Combination Drug Delivery Approach as an Effective Therapy for Various Diseases

1st Edition - March 27, 2022
Editor: Prashant Kesharwani
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 8 7 3 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 8 7 6 - 2

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control v… Read more

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code needed.

Institutional subscription on ScienceDirect

Request a sales quote

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches.

It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
Preface
Acknowledgments
Part A: Combination drug delivery approaches against various diseases
Chapter 1. Overcoming cancer drug resistance via nanomedicine-based combined drug delivery
Abstract
1.1 Introduction
1.2 Organic nanocarriers
1.3 Inorganic nanocarriers
1.4 Conclusion
References
Chapter 2. Overcoming the challenges of drug resistance through combination drug delivery approach
Abstract
2.1 Introduction
2.2 Drug resistance in cancer
2.3 Combination drug delivery approach to overcome antimicrobial resistance
2.4 Conclusion
References
Chapter 3. Combination drug delivery approaches in ophthalmology
Abstract
3.1 The eye
3.2 The need for new ophthalmic treatments
3.3 Drug–device combinations in ophthalmology
3.4 Challenges and future perspectives
References
Chapter 4. Combination drug delivery system to enhance the transdermal drug delivery of bioactive molecules
Abstract
4.1 Introduction
4.2 Physiological skin row versus percutaneous permeation of bioactive molecules
4.3 Strategies used to enhance transdermal transport
4.4 Physical parameters of permeability of lipid vesicles
4.5 Conclusions
Acknowledgments
References
Chapter 5. Combination drug delivery approaches in rheumatoid arthritis
Abstract
5.1 Introduction
5.2 Nanoparticles for rheumatoid arthritis therapy
5.3 siRNA and miRNA for rheumatoid arthritis therapy
5.4 Combinatory therapy for gene and drug delivery
5.5 Challenges and future perspectives
5.6 Conclusion
Disclosures
Acknowledgments
References
Chapter 6. Aptamer-mediated drug delivery system for cardiovascular diseases
Abstract
6.1 Introduction
6.2 Conventional drug delivery systems for cardiovascular diseases
6.3 Aptameric drug delivery systems for cardiovascular diseases
6.4 Future perspective
6.5 Conclusion
References
Chapter 7. Combination drug delivery approaches for viral infections
Abstract
7.1 Introduction
7.2 Combination drug therapy to counter various viral infections
7.3 Approach and scope of improvement of combination drug therapy to treat viral infections
7.4 Conclusion and future perspective
Acknowledgments
References
Chapter 8. Approaches and molecular tools for targeted drug delivery in malaria infected red blood cells
Abstract
8.1 What is the mechanism of action of antimalarial drugs?
8.2 Drug resistance is the bottleneck to malaria treatment
8.3 Targeted drug delivery: need of the hour
8.4 Lipid-based drug delivery carriers
8.5 Liposomes
8.6 Nanolipid carriers
8.7 Dendrimers
8.8 Solid lipid nanoparticles
8.9 Nanoemulsions
8.10 Self-microemulsifying drug delivery system
8.11 Nanoparticles as drug carriers
8.12 Peptides as a drug carrier
8.13 Aptamers as drug carriers
8.14 Drug-loaded erythrocytes
8.15 The viral particle as a delivery vehicle
References
Chapter 9. Combination drug delivery approaches for tuberculosis
Abstract
9.1 Introduction
9.2 Tuberculosis
9.3 Formulations and drug delivery routes for tuberculosis treatment
9.4 Alternative approaches for drug delivery in tuberculosis disease
9.5 Exploring combinatorial approaches for effective tuberculosis therapies: perspectives and challenges
9.6 Conclusion
Acknowledgments
References
Part B: Combination drug delivery approaches against cancer
Chapter 10. Combination drug delivery approaches for cancer therapy
Abstract
10.1 Introduction
10.2 Approaches and advantages of combination drug therapy
10.3 The role of nanocarriers in combination drug delivery approaches
10.4 Drug delivery approaches for cancer biology
10.5 Conclusion and future perspective
Acknowledgments
References
Chapter 11. Prodrug-based drug delivery approaches in cancer combination therapy
Abstract
11.1 Introduction
11.2 Prodrugs in cancer therapy
11.3 Prodrug activation mechanism
11.4 Prodrug and nanotechnological applications
11.5 Combination therapy in cancer
11.6 Conclusion
References
Chapter 12. Combination of anticancer drugs with microRNA as cancer therapeutics
Abstract
12.1 Introduction
12.2 MicroRNA as anticancer agent
12.3 Combination of microRNA with anticancer agents a novel tool for cancer therapy
12.4 Nanoparticle used to deliver cancer therapeutics
12.5 Applications in cancer and other diseases
12.6 Conclusion
Acknowledgment
References
Chapter 13. Nanotechnology-mediated combinational drug delivery approach for cancer therapy
Abstract
13.1 Introduction
13.2 Need for combinational drug therapy
13.3 Nanotechnology-driven combinational drug delivery
13.4 Nanotechnology-based sequential combination therapy
13.5 Conclusion
Conflict of interest
Acknowledgment
References
Part C: Combination drug delivery approaches challenges and future perspectives
Chapter 14. Premarket review and postmarket regulation of combination drug products
Abstract
14.1 Introduction
14.2 Market regulations
14.3 Device-based combination products
14.4 Drug-based combination product
14.5 Biologic product-based combination product
14.6 Preclinical and clinical development and regulations
14.7 Good clinical practice
14.8 Significant regulatory steps in PMA application process
14.9 FDA postmarket safety monitoring
14.10 Conclusion
References
Chapter 15. Concluding remarks and future perspective of combination drug delivery systems
Abstract
15.1 Introduction
15.2 Rationale for combination therapy
15.3 Combinations with chemotherapy
15.4 Immunotherapy–metabolic therapy
15.5 Theranostic NPs based on combination therapy and multimodal imaging
15.6 Challenges
15.7 Conclusion and future perspectives
References
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases

Purchase options

Save 50% on book bundles

Institutional subscription on ScienceDirect

Prashant Kesharwani