-depth look at the biomechanical properties of normal and diseased hearts. Finally, chapters cover modeling cardiac passive and contractile mechanics, biomechanical finite element simulations of the heart, patient-specific modeling of the heart and circulatory system, as well as the exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases.

  • Advances in Insect Physiology

    • 1st Edition
    • Volume 72
    • English
    Advances in Insect Physiology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Alternative Proteins

    • 1st Edition
    • Volume 155
    • English
    Alternative Proteins, Volume 154 provides a comprehensive overview of alternative proteins, exploring their sources, production technologies, nutritional profiles, and potential to transform the global food system. Covering plant-based, microbial, insect, and cultured (cell-based) proteins, the book examines the scientific advances, market trends, regulatory challenges, and sustainability implications of these innovative protein sources. Chapters in this new release include Introduction to Alternative Proteins, Molecular Properties of Plant-Based Proteins for Alternative Proteins, The Science of Alternative Proteins: Comparing Animal and Plant-Based Sources, Blue Proteins: Marine-Derived Alternatives for Sustainable Nutrition and Climate-Resilient Food Systems, and much more. Additional sections cover Insect Proteins for Alternative Proteins: Sustainable Solutions with Molecular Efficiency, Plant-Based Proteins: Key Sources and Production Methods, Fungal proteins as Eco-friendly Alternate Proteins, Algae and Microbial Proteins for Alternative Proteins: Untapped Molecular Resources, Integrating Siddha Dietary Principles with Alternative Protein Systems: A Pathway Toward Sustainable and Functional Nutrition, Alternative Proteins: Structure and Functional Properties, and a variety of extensive and timely topics.

  • Genetic Advances in Inborn Errors of Immunity

    • 1st Edition
    • Volume 117
    • English
    Genetic advances in inborn errors of immunity, published as Volume 117 of the serial Advances in Genetics, provides a comprehensive and up‑to‑date overview of the rapidly evolving genetic landscape underlying inborn errors of immunity (IEI). Bringing together authoritative contributions from leading experts, this volume examines how advances in genomics, molecular diagnostics, and functional immunology have transformed the understanding, classification, and clinical management of primary immunodeficiency disorders. The chapters span severe monogenic conditions to complex, polygenic phenotypes, highlighting both mechanistic insights and translational implications. Collectively, the volume serves as an essential reference for researchers and clinicians seeking to understand how genetic discoveries are reshaping immunology and precision medicine.

  • Thiamine Pyrophosphate (TPP)-Dependent Enzymes

    • 1st Edition
    • Volume 736
    • English
    Thiamine Pyrophosphate (TPP)-Dependent Enzymes, Volume 736 in the Methods in Enzymology series covers this diverse group of ubiquitous enzymes with timely chapters on Methods for Studying ThDP-dependent Mycobacterial MenDs (SEPHCHC Synthases), Mammalian 2-hydroxyacyl-CoA lyases, discovery and assays, Anti-infective target 1-deoxy-d-xylulose-5... synthase (DXS) and drug design for enzyme inhibition, Expression, Purification, and Mechanistic Studies of DXP synthases from Deinococcus radiodurans, Plasmodium falciparum, and Plasmodium vivax, Comparison of the catalysis of ThPP-dependent enzymes AHAS, ALS, and DXS, and much more.Additional sections cover Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis, Biochemical and Structural characterization of novel ‘split-gene’ archeal transketolases, 4-Hydroxybenzoylform... decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5: characterization and involvement in bacterial lignin degradation, Engineering of phosphoketolase from Bifidobacterium adolescentis for increased activity on non-phosphorylated substrates and application in a cell-free reaction system for ATP regeneration, Repurposing TPP-dependent enzymes with anodic oxidation for the conversion of aldehydes to enantioenriched carboxylic acids, and much more.

