Transporters in Drug Discovery and Development
Detailed Concepts and Best Practice
- 1st Edition - October 31, 2013
- Author: Yurong Lai
- Language: English
- Paperback ISBN:9 7 8 - 0 - 0 8 - 1 0 1 5 4 9 - 0
- Hardback ISBN:9 7 8 - 1 - 9 0 7 5 6 8 - 2 1 - 3
- eBook ISBN:9 7 8 - 1 - 9 0 8 8 1 8 - 2 8 - 7
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are th… Read more
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Request a sales quoteWritten by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.
- A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development
- Balanced coverage of molecular biology aspects and functional outcomes
- State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity
Scientists working in biopharmaceutical science, drug discovery/development in understanding the principles and techniques for testing drug candidates
Membrane transporters and the diseases corresponding to functional defects; P-glycoprotein (P-gp/MDR1)/ABCB1; Multidrug resistance- associated protein 2 (MRP2/ABCC2); Breast cancer resistance protein (BCRP)/ABCG2; The bile salt export pump (BSEP/ABCB11); Organic anion- transporting polypeptides (OATPs/SLCOs); Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug transporters in drug discovery and development; Transporter study methodologies.
- No. of pages: 780
- Language: English
- Edition: 1
- Published: October 31, 2013
- Imprint: Woodhead Publishing
- Paperback ISBN: 9780081015490
- Hardback ISBN: 9781907568213
- eBook ISBN: 9781908818287
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Yurong Lai
Yurong Lai is a senior principal scientist at a US-based pharmaceutical company. He received his M.D. from Fujian Medical University in China and a Ph.D. (Toxicology) from Sapporo Medical University in Japan. From 1998 to 2001, he was a research fellow of Japanese Society for Promotion (JSPS) in Department of Physiopathology, Graduate School of Medicine of Hokkaido University, followed by a position as Research Associate in Department of Pharmaceutics, University of Washington
Affiliations and expertise
A major US pharmaceutical company, USARead Transporters in Drug Discovery and Development on ScienceDirect