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Elsevier

Books in Life sciences

  • Artificial Intelligence in Immunoengineering

    Methods, Models, and Translational Applications
    • 1st Edition
    • Steven Zanganeh + 1 more
    • English
    Artificial Intelligence in Immunoengineering: Methods, Models, and Translational Applications examines how AI reshapes immunoengineering to design immune-modulating biomaterials, imaging systems, and diagnostic tools. The book presents an integrated view of data-driven approaches that accelerate discovery and translation in biomedicine. It surveys biological data from single-cell to spatial omics and proteogenomics and offers practical machine learning frameworks, generative and mechanistic models, and multimodal integration strategies. Sections address bench-to-bedside translation, validation pipelines, and regulatory considerations for AI-enabled immunoengineering tools.The book highlights the rapid progress of multidisciplinary research within immunotherapy and immunoengineering. Looking forward, the prospects of immunoengineering appear promising, with further advancements in disease prevention, diagnostics, and treatment on the horizon. Graduate students, academic researchers, clinician-scientists... and computational biologists will gain standardized workflows, mechanism-aware modeling, and reproducible pipelines that advance immunotherapies and diagnostics from concept to clinical impact.

  • Bioprospecting Native Microbiomes for Boosting Phytoremediation

    • 1st Edition
    • Vimal Chandra Pandey + 1 more
    • English
    Bioprospecting Native Microbiomes for Boosting Phytoremediation provides an inclusive overview of the use of metal-resistant native microbiomes for boosting the phytoremediation of polluted land for ecological and environmental restoration. The book offers a basic understanding of the principles and mechanisms of microbe-induced phytoremediation, microbiome resilience, adaptation to polluted lands, and metal-resistant native microbe-assisted phytotechnologies. It covers current trends, tools, and policies for the microbe-augmented remediation of an array of metals and metalloids. Other sections discuss key topics such as plant-metal-microbe interaction in polluted ecosystems, microbe-mediated phytoremediation for upgraded ecosystem services, and success stories on microbial-assisted phytoremediation.

  • Neurochemical Substrates of Addiction Medicine

    • 1st Edition
    • Mohammad Banazadeh + 2 more
    • English
    Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for researchers, clinicians, and students alike. This book is structured into four comprehensive sections, beginning with an examination of the distribution of neurotransmitters across key brain circuitry involved in addiction, such as the mesolimbic, striatal, frontal, insular, and thalamic systems. Each chapter meticulously describes how these circuits contribute to addictive behaviors and the underlying neurobiological mechanisms. The second section delves into the major neurotransmitter systems—including dopaminergic, glutamatergic, GABAergic, adrenergic, serotonergic, cholinergic, endogenous opioid, and purinergic systems—highlighting their roles in addiction.Following this, the book addresses the neuropharmacology of various drugs of abuse, including nicotine, opioids, alcohol, psychomotor stimulants, cannabinoids, psychedelics, sedative-hypnotics, caffeine, and antihistamines, detailing how these substances alter neurochemical pathways. The final section expands the discussion to behavioral addictions, exploring the neurochemical substrates associated with disorders such as pathological gambling, internet use, sexual addiction, and binge eating.

  • Plant Peptides

    Enzymatic Production and Health-Promoting Effects
    • 1st Edition
    • Tolulope Joshua Ashaolu + 2 more
    • English
    Plant Peptides: Enzymatic Production and Health-Promoting Effects provides up-to-date insights on the enzymatic production, bioactivity, and applications of plant-derived peptides. This comprehensive volume explores the role of plant-based proteins (PBPs) as sustainable alternatives to traditional animal proteins, highlighting their environmental and climatic benefits. The book examines the enzymology of proteolytic enzymes used to generate bioactive peptides from PBPs, detailing their bioaccessibility, stability, and bioavailability. It offers an in-depth analysis of the multifarious biological activities of these peptides, including their antioxidant, antimicrobial, and metal-binding properties. The book also addresses the technological and biological properties, limitations, and challenges of plant-based bioactive peptides for industrial uses.With a strong focus on practical implementation, the book discusses emerging strategies and advanced technologies for producing and analyzing bioactive peptides, such as in silico analysis, fermentation, and peptidomics. It provides insights into future research directions and potential applications, emphasizing the health-promoting effects of plant-based peptides in combating obesity, diabetes, hypertension, cancer, and neurodegenerative diseases. This book is an essential resource for food science researchers, nutritionists, and students of food science and nutrition.

  • Lanzkowsky's Manual of Pediatric Hematology and Oncology

    • 8th Edition
    • Jonathan D. Fish + 2 more
    • English
    Lanzkowsky's Manual of Pediatric Hematology and Oncology, Eighth Edition covers a wide array of topics, from molecular and genomic methodologies to specific hematologic disorders and various types of cancer, along with supportive care strategies. Each chapter is authored by leading experts who provide the latest evidence-based practices, diagnostic techniques, and treatment modalities, ensuring that practitioners have access to authoritative insights for informed clinical decision-making. This manual offers the tools and strategies necessary for delivering high-quality, evidence-based care, ultimately enhancing patient outcomes and improving the quality of life for young patients.Whether you are a trainee, an early-career physician, or a seasoned practitioner, this manual is an indispensable reference that will support your journey in pediatric hematology and oncology.

  • Basic Neurochemistry

    Principles of Molecular, Cellular, and Medical Neurobiology
    • 9th Edition
    • Scott Brady + 1 more
    • English
    Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, Ninth Edition is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions).This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.

  • Tourette Syndrome and Other Tic Disorders

    • 1st Edition
    • Mariam Hull
    • English
    The Neuroscience of Tourette's Syndrome and Other Tic Disorders provides a foundation of the latest research into tic disorders and the brain, as well as including a comprehensive framework for the evaluation of tics. Authors across multiple specialties present the most thorough and latest knowledge of Tourette syndrome to include underlying pathophysiology, clinical presentation, how to differentiate it from other tic disorders, particularly functional tics. Clinical case studies will also feature throughout to outline challenging cases with expert commentary on evaluation and management strategies.

