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Elsevier

Books in Life sciences

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 83
    • English
    Advances in Clinical Chemistry, Volume 83, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest, most up-to-date technologies related to the field of clinical chemistry, with this release presenting comprehensive updates on Urinary Nucleosides and Deoxynucleosides, Locked Nucleic Acid Technology for Highly Sensitive Detection of Somatic Mutations in Cancer, Liquid Biopsy: From Basic Research to Clinical Practice, Circulating Tumor Cells and Implications of the Epithelial-to-Mesenc... Transition, and more.

  • Advances in Agronomy

    • 1st Edition
    • Volume 147
    • English
    Advances in Agronomy continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied, and exemplary of the abundant subject matter addressed by this long-running serial.

  • Forensic Toxicology

    • 1st Edition
    • Max M. Houck
    • English
    Forensic Toxicology, the latest release in the Advanced Forensic Science Series that grew out of recommendations from the 2009 NAS Report, Strengthening Forensic Science: A Path Forward will serve as a graduate level text for those studying and teaching forensic toxicology. It is also an excellent reference for the forensic practitioner’s library or for use in their casework. Coverage includes a wide variety of methods used, along with pharmacology and drugs and professional issues they may encounter. Edited by a world-renowned, leading forensic expert, this updated edition is a long overdue solution for the forensic science community.

  • Sleep, Epilepsies, and Cognitive Impairment

    • 1st Edition
    • Peter Halasz + 1 more
    • English
    Translational research connects science and clinical medicine from "the bench to the bedside." In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good "brain-gymnastics" for reconsidering the ideas on epilepsy.

  • Sixth International Congress of Neurology

    Brussels, 21–28 July 1957
    • 1st Edition
    • L. van Bogaert + 1 more
    • English
    Neurology, Volume 1 presents the proceedings of the First International Congress of Neurological Sciences, held in Brussels, Belgium, on July 21–28, 1957. This book provides information pertinent to the fundamental aspects of neurology. Organized into 107 chapters, this compilation of papers begins with an overview of the significance of genetic factors in multiple sclerosis wherein its occurrence in more than one member of a family have a very limited value. This text then examines the two common disorders, namely, cervical spondylosis and disseminated sclerosis. Other chapters explain the mechanism of demyelination problem in considering the pathology of multiple sclerosis or any of the degenerative diseases of the nervous system. This book discusses as well the commonest types of headaches observed, including tension headache, migraine headache, post-traumatic headache, and those associated with hypertension. The final chapter deals with cerebellar ataxia, chronic respiratory infection, and telangiectasia. This book is a valuable resource for neurologists, psychiatrists, and neuropsychiatrists.

  • The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence

    Proceedings of the Society for the Study of Addiction, London, 1 and 2 September 1966
    • 1st Edition
    • C. W. M. Wilson
    • English
    The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence is a collection of proceedings presented at the International Symposium on the Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence, held in London on September 1-2, 1966 under the auspices of the Society for the Study of Addiction to Alcohol and Other Drugs. The symposium provided a forum for discussing the pharmacological and epidemiological aspects of drug dependence in adolescents. Comprised of 10 chapters, this volume begins with an overview of the chemistry and pharmacology of narcotic drugs in adolescence, as well as narcotic addiction in young people in the United States. The discussion then turns to pharmacology and clinical observations on stimulant drugs and hallucinogenic drugs; the epidemiology and social pharmacology of drugs of dependence; and features of adolescent drug dependence. Regulations aimed at controlling drugs of dependence are also analyzed in relation to the national incidence of adolescent dependence in certain countries such as Britain, Belgium, Israel, and the Netherlands. The remaining chapters focus on the language, evidence, and patterns of drug abuse, together with research in relation to drugs of dependence. This book will be of interest to pharmacologists, epidemiologists, and policymakers concerned with drug dependence.

