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    • Novel Methods and Pathways in Cancer Glycobiology Research

      • 1st Edition
      • Volume 157
      • February 2, 2023
      • English
      • Hardback
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      • eBook
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      Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the ‘Alliance’ is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI's efforts to diagnose early-stage cancer and provide curative anti-cancer therapies. The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

    • Advances in Virus Research

      • 1st Edition
      • Volume 117
      • October 11, 2023
      • English
      • Hardback
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      • eBook
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      Advances in Virus Research, Volume 117, the latest release in a series that highlights new advances in the field, includes invaluable updates written by an international board of authors. Chapters in this new release include Pathogenesis of neuroinvasive flaviviruses, Cellular entry and egress of astroviruses, Rift Valley Fever virus entry and infection, and more.

    • Epigenetics in Health and Disease

      • 1st Edition
      • Volume 197
      • April 3, 2023
      • English
      • Hardback
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      • eBook
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      Epigenetics in Health and Disease, Volume 197 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on An Introduction to epigenetics in health and disease, State-of-the-art techniques for epigenetics study, Computational biology in epigenetics, Artificial intelligence and machine learning in epigenetics, CRISPR-Cas systems in epigenetics modification for health, Mechanisms of DNA methylation and histone modifications, Non-coding RNA in epigenetics, Role of DNA Methylation in cardiovascular diseases, Role of epigenetics in renal diseases, and much more. Additional chapters update on Histone modifications in fat metabolism and obesity, Role of DNA methylation in diabetes and obesity, Epigenetic regulons in Alzheimer’s disease, Epigenetics in heredity disease, Epigenetics of aging, Epigenetics in cancer development, diagnosis and therapy, Microbiota and epigenetics: health impact, Epigenetics in Fetal Alcohol Spectrum disorder, and much more.

    • Volume Electron Microscopy

      • 1st Edition
      • Volume 177
      • June 23, 2023
      • English
      • Hardback
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      • eBook
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      Volume Electron Microscopy (vEM), Volume 177 is a collective term for a set of three-dimensional high-resolution ultrastructural imaging techniques that have delivered new insights into biological systems in recent years, garnering substantial interest in the life and clinical sciences. In this book, users will find a variety of vEM workflows and technologies, highlighting application areas with biologically relevant examples. Topics covered include Automated large volume sample preparation for vEM, Resin comparison for Serial Block Face Scanning Volume Electron Microscopy, Immunolabelling for SBF-SEM, Electron Microscopy in Plants, Serial section electron tomography, Automated Tape Collecting Ultramicrotomy (ATUM) for targeting neuropathology, Array tomography, and much more. Other sections focus on Mitochondria morphometry in 3d datasets of mouse brain obtained with serial block-face Scanning Electron Microscopy, Serial Block-face Scanning Electron Microscopy of Schmidtea mediterranea, Correlative multiscale microCT-SBF-SEM imaging of resin-embedded tissue, Methods of enhanced FIB-SEM sample preparation and image acquisition, Functional characterization of endo-lysosomal compartments by correlative live-cell and volume electron microscopy, and much more.

    • Advances in Marine Biology

      • 1st Edition
      • Volume 94
      • May 24, 2023
      • Jean-Francois Hamel
      • English
      • Hardback
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      • eBook
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      Advances in Marine Biology, Volume 94, the latest release in this series that highlights new advances in the field, presents interesting content written by an international board of authors. Chapters in this new release include The Falkland Islands marine ecosystem: a review of the seasonal dynamics and trophic interactions across the food web, An impact of non-native species invasions on the Caspian Sea biota, A global synthesis of microplastic contamination in wild fish species: challenges for conservation, implications for sustainability of wild fish stocks and future directions, and Addressing Underwater Noise: Joint Efforts and Progress on Its Global Governance.

