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Elsevier

Books in Organic chemistry

This collection offers extensive coverage of organic synthesis, reaction mechanisms, and functional group chemistry. Showcasing innovative research, green chemistry approaches, and industrial applications, it supports chemists, students, and researchers in designing new molecules and materials. Addressing drug discovery, polymers, and sustainable processes, these titles foster creativity and technical excellence in advancing organic chemistry for societal benefit.

  • Green Synthetic Approaches for Biologically Relevant Heterocycles

    Volume 1: Advanced Synthetic Techniques
    • 2nd Edition
    • Goutam Brahmachari
    • English
    Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.

  • Green Synthetic Approaches for Biologically Relevant Heterocycles

    Volume 2: Green Catalytic Systems and Solvents
    • 2nd Edition
    • Goutam Brahmachari
    • English
    Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume Two: Green Catalytic Systems and Solvents reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume Two explores green catalytic systems and solvents and the techniques surrounding this approach, including metal and magnetic catalysis to organocatalysis and solid acid catalysis, cycloaddition reactions, and varied approaches using ionic liquids. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 68
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 68, covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts surrounding developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products and their exciting developments in phytochemistry. As natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects, their uses in new drug developments in the pharmaceutical industry has become increasingly important. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, the ability to rapidly isolate and determine the structures and biological activity of natural products has created opportunities for future drug therapies and uses.

  • α-Tertiary Amines en Route to Natural Products

    • 1st Edition
    • Abdul Hameed + 2 more
    • English
    α-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. The book covers the class of natural products bearing the α,α-disubstituted α-amino acid motif. Featured natural product molecules include Altemicidin, Amathaspiramide (A-F), Kaitocephalin, Lactacystin, Salinosporamide, Manzacidins (A,C), Neooxazolomycin, Sphingofungins (E,F), (1S,3R)-1-Aminocyclo... Acid (ACPD), Total synthesis of cephalotaxine and related molecules, α-amino acids based natural products, α amino acid based natural products and Tetrodotoxin. This book is ideal for chemists working in the area of organic synthesis, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 100
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 100, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with chapters in this new release focusing on Chimeric RNAs in cancer, Pathophysiologic landscape of osteoarthritis, Advances in lung cancer biomarkers: The role of (metal-) metabolites and selenoproteins, Advances in cerebral palsy biomarkers, Cytokines in psoriasis, Biochemical analysis of oral fluids for disease detection, and more.

  • Progress in Heterocyclic Chemistry

    • 1st Edition
    • Volume 32
    • Gordon Gribble + 1 more
    • English
    Progress in Heterocyclic Chemistry, Volume 32, the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC), highlights the previous year’s literature on heterocyclic chemistry, along with articles on new developing topics of particular interest to heterocyclic chemists. Chapters highlighted in volume 32 are written by leading researchers in their field, providing a systematic survey of important, original material reported in the literature of heterocyclic chemistry in 2019. As with previous volumes in the series, this release will help academic and industrial chemists and advanced students keep abreast of developments in heterocyclic chemistry.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 78
    • English
    Advances in Carbohydrate Chemistry and Biochemistry, Volume 78, highlights new advances in the field, with this new volume presenting interesting chapters on a range of topics, including Vinyl Sulfone-Modified Carbohydrates: Michael Acceptors and 2π Partners for the Synthesis of Functionalized Sugars, Enantiomerically Pure Carbocycles and Heterocycles and a Biographical Memoire for Leslie Hough.

  • Advances in Triazole Chemistry

    • 1st Edition
    • Tahir Farooq
    • English
    Advances in Triazole Chemistry reviews the ever-widening scope of triazole chemistry. Triazole is an exceptional structural motif with a range of applications across scientific disciplines, including materials science, organocatalysis, agrochemicals, and medicinal chemistry. These many applications of different classes of triazoles have promoted the development of a range of synthetic strategies over the past few years, which are presented here along with recent and ecofriendly methods for the synthesis of all types of triazoles. The book also reviews the recent notable applications in chemical ligation, peptidomimetics, carbohydrate chemistry, nanotechnology, and polymer and materials science. This comprehensive resource is ideal for researchers using triazoles in various disciplines, as well as chemists working in the pharmaceutical, polymer, and agrochemical industries.

