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Elsevier

Books in Life sciences

  • Cellular Immunology LabFax

    • 1st Edition
    • English
    LABFAX volumes are purpose-designed data reference books for practicing scientists. Each book presents the key information for a major subject in one place and so saves hours of searching. The authors and editors of each LABFAX volume have searched the original literature for the accurate data they know the subject specialist needs.Cellular Immunology Labfax is a detailed compendium of information on the tissues and cells of the immune system, cell lines and hybridomas, antigens and receptors, the major histocompatibility complex, soluble immunoregulatory molecules, in vivo procedures, important features of species used in immunological research, and much more.The contents of Cellular Immunology Labfax have been carefully chosen to complement the data presented in Immunochemistry Labfax. It is therefore the companion volume to this text.

  • Single Neuron Computation

    • 1st Edition
    • Thomas M. McKenna + 2 more
    • English
    This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs.The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.

  • Immunogenetics

    • 1st Edition
    • Gabriel S Panayi + 1 more
    • English
    Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.

  • Bone Tumours in Man and Animals

    • 1st Edition
    • L. N. Owen
    • English
    Bone Tumours in Man and Animals covers advances in the understanding of the pathogenesis of bone neoplasia in humans and animals as well as their diagnosis and treatment. In the case of animals, particular emphasis is placed on dogs. This book is comprised of 15 chapters and begins by introducing the reader to the principles of diagnosis, including biopsy and bone scanning, and methods of treatment employed for bone tumors in human and animal patients, including surgery, radiotherapy, and chemotherapy. The following chapters focus on bone cysts and benign tumors of osseous origin; osteosarcoma in humans and animals such as dogs, cats, and mice; and tumors of cartilaginous origin such as solitary enchondroma, enchondromatosis, chondroblastoma, and chondromyxoid fibroma. Tumors arising from fibrous, fatty, neurological, or undifferentiated connective tissue are also considered, along with those arising from bone marrow or lymphoid tissue. This book concludes by offering suggestions for future research. This text is intended for clinicians, radiologists, and pathologists, both medical and veterinary, as well as for biologists, biochemists, and radiation physicists.

  • Cellular Pathology Technique

    • 4th Edition
    • C. F. A. Culling + 2 more
    • English
    Cellular Pathology Technique aims to maintain the twin objectives of producing a comprehensive bench book and a text for students that will take the Special Examination in Cellular Pathology of the Institute of Medical Laboratory Sciences. The organization of this fourth edition has been reshaped. Some sections were expanded such as those about the theory of staining, and new chapters were added dealing with immunolocalization, the endocrine system, and quantification. This book is organized into 10 parts. The introductory part provides basic information on cells and tissues and outlines the methodology in cellular pathology techniques. This is followed by chapters that deal with various aspects of cellular pathology including tissues, cells and cell products of special interests, electron microscopy, and immunocytochemistry. This book will be of interest to students of cellular pathology and those in the medical profession.

  • Extraretinal Photoreception

    Proceedings of the Symposium and Extraretinal Photoreception in Circadian Rhythms and Related Phenomena
    • 1st Edition
    • Michael Menaker
    • English

  • Reflections on Biochemistry

    In Honour of Severo Ochoa
    • 1st Edition
    • A. Kornberg + 2 more
    • English
    Reflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides, regulation, nucleic acids and the genetic code, protein biosynthesis, and cell biology. The essays celebrate Severo Ochoa's outstanding contributions to biochemistry spanning nearly half a century. This book is comprised of 47 chapters and begins with a biography of Ochoa and his scientific work in the field of biochemistry, particularly his research on intermediary metabolism, RNA synthesis, and the genetic code. The discussion then turns to energy metabolism, photosynthesis, and fermentation, touching on topics such as the role of lactic acid in the development of biochemistry and the biosynthesis of cell components from acetate. The next section is devoted to lipids, saccharides, and cell walls and includes chapters that deal with biotin, sulfur biochemistry, and dipicolinic acid. Subsequent chapters explore hormonal regulation of adipose tissue lipolysis; the structural relationship between genes and enzymes; bacteriophages, colicins, and ribosomes; and cell biology and neurobiology. This monograph will be of interest to biochemists and students of biochemistry.

  • The Evolution of the Bioenergetic Processes

    • 1st Edition
    • E. Broda
    • English
    The Evolution of the Bioenergetic Processes deals with the evolution of the bioenergetic processes, from fermentation to photosynthesis and respiration, and their interrelationships in prokaryotes and eukaryotes. Topics covered range from the origin of life to the evolution of eobionts, organisms, and energy-rich compounds. Fermentation, photoorganotrophy, and photosynthesis in bacteria and plants are also discussed. Comprised of 25 chapters, this book begins with an overview of energy and entropy in the biosphere, followed by a detailed treatment of the evolution of bioenergetics based on the pattern of the bioenergetic processes in extant organisms. The reader is then introduced to the events involved in the origin of life; the evolution of eobionts and organisms; and the origin of energy-rich compounds, particularly nucleotides of the adenylic acid system. Subsequent chapters focus on fermentation and photosynthesis; assimilation of carbon dioxide; photoorganotrophy, chemolithotrophy, and photolithotrophy; and aerobic and anaerobic respiration of prokaryotes. The book also considers the energy supply of protozoa and fungi before concluding with an analysis of the history of atmospheric oxygen. This monograph will be of interest to evolutionary biologists.