  • Crossing Viral Boundaries

    Zoonotic Infections and Strategies for Public Health Preparedness
    • 1st Edition
    • Zubaida Hassan + 1 more
    • English
    Crossing Boundaries in Zoonotic Viral Infections and Strategies for Public Health Preparedness addresses the urgent need for a deeper understanding of zoonotic viruses, which pose significant public health threats and require improved preparedness. It provides up-to-date insights into the biology, transmission, and epidemiology of key zoonotic virus families, explores the associated human diseases, and discusses diagnostic and treatment strategies. This comprehensive book systematically explores major zoonotic virus families, beginning with an introductory overview of virology, zoonoses, and human-animal interactions, setting the stage for understanding virus transmission and public health challenges. Each subsequent chapter delves into a specific virus family—covering their discovery, biology, transmission routes, cellular targets, disease mechanisms, diagnostics, treatments, outbreak case studies, and surveillance strategies. Additionally, the book introduces simulation tools for modeling viral pathogenesis and predicting cross-species transmission. It concludes with a synthesis of key themes, emphasizing global health policies, preparedness, and future directions for managing zoonotic viral threats effectively equipping future scientists with essential knowledge and resources to combat emerging zoonotic infections.

  • The Plasticity of Sex

    The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior
    • 2nd Edition
    • Marianne Legato J.
    • English
    The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior, Second Edition offers a thorough exploration of the biological, clinical, and social dimensions of human sexuality. This updated edition emphasizes the increasing recognition of the diversity of sexual identities and behaviors, particularly the spectrum between traditional male and female categories. It consolidates evidence-based research on the molecular and developmental biology of sex, gender identity, and sexual behavior, presenting a comprehensive resource for biomedical researchers, clinicians, and medical students. A key theme of this edition is the growing understanding of human sexuality as fluid and diverse, shaped by a variety of genetic, hormonal, and environmental factors. Over recent decades, there has been heightened interest in issues like gender identity, genital ambivalence, and sexual transition, with both the general public and medical professionals seeking more knowledge and guidance on these topics. The book underscores the need for a more inclusive approach, incorporating voices from diverse communities and recognizing the importance of broadening the scope of research beyond narrow sample sizes and traditional binary frameworks. The new edition highlights the ongoing challenges in understanding and addressing variations in human sexuality and the need for continued dialogue between science, society, and legal systems to create more inclusive frameworks for care and support. This work serves as an essential reference for anyone involved in the study or treatment of human sexuality.

  • Critical Care in Pregnant Patients

    Ultrasound
    • 1st Edition
    • Jorge Hidalgo + 3 more
    • English
    Critical Care in Pregnant Patients: Ultrasound, a volume in the Critical Care Obstetrics series, is a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women with various health compromises. The book's chapters reflect the growing scope of critical care obstetrics and the increasing importance and recognition of the hospital structure's field. All intensivists, regardless of primary discipline, must possess a core set of critical care skills to manage critically ill patients. The book's authors have gathered the best evidence-based material explicitly focused on how ultrasound can successfully manage potential scenarios of common and rare health complications. Users will find the basics of ultrasound and the latest technological advances of ultrasound that foster research and improve health outcomes in pregnant patients.

  • Cell Death Part G

    • 1st Edition
    • Volume 214
    • English
    Cell Death Part G presents current methods and advances for studying the mechanisms, regulation, and biological significance of cell death. The volume covers experimental and analytical approaches relevant to apoptosis, necrosis, autophagy, and other cell death pathways in both basic and translational research.

  • Artificial Intelligence in Clinical Medicine

    General Concepts and Specific Applications
    • 1st Edition
    • Marianne Legato J. + 1 more
    • English
    Artificial Intelligence in Clinical Medicine: General Concepts and Specific Applications explores the evolution and application of artificial intelligence (AI) in medicine, highlighting both its potential and challenges. The initial discussion outlines past failures in integrating AI into healthcare, followed by a review of FDA-approved AI medical devices and their implications for diagnostics. Subsequent sections examine the transformative impact of large language models, the ethical application of AI in clinical settings, and the role of AI in enhancing patient safety. Various specialties, such as cardiology and pulmonary disease, illustrate AI's capabilities in improving diagnostics and treatment. The discussions extend to diabetes care, dermatology, obstetrics, and radiology, emphasizing the need for ethical considerations and quality assessments to ensure AI aligns with human values and improves patient outcomes across diverse healthcare contexts.

  • Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

    • 1st Edition
    • Theresa Coetzer
    • English
    Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolyti... Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.

  • Food Bioactives and Their Role in Human Health and Nutrition

    • 1st Edition
    • Sajad Ahmad Wani + 1 more
    • English
    Food Bioactives and their Role in Human Health and Nutrition, is a comprehensive resource offering an in-depth look at essential bioactive compounds, such as polyphenols, flavonoids, plant sterols, omega-3 fatty acids, and probiotics, highlighting their importance in promoting health and preventing chronic diseases. Readers will gain insights into the chemical structures, sources, and bioavailability of these compounds, along with practical dietary recommendations tailored to address common lifestyle-related health challenges such as obesity, diabetes, and cardiovascular disease. Food Bioactives and their Role in Human Health and Nutrition, also addresses emerging trends and challenges in the field, including personalized nutrition approaches and the integration of functional foods and nutraceuticals. It examines the role of food processing on the stability of bioactives, ensuring that health professionals are equipped with the latest knowledge to optimize nutritional strategies.

  • Pediatric Gastroenterological Diagnosis

    A Diagnostic Primer
    • 1st Edition
    • Richard Thomas Lee Couper
    • English
    Pediatric Gastroenterological Diagnosis: A Diagnostic Primer focuses on the theoretical aspects of diagnosing pediatric gastroenterology diseases, including historical and current information. Sections cover pediatric gastroenterology diseases and provide practical advice for quick and accurate diagnosis. In addition, the book provides multiple pediatric tables and references, as well as brief clinical vignettes that identify potential pitfalls clinicians may encounter. This is the perfect reference for clinicians who struggle with complex diagnosis and problem-solving, and will be ideal for pediatric gastroenterology trainees and pediatric gastroenterologists.