  • Copper in N-Heterocyclic Chemistry

    • 1st Edition
    • Ananya Srivastava
    • English
    Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 54
    • English
    Advances in Physical Organic Chemistry, Volume 54, presents the latest reviews of recent work in physical organic chemistry. The book provides a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is a quantitative, molecular level understanding of phenomena across a diverse range of disciplines.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 77
    • David C. Baker
    • English
    Advances in Carbohydrate Chemistry and Biochemistry, Volume 77, the latest release in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on Temporary Ether Protecting Groups at the Anomeric Center in Complex Carbohydrate Synthesis and Mucopolysaccharidosi... Type II (Hunter Syndrome): Clinical and Biochemical Aspects of the Disease and Approaches to its Diagnosis and Treatment.

  • Emerging Carbon Materials for Catalysis

    • 1st Edition
    • Samahe Sadjadi
    • English
    Emerging Carbon Materials for Catalysis covers various carbon-based materials with a focus on their utility for catalysis. Each chapter examines the photo and electrocatalytic applications of a material, including hybrid systems composed of carbon materials. The range of chemical reactions that can be catalyzed with each material—as well as the potential drawbacks of each—are discussed. Covering nanostructured systems, as well as other microstructured materials, the book reviews emerging carbon-based structures, including carbon organic frameworks. Written by a global team of experts, this volume is ideal for graduate students and researchers working in organic chemistry, catalysis, nanochemistry, and nanomaterials.

  • Antifungal Compounds Discovery

    Natural and Synthetic Approaches
    • 1st Edition
    • Marina Sokovic + 1 more
    • English
    Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 67
    • Atta-ur Rahman
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Fluid-Solid Reactions

    • 2nd Edition
    • H. Y. Sohn
    • English
    Fluid-Solid Reactions, Second Edition takes a detailed and thorough look at the scope of fluid-solid reaction systems, focusing on the four phenomena: external mass transfer, pore diffusion, chemical reaction, and adsorption/desorptio... This completely revised new edition builds on the classic original edition through the introduction of cutting-edge new theories and applications, including the formulation and application of a new and convenient law that governs fluid-solid reaction kinetics. This book will be of primary interest to practicing engineers engaged in process research, development, and design in the many fields where fluid-solid reactions are critical to workflow and research. Fluid-solid reactions play a major role in the technology of most industrialized nations. These reactions encompass a very broad field, including the extraction of metals from their ores, the combustion of solid fuels, coal gasification, and the incineration of solid refuse.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 66
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 66 covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in new drug development for the pharmaceutical industry.

  • Carbohydrates in Drug Discovery and Development

    Synthesis and Application
    • 1st Edition
    • Vinod K. Tiwari
    • English
    Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades.This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-contain... molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more.

  • Specification of Drug Substances and Products

    Development and Validation of Analytical Methods
    • 2nd Edition
    • Christopher M. Riley + 2 more
    • English
    Specification of Drug Substances and Products: Development and Validation of Analytical Methods, Second Edition, presents a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development, validation of analytical methods, and their application in practice. This thoroughly revised second edition covers topics not covered or not substantially covered in the first edition, including method development and validation in the clinical phase, method transfer, process analytical technology, analytical life cycle management, special challenges with generic drugs, genotoxic impurities, topical products, nasal sprays and inhalation products, and biotechnology products.The book's authors have been carefully selected as former members of the ICH Expert Working Groups charged with developing the ICH guidelines, and/or subject-matter experts in the industry, academia and in government laboratories.

  • Comprehensive Natural Products III

    • 3rd Edition
    • Hung-wen Liu + 1 more
    • English
    Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community.