  • Gene Expression

    Protein Synthesis and Control RNA Synthesis and Control Chromatin Structure and Function
    • 1st Edition
    • Brian F. C. Clark + 2 more
    • English
    Gene Expression provides research papers on selected topics in gene expression, presented at the 11th meeting of the Federation of European Biochemical Societies, held at Copenhagen in August 1977. The book presents research knowledge provided by eminent researchers in the field of biochemistry. Each chapter contains material that is important to other researchers, such as on initiation mechanism of protein synthesis in prokaryotes; translocation mechanism of the ribosome; and analysis of ribosomal translocation by drugs. Mechanisms for the intracellular compartmentation of newly synthesized proteins; RNA synthesis and control; the sub-structure of nucleosome core particles; and future prospects on chromosome structure and function are detailed as well. The text will be of use to researchers and workers in the field of medicine, pharmacology, gene therapy, and biochemistry.

  • Catecholamines and Schizophrenia

    • 1st Edition
    • Steven W. Matthysse + 1 more
    • English
    Catecholamines and Schizophrenia reviews research linking catecholamines to schizophrenia. Topics include the relationship between stereotyped behavior and amphetamine psychosis, between antipsychotic drugs and catecholamine synapses, and between biogenic amines and behavior. The chemical neuropathology of schizophrenia, enzymology and regulation of catecholamine enzymes, and advances in histochemical technologies used in neurochemical pathology are also covered. This book consists of 47 chapters organized into six sections. After giving an overview of the pharmacology and physiology of stereotyped behavior, this book discusses the behavioral and biochemical aspects of amphetamine psychosis; stereoselective features of catecholamine disposition and their behavioral implications; and the effects of amphetamines on catecholamine metabolism. A two-factor theory of schizophrenia is also presented. The chapters that follow focus on the role of monoamine oxidase in schizophrenia and other behavioral disorders; the chemical pathology of schizophrenia; genetic control of biogenic amines; and dopamine-beta-hydrox... This book will be of value to students, researchers, and practitioners in fields ranging from neuropharmacology and physiology to biology, biochemistry, psychiatry, and psychology.

  • Albumin: Structure, Function and Uses

    • 1st Edition
    • Victor M. Rosenoer + 2 more
    • English
    Albumin Structure, Function and Uses reviews the many facets of serum albumin, including its history and evolutionary development, structure and function, synthesis, degradation, distribution and transport, and metabolic behavior. The use, misuse, and abuse of albumin in the treatment of disease are also discussed. This book is comprised of 17 chapters and begins with a commentary on how albumin is used, misused, and abused in the treatment of disease such as peptic ulcer, and a description of the real indications for its use. Concepts in albumin purification are then examined, along with the amino acid sequence of serum albumin and some aspects of its structure and conformational properties. Subsequent chapters explore the phylogenetics of albumin; albumin binding sites; clinical implications of drug-albumin interaction; genetics of human serum albumin; and hepatic synthesis of export proteins. Albumin catabolism and intracellular transport are also considered, together with surgical and clinical aspects of albumin metabolism. This monograph should be a useful resource for biochemists and clinicians.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Third Colloquium, Brugge, 1975
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids contains the proceedings of the 23rd Colloquium on "Protides of the Biological Fluids" held in Brugge, Belgium in 1975. The discussions were organized around three themes: proteinase inhibitors, clinical evaluation of plasma protein patterns, and affinity chromatography. Comprised of 117 chapters, this volume begins with an overview of carcinofetal proteins, followed by an analysis of proteinase inhibition. The reader is then introduced to the mechanism and structure of human alpha-1-proteinase inhibitor; some properties of a complex between ?2-macroglobulin and brinase; and the interaction of proteinase inhibitors with blastocyst proteinases involved in implantation. Subsequent chapters deal with the thermodynamics and kinetics of the interaction of trypsin with trypsin inhibitors; purification and characterization of acid-stable proteinase inhibitors from human seminal plasma; and the possible role of protease inhibitors in cartilage metabolism. The book also explores the structure and function of animal proteinase inhibitors as well as techniques and methods used in clinical evaluation of plasma protein patterns. This monograph will be of interest to biologists and research workers in biology.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Sixth Colloquim, 1978
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids contains the proceedings of the 26th Colloquium in 1978. Two topics are highlighted, the first one being the immune complexes and the second one being the cytoskeletal proteins. This book is organized into three sections, namely, Immune Complexes, Cytoskeletal Proteins, and Techniques. The Immune Complexes section states the biochemical problems and answers some intriguing clinical problems in this field. This section details the theory of the antigen/antibody reaction, the isolation of complexes, and the nature of the antigen. The Cytoskeletal Proteins section discusses the theoretical aspect of cell structure. The last section describes the assay methods and individual protein assays.

  • Regulation of Fatty Acid and Glycerolipid Metabolism

    FEBS 11th Meeting in Copenhagen 1977, Volume 46 Symposium A5
    • 1st Edition
    • Raymond Dils + 1 more
    • English
    Regulation of Fatty Acid and Glycerolipid Metabolism is a compilation of papers presented during the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. The book deals with the regulation of enzyme activity and the turnover that results from fatty acid metabolism, lipid metabolism in membranes, and disturbed fatty acid metabolism. One study presented in the book shows that cellular fatty acid synthetase levels are significantly decreased by different medium and long chain fatty acids in Candida lypolytica, a kind of yeast. The book also examines the serious incidence of increase in the rate of conversion of glucose to fatty acids when white adipose tissues from rats are exposed to insulin. The selection addresses this increase as an important example of acute hormonal regulation of fatty acid synthesis in mammalian tissues. The text also describes the enzyme adaptation to nutritional and hormonal changes and the role of lipids in membrane fusion. The book presents other studies regarding the incidence of vascular, dietary, and congenital factors on fatty acid metabolism in adipose tissue and liver that are conducted in rats. Another study suggests that hyperinsulinemia is a key factor in the development of the obesity syndrome. Microbiologists, microchemists, and laboratory researchers and scientists dealing with fat metabolism will appreciate this book.