  • Biosynthesis & Integration of Cell Metabolism

    • 1st Edition
    • B C Currell + 1 more
    • English
    Biotechnology by Open Learning: Biosynthesis and the Integration of Cell Metabolism focuses on the structure and activities of cells, including nitrogen fixation, biosynthesis, and metabolic pathways. The manuscript takes a look at precursor molecules for biosynthesis, uptake of nutrients, and nitrogen and sulfur assimilation. Discussions focus on the importance of nitrogen fixation in nature, assimilation of sulfate, ammonia, nitrate, and molecular nitrogen, passive diffusion through protein channels, nutritional requirements of cells, and membranes as permeability barriers. The book then explores amino acid and nucleotide biosynthesis and biosynthesis of lipids. Topics include commercial importance of polysaccharides of micro-organisms, biosynthesis of disaccharides, oligosaccharides and polysaccharides, occurrence of carbohydrates in living systems, and metabolic links between amino acid biosynthesis and the biosynthesis of purines and pyrimidines. The text examines the integration and regulation of metabolism and control of metabolic pathway flux, including patterns of regulation of metabolic pathways, coupling agents in metabolism, integration and regulation of metabolism, and maintenance of metabolic homeostasis through energy coupling. The manuscript is a valuable source of data for biotechnologists and researchers interested in biosynthesis and integration of cell metabolism.

  • Vitamin D

    Volume 1: Biochemistry, Physiology and Diagnostics
    • 4th Edition
    • Martin Hewison + 3 more
    • English
    Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.

  • Vitamin D

    Volume 2: Health, Disease and Therapeutics
    • 4th Edition
    • Martin Hewison + 3 more
    • English
    Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus.

  • Bladder Cancer

    • 1st Edition
    • Ja Hyeon Ku
    • English
    Bladder Cancer is designed for researchers and clinicians involved in urologic practice, including urologists, medical oncologists, pathologists and radiologists. It provides comprehensive guidance for treating and understanding bladder cancer and serves as an up-to-date reference reflecting evidence-based research. The biological behavior of this disease entity shows a heterogeneous pattern with diverse morbidity and mortality depending on a variety of factors, such as tumor characteristics (tumor stage, grade, size, number, shape, and histologic subtypes) and applied treatment modalities (surgery or non-surgical management). This book presents the substantial academic developments in the field of bladder cancer in one convenient reference.

  • The Rat Brain in Stereotaxic Coordinates: Compact

    • 7th Edition
    • George Paxinos + 1 more
    • English
    The Rat Brain in Stereotaxic Coordinates Compact, Seventh Edition is a smaller sized (8.5 x 11inch), abridged version of the most referenced work in neuroscience (over 35,000 citations). The compact edition provides the coronal plates and diagrams of the current seventh edition in a smaller, more convenient spiral format and at a student friendly price. This book includes an introduction on current concepts in neuroanatomy, such as neuromeres and brain development. Students and seasoned researchers will find the first major unified nomenclature ontology tree based on development that features coronal photographic plates and juxtaposed diagrams.

  • Heart Failure in the Child and Young Adult

    From Bench to Bedside
    • 1st Edition
    • Joseph Rossano + 4 more
    • English
    Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine.

  • Fundamentals of Biologicals Regulation

    Vaccines and Biotechnology Medicines
    • 1st Edition
    • Rebecca Sheets
    • English
    Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines serves as an introduction to the international regulatory arena in which biologicals are developed and offers an overview of the processes and insight into the scientific concepts underpinning global regulations. This book will provide multiple levels of readership with guidance on basic concepts, a detailed look at regulatory challenges, and practical insight into how regulators consider regulatory science and regulatory process issues across various regions. With numerous case studies, learning activities, and real-world examples across several classes of biotechnological products, this book is a valuable and comprehensive resource for graduate students, professors, regulatory officials, and industry scientists working with biologicals.

  • Omics Technologies and Bio-engineering

    Volume 1: Towards Improving Quality of Life
    • 1st Edition
    • Debmalya Barh + 1 more
    • English
    Omics Technologies and Bio-Engineering: Towards Improving Quality of Life, Volume 1 is a unique reference that brings together multiple perspectives on omics research, providing in-depth analysis and insights from an international team of authors. The book delivers pivotal information that will inform and improve medical and biological research by helping readers gain more direct access to analytic data, an increased understanding on data evaluation, and a comprehensive picture on how to use omics data in molecular biology, biotechnology and human health care.