  • Handbook of Chitin and Chitosan

    Volume 3: Chitin- and Chitosan-based Polymer Materials for Various Applications
    • 1st Edition
    • Sabu Thomas + 2 more
    • English
    The Handbook of Chitin and Chitosan: Chitin and Chitosan Based Polymer Materials for Various Applications, Volume Three, is a must-read for polymer chemists, physicists and engineers interested in the development of ecofriendly micro and nanostructured functional materials based on chitin and their various applications. The book addresses their isolation, preparation and properties and their composites, nanomaterials, manufacturing and characterizations. This is the third of three volumes in a series that contains the latest on the major applications of chitin and chitosan based IPN’s, blends, gels, composites and nanocomposites, including environmental remediation, biomedical applications and smart material applications.

  • Studies in Natural Products Chemistry

    Bioactive Natural Products
    • 1st Edition
    • Volume 65
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry: Bioactive Natural Products, Volume 65, the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, provides cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products. This has opened up exciting opportunities in the field of new drug development to the pharmaceutical industry.

  • Handbook of Chitin and Chitosan

    Volume 1: Preparation and Properties
    • 1st Edition
    • Sabu Thomas + 2 more
    • English
    The Handbook of Chitin and Chitosan: Preparation and Properties, Volume One, is a must-read for polymer chemists, physicists and engineers interested in the development of ecofriendly micro and nanostructured functional materials based on chitin and their various applications. The book addresses the entirety of working with these materials, from their isolation, preparation and properties, through composites, nanomaterials, manufacturing and characterizations. This is the first of three volumes in a series that contains the latest on the major applications of chitin and chitosan based IPN’s, blends, gels, composites and nanocomposites, including environmental remediation, biomedical applications and smart material applications.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 98
    • English
    Advances in Clinical Chemistry, Volume 98, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.

  • Antimalarial Agents

    Design and Mechanism of Action
    • 1st Edition
    • Graham L. Patrick
    • English
    Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists.

  • Recent Advances in Applications of Name Reactions in Multicomponent Reactions

    • 1st Edition
    • Majid M. Heravi + 1 more
    • English
    Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described.

  • The Alkaloids

    • 1st Edition
    • Volume 84
    • English
    The Alkaloids, Volume 84, is the newest release in a series that has covered the topic for more than 60 years. As the esteemed, leading reference in the field of alkaloid chemistry, this series covers all aspects of alkaloids, including their chemistry, biology and pharmacology. Sections are presented as high-quality, timeless reviews written by renowned experts in the field.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 59
    • David R. Witty + 1 more
    • English
    Progress in Medicinal Chemistry, Volume 59, provides a review of eclectic developments in medicinal G139 chemistry. Each chapter is written by an international board of authors, with this release focusing on Small Molecules - Giant Leaps for Immuno-Oncology, Reviewing P2X7, Reviewing ASK1, and Reviewing DNA-encoded libraries.

  • Recent Trends in Carbohydrate Chemistry

    Synthesis and Biomedical Applications of Glycans and Glycoconjugates
    • 1st Edition
    • Amélia Pilar Rauter + 4 more
    • English
    Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates covers biomedically relevant bacterial cell wall carbohydrates including recent findings on biosynthetic aspects, advances in the chemical assembly of bacterial lipopolysaccharide fragments and teichoic acids, and modern NMR approaches to unravel structural details. The first part introduces and provides the relevant background for synthetic glycoconjugate vaccines. The second section focuses on synthetic carbohydrate-based vaccines of therapeutic potential that are licensed or under development. This second volume of Recent Trends in Carbohydrate Chemistry is ideal for researchers working as synthetic organic chemists, as well as those interested in glycoconjugation, protein chemists, immunologists, and microbiologists, in academia as well as in industry.

