Coronavirus Drug Discovery

Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment

1st Edition - May 25, 2022
Editor: Chukwuebuka Egbuna
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 1 5 6 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 1 7 8 - 7

Coronavirus Drug Discovery, Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment is the first of three volumes presenting comprehensive information on drug di… Read more

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Coronavirus Drug Discovery, Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment is the first of three volumes presenting comprehensive information on drug discovery against COVID-19. This volume provides background information on the genesis of COVID-19, the epidemiology, transmission, pathogenesis, and mutagenesis. It also presents the various treatment options, drug discovery opportunities and vaccine developmental processes. Written by global team of experts from key institutions across the globe, this book is recommended to all concerned agencies, private research firms, and consortiums working on finding a solution to COVID-19 and its variants. By design, this book will be useful to drug developers, medicinal chemists, pharmacologists, health experts, researchers, students and faculty members in industry and academia.

Cover image
Title page
Table of Contents
Copyright
Contributors
Part I. Coronavirus pandemic and countermeasures
Chapter 1. Coronavirus pandemic: History, overview of different strains of coronaviruses and what went wrong
1.1. Introduction
1.2. Origin of coronavirus
1.3. Life cycle of SARS-CoV-2 and nomenclature of the strains of coronavirus
1.4. What went wrong in the history of COVID-19
1.5. Future projections: possible ways to tackle COVID-19
1.6. Conclusion
Chapter 2. COVID-19 outbreak: comprehensive update on epidemiology, transmission, and treatment opportunities
2.1. Introduction
2.2. Epidemiology, age demographics, and comorbidity status
2.3. Origin, cellular etiology, and pathogenesis
2.4. Genomic organization
2.5. Transmission
2.6. Replication cycle
2.7. Signs and symptoms
2.8. Potential therapeutic strategies
2.9. Conclusion and future perspectives
Chapter 3. Biomarkers, tools, and test kits for COVID-19
3.1. Introduction
3.2. Biomarker
3.3. Current diagnostic tools for COVID-19
3.4. Artificial intelligence–assisted rapid testing for COVID-19
3.5. Lowest cost diagnostic kits for COVID-19
3.6. Future projections
3.7. Conclusion
Chapter 4. Testing and diagnosis of SARS-CoV-2 infection
4.1. Introduction
4.2. Case definitions
4.3. Specimen type and priority
4.4. Specimen storage
4.5. Collecting and handling specimens safely
4.6. Diagnosis methods
4.7. Future projection
4.8. Conclusion
Chapter 5. Pathogenesis and mutagenesis of SARS-CoV-2: cellular attachment, entry, and infection
5.1. Introduction
5.2. Pathogenesis of SARS-CoV-2
5.3. Mutagenesis of SARS-CoV-2
5.4. Future perspectives
5.5. Conclusion
Chapter 6. Therapeutic options in coronavirus treatment: COVID-19 drug discovery update
6.1. Introduction
6.2. Novel coronavirus 2019
6.3. Drug discovery for COVID
6.4. Drug discovery related to COVID-19
6.5. Plasma therapy
6.6. Future projections
6.7. Conclusion
Chapter 7. Current therapeutic strategies to combat coronavirus disease 2019
7.1. Introduction
7.2. Antiviral agents
7.3. Supporting agents
7.4. Miscellaneous agents and therapies
7.5. Traditional herbal medicines
7.6. Future projections
7.7. Conclusion
Chapter 8. Myth surrounding the FDA disapproval of hydroxychloroquine sulfate and chloroquine phosphate as drugs for coronavirus disease 2019
8.1. Introduction
8.2. Chloroquine and COVID-19
8.3. Plaquenil (hydroxychloroquine sulfate)
8.4. Future projection
8.5. Conclusions
Chapter 9. Dexamethasone: a corticosteroid drug for the treatment of coronavirus disease 2019
9.1. Introduction
9.2. Pathophysiology of COVID-19
9.3. Treatment strategies
9.4. Corticosteroid therapies
9.5. Role of dexamethasone in COVID-19 treatment
9.6. Future projections
9.7. Conclusion
Chapter 10. Drug combination therapies for SARS-CoV-2 (COVID-19) treatment
10.1. Introduction
10.2. Pathophysiology of COVID-19
10.3. Clinical manifestations
10.4. Overview of COVID-19 management
10.5. Combination therapies
10.6. Future challenges
10.7. Conclusion
Chapter 11. Drug repurposing for SARS-CoV-2 (COVID-19) treatment
11.1. Introduction
11.2. Comparison of drug repurposing and de novo drug development processes
11.3. Selected COVID-19 drugs under repurposing considerations
11.4. Pros and cons of drug repurposing
11.5. Political antagonism that COVID-19 drug repurposing faced
11.6. Future perspectives
11.7. Conclusion
Chapter 12. SARS-CoV-2 vaccine development
12.1. Introduction
12.2. Common antiviral vaccine components
12.3. Types of vaccines related to coronaviruses
12.4. The use of proteins in vaccine development
12.5. Comparing a drug and a vaccine
12.6. Safety issues in vaccines
12.7. Future perspectives
12.8. Conclusion
Chapter 13. FDA Coronavirus Treatment Acceleration Program: approved drugs and those in clinical trials
13.1. Introduction
13.2. Food and Drug Administration
13.3. FDA coronavirus treatment acceleration program
13.4. Emergency use authorization approval of drugs by the FDA for combating COVID-19
13.5. Investigational antiviral agents under different clinical trials
13.6. Future projections
13.7. Conclusion
Part II. Global impacts and collaborative efforts against COVID-19
Chapter 14. The coronavirus global pandemic and its impacts on society
14.1. Introduction
14.2. Search methods
14.3. WHO recommendations
14.4. Treatment of COVID-19
14.5. Impact of cultural factors on the spread of the fight against coronavirus
14.6. Effects of the SARS-CoV-2
14.7. Interprofessional education and collaborative practice
14.8. Conclusion
Chapter 15. Coronavirus disease 2019 in Africa: why the recent spike in cases?
15.1. Introduction
15.2. COVID-19 in Southern African region
15.3. COVID-19 in Central African region
15.4. COVID-19 in Eastern Africa region
15.5. COVID-19 in Northern Africa region
15.6. COVID-19 in Western Africa region
15.7. Country-specific example: COVID-19 pandemic in Nigeria
15.8. Why is Nigeria and other African countries experiencing continuous spike in COVID-19 cases?
15.9. Future perspectives
15.10. Conclusion
Chapter 16. Interdisciplinary approach to biomedical research: a panacea to efficient research output during the global pandemic
16.1. Introduction
16.2. Interdisciplinary biomedical research and COVID-19
16.3. Interdisciplinary approach in biomedical education
16.4. Use of model organisms and advancements in drug development and treatment
16.5. Gene editing and stem cell technologies—an interdisciplinary look
16.6. Genetic engineering and improvements in microscopic techniques
16.7. Omics in biomedical research
16.8. Conclusion and future perspectives
Chapter 17. Roles of online social media platforms and artificial intelligence in diffusing the impact of COVID-19 as scientists find a cure
17.1. Introduction
17.2. Emergence of social media
17.3. Role of social media in pandemic
17.4. Conclusions and future perspectives
Index

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Chukwuebuka Egbuna