  • FDA's Drug Review Process and the Package Label

    Strategies for Writing Successful FDA Submissions
    • 1st Edition
    • Tom Brody
    • English
    FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data that are fragmentary, ambiguous, or that detract from the drug's approvability, and the book reveals how sponsors overcame FDA's concerns and how sponsors succeeded in persuading FDA to grant approval of the drug. The book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely text and data from NDAs and BLAs, as published on FDA's website. The source material for writing this book included about 80,000 pages from FDA's Medical Reviews, FDA's Clinical Pharmacology Reviews, and FDA's Pharmacology Reviews, from one hundred different NDAs or BLAs for one hundred different drugs. Each chapter focuses on a different section of the package label, e.g., the Dosage and Administration section or the Drug Interactions section, and demonstrates how the sponsor's data supported that section of the package label.

  • Die Design for Extrusion of Plastic Tubes and Pipes

    • 1st Edition
    • Sushil Kainth
    • English
    This book is a step-by-step guide to die design for tubes and pipes. It offers unique coverage of the topic from a highly practical perspective. Written for plastics processing and design engineers, technical and manufacturing managers, die designers and manufacturers. This comprehensive guide includes worked examples to illustrate problem solving and detailed drawings of complete dies for various applications. It covers mono- and multilayers pipes, as well as important melt flow variables (e.g., pressure drop, shear stress, shear rate, temperature variations, distribution variations) of key materials determined using FEM software.

  • Comprehensive Toxicology

    • 3rd Edition
    • Charlene McQueen
    • English
    Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology.

  • Boorman's Pathology of the Rat

    Reference and Atlas
    • 2nd Edition
    • Andrew W. Suttie + 6 more
    • English
    Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations.

  • Imaging of Brain Concussion, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 28-1
    • Roy Riascos + 1 more
    • English
    This issue of Neuroimaging Clinics of North America focuses on Imaging of Brain Concussion, and is edited by Drs. Roy Riascos and Eliana E. Bonfante-Mejia. Articles will include: Traumatic Brain Injury: definition, neurosurgery, trauma-orthopedics, neuroimaging, and psychology-psychiatr... Multimodality advanced imaging for brain concussions; Perfusion weighted images in brain concussion; PET and SPECT in brain concussion; Imaging of chronic concussion; Imaging of concussion in young athletes; Imaging on concussion in blast injury; Conventional CT and MR in brain concussion; Structural imaging: structural MRI in concussion; Susceptibility weighted imaging and MR spectroscopy in concussion; Functional imaging fMRI – BOLD and resting state techniques in mTBI; Diffusion Weighted and Diffusion Tensor Imaging in mTBI; and more!

  • Personalized Predictive Modeling in Type 1 Diabetes

    • 1st Edition
    • Eleni I. Georga + 2 more
    • English
    Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures.

  • Advances in Agricultural Animal Welfare

    Science and Practice
    • 1st Edition
    • Joy Mench
    • English
    Advances in Agricultural Animal Welfare fully explores developments in the key areas of agricultural animal welfare assessment and improvement. Analyzing current topical issues, as well as reviewing the historical welfare issues, the volume is a comprehensive review of the field. Divided into five sections, the book opens in Part One by reviewing advances in animal welfare science, examining cognitive psychology, genetics and genomics. Part Two then looks at transdisciplinary research in animal welfare, with coverage of bioethics, welfare and sustainability from both environmental and food safety perspectives. Part Three explores the process of translating science into policy and practice, followed by discussion on the global achievability of welfare standards in Part Four. Finally, Part Five highlights some emerging issues in agricultural animal welfare. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep, pigs, poultry and aquaculture. With its expert editor and international team of contributors, Advances in Agricultural Animal Welfare is a key reference tool for welfare research scientists and students, practicing vets involved in welfare assessment, and indeed anyone with a professional interest in the welfare of agricultural animals.