  • Recent Trends in Carbohydrate Chemistry

    Synthesis, Structure and Function of Carbohydrates
    • 1st Edition
    • Amélia Pilar Rauter + 4 more
    • English
    Carbohydrate chemistry provides access to carbohydrate-based natural products and synthetic molecules as useful biologically active structures relevant to many health care and disease-related biological processes. Recent Trends in Carbohydrate Chemistry: Synthesis, Structure, and Function of Carbohydrates　covers green and sustainable reactions, organometallic carbohydrate chemistry, synthesis of glycomimetics, multicomponent reactions, and chemical transformations leading to molecular diversity based on carbohydrates. These include inhibitors of glycogen phosphorylase, which are relevant in controlling type 2 diabetes and sugar sulfates. Polysaccharides, which are commonly modified chemically, are also examined with contributions covering polysaccharide synthesis and modification of polysaccharides to obtain new structures and properties. Recent Trends in Carbohydrate Chemistry: Synthesis, Structure, and Function of Carbohydrates is ideal for researchers working as synthetic organic chemists, and for those interested in biomolecular chemistry, green chemistry, organometallic chemistry, and material chemistry in academia as well as in industry

  • Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles

    • 1st Edition
    • Navjeet Kaur
    • English
    Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles provides a useful guide to key approaches being explored in this area. The volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Drawing on the experience of its expert author, the book is a useful guide on the key approaches being explored in this area. Following a user-friendly structure based on specific six-membered heterocycle ring groups, this volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 132
    • English
    Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

  • Green Approaches in Medicinal Chemistry for Sustainable Drug Design

    • 1st Edition
    • Bimal Banik
    • English
    Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6.

  • Lignocellulosics

    Renewable Feedstock for (Tailored) Functional Materials and Nanotechnology
    • 1st Edition
    • Ilari Filpponen + 2 more
    • English
    Lignocellulosics: Renewable Feedstock for (Tailored) Functional Materials and Nanotechnology gives a comprehensive overview of recent advances in using lignocellulosic substrates in materials science and nanotechnology. The functionalization and processing of lignocellulosics are described via a number of examples that cover films, gels, sensors, pharmaceutics and energy storage. In addition to the research related to functional cellulose nanomaterials, there has been an increased interest in research on lignin and lignocellulosics. This book explains how utilizing biomaterials as a raw material allows ambitious reconstruction of smart materials that are green and multifunctional. As lignin as a valuable material has gained a lot of attention in the last few years, shifting from purely extraction and fundamental characterization, and now also focusing on the preparation of exciting materials, such as nanoparticles, readers will find this to be a comprehensive resource on the topic.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 95
    • English
    Advances in Clinical Chemistry, Volume 95, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release including sections on Advances in diagnostic microfluidics, Vascular and valvular calcification biomarkers, Long noncoding RNAs in cancer: From discovery to therapeutic targets, Exosomes of male reproduction, Tryptophan in health and disease, Biochemistry of blood platelet activation, and the beneficial role of plant oils in cardiovascular diseases.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 131
    • English
    Advances in Heterocyclic Chemistry, Volume 131, the latest release in this definitive series in the field, contains highly specialized chapters on a variety of topics, including 1,5-Disubstituted 8-membered ring heterocycles, Recent Developments in the Chemistry of Sydnones and Sydnone imines, Synthesis of fulleroheterocycles, Synthetic approaches to nitroheterocycles by nitration and other methods, 1,3-Amino alcohols and their phenol analogs in heterocyclization reactions, Synthesis of various N-heterocycles using the four component, The Chemistry of Dihydrothienopyrrolo... Part 2, Recent developments in the radiolabeling of heterocyclic rings, Application of Electrochemical Oxidative Methods in the C(sp2)-H Functionalization of Heterocyclic Compounds, and more.

  • The Alkaloids

    • 1st Edition
    • Volume 83
    • Hans-Joachim Knolker
    • English
    The Alkaloids, Volume 83, is the newest release in a series that has covered the topic for more than 60 years. As the esteemed, leading reference in the field of alkaloid chemistry, this series covers all aspects of alkaloids, including their chemistry, biology and pharmacology. Sections are presented as high-quality, timeless reviews written by renowned experts in the field. New chapters in this release include Lamellarin alkaloids: Isolation, synthesis, and biological activity, Chemodiversity, chemotaxonomy and chemoecology of Amaryllidaceae alkaloids, and The indole-based subincanadine alkaloids and their biogenetic congeners.