  • Technology-Assisted Physical Gait Rehabilitation

    How Robotics, Data Science, and Neuroscience are Changing Modern Physical Therapy
    • 1st Edition
    • Tomislav Baček + 3 more
    • English
    Technology-Assisted Physical Gait Rehabilitation: How Robotics, Data Science, and Neuroscience are Changing Modern Physical Therapy explores computational modeling techniques, robotic assistance, data science, and other technological tools and how they can be jointly used in driving and guiding physical gait therapy in impairments such as stroke, traumatic brain injury, and incomplete spinal cord injury. This book gathers experts in robotics, human biomechanics, physical therapy, neuroscience, engineering, and medicine, presenting their ongoing work and discusses their views of the future direction of technology-assisted gait therapy, showcasing the latest advancements in the interdisciplinary and multidisciplinary field of technology-assisted gait therapy and strives to outline the developments in the coming years that are needed/likely to make the next big breakthrough in the field.

  • Diagnosis and Treatment of Infectious Diseases

    • 1st Edition
    • Saeed Soleiman Meigooni
    • English
    Diagnosis and Treatment of Infectious Diseases summarizes practical content in infectious diseases using keys topics for better coding and grasping of material. The book's author uses his experience from over 15 years of teaching and working in infectious diseases in more than ten hospitals with thousands of patients as a backdrop. All of its contents use a clinical perspective for a wide range of audiences, such as medical students, general practitioners, nurses, and others. As infectious diseases are among the most common diseases, and a cause of death in many societies, they can create health challenges in developed and developing countries.Medical students have a limited time for infectious diseases rotation in their curriculum and may not learn many infectious diseases syndromes during their entire medical course. Also, due to the high volume of infectious disease subjects in textbooks which overlap symptoms and signs of many microorganisms, they may forget some of the materials. Therefore, access to a comprehensive compact book such as this one seems necessary for any medical staff.

  • Diabetic Neuropathy

    • 1st Edition
    • Shahidul Islam
    • English
    "Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.

  • The Human Nervous System

    • 4th Edition
    • George Paxinos + 2 more
    • English
    The 4th Edition of the classic book The Human Nervous System continues to assemble contributions from world leaders in research on the brain, spinal cord and peripheral nervous system. This book has been edited by the best-known team of brain cartographers, and it has been completely revised to present the cutting edge of human neuroscience. The structure, connections and function are explained in depth, making this book essential to any student or scientist interested in brain anatomy and function.

  • Lysosomal Pathophysiology of Parkinson’s Disease

    • 1st Edition
    • Mattia Volta + 1 more
    • English
    Lysosomal Pathophysiology of Parkinson’s Disease delves into the genetic and genomic revelations that have transformed our understanding of Parkinson’s Disease at the molecular level. The book highlights the critical role of the autophagy-lysosome pathway in the disease's pathogenic processes, drawing a comprehensive timeline of disease onset and progression. It offers a detailed examination of how disruptions in this pathway contribute to the hallmarks of Parkinson’s Disease, providing invaluable insights for researchers and clinicians alike. Subsequent chapters extend these insights by comparing Parkinson’s Disease to other neurodegenerative disorders such as Alzheimer’s Disease and Frontotemporal Dementia. By exploring protein pathology and synaptic alterations, the book underscores the broader implications of autophagy-lysosome dysfunction. Additionally, it discusses how the molecular perspectives gleaned from Parkinson’s Disease can inform our understanding of these other conditions, presenting a unified approach to studying neurodegeneration.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Andrew Vinard + 2 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Insect Pathology

    • 3rd Edition
    • Nemat Keyhani + 2 more
    • English
    Insect Pathology, Third Edition offers the most comprehensive research on the topic of insect pathology, spanning the diversity of insects with a more diverse array of microbes. This book provides a full update on new approaches for studying the genetics, development, evolution, and ecology of insect pathogens. Written by leading researchers and experts, the book includes coverage of revolutionary genome editing tools, such as CRISPR-Cas9, which have been developed for multiple insect pathogen systems and provides insights into the molecular underpinnings of insect pathogens and their hosts. This book also updates modern molecular techniques, “omics” approaches, and newly applied findings. These new and revised topics are critical for understanding current perspectives in the field, making this book a needed reference for insect pathologists, entomologists, microbiologists, mycologists, nematologists, protistologists, ecologists, and practitioners of biological control of insect pests. New and long-time students of insect pathology will also find this new edition useful.