  • Cheetahs: Biology and Conservation

    Biodiversity of the World: Conservation from Genes to Landscapes
    • 1st Edition
    • English
    Cheetahs: Biology and Conservation reports on the science and conservation of the cheetah. This volume demonstrates the interdisciplinary nature of research and conservation efforts to study and protect the cheetah. The book begins with chapters on the evolution, genetics, physiology, ecology and behavior of the species, as well as distribution reports from range countries. These introductory chapters lead into discussions of the challenges facing cheetah survival, including habitat loss, declining prey base, human-wildlife conflict, illegal trade, and newly-emerging threats, notably climate change. This book also focuses on conservation strategies and solutions, including environmental education and alternative livelihoods. Chapters on the role of captive cheetahs to conservation and the long-term research of the species are included, as are a brief discussion of the methods and analyses used to study the cheetah. The book concludes with the conservation status and future outlook of the species. Cheetahs: Biology and Conservation is a valuable resource for the regional and global communities of cheetah conservationists, researchers, and academics. Although cheetah focussed the book provides information relevant to the study of broader topics such as wildlife conservation, captive breeding, habitat management, conservation biology and animal behaviour. Cover photograph by Angela Scott

  • Dyneins

    Dynein Mechanics, Dysfunction, and Disease
    • 2nd Edition
    • Stephen M. King
    • English
    Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease.

  • Advances in Cattle Welfare

    • 1st Edition
    • Cassandra Tucker
    • English
    Advances in Cattle Welfare provides a targeted overview of contemporary issues in dairy and beef cattle welfare. The volume addresses welfare-related topics in both research and on-farm applications. Opening with an introduction to cattle production systems, the book covers the three major areas of cattle welfare; on-farm welfare assessment, behavioral priorities of cattle and novel perspectives on specific aspects of management. Chapters examine the key issues within each area, including such topics as the goals and measures included in welfare assessments, the importance to cattle of access to pasture and engaging in social behavior, human-animal interactions, painful procedures, and disease and metabolic challenge. This book is an essential part of the wider ranging series Advances in Farm Animal Welfare, with coverage of cattle, sheep and pigs. With its expert editor and international team of contributors, Advances in Cattle Welfare is a key reference tool for welfare research scientists and students, veterinarians involved in welfare assessment, and indeed anyone with a professional interest in the welfare of cattle.

  • Textbook of Nephro-Endocrinology

    • 2nd Edition
    • Ajay K. Singh + 1 more
    • English
    Textbook of Nephro-Endocrinology... Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology... investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypoca... and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid–base disturbances, and pregnancy.

  • Encyclopedia of Cardiovascular Research and Medicine

    • 1st Edition
    • Volume 4
    • Douglas B. Sawyer + 1 more
    • English
    Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focus... basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine.

  • Multiple Sclerosis, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 36-1
    • Darin T. Okuda
    • English
    This issue of Neurologic Clinics, edited by Dr. Darin T. Okuda, focuses on Multiple Sclerosis. Topics include, but are not limited to, Myelin and Axonal Repair Strategies in Multiple Sclerosis; Common Clinical and Imaging Conditions Misdiagnosed as Multiple Sclerosis; Topographical Model for Multiple Sclerosis: A Novel Approach to Understanding Clinical Phenotypes and Disease Activity; Incidental Anomalies Characteristic of CNS Demyelination: Radiologically Isolated Syndrome; Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management; Progressive Forms of Multiple Sclerosis: Distinct Entity or Time Dependent Phenomena; Advanced Symptom Management Strategies in Multiple Sclerosis, Ethnic Considerations and Multiple Sclerosis Disease Variability; The Dynamics of the Gut Microbiome in Multiple Sclerosis in Relation to Disease; Spinal Cord Imaging in Relation to Clinical Status in Multiple Sclerosis, and more.

  • Manual of Chronic Total Occlusion Interventions

    A Step-by-Step Approach
    • 2nd Edition
    • Emmanouil Brilakis
    • English
    Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach, Second Edition, is an easy to read reference for coronary chronic total occlusion interventions (CTO). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, what pitfalls to watch out for, and troubleshooting tactics necessary for coronary chronic total occlusion interventions (CTO). This second edition is updated with new developments in the field. The 2nd edition covers techniques like the Carlino technique, "scratch and go", "BASE", double-blind stick and swap, and subintimal crush, along with tips about how to use the latest complex PCI equipment. It also covers recently published trials, CTO scores and hybrid series. Written to bring a practical and easy to read approach, this book is perfect for interventional cardiologists, interventional and general cardiology fellows, cardiology researchers, physicians, cardiac catheterization laboratory personnel, technical staff,industry professionals and everyone else interested in understanding the cutting edge and rapidly evolving field of coronary CTO interventions.　　