  • Regulatory Mechanisms of Carbohydrate Metabolism

    11th Meeting Copenhagen 1977
    • 1st Edition
    • Viggo Esmann
    • English
    Regulatory Mechanisms of Carbohydrate Metabolism contains the proceedings of the 11th meeting of the Federation of European Biochemical Societies, held at Copenhagen in 1977. The symposium is attended by thousands of biochemists and their associates to present and discuss the regulatory mechanisms of carbohydrate metabolism. The compendium records the nine sessions of the symposium encompassing 30 chapters of various discussions on the regulatory mechanisms of carbohydrate metabolism. Topics on metabolism of pyruvate in animals; mechanism of insulin secretion; the role of pyruvate in the regulation of carbohydrate metabolism; and control of muscle glycogen metabolism by protein kinases and phosphates are covered. Ketogenesis and carbohydrate metabolism; factors controlling glucagon secretion; and energy homeostasis and the regulation of carbohydrate metabolism are discussed as well. Biochemists, chemists, physicians, pharmacologists, and students of medicine will find this book a good source on insight.

  • Mechanisms of Toxicity and Metabolism

    Proceedings of the Sixth International Congress of Pharmacology
    • 1st Edition
    • N. T. Kärki
    • English
    Mechanisms of Toxicity and Metabolism is the sixth volume of the proceedings of the Sixth International Congress of Pharmacology, organized by the Finnish Pharmacological Society and held in Helsinki, Finland, on July 20-25, 1975. Contributors focus on the findings concerning the mechanisms of toxicity and metabolism and the developments in pharmacology and related areas of research. This volume has 24 chapters divided into four sections. After discussing the developmental aspects of drug metabolism and enzyme inhibitors of microbial origin, this book turns its attention to the interrelationships among various enzyme systems and physiological processes that are known to affect the distribution and metabolism of drugs. This text also highlights the reaction mechanisms of cytochrome P-450; the link between microsomal drug oxidation and glucuronidation; and the pharmacokinetics of the first pass effect. The reader is then introduced to the toxicity of food additives and the toxicity and metabolism of plasticizers and plastics. This volume concludes with a chapter that evaluates some of the biochemical and pharmacologic effects of di-2-ethylhexyl phthalate (DEHP). This book will appeal to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

  • Biochemical Aspects of New Protein Food

    FEBS Federation of European Biochemical Societies 11th Meeting Copenhagen 1977, Volume 44 Symposium A3
    • 1st Edition
    • Jens Adler-Nissen + 2 more
    • English
    Biochemical Aspects of New Protein Food examines the biochemical aspects of the use and consumption of new protein foods and determine future areas for research by biochemists. The symposium showcases the presentation of biochemical research that provides a better understanding of the characteristics of new protein foods; their methods of production; and solutions to problems in the evaluation of their nutritive properties. Chapters are devoted to the novel and conventional protein foods in the future; production of food from waste; and a comparative analysis of protein situation in developed versus developing countries. It is hoped that the symposium will be able to help overcome the problems of acceptability of the new foods and catapult it as an important part of human diet. Biochemists, food technologists, biologists, and food manufacturers will find the book interesting and informative.

  • Regulation of Secondary Product and Plant Hormone Metabolism

    FEBS Federation of European Biochemical Societies: 12th Meeting, Dresden, 1978
    • 1st Edition
    • M. Luckner + 1 more
    • English
    Regulation of Secondary Product and Plant Hormone Metabolism contains the proceedings of the 12th Meeting of the Federation of European Biochemical Societies held in Dresden, Germany in 1978. The meeting provided a forum for discussing progress in understanding the regulation of the metabolism of secondary products and plant hormones. It shows that the processes regulating secondary metabolism are similar in lower and higher plants, and that the molecular basis of cell differentiation and specialization is uniform in all groups of living organisms. Comprised of 22 chapters, this volume begins with an overview of the interrelationships between secondary products and hormones in plants, followed by a detailed account of the effects of phenolic compounds on auxin biosynthesis and vice versa. The reader is then introduced to non-ribosomal biosynthesis of biologically active peptides; channelling of intermediates during the biosynthesis of cyanogenic glycosides; and intracellular distribution of flavonoids in glandular cells. Subsequent chapters explore the regulation of gene expression in secondary biosynthesis; inhibition of phenylalanine ammonia-lyase by cinnamic acid derivatives; novel inhibitors of phenylpropanoid metabolism in higher plants; and stage-specific phenylpropanoid metabolism during pollen development. This book will be of interest to biochemists and geneticists.

  • Cyclic Nucleotides and Protein Phosphorylation in Cell Regulation

    FEBS Federation of European Biochemical Societies: 12th Meeting, Dresden, 1978
    • 1st Edition
    • E.-G. Krause + 2 more
    • English
    Volume 54, Symposium S7: Cyclic Nucleotides and Protein Phosphorylation in Cell Regulation documents the proceedings of the 12th Federation of European Biochemical Societies (FEBS) Meeting held in Dresden, Germany on July 5-7, 1978. This book discusses the biological significance and biochemical aspects of cyclic nucleotides and protein phosphorylation in cell regulation. The general aspects of cyclic nucleotide metabolism and action; cyclic nucleotides and nervous system; and cyclic nucleotides in muscle tissues are also elaborated. This publication likewise covers the cyclic nucleotides in secretion processes and miscellaneous aspects of cyclic nucleotide-dependent and independent protein phosphorylation. This volume is valuable to biochemists and biologists concerned with the cyclic nucleotides and protein phosphorylation in cell regulation.