  • Herbals and Their Antioxidant Effects on Human Health

    • 1st Edition
    • Süleyman Kaplan
    • English
    Herbals and their Effects on Human Health provides a comprehensive exploration of the diverse bioactive components found in medicinal plants and their relevance to human health. Divided into three distinct sections, beginning with a thorough examination of bioactive components and their health benefits, readers will discover the intricacies of traditional practices such as Ayurveda, the role of phytotherapy in managing metabolic disorders, and the therapeutic potential of antioxidants in various health contexts, including skin health and cardiovascular disease. The book further enhances its scientific rigor by including light and electron microscopic images that illustrate tissue and organ structures affected by herbal interventions. Subsequent sections focus on bioactive foods, highlighting their therapeutic effects through in-depth discussions on specific herbals and plants such as garlic, curcumin, garcinia kola and blueberries. This section not only examines their protective roles in conditions like chronic inflammation and diabetes but also addresses lesser-known foods and their health-promoting properties. The final section highlights the mechanisms of action of these compounds, examining their impact on biological systems and their neuroprotective effects.Herbals and their Effects on Human Health is an essential resource for food scientists, physicians, biomedical researchers, pharmacologists, and nutritionists seeking to deepen their understanding of how herbal and bioactive components influence health and wellness.

  • Pharmaceutical Microbiology

    Essentials for Quality Assurance and Quality Control
    • 2nd Edition
    • Tim Sandle
    • English
    The second edition of Pharmaceutical Microbiology: Essentials for Quality Assurance and Quality Control is an authoritative reference designed for pharmaceutical microbiologists, sterilization personnel, and production scientists. It addresses the evolving landscape of microbiological standards, regulatory requirements, and scientific innovations in the pharmaceutical industry. The book emphasizes the importance of maintaining compliance through updated practices, new testing methodologies, and comprehensive contamination control strategies, ensuring safety and quality in pharmaceutical manufacturing.This book provides invaluable insights for professionals seeking to optimize microbiological quality assurance, meet regulatory expectations, and adopt innovative technologies. It supports laboratory managers, microbiologists, and quality assurance specialists in implementing best practices, ensuring product safety, and staying abreast of scientific progress in pharmaceutical microbiology.

  • Precision Care in Gastroesophageal Reflux Disease

    Using Pathophysiology and Clinical Insights towards a Personalized Approach
    • 1st Edition
    • Walter W. Chan + 1 more
    • English
    Precision Care in Gastroesophageal Reflux Disease: Using Pathophysiology and Clinical Insights towards a Personalized Approach addresses the urgent need for personalized approaches in managing GERD. This reference explores the evolving understanding of GERD pathophysiology and the necessity to move beyond generalized treatments toward disease phenotyping and targeted therapy. It emphasizes integrating clinical insights with emerging diagnostic technologies to optimize patient outcomes. The book’s content is organized into sections covering disease phenotypes and pathophysiology, clinical presentation, diagnostic techniques, and management approaches. Chapters include detailed discussions on symptom mechanisms, hypervigilance, diagnostic endoscopy, esophageal function testing, and both medical and surgical treatment options. Contributions from international experts provide evidence-based perspectives on utilizing scoring systems, ancillary tests, and adjunctive therapies to support precision care. Precision Care in Gastroesophageal Reflux Disease equips clinicians, advanced practice providers, and trainees with state-of-the-art knowledge to tailor evaluation and treatment strategies for diverse GERD phenotypes. It is an essential resource for those seeking to apply precision medicine principles in gastroenterology, enhancing diagnostic accuracy and therapeutic effectiveness in clinical practice.

  • Introduction to Practical EPR Spectroscopy

    • 1st Edition
    • Wilfred R. Hagen
    • English
    Introduction to Practical Electron Paramagnetic Resonance (EPR) Spectroscopy of randomly oriented molecules finds wide application in chemistry, biology, and many other related disciplines. This graduate-level text guides the reader along the winding road of the undocumented pitfalls and unwritten rules-of-thumb that come with undertaking practical EPR spectroscopy. The aim is to provide a truly practical and complete introduction to this widely used method. With the required quantum mechanics limited to an indispensable minimum, the book comprehensively treats the basic theoretical and practical aspects of the methodology to educate the reader to the level of an independent EPR researcher in all aspects, including problem posing, sample preparation, machine operation, data collection and interpretation, numerical analysis, and scientific reporting.Many EPR books have been written as expositions of the quantum-mechanical background of magnetic resonance, but without addressing critical practical questions in the lab including but not limited to:what knobs to turnhow to make sampleswhat programs to use (or not use)how to present experimental resultsIntroduction to Practical EPR Spectroscopy offers a complete preparation (both theoretical and practical) to be an independent EPR spectroscopist in what may be a non-specialist laboratory. It is written primarily for PhD, master’s and postdoctoral students and their tutors across biochemistry, organic, inorganic, bioinorganic and physical chemistry, molecular biology, microbiology, molecular physics, materials science, and geology.

  • The Transcription Factor NRF2

    Biology, Disease and Translational Opportunities
    • 1st Edition
    • Narendra Kumar Sharma + 1 more
    • English
    The Transcription Factor NRF2: Biology, Disease and Translational Opportunities offers a detailed and authoritative reference on NRF2, a key regulator of cellular defence against oxidative stress. This book thoroughly examines the latest research, from molecular mechanisms to clinical applications, highlighting NRF2’s essential function in cell protection, disease prevention, and its promise as a therapeutic target. The book opens with an introduction to NRF2 and its role in cellular homeostasis before exploring its molecular structure, regulation and signalling mechanisms. Its antioxidant response is then discussed, followed by its impact on inflammation, autophagy, and resistance to environmental and chemical stresses. Later chapters cover NRF2’s role in cancer, neurodegenerative, cardiovascular, autoimmune, and metabolic diseases. Cutting-edge techniques are also provided, including AI-based and systems biology tools. Case studies emphasize translational potential and therapeutic development.The Transcription Factor NRF2: Biology, Disease and Translational Opportunities equips researchers, clinicians, and advanced students with critical knowledge to understand NRF2’s multifaceted functions and therapeutic potential. It serves as an essential guide for advancing research and strategies targeting NRF2 in a diverse array of medical conditions, and is an ideal reference for those working across cell biology, molecular biology, biomedicine and related fields.