  • Principles of Antiviral Drug Development

    Rapid Discovery Technologies and Practical Applications
    • 1st Edition
    • Ailin Liu
    • English
    Principles of Antiviral Drug Development: Rapid Discovery Technologies and Practical Applications systematically integrates the major experimental techniques and virtual drug screening methods involved in the discovery of antiviral drugs, and provides a detailed discussion of their applications: among them, the combination of virtual drug screening technologies coupled with experimental methods offers strong potential for the rapid discovery of antiviral agents. The book also discusses activity-guided extraction, isolation, and activity evaluation of active components in order to reveal the material basis of antiviral activity and preliminary mechanisms of action. The book also discusses: drug repurposing of approved medicines; and an analysis of the discovery and mechanistic studies of a series of antiviral natural products which offer important information on the needs of future research, development, together with the clinical application of new antiviral drugs.

  • Gold Nanoparticle Therapeutics in Alzheimer's Disease

    Revolutionizing Diagnosis and Treatment
    • 1st Edition
    • Arun Kumar Singh + 2 more
    • English
    Gold Nanoparticle Therapeutics in Alzheimer's Disease: Revolutionizing Diagnosis and Treatment is an essential resource that delves into the groundbreaking use of nanotechnology in the fight against one of the most challenging neurodegenerative disorders. This volume offers an in-depth exploration on how gold nanoparticles can be used to enhance the diagnosis, treatment, and overall understanding of Alzheimer's disease. By examining the molecular mechanisms that enable nanoparticles to cross the blood-brain barrier, the book highlights their role in inhibiting amyloid fibrils and their potential as precise diagnostic tools.Covering a wide range of topics, this comprehensive guide serves as an invaluable reference for researchers, clinicians, and industry professionals at the forefront of Alzheimer's research and nanomedicine.

  • Dry Eye Disease

    A Clinical Handbook
    • 1st Edition
    • James Stuart William Wolffsohn + 2 more
    • English
    Dry Eye Disease: A Clinical Handbook illuminates the translation of cutting-edge research on dry eye disease into practical situations, allowing clinical diagnosis and management of the condition using the latest evidence-based methods. It first presents research on the core pathophysiological features of dry eye disease, including tear film instability, hyperosmolarity, inflammation, and ocular surface damage. Thereafter, it champions a patient-centered approach to dry eye management, emphasizing the necessity of classifying the ocular surface disease(s) most relevant to each case. It discusses global disease distribution and the role of non-modifiable risk factors like age, sex, and ethnicity. Additionally, the book describes tools for monitoring symptoms over time and assessing subtle signs of the disease. Readers will find practical methods for improving patient outcomes both in clinical settings and at home.

  • Blood-Based Biomarkers for Alzheimers and Parkinsons Disease

    • 1st Edition
    • Volume 191
    • English
    Blood-Based Biomarkers for Alzheimer’s and Parkinson’s Disease, Volume 191 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on the development and application of circulating biomarkers in neurodegenerative disorders. It brings together contributions from an international panel, highlighting emerging strategies for early detection, diagnosis, and monitoring of Alzheimer’s and Parkinson’s diseases. Chapters explore a wide range of topics, including the Diagnostic Potential of Exosomes in Neurodegenerative Diseases and Cancer, Blood Biomarkers of Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s and Parkinson’s Diseases, GFAP and the Genetic Code of Astrocyte Activation in Alzheimer’s Disease, and much more.Additional chapters cover Blood-Based Emerging Biomarkers in Early Detection and Diagnosis of Alzheimer’s Disease, Advances in Nanomaterial-Based Biomarker Detection for Neurodegenerative Diseases, Blood-Based Biomarkers in Alzheimer’s and Parkinson’s Disease: From Molecular Pathology to Therapeutic Potential, Blood-Based Biomarkers and Their Role in AD/PD Diagnosis, The Emerging Landscape of Circulatory Biomarkers in Alzheimer’s Disease, Biofluid-Based Biosensors, Biomarkers of Vascular Dementia and Alzheimer’s Disease, Silent Clues in Blood: Proteomic Approach for Alzheimer’s Disease, and more.

