Glial Mechanisms in Sleep and Circadian Biology
- 1st Edition - February 2, 2026
- Imprint: Academic Press
- Editor: Marcos G. Frank
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 1 3 7 8 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 1 3 7 9 - 0
Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep.… Read more
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Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.
Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.
Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.
- Presents the latest research on the growing field of glial sleep biology
- Discusses how glial cells influence important sleep functions
- Reviews the clinical significance of glial activity in sleep
Scientists working in sleep biology will want a resource that includes the latest research about how glia contribute to sleep disorders and accompanying brain disease
1. Introduction
2. Interactions between the immune system, glia and sleep.
3. Glial chemical signaling and sleep.
4. Interactions between glia, sleep and brain metabolism.
5. Morphological and molecular changes in glia across the sleep-wake cycle.
6. Sleep-wake dependent changes in glial activity.
7. Intracellular signaling pathways in glial mediation of sleep.
8. Glial mediation of sleep: Insights from invertebrate models
9. The glymphatic system in sleep: Glial and neuronal mechanisms.
10. Glial mechanisms in circadian rhythms.
11. Glial mediation of sleep-dependent brain plasticity.
12. Conclusion
2. Interactions between the immune system, glia and sleep.
3. Glial chemical signaling and sleep.
4. Interactions between glia, sleep and brain metabolism.
5. Morphological and molecular changes in glia across the sleep-wake cycle.
6. Sleep-wake dependent changes in glial activity.
7. Intracellular signaling pathways in glial mediation of sleep.
8. Glial mediation of sleep: Insights from invertebrate models
9. The glymphatic system in sleep: Glial and neuronal mechanisms.
10. Glial mechanisms in circadian rhythms.
11. Glial mediation of sleep-dependent brain plasticity.
12. Conclusion
- Edition: 1
- Published: February 2, 2026
- Imprint: Academic Press
- Language: English
MF
Marcos G. Frank
Dr. Frank has been working in the field of sleep biology for over 25 years He received his PhD in neuroscience at Stanford and managed his own sleep laboratories at UPENN and WSU. During this time, his lab made seminal discoveries about the role of glia in sleep. In 2009, they provided the first evidence that glia influence sleep regulation in vivo. That study was published in the prestigious journal Neuron and to date has been cited 852 times. Since then, his lab has published several other important papers on this topic (e.g. Current Biology 2020, Journal of Neuroscience, 2023), and he has presented this work at several conferences and invited talks. He has also published several reviews on this topic and has experience editing scientific books on the topic of sleep.
Affiliations and expertise
Washington State University, Gleason Institute for Neuroscience, USA