  • Human-Centred AI For Intelligent Healthcare

    Approaches and Technologies
    • 1st Edition
    • Mahmoud Hassaballah + 1 more
    • English
    Human-Centred AI For Intelligent Healthcare: Approaches and Technologies provides state-of-the-art AI technologies and healthcare tailored to human needs, highlighting the various ways AI is reshaping patient care, diagnostics, treatment modalities, and overall healthcare systems. From the intricacies of precision medicine to interventions in mental health, this reference provides a diverse array of AI applications. It addresses ethical considerations while emphasizing the transformative potential that AI holds for the healthcare industry. This reference is an essential companion for healthcare professionals, researchers, policymakers, technologists, and enthusiasts navigating the swiftly evolving landscape of AI in healthcare. Bridging a critical gap in literature, it offers a consolidated resource that not only explores the multifaceted applications of AI in healthcare but also underscores the importance of maintaining a human-centric approach in the integration of these technologies. With a focus on forecasting future trends and implications, this reference equips readers with the knowledge to stay at the forefront of the dynamic field of healthcare technology and empowers them to anticipate changes and adapt their strategies proactively in the face of evolving healthcare landscapes.

  • The Future of Health and Economic Resiliency in Africa

    • 1st Edition
    • Muhammad Pate + 1 more
    • English
    Grown out of a Lancet Commission to look at the future of health and economic resiliency of Africa, The Future of Health and Economic Resiliency takes a multidisciplinary approach across numerous sectors of analysis, central to Africa’s future well-being. This book serves as a comprehensive analysis of the current state of the continent and what actions can be taken to improve health and resiliency moving forward. While previous analysis has been done regionally within the continent (sub-Saharan Africa, for example) or by specific health needs (HIV or poverty, for example), this book will be the first to synthesize a cross sector approach pan-Africa. By describing the context and through actionable solutions for the future, this book sets the framework for a more resilient Africa and global future. Future of Health and Economic Resiliency is a collaboration of top African experts and practitioners in public health, health systems, economics, financing, nutrition, climate, youth representation, and the private sector.

  • Tissue Organization in Development

    • 1st Edition
    • Volume 171
    • English
    Tissue Organization in Development explores how cells coordinate, communicate, and arrange themselves to build functional tissues during embryonic and postnatal development. The book brings together current perspectives on the molecular, cellular, and mechanical principles that govern tissue patterning, morphogenesis, and structural organization across developing systems. Covering key topics such as cell fate specification, cell–cell interactions, extracellular matrix dynamics, polarity, migration, and tissue remodeling, it highlights how complex biological form emerges from coordinated developmental processes. This volume provides a valuable resource for researchers, students, and professionals interested in developmental biology, cell biology, and tissue formation.

  • The Safety Aspects of Food Waste Valorization

    Maintaining Quality Assurance in Resource Recovery
    • 1st Edition
    • Sidonia Martínez Suárez + 1 more
    • English
    The Safety Aspects of Food Waste Valorization: Maintaining Quality Assurance in Resource Recovery highlights the importance of safe food waste practices and strategies to effectively transform waste into valuable resources. Co-edited by two female authors with many global, female contributors represented, the book looks at the environmental consequences of food waste and its impact on human health. It details the risks associated with the use of food waste, analyzes food safety in valorized agri-food by-products, with a focus on mycotoxins, and demonstrates how to minimize safety risks from a variety of industries, including date-palm industrialization, wine, produce, cattle, olive oil and dairy. Finally, the book provides practical business strategies for bioactive ingredients derived from food by-products and details the recovery of food waste from an environmental and economic perspective.

  • SGLT2 Inhibitors in Cardiovascular Diseases

    Mechanisms, Clinical Impact, and Future Directions
    • 1st Edition
    • Tong Liu
    • English
    SGLT2 Inhibitors in Cardiovascular Diseases: Mechanisms, Clinical Impact, and Future Directions reviews the impact of SGLT2 inhibitors on cardiovascular health in individuals with type 2 diabetes, chronic kidney disease, heart failure, and atherosclerosis. The book synthesizes preclinical and clinical evidence to highlight the cardiovascular benefits of these drugs, initially developed for hyperglycemia management. It details recent studies on SGLT2 inhibitors' effects on cognitive dysfunction, sudden death, ventricular arrhythmias, heart remodeling, and cancer risks in diabetic patients.In addition, it compares SGLT2 inhibitors with DPP4 inhibitors, emphasizing the efficacy of empagliflozin and dapagliflozin in reducing syncope and cardiovascular mortality, supported by trials like EMPA-REG OUTCOME and DECLARE-TIMI 58. Addressing a gap in literature, the book provides a comprehensive overview of SGLT2 inhibitors' cardiovascular benefits in high-risk populations, including atrial fibrillation and syncope. It offers valuable insights and recommendations for clinicians, researchers, and policymakers managing cardiovascular risk.

  • Biomechanics of the Heart

    From Model to Patient
    • 1st Edition
    • Patrick Clarysse + 3 more
    • English
    Biomechanics of the Heart: From Model to Patient provides readers with a comprehensive overview of the modeling and assessment of the heart’s biomechanics. The book addresses topics such as the physiology of normal and diseased hearts, cardiovascular imaging, modeling of myocardial tissue in the passive and active states, as well as state-of-the-art approaches for patient specific modeling of the heart’s mechanical function. This is all augmented by case studies and examples of exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases. Readers are introduced to modeling of the heart’s anatomical and muscular structure, a review of imaging techniques to analyze the geometry, content and dynamics of the heart, as well as an in-depth look at the biomechanical properties of normal and diseased hearts. Finally, chapters cover modeling cardiac passive and contractile mechanics, biomechanical finite element simulations of the heart, patient-specific modeling of the heart and circulatory system, as well as the exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases.