  • Regulatory Proteolytic Enzymes and Their Inhibitors

    11th Meeting Copenhagen 1977
    • 1st Edition
    • Staffan Magnusson + 2 more
    • English
    Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies on preproinsulin. The text then discusses the primary structures and presumed functions of immunoglobulin precursors. Another paper continues with the work of Reich and co-workers who found that transformation of cultured fibroblasts from different species by oncogenic viruses is related to the production and release of proteases that are responsible in activating the proenzyme plasminogen into plasmin. Another paper discusses plasminogen activation as having some relationship with pathological processes. The book also reviews the plasminogen activator secretion by normal and neoplastic human tissues. The text discusses the results when primary cultures established from biopsies of normal kidneys secreted plasminogen activators in amounts over those secreted by actual malignant tissues. The book then notes the role of neutral and acid proteinases in male reproduction and the role of plasminogen activators in female ovulation. This collection can be useful for micro-biologists, research biologists, molecular scientists, and students of molecular biology.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Fourth Colloquium, Brugge, 1976
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids contains the proceedings of the XXIVth Colloquium on Protides of the Biological Fluids held in Brugge, Belgium in 1976. Contributors explore relevant findings about protides of biological fluids and discuss topics such as pregnancy-associated proteins, carcino-fetal and carcinoplacental proteins, and molecular amplification. This volume consists of 151 chapters organized into three sections and begins with a discussion of the problems of specific placental and fetal proteins as well as the appearance of these proteins in maternal serum. The biochemistry and structure of human placental lactogen is considered together with its possible application in the diagnosis of abnormal pregnancy and the role of pregnancy specific proteins especially with regard to immunization during pregnancy. The next section focuses on oncofetal proteins, with particular reference to the biological significance of alpha-fetoprotein, its appearance during various types of cancer, and its increase in abnormal pregnancy. The isolation and properties of CEA and related antigens such as TPA, and the importance of their assay in early cancer detection as well as in follow-up studies of patients after surgery or therapy are described. The final section explores the use of molecular amplification in detection of trace amounts of proteins. It explains how radio-immunoassay, RIA, or ELISA can amplify a basic reaction between two molecules and increase its specificity as well as its limits of detection. This book will be of interest to scientists, students, and researchers working in the fields of biology and biochemistry.

  • Clinical Tumor Immunology

    • 1st Edition
    • Joseph Wybran + 1 more
    • English
    Clinical Tumor Immunology contains the proceedings of the Symposium of Clinical Tumor Immunology held in Brussels, Belgium, on May 26-29, 1975) and organized by the European Organization for Research on Treatment of Cancer in cooperation with the Department of Immunology of the University Hospital of Brussels. The papers explore progress in the field of clinical tumor immunology and cover topics ranging from general mechanisms in tumor immunity to tumor antigens and immunotherapy. A classification of leukemias and lymphomas is also presented. Comprised of 48 chapters, this book begins with an overview of the biological activities of the circulating thymic hormone, followed by a discussion on macrophage secretions affecting the growth of other cells. The reader is then introduced to immune cellular mechanisms at the site of the tumor; the use of the leukocyte migration technique in studies of tumor-directed cellular immunity in malignant melanoma; and immunological approaches to the identification of leukemic cells. Subsequent chapters deal with preclinical approaches in tumor immunochemotherapy; mediation of immune responses to human tumor antigens with "immune" RNA; and the role of transfer factor in human cancer. This monograph will be of interest to oncologists and immunologists.

  • Progress in Biophysics and Molecular Biology

    • 1st Edition
    • J. A. V. Butler + 1 more
    • English
    Progress in Biophysics and Molecular Biology, Volume 32 summarizes the significant progress that has been made in the fields of biophysics and molecular biology. Topics range from metabolic regulation and transfer RNA to cellular metabolism and prokaryotic and eukaryotic ribosomes. This volume consists of five chapters and begins with a discussion of mathematical models used in the study of metabolic regulation, with emphasis on the energy metabolism of eukaryotes. The next chapter examines the possible functions of transfer RNA minor components, paying particular attention to the principle of location-function relationships. The reader is also introduced to spatial-functional correlations in cellular metabolism and highlights the role of organize multienzyme systems, along with the fundamentals of ribosome structure and function in prokaryotes and eukaryotes. A chapter that analyzes the structures and functions of transfer RNA concludes the book. This book will be of interest to scientists, students, and researchers working in the fields of biophysics and molecular biology.

  • Recent Advances in Steroid Biochemistry

    • 1st Edition
    • J. R. Pasqualini
    • English
    Recent Advances in Steroid Biochemistry contains the proceedings of the Second International Symposium of the Journal of Steroid Biochemistry. Separating 38 papers as chapters, this book discusses the partial purification of steroid-receptor complexes; enzymatic techniques in steroid assay; mass fragmentography of steroid hormones; biological consequences of 18-hydroxylation; and steroidogenesis in adrenal cells. This text also explores the regulation of steroidogenesis in testis; androgen binding proteins in different testis compartments; nuclear acceptor sites for glucocorticoid receptors; estrogen receptors in the pancreas; and molecular mechanisms of steroid hormone action.

