Books in Organic chemistry

Benzodiazepine-Based Drug Discovery

1st Edition
August 16, 2022
Farzad Zamani + 1 more
English
Paperback
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eBook
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Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. This book offers a broad range of recent developments and detailed coverage of the synthesis and biological activities of the drugs based on benzodiazepine and benzothiazepine matrixes, and is an ideal reference guide to researchers working in organic and medicinal chemistry. The importance of these privileged pharmacophores is not limited to the treatment of psychotic disorders because minor changes in the structures can generate various biological activities. They represent a wide range of therapeutic functions such as anticonvulsant, antianxiety, anti-depressant, antiviral, anti-HIV, anti-inflammatory, anticoagulant, anti-obesity, endothelin antagonist, cholecystokinin antagonist, and vasopressin receptor antagonist activities.

Comprehensive Aryne Synthetic Chemistry

1st Edition
July 20, 2022
Hiroto Yoshida
English
Paperback
9 7 8 0 3 2 3 8 5 1 5 3 4
eBook
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Arynes have been important, well-recognized reactive intermediates in organic chemistry since the first speculation of their existence at the beginning of the 20th century. In recent years, synthetic chemistry with arynes has experienced a remarkable revival, leading to diverse new reactions that provide convenient and direct access to various aromatic compounds of high synthetic significance. Comprehensive Aryne Synthetic Chemistry summarizes the progress in the synthetic utilization of arynes for noncatalytic and transition metal-catalyzed reactions developed in the last 20 years. The book covers a broad range of topics including methods of generating arynes, regioselectivity, electrophilic couplings, pericyclic reactions, transition metal-catalyzed reactions, and cycloadditions. It is ideal for advanced students and researchers working in synthetic organic chemistry in academia and industry.

Studies in Natural Products Chemistry

1st Edition
Volume 74
July 19, 2022
Atta-ur Rahman
English
Hardback
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eBook
9 7 8 0 3 2 3 9 1 1 0 0 9

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

Advances in Heterocyclic Chemistry

1st Edition
Volume 138
July 4, 2022
Eric F.V. Scriven + 1 more
English
Hardback
9 7 8 0 3 2 3 9 8 8 5 9 9
eBook
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Advances in Heterocyclic Chemistry, Volume 138, the latest release in this definitive series on the field of heterocyclic chemistry, combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Topics in this new release include The Paal Knorr reaction in Heterocyclic Chemistry, Synthesis and Applications of Heterocyclic Sulfoximines, Recent advances in the synthesis of 4H-chromen-4-ones (2012-2021), Recent Developments in the Chemistry of Heteroporphyrins and Heterocarbaporphyrin... The Chemistry of 1,4-Dihydropyrrolo[3... and more.

Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden

1st Edition
July 1, 2022
David E. Lewis
English
Paperback
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eBook
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Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov’s Rule are addressed. The book introduces Walden’s original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.

Progress in Medicinal Chemistry

1st Edition
Volume 61
June 17, 2022
David R. Witty + 1 more
English
Hardback
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eBook
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Progress in Medicinal Chemistry, Volume 61 provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors.

Computer Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches

1st Edition
May 26, 2022
Mithun Rudrapal + 1 more
English
Paperback
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eBook
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Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches outlines the basic theoretical principles, methodologies and applications of different fundamental and advanced CADD approaches and techniques. Including information on current protocols as well as recent developments in the computational methods, tools and techniques used for rational drug design, the book explains the fundamental aspects of CADD, combining this with a practical understanding of the various in silico approaches used in modern drug discovery processes to assess the field in a comprehensive and systematic manner. Providing up-to-date, information and guidance for scientists, researchers, students and teachers, the book helps readers address specific academic and research related problems using illustrative explanations, examples and case studies, which are systematically reviewed.

Coronavirus Drug Discovery

1st Edition
May 25, 2022
Chukwuebuka Egbuna
English
Paperback
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eBook
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Coronavirus Drug Discovery, Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment is the first of three volumes presenting comprehensive information on drug discovery against COVID-19. This volume provides background information on the genesis of COVID-19, the epidemiology, transmission, pathogenesis, and mutagenesis. It also presents the various treatment options, drug discovery opportunities and vaccine developmental processes. Written by global team of experts from key institutions across the globe, this book is recommended to all concerned agencies, private research firms, and consortiums working on finding a solution to COVID-19 and its variants. By design, this book will be useful to drug developers, medicinal chemists, pharmacologists, health experts, researchers, students and faculty members in industry and academia.

New Strategies Targeting Cancer Metabolism

1st Edition
May 17, 2022
Galal H. Elgemeie + 1 more
English
Paperback
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eBook
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New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.

Studies in Natural Products Chemistry

1st Edition
Volume 73
May 17, 2022
Atta-ur Rahman
English
Hardback
9 7 8 0 3 2 3 9 1 0 9 7 2
eBook
9 7 8 0 3 2 3 9 1 0 9 8 9

Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products. Hence, these new discoveries have created new avenues and applications for their use.

Related subjects

Bioorganic chemistry

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Heterocyclic chemistry

Medicinal chemistry

Natural products chemistry

Organic synthesis

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Terpenes and steroids

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Books in Organic chemistry

Benzodiazepine-Based Drug Discovery

Comprehensive Aryne Synthetic Chemistry

Studies in Natural Products Chemistry

Advances in Heterocyclic Chemistry

Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden

Progress in Medicinal Chemistry

Computer Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches

Coronavirus Drug Discovery

New Strategies Targeting Cancer Metabolism

Studies in Natural Products Chemistry

Related subjects