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Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human… Read more
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Immediately download your ebook while waiting for your print delivery. No promo code needed.
Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D.
This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.
Academic, medical, and pharmaceutical researchers in bone biology, physiology, biochemistry; clinician researchers in endocrinology, nephrology, oncology, immunology, orthopedic surgery, and radiology
Volume 1: Biochemistry, Physiology and Diagnostics
Preface
David Feldman, J. Wesley Pike, Roger Bouillon, Edward Giovannucci, David Goltzman and Martin Hewison
In Memoriam: Robert P. Heaney, MD (1928-2016)
Robert R. Recker and Joan M. Lappe
In Memoriam: Milan Uskokovic, PhD (1924-2015)
Sylvia Christakos, Hubert Maehr, and Nanjoo Suh
Section I. History, Chemistry Metabolism, Circulation & Regulation
1. Historical Overview of Vitamin D
Hector F. DeLuca
2. Evolutionary Biology: Mysteries of Vitamin D in Fish
David R. Fraser
3. Evolution of Human Skin Color and Vitamin D
Nina G. Jablonski
4. Photobiology of Vitamin D
Michael F. Holick
5. The Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases)
Glenville Jones, David E. Prosser, and Martin Kaufmann
6. CYP24A1: Structure, Function, and Physiological Role
René St-Arnaud and Glenville Jones
7. The Vitamin D Binding Protein DBP
Roger Bouillon and Steven Pauwels
8. Regulation of renal and extra-renal 1α-hydroxylase
Dean P. Larner, John S. Adams, and Martin Hewison
Section II. Mechanism of Action
9. Genome-Wide Perspectives on Vitamin D Receptor-Meditated Control of Gene Expression in Target Cells
J. Wesley Pike, Mark B. Meyer, Seong Min Lee, Melda Onal, and Nancy Benkusky
10. Diverse mechanisms of transcriptional regulation by the vitamin D receptor
John H. White, Reyhaneh Salehi-Tabar, Vassil Dimitrov, and Manuella Bouttier
11. Structural basis for ligand activity in VDR
Anna Y. Belorusova and Natacha Rochel
12. Ligand Independent Actions of Vitamin D Receptor
Gilles Laverny and Daniel Metzger
13. Vitamin D and Chromatin
Carsten Carlberg
14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions with VDR
Mark B. Meyer, Nancy A. Benkusky, J. Wesley Pike
15. Vitamin D and microRNAs
Hengguang Zhao, Sri Ramulu N. Pullagura, Sandra Rieger and Thomas S. Lisse
16. Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions
Mathew T. Mizwicki, Anthony W. Norman
Section III. Mineral and Bone Homeostasis
17. Vitamin D Regulation of Osteoblast Function
Jeroen van de Peppel, Renny T. Franceschi, Yan Li, and Bram C.J. van der Eerden
18. Osteoclastogenesis and Vitamin D
Yuko Nakamichi, Naoyuki Takahashi, Nobuyuki Udagawa, and Tatsuo Suda
19. Vitamin D Activities in Osteocytes
Paul H. Anderson, Gerald J. Atkins, Howard A. Morris, and David M. Findlay
20. Regulation of Intestinal Calcium and Phosphate Absorption
James C. Fleet
21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6
Sylvia Christakos, Leila J. Mady, and Puneet Dhawan
22. Calcium homeostasis and eggshell biomineralization in female chicken
Yves Nys and Nathalie Le Roy
23. Mineralization in Mammals
Adele L. Boskey
24. Cartilage
Barbara D. Boyan, Maryam Doroudi, Kayla Scott, and Zvi Schwartz
25. Vitamin D and Bone: An Integrated Approach
Geert Carmeliet
Section IV. Extra-Skeletal Targets
26. Vitamin D and the Kidney
Peter J. Tebben and Rajiv Kumar
27. Vitamin D and the Parathyroids
Justin Silver and Tally Naveh-Many
28. The Calcium-sensing Receptor and Vitamin D
Geoffrey N. Hendy
29. Vitamin D in Dentoalveolar and Oral Health
Brian L. Foster and Philippe P. Hujoel
30. The Role of Vitamin D and its Receptor in Hair Follicle Biology
Marie B. Demay
31. Vitamin D, Calcium and the Epidermis
Daniel D Bikle
32. Vitamin D and the Cardiovascular System
Amy E. Riek, Rithwick Rajagopal, and Carlos Bernal-Mizrachi
33. Vitamin D Brain Development and Function
Darryl Eyles and John McGrath
34. Vitamin D, VDR and Adipose Tissue: Focus on Cellular Mechanisms
Carmen J. Narvaez, Donald G. Matthews, and JoEllen Welsh
35. Vitamin D and Skeletal Muscle
Christian M. Girgis
36. Understanding Vitamin D from mouse knockout models
David Goltzman, Geoffrey N. Hendy, Andrew C. Karaplis, Richard Kremer, Denshun Miao
Section V. Human Physiology
37. Pharmacology and pharmacokinetics
Inez Schoenmakers and Kerry S. Jones
38. Vitamin D Role in the Calcium and Phosphorus Economies
Robert P. Heaney and Laura A.G. Armas
39. Fetus, Neonate and Infant
Christopher S. Kovacs
40. Consequences of perinatal vitamin D deficiency on later bone health
Cyrus Cooper, Elizabeth M. Curtis, Rebecca J. Moon, Elaine M. Dennison, and Nicholas C. Harvey
41. Adolescence and Acquisition of Peak Bone Mass
Richard Lewis, Emma Laing, and Connie Weaver
42. Pregnancy, Lactation, and Post-Weaning Recovery
Christopher S. Kovacs
43. Role in Reproductive Biology and Reproductive Dysfunction in Women
Lubna Pal and Hugh S. Taylor
44. Vitamin D, reproductive biology, and dysfunction in men
Ida Marie Boisen, Lasse Bøllehuus Hansen, Li Juel Mortensen, and Martin Blomberg Jensen
45. Vitamin D and the Renin-Angiotensin System
Yan Chun Li
46. Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin
John J. Wysolmerski
47. FGF23 Counter Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity
L. Darryl Quarles
Section VI. Diagnosis and Management
48. Approach to the Patient with Metabolic Bone Disease
Michael P. Whyte
49. Detection of 1,25-Dihydroxyvitamin D in Human Serum using Receptor Assisted Chemiluminescent Hormone Assay (REACH) Technology
Fabrizio Bonelli, and Bruce W. Hollis
50. Mass Spectrometry Assays of Vitamin D Metabolites
Martin Kaufmann, Lusia Sepiashvili, and Ravinder J. Singh
51. Free Vitamin D: Concepts, Assays, Outcomes and Prospects
Rene F. Chun and Carrie M. Nielson
52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems and Interpretation
Christopher T. Sempos, Graham D. Carter, and Neil C. Binkley
53. Bone Histomorphometry
Juliet Compston, Linda Skingle, and David W. Dempster
54. Radiology of Rickets and Osteomalcia
Judith E. Adams
55. High-resolution Imaging Techniques for Bone Quality Assessment
Andrew J. Burghardt, Roland Krug, Sharmila Majumdar
56. The Role of Vitamin D in Orthopedic Surgery
Aasis Unnanuntana, Aleksey Dvorzhinskiy, Brian J. Rebolledo, Shevaun M. Doyle, Panagiota Andreopoulou, and Joseph M. Lane
Introduction to chapters 57 a and b
57a. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position
Roger Bouillon and Cliff Rosen
57b. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position
Reinhold Vieth and Michael F. Holick
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