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Elsevier

Essentials of Stem Cell Biology

  • 4th Edition - January 1, 2027
  • Latest edition
  • Editors: Robert Lanza, Anthony Atala
  • Language: English

Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advanceme… Read more

Description

Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advancements in stem cells. This comprehensive book, a collaboration of 7 editors and over 200 pioneering scholars and scientists, provides a thorough understanding of adult and embryonic stem cells. It combines fundamental concepts with cutting-edge research in specific organ systems, ensuring a robust foundation for anyone entering the field. Beyond the basics, the book delves into early development and the differentiation of ectoderm, mesoderm, and endoderm.

It covers methods, applications to human diseases, regulation, ethics, and patient perspectives, leaving no stone unturned in the stem cell domain.

Key features

  • Contains contributions from Nobel Laureates and leading international investigators
  • Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells
  • Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate
  • Presented in full color with a glossary, highlighted terms, and bibliographic entries replacing references

Readership

researchers, grad students, and professionals working with human stem cells in biology, tissue engineering, genetics, cancer research, virology, immunology, and biotechnology

Table of contents

Part I: Introduction to Stem Cells


1. 'Stemness': Definitions, Criteria, and Standards

2. Pluripotent Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges

3. Human Embryonic Stem Cells

4. Perinatal Stem Cells

5. Adult Stem Cells: Definitions, Dynamics, and the Bridge to Differentiated Cells

6. Induced Pluripotent Stem Cells

Part II: Basic Biology and Mechanisms


7. Cell Cycle Regulation in Hematopoietic Stem Cells

8. How Cells Change Their Phenotype

9. Differentiation in Early Development

10. Cell–ECM Interactions in Tissue Repair and Regeneration

Part III: Stem Cell Systems


11. Pluripotent Stem Cells: Production, Differentiation and Considerations for Therapeutic Applications

12. Placenta-Derived Stem Cells

13. Stem and Progenitor Cells Isolated from Cord Blood

14. Mesenchymal Stem Cells

15. Adipose Tissue-Derived Stem Cells

16. Skin Epithelial Stem Cells

17. Peripheral Blood Stem Cells

18. Skeletal Muscle Stem Cells

19. Stem Cells and the Regenerating Heart

20. Liver Stem Cells

21. Stem Cells in the Gastrointestinal Tract

22. Stem Cells in the Lungs

23. Stem Cell Properties of the Retinal Pigment Epithelium

24. Sensory Epithelial Stem Cells of the Ear

25. The Nervous System and Neural Stem Cells

26. Extracellular Vesicles in Stem Cell Biology: Signaling, Therapy, and Potential

Part IV: Applications


27. Fetal Stem Cell Transplantation: Current Status and Future Outlook

28. Amniotic Fluid Stem Cells: Biology, Isolation, and Therapeutic Potential

29. Stem Cells in Burns and Skin Ulcers

30. Cardiac Regeneration Medicine

31. Stem Cells in Kidney Regeneration

32. Orthopaedic Applications of Stem Cells

33. Mesenchymal Stromal Cells for Musculoskeletal Tissue Engineering

34. Stem Cells as a Potential Treatment for Diabetes

35. Cell Therapy for Liver Disease: From Hepatocytes to Stem Cells

36. Neural Stem Cells – New Therapeutic Mechanisms-of-Action in Neurodegenerative Diseases

37. Stem Cells for Brain Disease and Injury

38. Stem Cells for Eye Disease

39. Stem Cells for Lung Disease

40. Stem Cells for Gastrointestinal Disease

41. Stem Cells in Genitourinary Diseases

Part V: Clinical Translation, Regulation and Ethics


42. Stem Cell Manufacturing

43. Biobanking of Stem Cells: Current and Future Outlook

44. Investment Strategies for Stem Cells

45. Contemporary Bioethical and Policy Debates on Stem Cell and Embryo Model Research

46. Overview of the FDA Regulatory Process for Stem Cells

47. Stem Cells for Disease Modeling and Drug Discovery

Review quotes

Reviews of the previous edition:
"…serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells…From basic biology, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered."—Anticancer Research 34, 2014

"This book offers a thorough review of current research and therapeutic potential in the field of stem cell biology. The focus is on the therapeutic potential of stem cells, with the discussion of the current state of stem cell knowledge and stem cell therapies in various organs and tissues…any scientists interested in studying the field would benefit from this book's thorough treatment of the subject."Rating: 4 Stars —Doody.com, March 7, 2014

Product details

  • Edition: 4
  • Latest edition
  • Published: January 1, 2027
  • Language: English

About the editors

Robert Lanza

Editor
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.
Affiliations and expertise
Astellas Institute for Regenerative Medicine, Westborough, MA, USA

Anthony Atala

Editor

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.

Affiliations and expertise
G. Link Professor and Director, Wake Forest Institute for Regenerative Medicine; W. Boyce Professor and Chair, Department of Urology, Wake Forest University, Winston-Salem, USA