  • Neurosurgical Neuropsychology

    The Practical Application of Neuropsychology in the Neurosurgical Practice
    • 2nd Edition
    • Caleb M. Pearson + 2 more
    • English
    The second edition of Neurosurgical Neuropsychology: The Practical Application of Neuropsychology in the Neurosurgical Practice offers an in-depth review of the critical role neuropsychology plays in neurosurgical settings. This comprehensive resource covers essential preoperative techniques, including advanced functional neuroimaging methods such as fMRI and connectivity-based imaging, alongside traditional approaches like neurocognitive testing and the Wada procedure. This book highlights the significant contributions of neuropsychologists to the neurosurgical team, emphasizing their value in managing diverse patient populations, from candidates for Deep Brain Stimulation to those undergoing adult and pediatric epilepsy surgeries and neuro-oncology interventions. New chapters in this edition address contemporary topics such as the cognitive impact of epilepsy and epilepsy surgery, concussion, neuroplasticity, and the future role of artificial intelligence in neurosurgery. By updating existing content and incorporating fresh insights, this book serves as an essential guide for neurosurgeons, neuropsychologists, neuro-oncologists, epileptologists, and general neurologists who wish to enhance their understanding of neuropsychology's application in both preoperative and postoperative care.

  • Advances in Hepatorenal Syndrome Research

    Untangling Pathophysiology, Improving Diagnostic Strategies, and Leveraging Therapeutic Innovations
    • 1st Edition
    • Justin Belcher
    • English
    Advances in Hepatorenal Syndrome Research: Untangling Pathophysiology, Improving Diagnostic Strategies, and Therapeutic Innovations is a comprehensive review of the historical perspectives, prevalence, and prognosis of HRS, offering insights into its evolving clinical recognition and shifting paradigms of pathophysiology. Explore the multifaceted pathophysiology of HRS as experts navigate the complexities of cardiac dysfunction, inflammatory cytokines, and other modern understandings shaping the field. Explore differential diagnosis, uncovering alternative etiologies and current diagnostic criteria, while shedding light on biomarkers and novel diagnostic tests revolutionizing patient assessment. Contents will also guide readers through the utility of point-of-care ultrasound in intravascular volume assessment sets the stage for exploring medical therapy options, including vasoconstrictors and albumin usage. Written by a team of experts, this comprehensive reference highlights the intricate pathophysiology of hepatorenal syndrome while delivering the most up-to-date insights into diagnostic and therapeutic approaches. Historically overshadowed by grim prognoses, hepatorenal syndrome has undergone a renaissance of interest due to recent breakthroughs, revolutionizing treatment paradigms. Whether you're a seasoned practitioner or a burgeoning researcher immersing yourself in this dynamic field, this resource offers a thorough examination, encompassing novel diagnostic criteria, innovative biomarkers, and state-of-the-art treatments.

  • Diagnosis and Management of Gastrointestinal Bleeding

    • 1st Edition
    • Xingshun Qi + 1 more
    • English
    Diagnosis and Management of Gastrointestinal Bleeding is a comprehensive reference addressing the latest advances in the diagnosis and management of gastrointestinal hemorrhage. This reference responds to the growing body of evidence accumulated in recent years, filling a critical gap where no recent comprehensive resource exists. It targets practicing gastroenterologists and researchers seeking current, evidence-based guidance. The content is systematically organized into 14 chapters covering epidemiology, causes, risk factors, diagnosis, and treatment modalities including medical, endoscopic, and vascular interventional approaches. Special chapters focus on management in children and the elderly. Each chapter is authored by leading experts, providing detailed insights into prevention, treatment, and prognostic assessment of gastrointestinal bleeding. Diagnosis and Management of Gastrointestinal Bleeding equips clinicians with practical knowledge to improve patient care and offers researchers a synthesis of innovative findings and future research directions. Its inclusion of color figures and visual aids enhances comprehension. This reference is an essential resource for those involved in the clinical and research aspects of gastrointestinal bleeding management.

  • Advances in Food and Nutrition Research

    • 1st Edition
    • Volume 123
    • English
    Advances in Food and Nutrition Research provides the latest advances in the role of artificial intelligence in the precision nutrition and development of personalized foods, precision nutrition in autoimmune diseases, the need for vitamin D fortification in tropical regions, the health benefits of bioactive peptides, the factors affecting digestibility and glycemic index of rice, bio-based materials for intelligent sensing of food quality and safety, solid-state fermentation of cereal grains for modulating phenolic compounds, natural additives stabilized with nanoclays and the concomitant mycotoxin contamination in foods, especially on climate-related challenges for food safety.

  • Toxicology Disasters

    Causes and Consequences
    • 1st Edition
    • Sue Ford
    • English
    Toxicology Disasters: Cause and Consequences, a volume in the History of Toxicology and Environmental Health series, provides an historical overview of significant toxicological disasters which involved chemical exposure of humans, animals or the environment. The book documents the timeline of events and the legacy of the resulting exposure which occurred within a specific period of time, but with long lasting consequences. Case studies of toxicological incidents and a wide range of categories, including environmental, industrial, pharmaceutical, domestic and international are not only discussed from a historical perspective but also regarding their impacted toxicology, regulation and our current use of these chemicals.The book will help toxicologists, academics and students from environmental health and toxicology departments, environmental/occupa... health regulators, and industrial hygiene/safety personnel gain a better understanding of the arc of a toxicological disaster from its origins, root causes of the problem, and initial and long-term assessments and management.

  • A Comprehensive Guide to Surgical Oncology

    • 1st Edition
    • Aqeel Shakir Mahmood + 2 more
    • English
    A Comprehensive Guide to Surgical Oncology is an authoritative reference that meticulously covers the surgical management of various cancers. Each section delves into the latest surgical techniques, treatment protocols, and post-operative care strategies, supported by up-to-date research and clinical evidence. Enriched with detailed illustrations, case studies, and expert insights, this book is an indispensable resource for professionals and students alike. The primary purpose of this book is to provide a comprehensive, up-to-date resource that addresses the current challenges and advancements in surgical oncology. As cancer treatment evolves rapidly with continuous improvements in surgical techniques and multidisciplinary care, there is a pressing need for a new resource that synthesizes these developments into a coherent guide. This book aims to fill that gap by offering a thorough overview of the latest surgical oncology practices, thereby enhancing the knowledge and skills of its readers. This book solves several key problems for its readers by bridging the gap between rapidly advancing research and clinical practice, ensuring access to the latest information. It consolidates a vast amount of information into one comprehensive volume, saving readers the time and effort of consulting multiple sources. Providing practical guidance on the surgical management of a wide range of cancers, it helps practitioners make informed decisions in clinical settings. For students and trainees, it serves as a valuable educational tool that covers both foundational knowledge and advanced concepts in surgical oncology, offering multidisciplinary insights that foster a better understanding of the collaborative efforts required in cancer treatment.

