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The Alzheimer’s Spectrum: From Neural Stress to AI-Driven Care

  • 1st Edition, Volume 192 - February 1, 2027
  • Latest edition
  • Editors: Riddhi Upadhyay, Murugan Sevanan
  • Language: English

The Alzheimer’s Spectrum: From Neural Stress to AI-Driven Care, published as Volume 192 of the serial International Review of Neurobiology, provides a comprehensive and multidis… Read more

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Description

The Alzheimer’s Spectrum: From Neural Stress to AI-Driven Care, published as Volume 192 of the serial International Review of Neurobiology, provides a comprehensive and multidisciplinary examination of Alzheimer’s disease (AD) across its biological, psychological, and technological dimensions. This volume integrates current research on neuropsychiatric factors such as depression, stress, and anxiety with advances in neuroanatomy, systems neuroscience, and emerging AI-driven diagnostic and therapeutic approaches. Chapters explore key brain regions and circuits implicated in AD—including the thalamus, prefrontal cortex, hippocampus, and memory-emotion networks—while also addressing comorbidities, extracellular vesicles as biomarkers, and innovative treatment strategies. The inclusion of computational approaches, model organisms, and novel therapeutic avenues reflects a strong translational focus, bridging mechanistic understanding with clinical and digital health applications. Collectively, this volume serves as an authoritative resource for understanding the Alzheimer’s continuum from early cognitive impairment to advanced disease and care optimisation.

Key features

  • Integrates neuropsychiatric, molecular, and systems-level perspectives on Alzheimer’s disease
  • Explores the role of stress, depression, and anxiety in AD onset and progression
  • Provides in-depth coverage of brain structures and neural circuitry relevant to cognition and emotion
  • Highlights advances in AI-driven care, computer-aided diagnosis, and digital therapeutics
  • Examines emerging biomarkers, model organisms, and unconventional therapeutic strategies
  • Presents contributions from international experts across neuroscience, clinical research, and computational fields

Readership

Neuroscientists and neurobiologists specialising in neurodegenerative diseases; Clinical neurologists, psychiatrists, and geriatric medicine specialists; Researchers in cognitive neuroscience and neuropsychology; Biomedical and translational researchers focusing on dementia and ageing; Computational neuroscientists and AI-in-healthcare professionals; Advanced postgraduate students in neuroscience, medicine, and related disciplines

Table of contents

1. Measures of Depression in Alzheimer’s Disease

2. Depression as a Risk Factor for Dementia

3. Stress and Anxiety in Alzheimer’s Disease

4. Stress and Dementia

5. Psychological Stress, Mild Cognitive Impairment (MCI), and AD

6. The Thalamus and Cognitive Processing in AD

7. Prefrontal Cortex Connectivity Loss in AD

8. Memory Circuits and Emotional Processing in AD

9. Hippocampal Atrophy and Its Consequences in AD

10. Comorbidity in Alzheimer’s Disease

11. Extracellular Vesicles in Alzheimer’s Disease: New Perspectives on Diagnosis and Therapy

12. AI-Driven Care Behavioural Treatment on the Alzheimer's Spectrum

13. Computer-Aided Diagnosis (CAD) Methods in AD Research

14. Model Organisms Used in Alzheimer's Disease Studies

15. The Role of Silkworm Derivatives in Alzheimer’s Disease

16. Novel Therapies

17. Decoding Pathogenesis, Systems Biology, and Intelligent Therapeutics in Alzheimer’s Disease

Product details

  • Edition: 1
  • Latest edition
  • Volume: 192
  • Published: February 1, 2027
  • Language: English

About the editors

RU

Riddhi Upadhyay

Riddhi Upadhyay is an ardent Ph.D. scholar with a specialised focus on the realm of neurodegenerative diseases. Her research centres on these complex conditions, reflecting her deep commitment to unraveling their mysteries and advancing treatment approaches. Riddhi's academic journey commenced with an Honors Bachelor's degree in Zoology from The Maharaja Sayajirao University of Baroda (MSUB). She then pursued a Master's degree in Molecular Medicine from the Institute of Advanced Research (IAR), enhancing her knowledge and research acumen.

One of her notable accomplishments was her involvement in a project titled “Study of neuroprotective potential associated with Oleuropein (Olea europaea leaf extract) using Drosophila melanogaster as an Alzheimer's Disease model” during her masters. In this endeavour, she gained invaluable hands-on experience in handling Drosophila melanogaster, along with exposure to a range of behavioural and biological assays. Furthermore, Riddhi served as a Teaching Assistant at Ahmedabad University in Gujarat, where she honed her skills in survey-based analysis and environmental impact factor assessment.

Her research pursuits are dedicated to crafting treatment strategies aimed at alleviating isolation-induced stress triggered by neurodegenerative diseases. With a solid academic foundation and an unwavering passion for research, Riddhi brings a unique perspective to her work. Her expertise spans the fields of behavioural science and the profound impact of disrupted homeostasis in the central nervous system. Riddhi’s contributions to her research, by her publication of a book chapter with two book chapters and one research article. Through her scientific and analytical prowess, she strives to develop safe and effective therapeutic approaches, enriching the landscape of neurodegenerative disease treatment.

Affiliations and expertise
PhD scholar, Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, India

MS

Murugan Sevanan

Dr. S. Murugan is an esteemed Associate Professor in the Department of Biotechnology at Karunya Institute of Technology and Sciences, a distinguished Deemed University situated in Coimbatore. He boasts a rich academic background, holding an M.Sc. in Microbiology from Manonmaniam Sundaranar University and a Ph.D. in Microbiology from Bharathiar University.

His illustrious career spans over 25 years, during which he has exhibited profound dedication to the realm of education. Dr. Murugan's scholarly contributions are remarkable, encompassing 72 research articles, 5 articles pertaining to career development, and 7 general articles in esteemed international journals. Additionally, he has showcased his erudition by crafting 6 insightful book chapters.

Dr. S. Murugan's commitment extends beyond research and publications. He has played a pivotal role in nurturing academic excellence by guiding 7 Ph.D. students and currently overseeing the mentorship of 7 promising Ph.D. scholars. His affiliations with prestigious organisations underscore his professional stature. Beyond academia, Dr. Murugan's endeavours in community health initiatives underscore his holistic approach to well-being. This showcases his commitment to fostering a positive impact beyond the academic sphere. His multifaceted contributions exemplify a distinguished educator, researcher, and advocate for community welfare.

Affiliations and expertise
Associate professor, Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, India