
Advanced MR Techniques for Neurodegenerative Diseases
- 1st Edition, Volume 13 - May 1, 2026
- Editors: Kannie Wy Chan, Paul G Unschuld, Peter CM Van Zijl, Linda Knutsson
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 4 2 5 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 1 4 2 6 - 4
Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides… Read more
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Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.
Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.
- The basics of perfusion MRI approaches
- Current approaches for imaging the glymphatic system
- Non-invasive molecular imaging using CEST MRI
- The use of rsfMRI to assess neurodegeneration
- Microscopic tissue property assessment using diffusion MRI and magnetic susceptibility MRI
Part 2: Basics of the relevant MRI technology (Acquisition, analysis and interpretation for neurodegenerative diseases)
2.1 Perfusion
2.1.1 Arterial Spin Labelling
2.1.2 Dynamic Contrast Enhanced MRI
2.1.3 Dynamic Susceptibility MRI
2.2 Flow (MRA, CSF, large vessel
2.3 Chemical Exchange Saturation Transfer and Magnetization Transfer Contrast–
2.4 Magnetic Resonance Spectroscopy
2.5 Resting State fMRI
2.6 Microscopic Diffusion Imaging
2.7 Susceptibility Weighted imaging and Quantitative Susceptibility Mapping
Part 3: Imaging the glymphatic system
3.1 Glymphatic system
3.2 DCE MRI of glymphatic system
3.3 CSF imaging
3.4
Part 4: Neurodegenerative diseases and neurovascular pathology - current state-of-art in MRI
4.1 Alzheimer’s disease -
4.1.1 The disease
4.1.2 Imaging animal models
4.1.3 Human imaging state of the art
4.2 Vascular dementia and cerebral small vessel
4.2.1 The disease
4.2.2 Imaging animal models
4.2.3 Human imaging state of the art
4.3 Parkinson’s and Lewy body dementia
4.3.1 The disease
4.3.2 Imaging animal models
4.3.3 Human imaging state of the art
4.4 Huntington’s disease
4.4.1 The disease
4.4.2 Imaging animal models
4.4.3 Human imaging state of the art
4.4.4
4.5 Amyotrophic Lateral Sclerosis
4.5.1 The disease
4.5.2 Imaging animal models
4.5.3 Human imaging state of the art
4.6 Multiple Sclerosis
4.6.1 The disease
4.6.2 Imaging animal models
4.6.3 Human imaging state of the art
Part 5: Future research challenges and directions - Editors
- Edition: 1
- Volume: 13
- Published: May 1, 2026
- Language: English
KC
Kannie Wy Chan
PU
Paul G Unschuld
PV
Peter CM Van Zijl
LK
Linda Knutsson
Dr. Linda Knutsson is a Professor at the F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute. She also is a Professor of Medical Radiation Physics at Lund University, Sweden and group leader of the MR-physics group in Lund (40 members).
Dr. Knutsson’s research is mainly focused on perfusion (microvascular blood flow) and perfusion-related measurements using MRI. The main target parameters are cerebral blood flow, cerebral blood volume, mean transit time, permeability and oxygen extraction fraction. Relevant methods that Dr. Knutsson is working with are arterial spin labelling (ASL), dynamic contrast enhanced (DCE) MRI and dynamic susceptibility contrast (DSC) MRI. Dr. Knutsson’s research also includes an emerging technique called chemical exchange saturation transfer (CEST) MRI to retrieve perfusion and perfusion related parameters using natural sugar. For her research contributions she received the Kurt Lidén’s Award - 2015, from the Swedish Society of Radiation Physics.