  • Pectin

    Sources, Technological Properties and Functional Applications
    • 1st Edition
    • F.A. Masoodi + 2 more
    • English
    Pectin: Sources, Technological Properties, and Functional Applications provides a comprehensive overview of pectin, detailing its structure, chemistry, properties, functionality, and diverse applications. The book offers valuable insights into how pectin's intrinsic properties affect its functionality and suitability for various end uses. It also explores the sourcing of pectin from food and agro-industrial sources, with a comparative assessment of conventional and emerging extraction technologies, and emphasis on sustainability through waste valorisation. The book is organized into three sections: Pectin Chemistry and Functionality, Valorisation of Agro-Industrial Waste Streams for Sourcing Pectin, and Functional Applications of Pectin in the Food Industry and Allied Arenas. It serves as a valuable resource for academicians, scientists, researchers, industry professionals, and students in Food Science, Chemistry, Chemical Engineering, Material Science, Pharmaceutical Sciences and related fields. Being particularly relevant to those working with food by-product valorization, hydrocolloids, biopolymers, colloid chemistry, and materials science, the book provides insights into the applications of pectin in food packaging, emulsification, encapsulation, and drug delivery.

  • Self-Learning AI in Healthcare

    Agentic Systems for Smarter Medicine
    • 1st Edition
    • Rajesh Kumar Dhanaraj + 4 more
    • English
    Self-Learning AI in Healthcare: Agentic Systems for Smarter Medicine covers the transformative potential of advanced artificial intelligence within modern medicine. The book addresses the critical need for self-learning and agentic AI systems that autonomously adapt, refine decision-making, and navigate complex clinical environments with minimal intervention. Chapters provide foundational insights into the rise of self-learning AI and neural networks tailored for adaptive medical systems. Subsequent chapters delve into unsupervised, semi-supervised, and reinforcement learning for autonomous healthcare decision-making, alongside decentralized edge AI approaches. Specialized sections cover personalized medicine, hospital workflow optimization, remote patient monitoring, early disease detection, federated learning for privacy preservation, and more.Further, this book explores AI applications in drug discovery, mental health support, radiology, digital twins, and medical robotics, culminating with an examination of future challenges, ethics, and regulatory frameworks shaping self-learning AI’s trajectory in healthcare. It is tailored to serve a diverse yet specialized audience spanning academic, professional, and research sectors. Healthcare IT professionals and clinical informatics specialists will gain practical guidance for implementing adaptive AI solutions within complex healthcare environments. AI researchers and data scientists focused on developing self-learning models will find cutting-edge methodologies and case studies that advance medical applications.

  • Peptide-Derived Drug Discovery

    Design Strategies, Discovery Methods and Applications in Therapeutic Challenges
    • 1st Edition
    • Jian Zhang
    • English
    Peptide-Derived Drug Discovery: Design Strategies, Discovery Methods and Applications in Therapeutic Challenges provides a comprehensive exploration of peptide-like drugs, detailing their structural features and physico-chemical properties while demonstrating their application in the rational design of drug-like peptides. The book also highlights the latest advancements in peptide science, focusing on innovative technologies such as high-throughput screening methods for the macrocyclic peptide-based drug discovery. By showcasing novel approaches and offering step-by-step strategies to overcome key development challenges, this book delivers cutting-edge knowledge to advance the development of next-generation peptide therapeutics

  • Drug Discovery Stories, Volume 3

    From Bench to Bedside
    • 1st Edition
    • Bin Yu
    • English
    Drug Discovery Stories: From Bench to Bedside, Volume 3 presents a collection of cases on the development of highly successful pharmaceuticals. The coverage of chapters in the book include the structural biology and biological functions of the targets of interest, the identification of hit compounds, hit-to-lead optimization, binding mode of the key compounds with the target of interest, key biological and PK data of lead compounds, clinical results if any, other candidate compounds in preclinical and clinical stage against the same target, and other relevant points in the journey to develop the drug. Chapters in this volume in the Drug Discovery Stories series include a discussion of technological innovations in drug discovery, the impact of AI and Machine Learning, and then move on to discuss drugs like Landiolol, Deuruxolitinib, Berdazimer sodium, Cefepime, Aprocitentan, Givinostat, Vadadustat, Danicopan, Tovorafenib, Lazertinib, Journavx, Symbravo, Grafapex, Alyftrek, and Tryngolza. A final chapter provide conclusions on all cases presented in the book. Drug Discovery Stories: From Bench to Bedside, Volume 3 accurately reflects the current advancements in drug discovery by sharing the path researchers took that led them to create these impactful drugs. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology.

  • Lobular Breast Cancer

    An All-Round Multidisciplinary Overview
    • 1st Edition
    • Giovanni Corso + 1 more
    • English
    Lobular Breast Cancer: An All-Round Multidisciplinary Overview is a comprehensive academic resource that addresses the complex biology, diagnosis, and treatment of invasive lobular breast cancer. This book synthesizes current research and clinical practices, offering an integrated perspective from leading international experts. It covers key topics such as genetics, pathology, imaging, surgical approaches, and systemic therapies, emphasizing recent advances and future directions. The content is organized into clearly delineated sections, including epidemiology, molecular biology, imaging techniques, and therapeutic strategies, with dedicated chapters on emerging technologies like artificial intelligence. The multidisciplinary approach ensures that clinicians and researchers gain a thorough understanding of lobular breast cancer’s unique features, diagnostic challenges, and tailored treatment options, fostering evidence-based decision-making. This book benefits its academic audience by providing up-to-date, evidence-based insights, practical guidance for clinical management, and a foundation for future research. It supports professionals in staying current with evolving standards, improving patient outcomes, and advancing scientific knowledge in this specialized field.