  • Frontiers in Catecholamine Research

    Proceedings of the Third International Catecholamine Symposium Held at the University of Strasbourg, Strasbourg, France May 20–25, 1973
    • 1st Edition
    • Earl Usdin + 1 more
    • English
    Frontiers in Catecholamine Research is a collection of papers presented at the Third International Catecholamine Symposium, held at the University of Strasbourg, Strasbourg, France, on May 20-25, 1973. This book is organized into nine parts encompassing 205 chapters. The text begins with a discussion on clinically and experimentally used drugs that have been developed or whose mechanism of action has been clarified through monoamine research. Parts II and III deal with enzymes related to catecholamine studies, their properties, regulation, genetics, mechanism of action, and localization. Parts IV and V examine the concepts of synaptic dynamics of brain regulators and the isolation, characterization, methods of analysis, and mechanism of action of catecholamines. Part VI focuses on the complexities that surround the extrapolation of catecholamine function into the realms of electrophysiology and behavior. Part VII discusses the metabolism, behavioral, neurological, and physiological effects of amphetamine and other drugs of abuse. The concluding parts describe the role of catecholamine and its metabolism in neurologic diseases, such as schizophrenia.

  • The Biochemistry of Development

    International Series of Monographs on Pure and Applied Biology
    • 1st Edition
    • Jean Brachet
    • P. Alexander + 1 more
    • English
    The Biochemistry of Development focuses on advances in chemical embryology. The book first discusses gametogenesis, including the processes of oogenesis and spermatogenesis. The text describes fertilization and related aspects, such as physical, morphological, and metabolic changes during fertilization. The selection also underscores the process of cleavage. Concerns include morphology and cytochemistry of dividing eggs; importance of nucleic acids and proteins; formation of the furrow; and biochemistry of cleavage. The text also looks at the chemical embryology of invertebrate eggs. Examinations are done on the eggs of worms, mollusks, sea urchins, and ascidians. The book also evaluates the chemical embryology of vertebrate eggs. RNA and protein metabolism of intact eggs; chemical nature of inducing substances; and physical properties of inducing agents are underscored. The text also offers information on the biochemistry of differentiation and the biochemical interactions between the nucleus and the cytoplasm during morphogenesis. The selection is highly recommended for readers wanting to study chemical embryology.

  • Advances in the Biosciences

    International Conference on Prostaglandins, Vienna, September 25 to 28, 1972
    • 1st Edition
    • Stig M. Bergström
    • English
    Advances in the Biosciences 9 is a collection of presented papers on the International Conference on Prostaglandins, held in Vienna, Austria on September 25 to 28, 1972. The book consists of 114 chapters of various topics in the field of prostaglandins. The meeting touches on several main topics such as new active analogs of prostaglandins; effect of aspirin and indomethasin and other compounds relative to the study of the role of the prostaglandins in the living organism; and the evaluation of the various analytical methods for the determination of the extremely minute amounts of prostaglandin occurring in the living organism. Biologists, pharmacologists, endocrinologists, physicians, biochemists, and medical technologists will find the contents of this book invaluable.

  • Immunological Surveillance

    • 1st Edition
    • Macfarlane Burnet
    • English

  • Alligator Metabolism Studies on Chemical Reactions in Vivo

    • 1st Edition
    • Roland A. Coulson + 1 more
    • English
    Alligator Metabolism: Studies on Chemical Reactions in Vivo presents a summary of research in vivo on the metabolism of alligators. The volume contains updates of earlier investigations which were presented in Biochemistry of the Alligator, a Study of Metabolism in Slow Motion (1964). Since then, with the aid of better equipment and better methods, it seemed time to correlate and summarize the findings of researchers who have used this remarkable experimental animal with profit. The primary purpose of almost all the research was not to determine the nature of the alligator, but to understand biochemical reactions in vivo and the alligator was a means to that end. The book begins with a chapter on natural history for those scientists, wild-life experts, alligator farmers, zoo keepers etc., whose primary interest is in the nature and habits of the intact alligator. This is followed by separate chapters that deal with metabolic rate, anaerobic glycolysis, digestion-growth-pro... synthesis, carbohydrate metabolism, amino acid metabolism, respiration and acid-base balance, and kidney function.

  • A Laboratory Manual of Analytical Methods of Protein Chemistry

    • 1st Edition
    • P. Alexander + 1 more
    • English
    A Laboratory Manual of Analytical Methods of Protein Chemistry, Volume 5 presents the laboratory techniques for protein and polypeptide study. This book discusses the staining procedure for histones, which has a high degree of selectivity for basic proteins and the unique ability to visualize qualitative differences in terms of color changes. Organized into four chapters, this volume begins with an overview of the formalin-mediated ammoniacal-silver staining procedure as a selective stain for basic proteins and its application per cell and per extract. This text then examines the optical rotatory dispersion (ORD), which has advanced into a powerful tool for describing the conformations and conformational changes of biopolymers. Other chapters consider the application of ultrasensitive calorimetry to thermodynamic problems. This book discusses as well the principle of the technique, its instrumentation, and experimental procedures. The final chapter deals with the hydrodynamic densities and preferential hydration values for protein precipitates in concentrated salt solutions. This book is a valuable resource for chemists and biochemists.

  • Acetylcholine

    An Approach to the Molecular Mechanism of Action
    • 1st Edition
    • M. J. Michelson + 1 more
    • P. Alexander + 1 more
    • English
    Acetylcholine: An Approach to the Molecular Mechanism of Action is an in-depth study of neurotransmitter system, with much focus on acetylcholine and its action and the cholinergic synapse. The book, divided into seven chapters, covers the following topics: the function of the cholinergic synapse; the movement of ions across membranes; the excitatory postsynaptic potential; the nature of cholinoreceptors and cholinesterases; the structure of its active centers; and the pattern of arrangement of the receptors of the cholinoreceptive membrane. The book also covers the quantitative evaluation of the action of neurotransmitters; the reactive capacity of the acetylcholine molecule and its effects on nerve endings and nerve fibers; and the release of mediators and hormones. The text is recommended for those who specialize in the fields of biology, medicine, biochemistry, and pharmacology, especially those wish to study about the neurotransmitter system, cholinoreceptors, the cholinergic synapse, the acetylcholine, and its action.