  • Sleep Neurology

    • 1st Edition
    • Anne Marie Morse
    • English
    Sleep Neurology explores the intricate relationship between sleep and neurological health, bridging the gap between theoretical knowledge and practical application. This comprehensive reference highlights the role of sleep in overall health and provides an examination of how sleep influences a wide range of neurological disorders. From neurodevelopmental issues to neurodegenerative diseases, this book offers a detailed review of how sleep science can be applied to improve patient outcomes in various neurological conditions. Structured around key neurological topics, the book offers insights into conditions such as epilepsy, stroke, and traumatic brain injury, emphasizing the importance of sleep management in their treatment. Each chapter not only discusses the scientific underpinnings of sleep but also provides tangible strategies for integrating sleep health into primary neurological care.

  • Personalized Cancer Medicine through Multiomics

    • 1st Edition
    • Mohammad Azhar Aziz + 1 more
    • English
    Personalized Cancer Medicine through Multiomics explores the integration of multiomics to transform cancer diagnosis and treatment. The book delves into how the convergence of genomics, transcriptomics, proteomics, and metabolomics offers a comprehensive understanding of cancer biology, surpassing traditional single-omics approaches. Sections detail advancements in high-throughput technologies and computational methods, including machine learning, that enable the analysis of complex cancer datasets. Additional content discusses how multiomics identifies unique molecular signatures, novel therapeutic targets, and biomarkers, facilitating precise and individualized treatment strategies, particularly for a heterogeneous cancers.For academics, this book serves as an essential resource, compiling fragmented research into a single, coherent volume. It provides foundational knowledge, the latest advancements, and practical applications of multiomics in personalized medicine. Researchers will benefit from interdisciplinary approaches, real-world examples, and cutting-edge methodologies, making it an invaluable reference for advancing their work in oncology.

  • Electrocardiography of Laboratory Animals

    • 3rd Edition
    • Meg M. Sleeper + 1 more
    • English
    Electrocardiography of Laboratory Animals, Third Edition, provides the latest information on critical topics such as safety electrocardiography, toxicology, safety pharmacology, and telemetry, ensuring that readers are well-equipped with the knowledge required for accurate ECG interpretation in preclinical studies. The book begins with the fundamental principles of electrocardiography and its applications in drug safety evaluation but then covers electrocardiography in a wide range of laboratory animals, including rodents, guinea pigs, rabbits, cats, dogs, and various non-human primates such as marmosets, cynomolgus monkeys, rhesus monkeys, baboons, and chimpanzees.Addition... it reviews the ECG characteristics of minipigs, nanopigs, and micropigs. The text also includes chapters on telemetry and echocardiography in preclinical safety studies, as well as discussions on important parameters like PR (PQ), QRS, and QT intervals. The book concludes with chapters on cardiac assays, biomarkers, stem cells, and cardiovascular medical devices, providing a holistic view of cardiovascular research. It is an essential resource for biological and medical researchers, veterinarians, zoologists, and students.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1st Edition
    • Volume 44
    • English
    Advances in Biomembranes and Lipid Self-Assembly, Volume 43 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Content in this new release covers Engineered probiotics for producing phosphoinositol-sn-l... as biosurfactant modulators: Their hydropathy, in potentiating surface tension and scaffold properties into model emulsions.

  • Epigenetics and miRNA in Neurodegenerative Diseases

    From Molecular Mechanisms to Clinical Applications
    • 1st Edition
    • Lance R. McMahon + 2 more
    • English
    Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications explores the crucial role of epigenetic modifications and microRNAs in the onset, progression, and treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease. This comprehensive book bridges cutting-edge molecular research with real-world clinical applications, covering biomarker discovery, novel therapeutics, gene editing, and AI-driven bioinformatics. With clear explanations, case studies, and future perspectives, it serves as an essential resource for researchers, clinicians, and biotech professionals working toward innovative solutions for neurodegenerative disease diagnosis and treatment