  • Studies in Natural Products Chemistry

    Bioactive Natural Products
    • 1st Edition
    • Volume 64
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 64, covers the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques that have made it possible to rapidly isolate and determine the structures and biological activity of natural products. The book highlights these new and exciting opportunities in the field of new drug development to the pharmaceutical industry. As natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects, this book is an ideal resource on the material presented.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 130
    • English
    Advances in Heterocyclic Chemistry, Volume 130, the latest release in this definitive series, provides a comprehensive review that combines descriptive synthetic chemistry and mechanistic insights to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. New chapters in this release include Recent Developments in the Radiolabeling of Heterocyclic Rings, Chemistry of Azetidines, Tricyclic Fused Bithiophenes and Related Analogues: Important Building Blocks for Conjugated Materials, Application of Electrochemical Methods in the Synthesis of Heterocyclic Compounds and Elucidation of Their Properties, Organometallic Complexes of Chelating Azines, and more.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 94
    • English
    Advances in Clinical Chemistry, Volume 94, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest technologies relating to the field of clinical chemistry, with specific chapters in this new release covering Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome, Clotting factors - Clinical biochemistry and their roles as plasma enzymes, Myokines: The endocrine coupling of skeletal muscle and bone, Epigenetic reprogramming and potential application of epigenetic-modifying drugs in acquired chemotherapeutic resistance, and more.

  • Powdered Crude Drug Microscopy of Leaves and Barks

    • 1st Edition
    • Vidhu Aeri + 2 more
    • English
    Powdered Crude Drug Microscopy of Leaves and Barks investigates various microscopic techniques used in the examination of structural and cellular features in order to determine their botanical origin. These methods are useful in identifying species with similar morphological characters. Today, there is a variety of methods available to authenticate herbal drugs, ranging from simple morphological examination to physical and chemical analysis, and DNA molecular biology. Due to cost, powder microscopy is the most practical method for primary authentication. Botanical microscopy is a unique, valuable, rapid and cost-effective assessment tool, and plays an important role in the authentication and assessment of medicinal plants. This book is an essential resource for students and researchers involved in the study of plants and natural products, as well as professionals in industries manufacturing plant-based products for use during quality control and assurance steps.

  • Small Molecule Drug Discovery

    Methods, Molecules and Applications
    • 1st Edition
    • Andrea Trabocchi + 1 more
    • English
    Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.

  • Alpha-glucosidase Inhibitors

    Clinically Promising Candidates for Anti-diabetic Drug Discovery
    • 1st Edition
    • Usman Ghani
    • English
    Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery presents information that researchers can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of α -glucosidase inhibitor leads and adaptations, and highlighting their importance within the field of anti-diabetic drug discovery, the book provides chemical structures, detailed background information and in vivo and in vitro biological activity data, and more economical adaptations of these structures. Drawing on the author’s expert research in the field, this book highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work. It is a useful tool not only for anti-diabetic drug development researchers, but also for those whose research may be enhanced by an understanding of α -glucosidase inhibitor chemistry and activity.

  • Current Developments in Photocatalysis and Photocatalytic Materials

    New Horizons in Photocatalysis
    • 1st Edition
    • Xinchen Wang + 2 more
    • English
    Photocatalytic materials can improve the efficiency and sustainability of processes and offer novel ways to address issues across a wide range of fields—from sustainable chemistry and energy production to environmental remediation. Current Developments in Photocatalysis and Photocatalytic Materials provides an overview of the latest advances in this field, offering insight into the chemistry and activity of the latest generation of photocatalytic materials.After an introduction to photocatalysis and photocatalytic materials, this book goes on to outline a wide selection of photocatalytic materials, not only covering typical metal oxide photocatalysts such as TiO2 but also exploring newly developed organic semiconducting photocatalysts, such as g-C3N4.Drawing on the experience of an expert team of contributors, Current Developments in Photocatalysis and Photocatalytic Materials highlights the new horizons of photocatalysis, in which photocatalytic materials will come to play an important role in our day-to-day lives.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 14
    • Michael Harmata
    • English
    Strategies and Tactics in Organic Synthesis, Volume 14, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