  • Hazard Analysis and Risk Based Preventive Controls

    Building a (Better) Food Safety Plan
    • 1st Edition
    • Patricia A. Wester
    • English
    Hazard Analysis and Risk Based Preventive Controls: Building a (Better) Food Safety Plan is directed to those food safety professionals charged with ensuring or assisting with FSMA’s preventative controls (PC) implementation and compliance in their routine job duties. The target audience includes those currently involved in the development, management, and execution of HACCP and/or other advanced food safety management systems, as well as those interested in advancing their knowledge base to gain a more thorough comprehension of HARPC requirements. FSMA topics covered include: identifying the food safety team and PCQI; creating the HARPC implementation strategy; starting the food safety plan; conducting a thorough hazard analysis; identifying adequate preventive control measures; determining appropriate PC management components; recognizing applicable verification and validation activities; supply chain management program; recall plans. Other operational topics include: document control systems; internal audit programs; third party audit management; regulatory visit preparation; and maintaining compliance.

  • Encyclopedia of Marine Mammals

    • 3rd Edition
    • Bernd Würsig + 2 more
    • English
    The Encyclopedia of Marine Mammals, Third Edition covers the ecology, behavior, conservation, evolution, form and function of whales, dolphins, seals, sea lions, manatees, dugongs, otters and polar bears. This edition provides new content on anthropogenic concerns, latest information on emerging threats such as ocean noise, and impacts of climate change. With authors and editors who are world experts, this new edition is a critical resource for all who are interested in marine mammals, especially upper level undergraduate and graduate students, researchers, and managers, and is a top reference for those in related fields, from oceanographers to environmental scientists.

  • Hepatitis C in Developing Countries

    Current and Future Challenges
    • 1st Edition
    • Sanaa M. Kamal
    • English
    Hepatitis C in Developing Countries: Current and Future Challenges explores the current state of HCV in several countries, including Africa, Asia and South America. It maintains a dedicated focus on the epidemiology, clinical patterns, virologic diversity, coinfections, natural history and progression, complications, and response to standard of care (SOC) pegylated interferon and ribavirin therapy of HCV with recommendations specific to middle and low income countries. Readers will find detailed information on the burden of HCV infection from a global health and economic perspective, along with data from multicenter trials on DAAs that have enrolled patients infected with HCV non-genotype 1.

  • Inhaled Pharmaceutical Product Development Perspectives

    Challenges and Opportunities
    • 1st Edition
    • Anthony J. Hickey
    • English
    Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future.

  • Neurofeedback

    Tools, Methods and Applications
    • 1st Edition
    • Pascale Vincent
    • English
    The artificial intelligence of robots capable of learning from their errors and modifying their behavior accordingly is modeled on the activity of neurons in the brain.Emotional stress, traffic accidents, bereavement; these are all factors that can disrupt this neural activity, sometimes to the point of generating suffering that can be difficult to relieve. Neurofeedback, derived from neuroscience, is a computerized technique for training and re-balancing the brain’s electrical activity using neuroplasticity, which allows the brain to self-correct and regain a stable equilibrium, thus promoting recovery from traumas and a return to well-being. Neurofeedback: Tools, Methods and Applications deals with neurofeedback, explaining the functioning of the tool, its action on the equilibration of neural activity, and the differences between classical and dynamic systems. The results of the author's research and observations, the applications of these two tools, and the effects produced on the patients are explored, along with testimonies that describe and explain concepts in detail.Different neurofeedback tools are presented in this book, together with their function and explicit specificities adapted to the needs of each user. Their applications to psychological and cognitive disorders make neurofeedback an efficient and promising neurotherapy technique.

  • Dyneins

    The Biology of Dynein Motors
    • 2nd Edition
    • Stephen M. King
    • English
    Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.

  • Fruit Juices

    Extraction, Composition, Quality and Analysis
    • 1st Edition
    • Gaurav Rajauria + 1 more
    • English
    Fruits Juices is the first and only comprehensive resource to look at the full scope of fruit juices from a scientific perspective. The book focuses not only on the traditional ways to extract and preserve juices, but also the latest novel processes that can be exploited industrially, how concentrations of key components alter the product, and methods for analysis for both safety and consumer acceptability. Written by a team of global experts, this book provides important insights for professionals in industrial and academic research as well as in production facilities.