    • African Flora to Fight Bacterial Resistance, Part II

      • 1st Edition
      • Volume 107
      • February 22, 2023
      • English
      • Hardback
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      African Flora to Fight Bacterial Resistance, Part Two: The Best Source of Herbal Drugs and Pharmaceuticals, Volume 107 offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle bacterial drug resistance. Chapters cover Phytochemistry and antibacterial potential of the genus Allanblackia, Phytochemistry and antibacterial potential of the genus Beilschmiedia, Phytochemistry and antibacterial potential of the genus Fagara, Phytochemistry and antibacterial potential of the genus Garcinia, Harungana madagascariensis as a source of antibacterial agents, Hypericum roeperianum as a source of antibacterial agents, and much more.

    • Advances in Biomembranes and Lipid Self-Assembly

      • 1st Edition
      • Volume 38
      • November 27, 2023
      • English
      • Hardback
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      • eBook
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      Advances in Biomembranes and Lipid Self-Assembly, Volume 38 in this updated series, highlights new advances in the field, with this new volume presenting interesting chapters on Interaction of inorganic debris particles with cells, Interactions between biomembrane embedded nanoparticles mediated by lipid bilayer, Topological defect driven nanoparticle assemblies, and more.

    • Meiosis in Development and Disease

      • 1st Edition
      • Volume 151
      • January 11, 2023
      • English
      • Hardback
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      Meiosis in Development and Disease, Volume 151 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The initiation stages of meiosis, The molecular basis and dynamics of meiotic cohesions, and their significance in human infertility, Chromatin, recombination, and the centromeres, Sites and structures that mediate segregation when crossing over calls out sick/Life (or at Least Meiosis) Without Crossing Over, Crossover maturation inefficiency, Non coding RNA mediated gene regulation in meiosis, Short chromosomes in meiotic recombination, Chromatin level changes during meiosis initiation vs. oncogenesis, and much more. Other sections of note include Chromosomal speciation revisited: Meiotic recombination and synapsis of evolutionary diverged homologs, Recombination suppression at specific chromosome regions, Unwinding during stressful times - mechanisms of helicases in meiotic recombination, Meiotic functions of PCH-2/TRIP13 and HORMADs, Crossover interference, Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics, The breadth of meiotic drive genes and mechanisms across the tree of life, and many more interesting topics.

    • Advances in Food and Nutrition Research

      • 1st Edition
      • Volume 106
      • September 14, 2023
      • Fidel Toldra
      • English
      • Hardback
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      • eBook
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      Advances in Food and Nutrition Research, Volume 107 provides the latest advances on emerging bioactive compounds with putative health benefits and their controlled release and application in foods and nutraceuticals, as well as information on food technologies, including 3D printing, safety of raw materials, and viruses in foods. Chapters in this new release cover Tackling food allergens - the role of food processing on proteins’ allergenicity, Plant bioactive peptides for cardiovascular disease prevention, Caffeine and sport, Nanostructured steady-state nanocarriers for nutrients preservation and delivery, Flavor perception and health benefits of tea, Next Generation Plant-based Meat Alternatives: Sources, manufacturing and consumer acceptance, and more. Other sections cover Bioprotective cultures and bacteriocins as food preservatives and Raman Spectroscopy: principles and recent applications in Food Safety.

    • Radiation Oncology and Radiotherapy Part B

      • 1st Edition
      • Volume 174
      • January 31, 2023
      • English
      • Hardback
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      • eBook
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      Radiation Oncology and Radiotherapy, Part B, Volume 174 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics including CT-assisted focal irradiation of tumors in mice, Methods to preserve correct dosimetry in small animal irradiators, Monitoring TGFbeta signaling in irradiated tumors, Cytofluorometric characterization of the lymphoid compartment of irradiated tumors, Cytofluorometric characterization of the myeloid compartment of irradiated tumors, Mass cytometry to characterize the immune infiltrate of irradiated tumors, Characterization of the immune infiltrate in irradiated mouse tumor by multiplex immunofluorescence, and much more. Other chapters cover Methods to study FOXP3+CD8+ cells in irradiated bone metastases, Luminex-based characterization of cytokine signaling by irradiated tumors, Explant-based assessment of anticancer immunity in irradiated tumors, Pipeline to characterize the TCR repertoire of irradiated tumors, Pipeline to identify tumor neoantigens exposed by radiation, and more.

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