  • Protides of the Biological Fluids

    Proceedings of the Twentieth Colloquium, Brugge, 1972
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids: Twentieth Volume is a collection of studies about three selected topics from the general field of protein chemistry. The book is divided into four sections. Section A covers monoclonal immunoglobulins and its properties and structure; the amyloid substance; and antibody function. Section B covers active polypeptides derived from plasma proteins; the kinin system; the angiotensin and renin system; anaphylatoxins; and protease inhibitors. Section C covers microcalorimetry in biological systems; biological system and its relation with thermodynamics; and the application of microcalorimetry to biological systems. The book also includes a Section D, which does not consider any of the selected topics, but instead focuses on other techniques such as the double line method; radioimmunoassay of alpha-fetoprotein; and the IgM latex test. The text is recommended for students and reseearchers in the fields of biology, biochemistry, and other related fields, especially those who wish to learn more about monoclonal immunoglobulins, fibrinopeptides, and the effect of microcalorimetry in biological systems.

  • Structure and Function of Oxidation–Reduction Enzymes

    Proceedings of the Wenner-Gren Symposium Held at the Wenner-Gren Center, Stockholm, 23–27 August, 1970
    • 1st Edition
    • Ã…. Ã…keson + 1 more
    • English
    Structure and Function of Oxidation–Reduction Enzymes is a collection of papers presented at the Wenner-Gren Symposium held at the Wenner-Gren Center, Stockholm on August 23-27, 1970. It provides important understanding of the structure and function of oxidation-reduction enzymes: iron, flavin, and nicotinamide enzymes. This book discusses the functional differences among varying structures such cytochrome c, haemoglobins, dehydrogenases, flavins, oestrogens, and peroxidases. It concludes by presenting future expectations, including some questions that need to be addressed. This volume will be of great value to those interested in the present-day research on oxidation-reduction enzymes.

  • Modelling and Control of Biotechnological Processes

    Proceedings of the 1st IFAC Symposium, Noordwijkerhout, The Netherlands, 11 – 13 December 1985
    • 1st Edition
    • A. Johnson
    • English
    Modelling and Control of Biotechnological Processes contains the proceedings of the International Federation of Automatic Control's First Symposium on Modeling and Control of Biotechnological Processes held in Noordwijkerhout, The Netherlands, on December 11-13, 1985. The papers explore modeling and control of biotechnological processes such as fermentation and biological wastewater treatment. This book consists of 37 chapters divided into 11 sections and begins with a discussion on the control of fermentation processes; modeling of biotechnical processes; and application of measurement and estimation techniques to biotechnology. The following sections focus on adaptive control theory, applications of adaptive control, and control and modeling of bioreactors. The reader is also introduced to measurement techniques and sensors, with emphasis on pyrolysis mass spectrometry; rapid bioelectrochemical methods; and a self-tuning controller for multiloop controlled fed-batch fermentation. The remaining sections deal with parameter identification and estimation; Kalman filtering techniques; optimization of production processes; modeling of microkinetics; and optimization theory. This monograph will be of interest to researchers and practitioners in the field of biotechnology.

  • Assay of Protein and Polypeptide Hormones

    International Series of Monographs in Pure and Applied Biology Modern Trends in Physiological Sciences
    • 1st Edition
    • H. Van Cauwenberge + 1 more
    • P. Alexander + 1 more
    • English
    International Series of Monographs in Pure and Applied Biology, Modern Trends in Physiological Sciences, Volume 33: Assay of Protein and Polypeptide Hormones focuses on the assays of protein and polypeptide hormones. The selection first discusses the general principles of protein and polypeptide hormone assays, including conditions and basic factors for bioassays and status of biological assays. The book looks at the assays of hypophyseal hormones, such as growth hormones, adrenocorticotropin (ACTH), thyrotropin, gonadotropins, prolactin, vasopressin, and oxytocin. Concerns include radioimmunoassay, standards of thyrotropin, immunoassay of hypophyseal gonadotropins, and bioassay of prolactin. The book evaluates the assays of pancreatic hormones, such as insulin and glucagon. Chemical structure and properties of insulin and radioimmunoassay of glucagon are explained. The text also focuses on the assays of erythropoietin, renin, human chorionic gonadotropin, and human placental lactogen (HPL). Concerns include augmentation of red cell volume; biological application of renin assays; and similarities and differences between hypophyseal somatotropin and HPL. The selection is a valuable source of data for readers interested in the assays of protein and polypeptide hormones.

  • Biologically Active Amines Found in Man

    Their Biochemistry, Pharmacology, and Pathophysiological Importance
    • 1st Edition
    • Franz Franzen + 1 more
    • English
    Biologically Active Amines Found in Man: Their Biochemistry, Pharmacology, and Pathophysiological Importance deals with the biochemistry, pharmacology, and pathophysiology of biologically active amines present in the human body. Emphasis is placed on amines derived by decarboxylation of α-amino acids in human beings and some of their especially interesting metabolites. This book consists of four chapters and opens with an overview of biogenic amines and their origin, followed by a discussion on their biochemistry, pharmacology, and pathophysiology. The metabolism and inactivation of biologically active amines such as tyramine, dopamine, noradrenaline, adrenaline, tryptamine, serotonin, and histamine are examined, along with their incorporation into the body protein and their rate of turnover. The influence of biologically active amines on the function of the kidneys, microcirculation, and respiratory metabolism is also considered. Finally, illnesses in which indigenous amines have known or possible/probable pathophysiological significance are described. This monograph will be of interest to biologists, biochemists, pharmacologists, and pathophysiologists.