  • Propolis

    Science, Innovation, and Healthcare Applications
    • 1st Edition
    • Jairo Kenupp Bastos
    • English
    Propolis: Science, Innovation, and Healthcare Applications is a key reference for understanding the diverse applications of propolis in healthcare and industry. As a natural product derived from bees, propolis has a long history and notable potential in pharmacology and biotechnology. This book serves as a consolidated resource that brings together current knowledge, research, and developments related to propolis, including coverage of three types—Brazilian green propolis (BrGPs), red propolis (RP), and poplar propolis (PP)—making it valuable for both scholars and practitioners. The Table of Contents covers a broad range of topics, including the origin and formation of propolis, its chemical composition, and contemporary analytical methods. It also examines the biological properties of propolis, such as its antimicrobial, antiviral, and neuroprotective effects, along with information on regulatory standards and future research areas. Each chapter is structured to provide a balance of theoretical context and practical insights. Designed for academics, researchers, and industry professionals, the book offers detailed technical information and guidance on quality control and regulatory compliance. By addressing key issues in the commercialization of propolis-based products, this reference supports a deeper understanding and effective utilization of this natural substance.

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • Medical and Health Genomics of South Asia

    • 1st Edition
    • Dhavendra Kumar + 1 more
    • English
    Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region. Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

  • Insights and Implications of Pseudo Esterase Activity of Human Serum Albumin in Diabetic Kidney Disease

    • 1st Edition
    • Dibyajyoti Banerjee + 1 more
    • English
    Insights and Implications of Pseudo Esterase Activity of Human Serum Albumin in Diabetic Kidney Disease provides a comprehensive exploration of diabetic nephropathy, emphasizing the critical need for early detection methods prior to the onset of microalbuminuria. The book's primary focus is on the study of pseudoesterase activity in urinary albumin and other proteins as a potential biomarker for early diagnosis of diabetic kidney disease. This resource bridges a significant gap in current literature by providing an in-depth analysis of how this enzymatic activity can inform the classification and management of diabetic nephropathy.Chapters cover foundational knowledge of diabetes and its complications, the mechanisms of diabetic nephropathy, and detailed discussions on human serum albumin and its enzymatic activities. Each chapter covers the biochemical characterization of pseudoesterase activity, methods for its detection, and the significance of urinary proteomic profiling. Final chapters highlight future research opportunities and the potential for developing point-of-care testing tools, positioning this work as a critical resource for advancing the field of diabetic kidney disease research and clinical practice.

  • Molecular Pathophysiological Basis of Lifestyle-Related Diseases

    Case Studies and Clinical Management
    • 1st Edition
    • Tetsuya Watanabe
    • English
    Molecular Pathophysiological Basis of Lifestyle-Related Diseases: Case Studies and Clinical Management presents an integrated molecular and biophysical account of lifestyle-related diseases, including type 2 diabetes, hypertension, atherosclerosis, chronic kidney disease, periodontitis, and neurodegenerative disorders. Rather than treating these conditions as isolated clinical entities, it examines their shared origins in chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, metabolic dysregulation, sympathetic overactivity, and psycho-emotional stress. Drawing on mathematical, physical, chemical, and molecular principles, the book explains how measurable pathological events emerge from disrupted tissue function and how these mechanisms shape clinical signs, disease progression, and patient management. Clinical case studies and management strategies connect mechanistic pathophysiology to real-world decision-making, making the volume useful for clinicians, researchers, and advanced students seeking a deeper understanding of prevention, diagnosis, and treatment. By bridging redox biology, neuroendocrine regulation, cardiovascular and renal physiology, and metabolic disease, the book offers a coherent framework for understanding the global rise of lifestyle-related disorders and for developing more targeted clinical and research responses. It is intended for clinical doctors, medical researchers, pathophysiology scientists, biologists, and physicists in biomedical research or bioengineering.

  • Molecular Pathology

    The Molecular Basis of Human Disease
    • 3rd Edition
    • Gregory J. Tsongalis + 1 more
    • English
    Molecular Pathology: The Molecular Basis of Human Disease, Third Edition is a comprehensive reference that explores the molecular mechanisms and basis of major human diseases. Expertly crafted, this book is designed for use as a teaching tool for medical students, biomedical graduate students, and allied health students. It serves as an advanced resource for pathology residents, postdoctoral fellows, basic scientists, and physician scientists engaged in disease-related research, presenting traditional pathology in the context of translational molecular medicine. In this new edition, the chapters have been fully updated and rearranged for better logical flow.Notably, four new chapters have been included, covering topics such as the pathogenesis of fibrotic diseases, mechanisms of mutation, molecular basis of soft tissue disease and pathology, and pathogenesis and pathophysiology. The book remains an invaluable reference for anyone seeking a deeper understanding of the molecular aspects of human disease.

  • Cytomegalovirus

    From Biology to Clinical Aspects
    • 1st Edition
    • Adriana Calderaro
    • English
    Cytomegalovirus: From Biology to Clinical Aspects delves into the intricate world of Cytomegalovirus (CMV), offering a comprehensive exploration of its fundamental biology and clinical implications. This book serves as an essential resource for understanding CMV from its epidemiology and infection routes to its pathogenesis and immunity. It addresses the virus’s impact on various demographics and provides insights into diagnostic and treatment strategies. The book covers critical aspects such as vulnerability indicators, cellular damage, laboratory detection, and management strategies. It stands out as a valuable reference for current clinical practices and fundamental scientific knowledge on CMV, offering methods to interpret diagnostic results.

  • AI and Food Systems

    Transforming Production, Safety, Sustainability and Consumer Experience
    • 1st Edition
    • Diana Bogueva
    • English
    AI in Food Systems: Transforming Production, Safety, Sustainability and Consumer Experience explores the transformative role of Artificial Intelligence (AI) in all aspects of food systems, analyzing its impact on food production, safety, quality, sustainability, and consumer behavior. It examines how AI-driven technologies such as machine learning, deep learning, and predictive analytics are revolutionizing agriculture, food processing, personalized nutrition, and supply chain management. As AI-driven innovations rapidly reshape the food industry, there is an urgent need for a resource that critically examines both opportunities and challenges, including ethical concerns, regulatory frameworks, and public perception. Rather than taking a topic-specific approach into aspects of AI in agriculture or food technology, this book takes a holistic approach, integrating insights from multiple disciplines to address the broader implications of AI on global food security, sustainability, and nutrition. By bridging gaps in current knowledge, AI and Food Systems: Transforming Production, Safety, Sustainability and Consumer Experience serves as a vital reference for academics, industry professionals, policymakers, and consumers, ensuring that AI’s role in food systems is both well-understood and responsibly harnessed for a more efficient, transparent, and equitable food future.