  • Green Polymeric Materials in Drug Delivery

    Sustainable Solutions for Therapeutic Applications
    • 1st Edition
    • Parteek Prasher + 5 more
    • English
    Green Polymeric Materials in Drug Delivery: Sustainable Solutions for Therapeutic Applications addresses the critical intersection of polymer science, pharmaceutical technology, and environmental sustainability. This reference responds to the urgent need for eco-friendly drug delivery systems that improve therapeutic outcomes while minimizing ecological impact. It offers researchers and professionals a detailed exploration of green polymers derived from renewable sources and their transformative potential in healthcare. The comprehensive contents cover fundamental principles, synthesis, biocompatibility, formulation strategies, and innovative applications including nanomaterials, hydrogels, vesicular systems, and vaccine delivery. Chapters authored by leading experts examine targeted delivery routes such as mucosal, ocular, transdermal, and neural pathways. Regulatory frameworks and clinical trial insights further support translation from research to practice. Emerging technologies like AI-assisted formulation and 3D printing of implants are also discussed. This reference benefits polymer chemists, pharmaceutical scientists, regulatory experts, and clinicians by providing authoritative knowledge on sustainable materials for drug delivery. It equips readers with the scientific foundation and practical case studies necessary to advance green polymeric technologies in therapeutic development, fostering a sustainable future in pharmaceutical innovation and patient care.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 48
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 48, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered include ADRs, ADEs and SEDs: A Bird’s Eye View, Lithium, Drugs of abuse, Side effects of drugs used in the treatment of Alzheimer's disease, Sedatives and hypnotics, Antipsychotic agents, Anti-epileptic Medications, Side effects of opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, Side effects of local anesthetics and therapeutic gases, and more.Other sections covered include Antihistamines (H1 receptor antagonists), Drugs that act on the respiratory tract, Positive inotropic drugs and drugs used in dysrhythmias, Beta adrenergic antagonists and antianginal drugs, Drugs acting on the cerebral and peripheral circulations, Antihypertensive drugs, and much more.

  • Animal Models of Disease Part F

    • 1st Edition
    • Volume 212
    • English
    Animal Models of Disease, Part F, Volume 212 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • The NeuroComplex Interaction of Appetite Regulation

    Brain, Body and Environment
    • 1st Edition
    • Nasrollah Moradikor + 1 more
    • English
    The NeuroComplex Interaction of Appetite Regulation: Brain, Body and Environment presents the latest research on why we eat, what makes us hungry, and how our brain controls our cravings. The book covers the data for how the brain, hormones, and different factors such as stress, the environment, and even food itself affects our desire to eat. Written for academics and researchers, this book helps facilitate a comprehensive understanding on how the brain influences appetite regulation, allowing readers to understand how neurobiological mechanisms can help treat patients involved with obesity, eating disorders, or other related conditions.Readers will find this to be a reliable resource that connects current neuroscience research with practical applications in appetite and behavior.

  • Neurogynecology and Associated Neurological Disorders

    • 1st Edition
    • Vishal Chavda + 2 more
    • English
    Neurogynecology and Associated Neurological Disorders addresses the emerging interdisciplinary field linking neurology and gynecology, focusing on how neurological disorders impact female reproductive health throughout the lifespan. The book covers foundational neuroanatomy, hormonal influences on neurological function, and specific disorders including headaches, epilepsy, pelvic neuropathies, and mental health conditions related to reproductive stages. It includes clinical guidelines, case studies, diagnostic tools, and treatment protocols tailored to hormonal phases and life stages. The integration of neurobiological mechanisms with gynecological considerations offers readers a robust framework for interdisciplinary collaboration.Reader... will find this to be a great reference that responds to the growing clinical need for integrated understanding and management of conditions such as menstrual migraines, pregnancy-related neuropathies, and menopausal neurological changes.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1st Edition
    • Deepak Kumar + 4 more
    • English
    Geostatistical Approaches to Environmental and Public Health Issues discusses how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. The book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, it highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, sections demonstrate how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies.By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty. It bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners.

