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Histone Deacetylases in Neurodegenerative Disease Part B

  • 1st Edition, Volume 734 - September 15, 2026
  • Latest edition
  • Editors: Subashchandrabose Chinnathambi, David Christianson, Karen N. Allen
  • Language: English

Histone Deacetylases in Neurodegenerative Disease, Part B, Volume 734 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting in… Read more

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Description

Histone Deacetylases in Neurodegenerative Disease, Part B, Volume 734 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics surrounding the Interaction of HDAC6 ZnF UBP with Tau affects its stability by NMR and Simulation studies, Protocols for In Vitro Analysis of Liquid-Liquid Phase Separation of Proteins, Histone deacetylases in NS, Histone Deacetylase 6 ZnF UBP domain enhances podosome formation in neuronal cells studied by high-resolution confocal microscopy, Methodological approach to Investigate Peroxiredoxin 1 Deacetylation by Histone Deacetylase 6, Critical structural features of HDAC11 inhibitors, and much more.

Additional chapters in this release include Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration, Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant Huntingtin, Protein acetylation dynamics (histone and non-histone) and role protein deacetylases in disease, Epigenetic Clues: Predicting Maternal Depression Through DNA Methylation, A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in brain trauma, Decoding the Acetylation Journey from Neural Crest to Melanocyte, and more.

Key features

  • Provides the latest information on Enzymology research
  • Offers outstanding and original reviews on a range of research topics surrounding Histone Deacetylases in Neurodegenerative Disease, Part B
  • Serves as an indispensable reference for researchers and students alike

Readership

Scientists, students, doctors

Table of contents

1. Interaction of HDAC6 ZnF UBP with Tau affects its stability by NMR and Simulation studies
Subashchandrabose Chinnathambi

2. Protocols for In Vitro Analysis of Liquid-Liquid Phase Separation of Proteins
Timir Tripathi and Niharika Naga

3. Histone deacetylases in NS
Chandrima Das

4. Histone Deacetylase 6 ZnF UBP domain enhances podosome formation in neuronal cells studied by high-resolution confocal microscopy
Subashchandrabose Chinnathambi

5. Methodological approach to Investigate Peroxiredoxin 1 Deacetylation by Histone Deacetylase 6
Aparna Banerjee Dixit

6. Critical structural features of HDAC11 inhibitors
Shovanlal Gayen, Indrasis Dasgupta and Srijoni Sinha

7. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration
Marco Prinz

8. Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant Huntingtin
Prasad Kasthuri, Ayush Nigam, Prasun Kumar Bhunia and Trayambak Basak

9. Protein acetylation dynamics (histone and non-histone) and role protein deacetylases in disease
Devyani Haldar

10. Epigenetic Clues: Predicting Maternal Depression Through DNA Methylation
Kuppan Gokulakrishnan

11. A short guide on in vivo transfection of flag-HDAC4 in dentate gyrus for study of adult neurogenesis in brain trauma
Rajaneesh Kumar Gupta

12. Decoding the Acetylation Journey from Neural Crest to Melanocyte
Vivek T. Natarajan

13. Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid-β (Aβ) oligomers
Flávia Carvalho Alcantara Gomes

14. Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model Mouse
Nihar Ranjan Jana

15. Methodology and Application of ChiP in studying translational dysregulation neurological disorders
Sumana Chakravarty

16. Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication
Anant Bahadur Patel

17. TBD
Samir Patra

18. TBD
Sushabhan Sadhukhan

19. Methodological Frameworks to Probe Histone Acetylation–Driven Circuit Plasticity in SYNGAP1–Associated Neurodevelopmental Disorders
Tapas K. Kundu

Product details

  • Edition: 1
  • Latest edition
  • Volume: 734
  • Published: September 15, 2026
  • Language: English

About the editors

SC

Subashchandrabose Chinnathambi

Subashchandrabose Chinnathambi is Additional Professor Department of Neurochemistry National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India.
Affiliations and expertise
Additional Professor Department of Neurochemistry National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India

DC

David Christianson

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.

Affiliations and expertise
University of Pennsylvania, USA

KA

Karen N. Allen

Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering
Affiliations and expertise
Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, MA, USA