  • Endoscopic/Robotic Thyroidectomy Surgery

    Using the Gasless Unilateral Axillary Approach
    • 1st Edition
    • Chuanming Zheng + 1 more
    • English
    Endoscopic/Robotic Thyroidectomy Surgery: Using the Gasless Unilateral Axillary Approach is a comprehensive and systematic resource on endoscopic/robotic thyroidectomy using the gasless unilateral axillary approach comprehensive and systematically presented resource on the gasless axillary approach to endoscopic/robotic thyroidectomy. It includes a detailed introduction to all aspects of surgical treatment including anesthesia coordination and robotic surgery. The book provides practical guidance on postoperative complication management and postoperative care and describes specific methods for technical simulation training and functional exercises. While many journal papers on specific aspects of this surgical approach have been published, no book is currently available.

  • Remote Sensing and Machine Learning in Conservation

    Applications and Techniques
    • 1st Edition
    • Alireza Sharifi
    • English
    Remote Sensing and Machine Learning in Conservation: Applications and Techniques presents a structured, decision-oriented guide to the responsible use of Earth observation, geospatial analysis, and artificial intelligence in biodiversity conservation and ecosystem management. It connects conservation questions with appropriate evidence, data preparation, model development and validation, uncertainty communication, ecological interpretation, and decision-ready outputs.Beginning with the foundations of remote sensing, it explains major machine-learning and deep-learning approaches, from supervised classification to Vision Transformers and reinforcement learning. Chapters then show how remote sensing and GeoAI support habitat mapping, species distribution modeling, biodiversity assessment, ecosystem-change detection, water and coastal conservation, wildlife monitoring, climate adaptation, invasive-species detection, restoration planning, and threat monitoring.Dedicated chapters translate theory into practice through project design, cloud-based platforms, open data, reproducible workflows, validation, dashboards, and operational monitoring, and address data governance, privacy, bias, accountability, Indigenous and local knowledge, participation, and responsible use. The closing chapter examines foundation models, multimodal GeoAI, ecosystem digital twins, real-time and edge AI, participatory monitoring, and future research priorities, helping readers move from tool-driven analysis toward scientifically grounded and actionable conservation evidence.

  • Trauma Informed Care in Pediatric Acute and Critical Care Settings

    An Approach for Promoting Resilience and Recovery
    • 1st Edition
    • Trevor A. Hall + 1 more
    • English
    Trauma Informed Care in Pediatric Acute and Critical Care Settings: An Approach for Promoting Resilience and Recovery is a groundbreaking resource addressing the urgent need for trauma-informed care (TIC) in pediatric intensive care units (PICUs) and acute care settings. Each year, countless children and their families navigate the overwhelming challenges of hospitalization due to life-threatening injuries or illnesses. This book explores the profound psychological impacts of such experiences and underscores the necessity of integrating TIC principles to foster resilience and enhance recovery. Within its pages, readers will discover a comprehensive exploration of TIC elements and principles, such as recognizing signs of psychological trauma, ensuring safety, and promoting trustworthiness and empowerment. The text examines pediatric medical traumatic stress, secondary trauma, and the importance of TIC for long-term health outcomes. Featuring contributions from a multidisciplinary team of experts, the book offers practical strategies for developing and sustaining TIC programs. It provides insights into the unique environment of pediatric acute settings, the roles of healthcare professionals, and the global landscape of healthcare systems, while also addressing essential aspects of follow-up care. Trauma Informed Care in Pediatric Acute and Critical Care Settings: An Approach for Promoting Resilience and Recovery equips healthcare professionals with the knowledge to improve patient care, reduce professional burnout, and advance the field of pediatric acute care. With its focus on awareness, readiness, detection, management, and integration of TIC principles, this essential guide is poised to transform the experience of children, families, and healthcare teams by fostering a culture of healing and resilience.

  • The Pancreatic Tumor Microenvironment

    Systems Biology of Stroma–Microbiome Interactions for Precision Therapy
    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English
    The Pancreatic Tumor Microenvironment: Systems Biology of Stroma–Microbiome Interactions for Precision Therapy unites leading experts to integrate stromal biology and microbiome science into a single, translational roadmap for pancreatic cancer. It frames tumor progression and treatment resistance as emergent properties of an ecosystem, not isolated cells. The book surveys the composition and heterogeneity of the tumor microenvironment; cancer associated fibroblast plasticity; extracellular matrix and signaling dynamics; immune suppression; metabolic and hypoxic reprogramming; and gut/tumor associated microbiomes. Methodological chapters highlight single cell, spatial and multi omics approaches, experimental models, biomarkers, and clinical trial design, culminating in combination strategies and future directions. Readers gain a mechanistic, systems level synthesis that clarifies conflicting literature, prioritizes targets, and bridges basic, translational, and clinical domains—accelerating precision oncology and informing study design, patient stratification, and therapeutic combinations.

  • Insect Bioactives

    Innovations in Food, Feed, Pharma and Cosmetics
    • 1st Edition
    • Abdalbasit Adam Mariod + 2 more
    • English
    Insect Bioactives: Innovations in Food, Feed, Pharma and Cosmetics serves as a comprehensive resource for researchers and professionals seeking to harness the power of insects as sustainable bioactive sources and beneficial health and wellness solutions. The book identifies the nutritional and chemical composition of insects, presenting them as versatile ingredients for the development of functional foods, nutraceuticals, animal feed and cosmetics. By examining how edible insects can be reared on agri-food by-products and organic waste, this volume illustrates how feeding strategies can influence their nutritional and bioactive profiles. The text also addresses potential allergenic risks and consumer behavior insights, equipping readers with strategies to promote acceptance of insect-based products in the market.Structured into eight sections, Insect Bioactives: Innovations in Food, Feed, Pharma and Cosmetics covers a wide array of topics essential for understanding insect bioactives. From the foundational overview of insect-based compounds to their applications in functional foods, animal feed, pharmaceuticals, and cosmetics, each section provides insights into the health benefits and technological innovations associated with insect bioactives. The text also discusses regulatory considerations and features case studies that showcase successful applications in various industries.

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