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Studies in Natural Products Chemistry

1st Edition - July 19, 2022

Editor: Atta-ur Rahman

Hardback ISBN:

9 7 8 - 0 - 3 2 3 - 9 1 0 9 9 - 6

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 1 1 0 0 - 9

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the… Read more

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Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.

Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

Cover
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Recent advances of the stereoselective bimodal glycosylations for the synthesis of various glucans
Abstracts
Introduction
Bimodal approach toward d-glucan synthesis using 2-O-TAB group
Application of 2-O-TAB group toward stereoselective mannosylation
Synthesis of various d-glucan using 2-O-TAB approach
Acknowledgment
References
Chapter 2: Plant-derived diterpenes for breast cancer treatment: New perspectives and recent advances
Abstract
Introduction
Identification of new diterpenes with anti-breast cancer activity
Diterpenes with antiproliferative activity
Inhibition of tumor angiogenesis and metastasis by diterpenes
Induction of cell death mechanisms by diterpenes
Diterpenes as a therapeutic option in drug-resistant cell lineages
Nanotechnology as an enhancer of diterpene activity
Sites of interaction and structure–activity relationship
Conclusion
References
Chapter 3: Flavonoids and anticancer activity: Structure–activity relationship
Abstract
Introduction
General aspects of flavonoids
Classification of flavonoids
Overview of SAR studies of flavonoids
The role of epigenetic modifications in SAR studies
Multidrug residence (MDR) and SAR
Recent three-dimensional quantitative structure–activity relationship (3D-QSAR) studies on flavonoids
Conclusion
References
Chapter 4: Bioactive dihydrophenanthrenes from plants
Abstract
Introduction
Biosynthesis of dihydrophenanthrenes
Separation and identification of dihydrophenanthrenes
Structural types
Biological activities
Conclusions
References
Chapter 5: Metabolomics applied to the discovery of new bioactive pharmaceuticals in complex matrices
Abstract
Introduction
Analytical challenges on complex mixtures
Analytical methods
Bioinformatic tools
Biological models
Conclusion
Acknowledgment
References
Chapter 6: Biosynthesis of polyunsaturated fatty acids by metabolic engineering of yeast Yarrowia lipolytica
Abstract
Introduction
Genetic engineering strategy inducing PUFA production
Biosynthesis of microbial PUFAs
Biosynthesis of lipids in modified Yarrowia lipolytica
Enhanced PUFA production using different carbon sources
Pilot—Scale process for microbial PUFA production
Engineering Y. lipolytica for production of lipid compounds other than PUFAs
Engineering Y. lipolytica for biodiesel production
Conclusion
Acknowledgment
References
Chapter 7: Aspergillus versicolor as a source of diversified metabolic products with pharmacological activities
Abstract
Introduction
Isolation of secondary metabolites
Conclusion
References
Chapter 8: Antihyperuricemic peptides: A review focused on xanthine oxidase inhibitory activities
Abstract
Introduction
Preparation and properties of antihyperuricemic peptides
The interactions between XOD and antihyperuricemic peptides
Conclusion and perspectives
References
Chapter 9: Novel cold process applications for the preservation of bioactive components of several natural functional foods
Abstract
Introduction
General considerations about novel LTHV-assisted fluidized bed drying
Conclusion
References
Chapter 10: Advances in biological activities of essential oils
Abstract
Introduction
Encapsulation of essential oils
Interactions of essential oils
ACE-inhibitory activities of essential oils
α-Amylase and α-glucosidase inhibitory activities of essential oils
Xanthine oxidase inhibitory activities of essential oils
Conclusions
References
Chapter 11: Natural polymers for wound dressing applications
Abstract
Introduction
Commonly used polymers and elements in fabrication of wound dressings
Novel strategies in fabrication of wound dressings
Commercial wound dressings by natural polymers
Conclusions and future outlook
References
Chapter 12: Insight into coronaviruses and natural products-based approach for COVID-19 treatment
Abstract
Introduction
Coronavirus
Potential therapeutic targets for COVID-19 treatment
Anticoronaviral natural products
Molecular docking and pharmacokinetic study: For support
Conclusion
References
Index