  • The Metabolon

    • 1st Edition
    • Volume 739
    • English
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Perianal Crohn’s Disease

    Diagnosis and Treatment
    • 1st Edition
    • Bolin Yang + 2 more
    • English
    Perianal Crohn’s Disease: Diagnosis and Treatment includes the latest knowledge, concepts, first-hand theoretical views, and clinical experience of clinical frontline experts in the field of inflammatory bowel disease. The book systematically describes disease phenotypes, clinical features, examination methods, diagnoses, and treatments. It takes a scientific, practical, and systematic account of both common and rare conditions associated with Perianal Crohn’s Disease, offering informative content, clinical case information, cutting-edge viewpoints, and current, authoritative research findings. The book contains a depth of current clinical experience, including the use of photographs to support examples of conditions, methods, and techniques. In addition, it provides clear ideas and a wealth of clinical information for the clinical diagnosis and management of perianal Crohn's disease.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 137
    • English
    Advances in Applied Microbiology presents the latest developments and innovative research in applied microbiology, covering topics such as microbial biotechnology, environmental applications, industrial processes, and medical advancements. It offers valuable insights into the practical uses of microorganisms in solving real-world challenges, making it an essential resource for researchers, professionals, and students in microbiology and related fields.

  • Cell Death Part F

    • 1st Edition
    • Volume 211
    • English
    Cell Death: Part F, Volume 211 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores Methods to Assess BAX Conformation, Activation, Translocation, and Mitochondrial Outer Membrane Permeabilization, Proximity biotin labelling identification of Bcl-2 protein interactions in live cells, Bimolecular fluorescence complementation assays for investigating Bcl-2 family protein interactions, Assessing apoptotic sensitivity in primary mouse B cells by BH3 profiling, Liposome permeabilization assays to monitor pore formation by cell death proteins, Flow Cytometry Assessment of Mitochondrial Membrane Potential, Biomass, and ROS in OXPHOS-Dependent and Glycolytic Cancer Cells during Cell Death Induction, and much more.Additional chapters cover Assessment of Viability Versus Cell Death: What is What?, Flow cytometry-based drug response profiling of primary B-precursor ALL cells in co-culture with bone marrow-derived stromal cells, An in vitro model of efferocytosis in macrophage foam cells to probe lipid-driven dysregulation of dead cell clearance, Measuring tumor cell killing using in vivo bioluminescence imaging, and more.

  • Morbidity Prevention in Aging

    The Role of Salutogenesis Amidst Crises
    • 1st Edition
    • Nestor Asiamah + 3 more
    • English
    Morbidity Prevention in Aging: The Role of Salutogenesis Amidst Crises addresses the urgent need to rethink disease prevention strategies for an aging population. The book begins by exploring how age-friendly environments support health-seeking behaviors. The next section focuses on developing personal skills such as resilience and self-efficacy for maintaining health during crises. Section III examines the reorientation of health services to support preventive care, including community care and diet promotion, while Section IV addresses the creation of policies that facilitate health-promoting interventions and integrate prevention strategies. Community engagement and empowerment in promoting health is emphasized in the fifth section.The book concludes by providing a framework for understanding disease prevention amidst crises, focusing on diverse racial, cultural, and socioeconomic experiences and ensuring equitable opportunities for lifelong disease prevention. This groundbreaking book emphasizes a salutogenic approach that focuses on factors promoting health rather than merely treating diseases. It provides a comprehensive framework for understanding how to maintain health and prevent diseases across the lifespan, even amidst challenges such as wars, climate change, and industrial hazards.

  • Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology

    • 1st Edition
    • Swagat Kumar Das + 2 more
    • English
    Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology delves into historical perspectives, current trends, and future projections for research and development of immunological and biopharmaceutical products. Sections explore immunostimulants, natural and synthetic immunostimulants in aquaculture and animal husbandry, immunomodulators, immune boosters, pre- and probiotics in health promotion, cutting-edge immunological techniques for disease diagnosis, immunotherapy in cancer treatment, and transplantation immunology. Following chapters explore the impact on pharmaceutical biotechnology, with discussions on traditional and modern approaches in drug delivery, in silico drug delivery modeling, biocomposites and their pharmaceutical applications, recent advances in monoclonal antibodies production, vaccine development, and much more. Finally, the book covers the pivotal role of AI, machine learning, and data analytics in the clinical study of immunotherapy and pharmaceutical drugs, thus paving the way for enhanced research and development efficiency. Researchers in industry and academia alike will gain valuable insights into the novel principles behind designing and developing immunological and drug products, making this title an essential resource.

  • Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins

    Insights into Pathogenic Mechanisms
    • 1st Edition
    • Parissa Farnia + 3 more
    • English
    Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins: Insights into Pathogenic Mechanisms explores the structural and functional dynamics of nontuberculous mycobacterium (NTM) proteins, focusing on their roles in pathogenicity, the mechanisms underlying microbial infections, and the potential for developing targeted therapeutic strategies to combat these emerging pathogens. The book begins with a foundational overview of nontuberculous mycobacteria (NTM), distinguishing them from Mycobacterium tuberculosis, their epidemiology, clinical significance, and structural biology. It discusses key structural features of NTM proteins and advanced techniques for protein structure determination, proteomic analyses, and bioinformatics approaches.Additiona... sections investigate the pathogenic mechanisms and the complexities of the host-pathogen interaction. Concluding with insights into emerging research, interdisciplinary collaboration, future treatment, and prevention strategies, this book is a helpful resource for researchers and healthcare professionals engaged in the study of infectious diseases.

  • Drug Discovery

    Traditional Approaches and Advanced Strategies
    • 1st Edition
    • Renren Bai
    • English
    Drug Discovery: Traditional Approaches and Advanced Strategies is a foundational monograph that connects established methodologies, cutting-edge technologies, and the transformative impact of AI and other emerging tools in the drug discovery landscape. Sections provide an overview of drug discovery and development, introducing current trends and the evolving landscape of the field, explore traditional approaches alongside advanced strategies, covering topics such as drug target discovery, lead optimization, and the revolutionary role of artificial intelligence in drug discovery, and investigate promising emerging technologies, including targeted protein degradation and innovative design strategies. Equipping readers with insights into the future of drug development, this is a vital resource for academic and industrial researchers, students, and professionals seeking to stay at the forefront of drug discovery. By integrating traditional methodologies with the latest advancements, this book not only enhances understanding but also inspires innovation. With practical case studies and real-world applications, it empowers researchers to effectively implement new technologies, ultimately improving the efficiency and success rates of their R&D endeavors.

  • Biosimilars in Cancer

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    Biosimilars in Cancer is a comprehensive resource on the role of biosimilars in treating various cancer types. The book offers a succinct yet thorough overview of current trends in oncology, covering 21 different cancers from liver to breast cancer. Chapters provide detailed insights into trends, fundamental facts, and practical and clinical data, making it an invaluable tool for academics and practitioners. The book empowers researchers and clinicians to enhance understanding and improve patient outcomes through the effective use of biosimilars in oncology. Targeted primarily at pharmaceutical researchers, biomedical scientists, and clinicians, it supports the growing oncology biosimilars market.In addition, the book provides critical insights for those involved in cancer diagnostics and clinical trials, helping them stay ahead in this rapidly progressing field.

  • Understanding Molecular Processes using Electrochemical Methods

    • 1st Edition
    • Ashis Kumar Satpati + 1 more
    • English
    Understanding Molecular Processes using Electrochemical Methods offers a detailed compendium of techniques for molecular analysis. The book considers step and sweep techniques, scanning electrochemical microscopy, spectroelectrochemic... techniques, electrochemiluminesc... and scanning probe techniques while also exploring COSMOL multiphysics simulation, electroanalysis in biomedical and clinical applications, and future prospects for electrochemical techniques. Chapters focus on evaluating redox reactions, biological interactions, kinetics, quorum sensing, biofilm formation, surface modification and more molecular aspects. This volume offers a deep-dive into the fundamental principles behind the latest electrochemical techniques, equipping researchers with practical guidance for their own experiments.Users will find this to be an ideal reference for researchers working across a range of disciplines including molecular biology, bioanalytical chemistry, biomedical science, and translational medicine.

