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Studies in Natural Products Chemistry

  • 1st Edition
  • Volume 74
  • July 19, 2022
  • Atta-ur Rahman
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 1 0 9 9 - 6
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 1 0 0 - 9
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

Advances in Heterocyclic Chemistry

  • 1st Edition
  • Volume 138
  • July 4, 2022
  • Eric F.V. Scriven + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 8 8 5 9 - 9
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 8 6 0 - 5
Advances in Heterocyclic Chemistry, Volume 138, the latest release in this definitive series on the field of heterocyclic chemistry, combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Topics in this new release include The Paal Knorr reaction in Heterocyclic Chemistry, Synthesis and Applications of Heterocyclic Sulfoximines, Recent advances in the synthesis of 4H-chromen-4-ones (2012-2021), Recent Developments in the Chemistry of Heteroporphyrins and Heterocarbaporphyrins, The Chemistry of 1,4-Dihydropyrrolo[3,2-b]pyrroles, and more.

Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden

  • 1st Edition
  • July 1, 2022
  • David E. Lewis
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 0 2 7 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 0 2 6 - 0
Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov’s Rule are addressed. The book introduces Walden’s original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.

Computer Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches

  • 1st Edition
  • May 26, 2022
  • Mithun Rudrapal + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 0 6 0 8 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 4 3 3 - 8
Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches outlines the basic theoretical principles, methodologies and applications of different fundamental and advanced CADD approaches and techniques. Including information on current protocols as well as recent developments in the computational methods, tools and techniques used for rational drug design, the book explains the fundamental aspects of CADD, combining this with a practical understanding of the various in silico approaches used in modern drug discovery processes to assess the field in a comprehensive and systematic manner. Providing up-to-date, information and guidance for scientists, researchers, students and teachers, the book helps readers address specific academic and research related problems using illustrative explanations, examples and case studies, which are systematically reviewed.

Coronavirus Drug Discovery

  • 1st Edition
  • May 25, 2022
  • Chukwuebuka Egbuna
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 8 5 1 5 6 - 5
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 5 1 7 8 - 7
Coronavirus Drug Discovery, Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment is the first of three volumes presenting comprehensive information on drug discovery against COVID-19. This volume provides background information on the genesis of COVID-19, the epidemiology, transmission, pathogenesis, and mutagenesis. It also presents the various treatment options, drug discovery opportunities and vaccine developmental processes. Written by global team of experts from key institutions across the globe, this book is recommended to all concerned agencies, private research firms, and consortiums working on finding a solution to COVID-19 and its variants. By design, this book will be useful to drug developers, medicinal chemists, pharmacologists, health experts, researchers, students and faculty members in industry and academia.

New Strategies Targeting Cancer Metabolism

  • 1st Edition
  • May 17, 2022
  • Galal H. Elgemeie + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 7 8 3 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 7 8 4 - 9
New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.

Studies in Natural Products Chemistry

  • 1st Edition
  • Volume 73
  • May 17, 2022
  • Atta-ur Rahman
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 1 0 9 7 - 2
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 0 9 8 - 9
Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products. Hence, these new discoveries have created new avenues and applications for their use.

Isolated Pyranones

  • 1st Edition
  • April 27, 2022
  • Vishnu Ji Ram + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 2 1 6 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 3 2 1 2 - 5
Isolated Pyranones: Multifaceted Building Blocks for Molecular Diversity covers the latest findings on synthesis and chemical reactivity of highly functionalized pyran-2-ones and pyran-4-ones, their reduced analogs and compounds derived from them through chemical reactions, and their applications in drug discovery and material sciences. It covers the mechanisms of the reaction and step by step formation of final products. Numerous pyranones from natural and synthetic origins, as well as their derived products, have shown diverse pharmacological activities and some are in clinical use. The applications of these compounds are not limited to drug development and imaging agents, and they are also used in material science as organic semiconductors, liquid crystals, organic light emitting diodes (OLEDs), organic catalysts, solid state lasers, photovoltaic and photoconductive devices. The book is ideal for organic, bioorganic, physical, material and natural product chemists working to generate diverse molecular entities through ring transformation reactions of pyranones, and those working in material science to generate new chemical entities.

Raney Nickel-Assisted Synthesis of Heterocycles

  • 1st Edition
  • April 4, 2022
  • Navjeet Kaur
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 9 4 9 2 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 4 9 3 - 4
Raney Nickel-Assisted Synthesis of Heterocycles covers the synthesis of heterocycles using Raney nickel. The book focuses on the use of Raney-Ni, a common catalyst in hydrogenation reaction and its uses in the synthesis and preparation of heterocycles. Furthermore, it explains how the development of new approaches and strategic deployments in known approaches for the formation of complex heterocyclic compounds continue to drive the field of synthetic organic chemistry, along with updates on efforts to prepare heterocycles through the development of new and efficient synthetic transformations. Heterocyclic chemistry is an inexhaustible source of novel compounds, providing the most diverse chemical, physical and biological properties through the design of a wide range of combinations of carbon, hydrogen and heteroatoms. Significant focus has been paid to novel approaches to the formation of heterocyclic compounds, which are of practical use acting as modifiers and additives in a wide range of industries such as reprography, plastics, cosmetics, vulcanization accelerators, solvents, antioxidants and information storage.

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases

  • 1st Edition
  • March 27, 2022
  • Prashant Kesharwani
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 8 5 8 7 3 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 5 8 7 6 - 2
Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations.

Related subjects

Bioorganic chemistry

Carbohydrate chemistry

Combinatorial chemistry

Heterocyclic chemistry

Medicinal chemistry

Natural products chemistry

Organic synthesis

Pharmaceutical chemistry

Physical organic chemistry

Phytochemistry

Stereochemistry