  • Alcohol and Abnormal Protein Biosynthesis

    Biochemical and Clinical
    • 1st Edition
    • Marcus A. Rothschild + 2 more
    • English
    Alcohol and Abnormal Protein Biosynthesis: Biochemical and Clinical focuses on the methods for measuring protein metabolism and the effects of alcohol and altered protein intake as they affect the heart, liver, skeletal muscle, and the brain. Organized into six sections, this book begins with an overview on malnutrition and alcoholism, as well as available techniques for the study of protein synthesis. Subsequent section details the adaptation of protein synthesis and transport to alcohol and malnutrition. Section three discusses the skeletal and cardiac muscle protein metabolism. The last three sections describe the reaction of hepatic protein synthesis to malnutrition and alcohol; effects of alcohol on brain RNA metabolism; and alcohol associated cardiac and hepatic disease.

  • Vaccines

    New Approaches to Immunological Problems
    • 1st Edition
    • Ronald W. Ellis
    • English
    Vaccines: New Approaches to Immunological Problems presents the advances in the range of strategies and approaches for producing vaccines. The book is comprised of 20 chapters that cover the properties of different vaccines. The coverage of the text includes vaccines for cholera, malaria, helminth, and influenza. The book also discusses topics about the key elements of modern technologies that can be applied to different vaccines, such as active immunization strategies using anti-idiotypic antibodies; passive immunoprophylaxis with human monoclonal antibodies; and immunological adjuvants and their mode of action. The text will be of great use to scientists involved in the research and development of vaccines, such as molecular biologists, biochemists, and virologists.

  • Amines and Schizophrenia

    • 1st Edition
    • Harold E. Himwich + 2 more
    • English
    Amines and Schizophrenia is a collection of articles that survey and discuss the biochemical basis present, if any, in schizophrenia, focusing on the role of certain amines. The book discusses certain hypotheses dealing with the field of bio-chemistry as the basis for diseases such as schizophrenia, manic-depressive psychosis, and related diseases. Discussions start with the properties of mescaline, because the psychotic effect of the drug has some aspects similar to that of a schizophrenic syndrome. One paper examines the presence of certain amines, such as norepinephrine, dopamine, and serotonin in the brain, including their role in the synaptic transmission of nerve impulses in the central nervous system. Other papers review the role of derangements of tryptophan metabolism in psychotic behavior; the metabolic interrelationships of tryptophan and methionine in mental illness; and the results obtained with psychomimetic and non-psychomimetic congeners of three classes of indoleamines including LSD. The book gives more details on the actions of various biological amines on single neurons in the limbic system of the brain. The text also evaluates the use of hallucinogenic drugs in considering their heuristic value in the study of the biochemical basis of mental function. The selection will prove relevant for psychologists, psychiatrists, drug researchers, pharmacologists, and chemical laboratory workers and technicians.

  • Proceedings of the First International Congress of Parasitology

    Roma, 21-26 September 1964
    • 1st Edition
    • Augusto Corradetti
    • English

  • Urea as a Protein Supplement

    • 1st Edition
    • Michael H. Briggs
    • English
    Urea as a Protein Supplement presents the significant advances that have been made in ruminant nutrition. This book examines the role of the rumen flora and fauna as synthesizers of protein from non-protein nitrogen sources such as ammonium compounds and urea. Organized into four parts encompassing 23 chapters, this book starts with an overview of the use of urea and other non-protein nitrogen sources in ruminant nutrition. This text then explores the various methods that may be used for the preparation of urea, which involves the dehydration of ammonium carbamate produced by the reaction of carbon dioxide and ammonia at high pressure and temperature. Other chapters consider the ways in which urea could be utilized to increase protein supplies. The final chapter deals with the hydrolysis of urea by urease to ammonia and carbon dioxide, which has been used as a method for determining urea for many years. Agricultural scientists and farmers will find this book useful.

  • Histochemistry

    An Explanatory Outline of Histochemistry and Biophysical Staining
    • 1st Edition
    • Richard W. Horobin
    • English
    Histochemistry: An Explanatory Outline of Histochemistry and Biophysical Staining describes the histochemical staining of cells and tissues as a major tool applied in biological and medical investigations, both in basic research and in practical applications such as clinical diagnosis. The book may be considered as a guide to understanding the scientific basis of staining procedures and alternate actions to take when common methods do not proceed as expected. The first chapter gives general theoretical ideas from which most part of the book is largely organized around. As the book considers the arts and crafts making up the practice of histochemistry and biological staining, emphasis is given to the common physicochemical aspects of the technically diverse methodologies involved. Hence, the author has drawn ideas and information from physicochemically and biochemically related fields, such as chromatography, pharmacology, photography, tanning, and textile dyeing. The bulk of the book is structured around groups of practical procedures, such as fixation, staining with dyestuffs, metal impregnation, and selective extraction as a test of significance. Lastly, general essays on the usefulness of staining theories and on the problems arising from reagent impurities are given as examples. The text is suitable for students and researchers in the fields of physiology, biochemistry, and pharmacology. Clinical laboratory scientists and those involved in the life sciences and biotechnology will benefit from reading the book.