  • Diagnostic Application of Blood-based Biomarkers for Neurodegenerative Diseases

    • 1st Edition
    • Meenakshi Dhanawat + 4 more
    • English
    Diagnostic Application of Blood-based Biomarkers for Neurodegenerative Diseases is a comprehensive exploration of the pivotal role blood-based biomarkers play in diagnosing and managing neurological disorders. This comprehensive guide emphasizes the need for early detection and intervention in conditions such as Alzheimer’s disease, Parkinson’s disease, and neuroinflammation. Each chapter delves into specific biomarkers, including glial fibrillary acidic protein and neurofilaments, elucidating their diagnostic potential. This book highlights recent advancements in the application of blood biomarkers across various neurodegenerative diseases, underscoring the integration of artificial intelligence in biomarker discovery. By bridging research and clinical practice, it serves as an essential resource for professionals in diagnostic sciences, pharmaceutical research, and clinical pharmacology. Ultimately, this volume aims to reshape the landscape of early diagnosis, offering insights that promise to enhance personalized treatment strategies and improve patient outcomes in the fight against debilitating neurological disorders.

  • Environmental Antimicrobial Resistance

    A Complete Handbook
    • 1st Edition
    • Dijendra Nath Roy + 1 more
    • English
    Environmental Antimicrobial Resistance: A Complete Handbook provides a comprehensive exploration of the challenges and solutions related to antimicrobial resistance (AMR) in the environment. This book addresses global scenarios, sources of antimicrobial drugs, and the fate and transport of these drugs in the environment and living organisms. It explains the approach, protocols, and experiments for detecting and mitigating antimicrobial resistance phenomena, making it an essential resource for understanding and combating AMR. Additional sections highlight the silent pandemic of AMR, emphasizing the mismanagement of antimicrobials in humans and animals as key contributors.Finally... the book discusses global impacts, including the economic burden on low- and middle-income countries and the efforts of the WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS). With a systematic approach, it provides researchers and academicians with routine and advanced knowledge in the field of environmental antimicrobial resistance, including detection and mitigation strategies. This handbook is designed to meet the educational needs of students and professionals in the life sciences, environmental science, microbiology, and pharmacy. It offers comprehensive coverage of the current status, reasons for emerging drug-resistant microorganisms, and solutions for mitigating environmental antimicrobial resistance.

  • Super-Resolution Nanoscopy for Protein Imaging

    • 1st Edition
    • Varun Vyas
    • English
    Super-Resolution Nanoscopy for Protein Imaging decodes the intricate world of protein visualization using cutting-edge nanoscopic techniques. This comprehensive guide is crafted to equip master students, PhD candidates, and early-stage researchers with essential knowledge and practical insights into advanced protein imaging technologies. The book covers foundational principles, innovative methodologies, and real-world applications, providing a complete resource for mastering the complexities of protein imaging. This book offers a unique compilation of diverse nanoscopic methods, overcoming the limitation of technique-specific texts currently available.By collecting scattered information into a single volume, it delivers an in-depth exploration of imaging techniques, from Atomic Force Microscopy (AFM) to Electron Microscopy (EM), and Single Molecule Fluorescence Imaging. Each section delves into instrumentation, sample preparation, data analysis, and the latest developments, making it an indispensable reference for understanding how to visualize proteins in their natural environments.

  • Microbial Fertilizers

    Innovations and Applications for Sustainable Agriculture
    • 1st Edition
    • Ajay Kumar + 3 more
    • English
    Microbial Fertilizers: Innovations and Applications for Sustainable Agriculture explores the latest developments, applications, and challenges in the formulation and commercialization of novel microbial-based biofertilizers. Covering a wide array of topics, the book begins by covering the selection and diversity of microbial fertilizers. It explores the molecular and biochemical mechanisms of their plant-microbe interactions and how they can enhance nutrient availability and improve environmental stress tolerance. Additionally, the book addresses the commercialization and market trends of microbial fertilizers like the use of formulation technologies to improve microbial viability and stability in various product formats for better practical application.The book also explores cutting-edge omics approaches that facilitate comprehensive profiling of microbial communities and their roles in soil fertility and plant health as well as innovative technologies like the integration of synthetic biology and genetic engineering to tailor microbial strains for specific functions and the use of nanotechnology with microbial fertilizers for targeted nutrient delivery and controlled release systems. With a focus on overcoming the environmental challenges and leveraging opportunities for sustainable application, this book is an essential resource that provides insights into how microbial fertilizers can contribute to sustainable agriculture in the face of climate change.

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