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Studies in Natural Products Chemistry

1st Edition - May 17, 2022

Editor: Atta-ur Rahman

Hardback ISBN:

9 7 8 - 0 - 3 2 3 - 9 1 0 9 7 - 2

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 1 0 9 8 - 9

Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of… Read more

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Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products.

Hence, these new discoveries have created new avenues and applications for their use.

Cover image
Title page
Table of Contents
Studies in Natural Products Chemistry
Copyright
Contributor
Preface
Chapter 1. Recent advances in pluramycins, biological activity, and synthetic strategies
1. Introduction
2. Biological activities of the pluramycin family
3. Biosynthesis
4. Recent synthetic reports of pluramycins
5. Conclusion
Abbreviations
Chapter 2. Anticancer naphthoquinone derivatives: an updated patent review (2012–19)
1. Introduction
2. Naphthoquinone patents
3. Conclusion
Chapter 3. Recent patents on anticancer potential of sesquiterpene lactones
1. Introduction
2. Sesquiterpene lactones
3. Sesquiterpene lactone nucleus
4. Anticancer properties of sesquiterpene lactones
5. Germacranolides
6. Pseudoguaianolides
7. Guaianolides
8. Eudesmanolide
9. Elemanolides
10. Other sesquiterpenes
11. Conclusion
Chapter 4. Resveratrol: a potential drug candidate with multispectrum therapeutic application
1. Introduction
2. SAR of resveratrol and its analogues
3. Biological activities of resveratrol and its derivatives (preclinical and clinical studies)
4. Mechanism of action through which resveratrol exerts its biological effects
5. Side effects
6. Conclusion and future perspectives
Abbreviations
Chapter 5. Recent developments on bioactivities of mushrooms: structure–activity nexus therapeutic potentials
1. Introduction
2. Methodology
3. Chemistry and bioactive components in mushrooms
4. Reported activities against notable diseases
5. Structure–activity relationship of natural bioactives from mushrooms
6. Results and discussion
7. Conclusion
Abbreviations
Chapter 6. Coumarin derivatives: biomedicinal properties and interactions with carrier proteins
1. Introduction
2. Carrier proteins: serum albumins
3. Coumarin derivatives: structure and functions
4. Experimental methods to study protein–ligand interactions
5. Binding of coumarins with serum albumins
6. Structure–activity relationship
7. Conclusion
Chapter 7. Advances in the green extraction methods and pharmaceutical applications of bioactive pectins from unconventional sources: a review
Highlights
1. Introduction
2. Unconventional pectic polysaccharides
3. Unconventional pectin extraction methods
4. Conventional and emerging analytical techniques
5. Structural and chemical modifications of unconventional pectin
6. Applications of unconventional pectins for desirable biological effects
7. Trends and future opportunities
8. Conclusion
Abbreviations
Chapter 8. Bioactive stilbenes from plants
1. Introduction
2. Structure types
3. Molecular identification of stilbenes
4. Biological activities
5. Conclusion
Chapter 9. Curcumin as a privileged scaffold molecule for various biological targets in drug development
1. Introduction
2. Chemistry and SAR of curcumin and its analogs
3. Therapeutic effects of curcumin (preclinical studies in vitro and in vivo)
4. Curcumin in clinical trials
5. Novel delivery strategies employed to overcome bioavailability of curcumin
6. Conclusion
Abbreviations
Chapter 10. The potential use of agro-industrial by-products as sources of bioactive compounds: a nanotechnological approach
1. Introduction
2. Agro-industrial by-products as food additives
3. Ethanol and fuel production
4. Antibiotic production
5. Feed production
6. Other usages of agro-industrial by-products
7. Applications of agro-industrial wastes in nanotechnology
8. Conclusion
Chapter 11. Marine-derived antidiabetic compounds: an insight into their sources, chemistry, SAR, and molecular mechanisms
1. Introduction
2. Marine sources as upcoming antidiabetic agents
3. Marine-derived molecules with target selective activity
4. Chemistry and SAR analysis of some selective marine antidiabetic leads
5. Molecular investigations on diabetic targets
6. Upcoming challenges and future prospects
7. Conclusion
Index