  • The Cardiovascular System

    Development, Plasticity and Physiological Responses
    • 1st Edition
    • Volume 36B
    • A. Kurt Gamperl + 3 more
    • English
    The Cardiovascular System: Phenotypic and Physiological Responses, Volume 37, part of a two-volume set, provides comprehensive coverage of the current state of knowledge in this very active and growing field of research, also highlighting the tremendous diversity in cardiovascular morphology and function among the various fish taxa and the anatomical and physiological plasticity shown by this system when faced with various abiotic and biotic challenges. Specific chapters in this updated book include Research Technologies/Methodo... for Studying Fish Cardiovascular Function, Cardiovascular Development in Embryonic and Larval Fishes, Cardiovascular Responses to Limiting Oxygen Levels, and Temperature and the Cardiovascular System. The book's chapters integrate molecular and cellular data with the growing body of knowledge on heart and in vivo cardiovascular function, and as a result, provide insights into some of the most interesting, and important, questions that still need to be answered in this field.

  • Platform Technologies in Drug Discovery and Validation

    • 1st Edition
    • Volume 50
    • English
    Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides.

  • Temporal Sampling and Representation Updating

    • 1st Edition
    • Volume 236
    • English
    Temporal Sampling and Representation Updating, Volume 236, addresses the gap between laboratory studies using static or predictable stimuli and the more complex change that is a characteristic of the real world. Topics in this new volume include a section on Unfolding the time course of emotion perception, Temporal sampling and representation updating for action in interception and grasping tasks, The influence of Cognitive Control and Attention on Temporal Sampling: Lessons from the Attentional Blink, Synchronizing tracking eye movements with the motion of a visual target, and Sampling feature distributions with visual search in heterogeneous displays.

  • Sustainable Management of Arthropod Pests of Tomato

    • 1st Edition
    • Waqas Wakil + 2 more
    • English
    Sustainable Management of Arthropod Pests of Tomato provides insight into the proper and appropriate application of pesticides and the integration of alternative pest management methods. The basis of good crop management decisions is a better understanding of the crop ecosystem, including the pests, their natural enemies, and the crop itself. This book provides a global overview of the biology and management of key arthropod pests of tomatoes, including arthropod-vectored diseases. It includes information that places tomatoes in terms of global food production and food security, with each pest chapter including the predators and parasitoids that have specifically been found to have the greatest impact on reducing that particular pest. In-depth coverage of the development of resistance in tomato plants and the biotic and abiotic elicitors of resistance and detailed information about the sustainable management of tomato pests is also presented.

  • Risk Management of Complex Inorganic Materials

    A Practical Guide
    • 1st Edition
    • Violaine Verougstraete
    • English
    Risk Management of Complex Inorganic Materials: A Practical Guide facilitates the risk assessment and management of complex inorganic materials around the world by providing accessible and specific guidance on their assessment. Inorganic complex materials, such as ores and concentrates, metal containing- glasses, ceramic and inorganic pigments, alloys, and UVCBs produced during the manufacturing of metals present specificities not addressed by most guidance documents. This book explains the main characteristics of inorganic complex materials affecting their hazard and risk assessment and management, including their source and main uses, also covering hazard and exposure assessment, risk characterization and risk management. It is an essential reference for regulators involved in risk assessment and risk management, industry experts charged of compliance with chemical management program requirements, consultants preparing chemicals management files for companies and regulators, and academics involved in research on complex inorganic materials.

  • HIV/AIDS

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy + 1 more
    • English
    HIV/AIDS: Oxidative Stress and Dietary Antioxidants provides comprehensive coverage of oxidative stress in HIV/AIDS, focusing on both the pathological process around molecular and cellular metabolism and the complications that can arise due to nutritional imbalance. It provides a pathway for researchers and clinicians to gain an in-depth understanding of the role of oxidative stress, bridging the transdisciplinary divide between virologists, immunologists, physicians, clinical workers, food scientists and nutritionists to advance medical sciences and enable preventative treatment strategies. Very often oxidative stress is a feature of HIV/AIDs or of the treatment of HIV/AIDs. While immunologists, physicians and clinical workers understand the processes in HIV/AIDs, they may be less conversant in the science of nutrition and dietetics. Similarly, nutritionists and dietitians may be less conversant with the detailed clinical background and science of HIV/AIDs.