  • Mechanisms of Release of Biogenic Amines

    Proceedings of an International Wenner-Gren Center Symposium Held in Stockholm, February 1965
    • 1st Edition
    • U. S. Von Euler + 2 more
    • English
    Wenner-Gren Center International Symposium Series, Volume 5: Mechanisms of Release of Biogenic Amines provides information pertinent to the fundamental aspects of the release of biogenic amines. This book discusses the physiology, biochemistry, and pharmacology of the biogenic amines. Organized into 39 chapters, this volume begins with an overview of the release of amines, which is implicated in functional disturbances characteristic of different diseases. This text then examines the concepts of cell structure that are significant to the release of neurohumoral agents. Other chapters consider the fluorescence reaction, which made it possible to work out a practical histochemical procedure. This book describes as well a few examples in which the monoaminergic transmitter is not revealed as a diffuse cytoplasmic fluorescence. The final chapter deals with acetylcholine as the only brain amine investigated, which could be influenced by the tremorgenic agents during the period of tremor. This book is a valuable resource for biochemists, morphologists, pharmacologists, and physiologists.

  • The Provision and Use of Library and Documentation Services

    Some Contributions from the University of Sheffield Postgraduate School of Librarianship
    • 1st Edition
    • W. L. Saunders
    • English
    The Provision and Use of Library and Documentation Services is a collection of papers that deals with library interdependent considerations of use and service. One paper discusses the value, organization, and exploitation of trade literature, citing the importance of maintaining a file of trade catalogues to narrow the gap between industrial activity and academic research. Another paper reports a high library membership (80% - 100%) on a survey of library provision and services in four correctional institutions in London. The author notes that professional advice should also be available to help the prisoner read effectively. One author reviews the library services for undergraduates particularly problems of inadequate services and facilities. Other authors discuss the pattern of borrowing in several libraries which generalizes the borrowing behavior of academic communities, such as the rising levels of foreign language and "off-subject" borrowing. Of interest is one author's analysis of the way scientists use libraries in terms of finding information, reading, and use of facilities. His conclusion: scientists have no clear-cut opinion on the best method of acquiring information. This book is suitable for librarians, administrators of private or public library systems, for students and academicians in the field of library science.

  • International Congress for Microbiology

    Moscow, 1966
    • 1st Edition
    • Sam Stuart
    • English
    IX International Congress for Microbiology discusses the genetic regulation of microbial metabolism. This book presents the recommendations and suggestions on the nomenclature and classification of viruses. Organized into eight parts encompassing 72 chapters, this compilation of papers starts with an overview of the genetic code, which expresses the relationship between nucleotide triplets in messenger RNA and amino acids in proteins. This text then discusses the two aspects of the regulation of the physiology of Escherichia coli. Other chapters explore the ergot alkaloids and examine the problem of ergot alkaloid production and biosynthesis. This book discusses as well the antibiotic inhibitors of protein synthesis that are major clinical drugs, including chloramphenicol, tetracycline, streptomycin, erythromycin, and other aminoglycosides. The final chapter deals with karyological investigation of the cells during transformation by Rous virus (RSV), which shows that these cells retain a diploid character. This book is a valuable resource for epidemiologists, microbiologists, and experts in infectious diseases.

  • Proceedings of the Fifth International Seaweed Symposium, Halifax, August 25–28, 1965

    • 1st Edition
    • E. Gordon Young + 1 more
    • English

  • Enzyme Chemistry of Phenolic Compounds

    Proceedings of the Plant Phenolics Group Symposium, Liverpool, April 1962
    • 1st Edition
    • J. B. Pridham
    • English
    Enzyme Chemistry of Phenolic Compounds documents the proceedings of the Plant Phenolics Group Symposium held at Liverpool on April 11-12 1962. This book focuses on the interaction of enzymes and phenolic compounds, oxidation-reduction systems in plants and microorganisms, and phenolase complex. Other topics discussed include purification of phenol oxidases; enzyme-substrate specificity in potato polyphenol oxidase; tocopherols; and role of ubiquinone and plastoquinone in plant metabolism. Hydrolytic enzymes; enzyme inhibition by phenolic compounds; tannin inhibition of plant mitochondria; and aromatic acid-reducing systems in fungi are also deliberated in this selection. This publication is beneficial to students and biochemists researching on enzyme and phenolic compounds.

  • The Biochemistry of Poliomyelitis Viruses

    A Synopsis of Poliomyelitis Infection and Research
    • 1st Edition
    • Ernest Kovács
    • P. Alexander + 1 more
    • English
    The Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research. This volume presents a general introduction to viruses as to their descriptions and biological, biochemical, and epidemiological aspects. Clinical poliomyelitis, test measurements in the cerebrospinal fluid, and the actions of the poliomyelitis virus are explained. The isolation of the poliomyelitis virus and some aspects of its immunology and serology through refinements of serologic tools and special techniques, plus the state of poliovirus purification, are noted. This book also gives assumptions about the virus' synthetic activities in vivo based on experiments conducted in other viral diseases other than the polio virus. This text also notes that important discoveries such as those made by Gierer and Schramm or Fraenkel-Conrat provide updated poliomyelitis research. Other research studies are taken into consideration and emphasis is given to the biochemical concept of the polio infection and the related features induced during infection such as the presence of tumors. The most promising trend in research is in the study of enzymes of infected cells leading to an understanding of the biochemistry of viral diseases. The use of inference microscopy and X-ray analysis of cell mass is recommended. This book will prove invaluable for microbiologists, disease investigators, clinical workers, and research scientists.

  • Cell Biology of the B Cell Receptor

    • 1st Edition
    • Volume 123
    • Hidde Ploegh
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • The Evolution of the Microscope

    • 1st Edition
    • S. Bradbury
    • English
    The Evolution of the Microscope covers some of the features of the history of the microscope and the rationale of the design features found in microscopes. The book discusses the first microscopes, the compound microscope in England (1650-1750), simple or single-lens microscopes, and the development of the achromatic microscope. The text also describes the microscope in Victorian times as well as the optical microscope since 1880. The search for greater resolving power such as the ultra-violet and electron microscopes is considered. Scientists and microscopists will find the book invaluable.

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