  • Monodispersed Particles

    • 2nd Edition
    • Tadao Sugimoto
    • English
    Monodispersed Particles, Second Edition, covers all aspects of monodispersed particles, including inorganic and polymer particles and their composites. The book consists of four parts: fundamentals, preparation, analyses, and applications. Specifically, the fundamental part covers the theoretical insight into the surface energy of particles and its application to the formulation of the new theories of nucleation, growth and habit formation of monodispersed particles. In addition, the theories of recrystallization and solid-solution formation are introduced. These fundamental theories are applied to the precise control of their size, size distribution, shape, internal structure, and composition, leading to the design of diverse monodispersed functional particles widely used in basic science and modern industry.This second edition is fully updated and revised, detailing new theories and recent progress in the field of nanoparticles, including advanced nucleation theory, arrested growth mechanism for monodispersed nanoparticles, and energetics of habit formation. Additionally, the text covers in-depth insights into the anisotropic growth of Au and Ag nanoparticles, the formation mechanisms of polycrystalline Au spheres, iron oxide nanoparticles in heat-up and hot-injection processes, amorphous TiO2 spheres in a sol-gel system, anatase TiO2 in a gel-sol system and their shape control, AgCl nanoparticles in a reverse micelle system, organic-inorganic hybrid liquid crystals, and extensive biomedical applications.

  • Biological Chirality

    • 1st Edition
    • Gyula Palyi
    • English
    Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area.

  • Studies in Natural Products Chemistry

    Bioactive Natural Products
    • 1st Edition
    • Volume 63
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 63, covers the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques that have made it possible to rapidly isolate and determine the structures and biological activity of natural products. The book highlights these new and exciting opportunities in the field of new drug development to the pharmaceutical industry. As natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects, this book is an ideal resource on the material presented.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 53
    • Ian Williams + 1 more
    • English
    Advances in Physical Organic Chemistry, Volume 53, presents the latest reviews of recent work in physical organic chemistry. It provides a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is a quantitative, molecular level understanding of phenomena across a diverse range of disciplines. Chapters in this updated release include Theoretical models for activation and reaction energies in chemical reactions, Chiral induction in asymmetric dual catalysis, and The transition state.

  • Progress in Heterocyclic Chemistry

    • 1st Edition
    • Volume 31
    • Gordon Gribble + 1 more
    • English
    Progress in Heterocyclic Chemistry, Volume 31 is the latest release in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature and articles on developing topics in heterocyclic chemistry. Chapters in this new release are written by leading researchers in their field and constitute a systematic survey of the important original material reported in the literature in of heterocyclic in 2018. As with previous volumes in the series, this updated volume will enable academics, industrial chemists and advanced students stay abreast of developments in heterocyclic chemistry.

  • Organometallic Chemistry of Five-Membered Heterocycles

    • 1st Edition
    • Alexander Sadimenko
    • English
    Organometallic Chemistry of Five-Membered Heterocycles explores the synthesis, coordination modes, reactivity of coordinated five-membered monoheterocycles, and organometallic complexes of their numerous derivatives, including chelating ligands, oligomers, and macrocycles. Beginning with the introduction of organometallic compounds, this book dives deep into the reactivity of coordinated five-membered monoheterocycles and the derivatives of fundamental ligands. This book is an ideal reference for researchers working in organometallic, heterocyclic, materials, or organic chemistry, and catalysis. The readers will gain a comprehensive understanding of modern synthetic methods, reactivity trends of heteroaromatic ligands, and the methods of modern materials construction.

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