  • Fungal Phylogenetics and Phylogenomics

    • 1st Edition
    • Volume 100
    • English
    Fungal Phylogenetics and Phylogenomics, Volume 100, the latest release in the Advances in Genetics series, presents users with new chapters that delve into such topics as the Advances of fungal phylogenomics and the impact on fungal systematics, Data crunching for fungal phylogenomics: insights into data collection and phylogenetic inference based on genome data for fungi, Genomic and epigenomic traits of emerging fungal pathogens, Advances in fungal gene cluster diversity and evolution, Phylogenomics of Fusarium oxysporum species complex, Phylogenomic analyses of pathogenic yeasts, and the Phylogenetics and phylogenomics of rust fungi. The series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • The Human Microbiome

    • 1st Edition
    • Volume 44
    • English
    Methods in Microbiology, Volume 44 presents the latest volume in the most prestigious series devoted to techniques and methodology in the field, with updated chapters that cover Metabolomics and the vaginal microbial ecosystem and health, Esophageal microbiome, Bioinformatics methods, Evolution of biomolecules, genomes and communities, and Gut microbial metabolism or the acquisition of the gut microbiome. Established for over 30 years, this comprehensive series provides ready-to-use recipes, the latest emerging techniques, and novel approaches on tried, tested and established methods.

  • Cerebrospinal Fluid in Neurologic Disorders

    • 1st Edition
    • Volume 146
    • English
    Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice.

  • The Lateralized Brain

    The Neuroscience and Evolution of Hemispheric Asymmetries
    • 1st Edition
    • Sebastian Ocklenburg + 1 more
    • English
    The Lateralized Brain: The Neuroscience and Evolution of Hemispheric Asymmetries is an up-to-date teaching resource for neuroscience faculty members that teach courses concerning hemispheric asymmetries. The book provides students with all relevant information on the subject, while also giving aspiring researchers in the field an up-to-date overview of relevant, previous work. It is ideal for courses on hemispheric asymmetries, that is, the functional or structural differences between the left and the right hemispheres of the brain, and also highlights how the widespread use of modern neuroimaging techniques, such as fMRI and DTI has completely changed the way hemispheric asymmetries are currently investigated. According to the preface, the main aim of The Lateralized Brain is to provide "an up-to-date teaching resource on hemispheric asymmetries … [and] to introduce undergraduate students of all levels to the fascinating topics of hemispheric asymmetries" (p. xv)… (Sebastian Ocklenburg and Onur Güntürkün) have succeeded admirably in their stated aim and are to be congratulated on undertaking the mammoth task they set themselves. They can be proud of what they have accomplished.~ Alan A. Beaton, Department of Psychology, Swansea University, Swansea, UK, in Laterality: Asymmetries of Body, Brain and Cognition, July, 2018.

  • Principles and Practice of Clinical Research

    • 4th Edition
    • John I. Gallin + 2 more
    • English
    Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and “omic” platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research.

  • Skin Tissue Models

    • 1st Edition
    • Alexandra P. Marques + 3 more
    • English
    Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury – from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies. The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models.

  • Meat Analogs

    Challenges and Perspectives
    • 1st Edition
    • Christophe Terrien
    • English
    Meat Analogs: Challenges and Perspectives provides an overview on the subject that is followed by an inventory of research perspectives to highlight the importance of issues and research relating to meat analogs. It explores the severe demographic, ecological, and economic and sociological constraints and uncertainties that exist in the allocation of food production resources. Alternative solutions, in particular meat substitutes, aka, meat analogs or mock-meats are discussed, as are dietary patterns and the control of markets.

  • Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health

    • 1st Edition
    • Suresh C Sikka + 1 more
    • English
    Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men’s reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health.

  • Handbook of Neuroemergency Clinical Trials

    • 2nd Edition
    • Brett E. Skolnick + 1 more
    • English
    Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development.

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