The Alkaloids
- 1st Edition, Volume 92 - October 4, 2024
- Editor: Hans-Joachim Knolker
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 7 4 4 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 7 4 5 - 8
The Alkaloids: Chemistry and Biology, Volume 92, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemis… Read more
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Request a sales quote- Provides the latest information on the study of alkaloids
- Covers alkaloid chemistry, biology, pharmacology, and medical applications
- Contains more than 80 published volumes in this interesting field of study
- The Alkaloids, 92
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One Structure, biosynthesis and activity of indolactam alkaloids
- Abstract
- Keywords
- 1 Introduction and scope
- 2 Isolation and structural elucidation
- 2.1 Teleocidins, lyngbyatoxins and olivoretins
- 2.2 The indolactam core
- 2.3 Blastmycetins
- 2.4 Pendolmycins
- 2.5 Cytoblastin
- 3 Biosynthesis
- 4 Biological activity
- 4.1 Symptoms
- 4.2 Toxicological studies
- 4.3 Mechanism of action
- 4.4 Clinical potential
- 5 Organic synthesis of the indolactam core structure
- 6 Conclusions
- References
- Chapter Two The synthetic chemistry of sarpagine–ajmaline-type alkaloids
- Abstract
- Keywords
- 1 Introduction
- 1.1 The sarpagine and ajmaline type alkaloids and their typical structure units
- 1.2 Recent phytochemical studies toward the sarpagine and ajmaline alkaloids
- 2 An overview of synthetic strategies toward the key indole-fused azabicyclo[3.3.1]nonane structure units
- 2.1 The strategies involving Pictet–Spengler cyclization and/or Mannich-type cyclization
- 2.2 The tactics using transition-metal-mediated reactions
- 2.3 [4 + 2] cyclization approaches
- 2.4 The late-stage indole annulation strategies
- 3 Synthetic studies toward the sarpagine- and ajmaline-type alkaloids
- 3.1 The synthesis of sarpagine- and macroline-related alkaloids
- 3.2 Studies toward the ajmaline-type alkaloids
- 4 Conclusion
- Acknowledgments
- References
- Cumulative Index of Titles
- Index
- No. of pages: 352
- Language: English
- Edition: 1
- Volume: 92
- Published: October 4, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443297441
- eBook ISBN: 9780443297458
HK
Hans-Joachim Knolker
10.1978 - 02.1983 Chemistry studies at the Universities of Göttingen and Hannover; diploma thesis on “Regioselective Transformations of Bicyclo[3.3.0]octanes” in the research group of Prof. Dr. E. Winterfeldt, University of Hannover
03.1983 - 05.1985 Ph.D. thesis on "Stereoselective Cyclopentanone Annulations" with Prof. E. Winterfeldt at the University of Hannover
12.1985 - 12.1986 Postdoctoral studies with Prof. K. P. C. Vollhardt at the Department of Chemistry, University of California, Berkeley, USA, working on "Cobalt-Mediated [2+2+2] Cycloadditions of Imidazoles"
01.1987 - 02.1990 Habilitation at the University of Hannover on "Transition Metal-Mediated Syntheses of Heterocycles"
03.1990 ADUC award 1989 of the German Chemical Society
07.1990 Lecturer award of the Fund of German Chemical Industry
01.1991 Gerhard-Hess award of the Deutsche Forschungsgemeinschaft (DFG)
02.1991 Offer of a professorship for Organic Chemistry at the University of Münster
02.1991 Offer of a chair for Organic Chemistry at the University of Karlsruhe
04.1991 Offer of a professorship for Organic Chemistry at the University of Bonn
05.1991 Offer of a chair for Organic Chemistry at the University of Marburg
08.1991 - 11.2001 Full professor of Organic Chemistry at the University of Karlsruhe
10.1995 - 09.1997 Chairman of the Chemistry Department at the University of Karlsruhe
10. - 11.1998 Visiting professor at the University of Tsukuba, Japan, as fellow of the Japan Society for the Promotion of Science (JSPS)
01.2000 Visiting professor in India on invitation of the Indian National Science Academy (INSA)
11.2000 Offer of a chair of Organic Chemistry at the Technical University of Dresden
02.2001 Offer of the Regius Chair of Chemistry at the University of Glasgow
07.2001 Offer of a chair in Synthetic Organic Chemistry at the University of Oslo
since 12.2001 Professor of Organic Chemistry at the Technical University of Dresden
03.2006 Election as an Ordinary Member of the Saxon Academy of Sciences
12.2006 Admission as “Fellow of the Royal Society of Chemistry (FRSC)”
10. - 11.2007 Visiting professor at Kyushu University, Japan, as fellow of the Japan Society for the Promotion of Science (JSPS)
01.2008 - 12.2011 Member of the presidium of the Saxon Academy of Sciences
since 01.2011 Editor-in-Chief of “The Alkaloids” (Academic Press, London)
Research Publications: more than 230 scientific articles, reviews and patents